Morphological Correlates of Mechanotransduction in Acousticolateral Hair Cells

The development of ideas on mechanotransduction in acousticolateral hair cells is described, leading to the current idea that transduction depends on deflection of the bundle of stereocilia by a force parallel to the plane of the sensory epithelium. Electrophysiological experiments are summarised, suggesting that transduction depends on a shear between the different rows of stereocilia, and that the transducer channels are situated towards the tips of the stereocilia. Analysis of the ways that shear between the rows of stereocilia could be detected suggests that tip links are the structures which are most likely to transmit the stimulus-induced forces to the transducer channels on the membrane. The directional selectivity of mechanotransduction is associated with the position of the kinocilium and gradation in heights of the stereocilia; evidence is presented suggesting that in the lateral line these are partly determined by the mitosis giving rise to the hair cell. Tip links differentiate out of links which initially join the stereocilia in all directions, with their final spatial organisation, which sets the directional selectivity of mechanotransduction, probably being determined by the gradient in growth of the stereocilia

A novel onset detection technique for brain?computer interfaces using sound-production related cognitive tasks in simulated-online system

Objective. Self-paced EEG-based BCIs (SP-BCIs) have traditionally been avoided due to two sources of uncertainty: (1) precisely when an intentional command is sent by the brain, i.e., the command onset detection problem, and (2) how different the intentional command is when compared to non-specific (or idle) states. Performance evaluation is also a problem and there are no suitable standard metrics available. In this paper we attempted to tackle these issues. Approach. Self-paced covert sound-production cognitive tasks (i.e., high pitch and siren-like sounds) were used to distinguish between intentional commands (IC) and idle states. The IC states were chosen for their ease of execution and negligible overlap with common cognitive states. Band power and a digital wavelet transform were used for feature extraction, and the Davies?Bouldin index was used for feature selection. Classification was performed using linear discriminant analysis. Main results. Performance was evaluated under offline and simulated-online conditions. For the latter, a performance score called true-false-positive (TFP) rate, ranging from 0 (poor) to 100 (perfect), was created to take into account both classification performance and onset timing errors. Averaging the results from the best performing IC task for all seven participants, an 77.7% true-positive (TP) rate was achieved in offline testing. For simulated-online analysis the best IC average TFP score was 76.67% (87.61% TP rate, 4.05% false-positive rate). Significance. Results were promising when compared to previous IC onset detection studies using motor imagery, in which best TP rates were reported as 72.0% and 79.7%, and which, crucially, did not take timing errors into account. Moreover, based on our literature review, there is no previous covert sound-production onset detection system for spBCIs. Results showed that the proposed onset detection technique and TFP performance metric have good potential for use in SP-BCIs

The Palomar Transient Factory photometric catalog 1.0

We construct a photometrically calibrated catalog of non-variable sources from the Palomar Transient Factory (PTF) observations. The first version of this catalog presented here, the PTF photometric catalog 1.0, contains calibrated R_PTF-filter magnitudes for about 21 million sources brighter than magnitude 19, over an area of about 11233 deg^2. The magnitudes are provided in the PTF photometric system, and the color of a source is required in order to convert these magnitudes into other magnitude systems. We estimate that the magnitudes in this catalog have typical accuracy of about 0.02 mag with respect to magnitudes from the Sloan Digital Sky Survey. The median repeatability of our catalog's magnitudes for stars between 15 and 16 mag, is about 0.01 mag, and it is better than 0.03 mag for 95% of the sources in this magnitude range. The main goal of this catalog is to provide reference magnitudes for photometric calibration of visible light observations. Subsequent versions of this catalog, which will be published incrementally online, will be extended to a larger sky area and will also include g_PTF-filter magnitudes, as well as variability and proper motion information.Comment: 6 pages, 6 figures, PASP in pres

Frequency decoding of periodically timed action potentials through distinct activity patterns in a random neural network

Frequency discrimination is a fundamental task of the auditory system. The mammalian inner ear, or cochlea, provides a place code in which different frequencies are detected at different spatial locations. However, a temporal code based on spike timing is also available: action potentials evoked in an auditory-nerve fiber by a low-frequency tone occur at a preferred phase of the stimulus-they exhibit phase locking-and thus provide temporal information about the tone's frequency. In an accompanying psychoacoustic study, and in agreement with previous experiments, we show that humans employ this temporal information for discrimination of low frequencies. How might such temporal information be read out in the brain? Here we demonstrate that recurrent random neural networks in which connections between neurons introduce characteristic time delays, and in which neurons require temporally coinciding inputs for spike initiation, can perform sharp frequency discrimination when stimulated with phase-locked inputs. Although the frequency resolution achieved by such networks is limited by the noise in phase locking, the resolution for realistic values reaches the tiny frequency difference of 0.2% that has been measured in humans.Comment: 16 pages, 5 figures, and supplementary informatio

Photometric redshifts as a tool to study the Coma cluster galaxy populations

We investigate the Coma cluster galaxy luminosity function (GLF) at faint magnitudes, in particular in the u* band by applying photometric redshift techniques applied to deep u*, B, V, R, I images covering a region of ~1deg2 (R 24). Global and local GLFs in the B, V, R and I bands obtained with photometric redshift selection are consistent with our previous results based on a statistical background subtraction. In the area covered only by the u* image, the GLF was also derived after applying a statistical background subtraction. The GLF in the u* band shows an increase of the faint end slope towards the outer regions of the cluster (from alpha~1 in the cluster center to alpha~2 in the cluster periphery). This could be explained assuming a short burst of star formation in these galaxies when entering the cluster. The analysis of the multicolor type spatial distribution reveals that late type galaxies are distributed in clumps in the cluster outskirts, where X-ray substructures are also detected and where the GLF in the u* band is steeper.Comment: 14 pages, 2 figures in jpeg format, accepted in A&

The Ha luminosity function and star formation rate up to z~1

We describe ISAAC/ESO-VLT observations of the Ha(6563) Balmer line of 33 field galaxies from the Canada-France Redshift Survey (CFRS) with redshifts selected between 0.5 and 1.1. We detect Ha in emission in 30 galaxies and compare the properties of this sample with the low-redshift sample of CFRS galaxies at z~0.2 (Tresse & Maddox 1998). We find that the Ha luminosity, L(Ha), is tightly correlated to M(B(AB)) in the same way for both the low- and high-redshift samples. L(Ha) is also correlated to L([OII]3727), and again the relation appears to be similar at low and high redshifts. The ratio L([OII])/L(Ha) decreases for brighter galaxies by as much as a factor 2 on average. Derived from the Ha luminosity function, the comoving Ha luminosity density increases by a factor 12 from =0.2 to =1.3. Our results confirm a strong rise of the star formation rate (SFR) at z<1.3, proportional to (1+z)^{4.1+/-0.3} (with H_0=50 km/s/Mpc, q_0=0.5). We find an average SFR(2800 Ang)/SFR(Ha) ratio of 3.2 using the Kennicutt (1998) SFR transformations. This corresponds to the dust correction that is required to make the near UV data consistent with the reddening-corrected Ha data within the self-contained, I-selected CFRS sample.Comment: 16 pages, 16 figures and 3 tables included, figures and text updated, same results as in the 1st version, accepted in MNRA

Awareness and utilization of HIV testing and prevention services among female sex workers in Dnipro, Ukraine: implications for prevention program strengthening from the dynamics study

INTRODUCTION: Approximately 240,000 people live with HIV in Ukraine, concentrated among key populations, including sex workers. Non-governmental organizations (NGOs) play an important role in the funding and delivery of HIV testing and prevention services in Ukraine. These services are set within the context of national healthcare reforms as well as ongoing armed conflict. This study seeks to describe and understand the usage of HIV testing and prevention services among sex workers in the eastern Ukrainian city of Dnipro. METHODS: A cross-sectional bio-behavioral survey was administered in September 2017-March 2018 among 560 sex workers working in Dnipro. Descriptive analyses of survey data are presented alongside multivariable logistic regression models identifying factors associated with NGO awareness and HIV testing in the past 12 months; adjusted odds ratios (AOR) and 95% confidence intervals (95% CI) are reported. RESULTS: Sixty-two percent of respondents were aware of NGOs offering HIV services. Sixty-eight percent had tested for HIV in the past 12 months, and 51% of those who reported the location of their most recent test were tested at an NGO. Those with 5-9 years in sex work had greater odds of being aware of NGOs (AOR = 5.5, 95%CI: 3.2-9.7) and testing for HIV (AOR = 3.4, 95%CI: 2.0-6.0) compared to those new to the profession. Contact with outreach workers was strongly associated with increased odds of testing (AOR = 13.0, 95%CI: 7.0-24.0). Sex workers in "offices" (brothel-like venues) reported higher odds of testing than all other workplaces, while those in entertainment venues (AOR = 0.3, 95%CI: 0.2-0.5) and public places (AOR = 0.2, 95%CI: 0.1-0.3) reported lower rates. Receiving prevention services, such as free condoms, was associated with increased testing (AOR = 16.9, 95%CI: 9.7-29.3). DISCUSSION: NGOs in Dnipro, Ukraine play an important role in HIV testing and prevention for women involved in sex work. However, focused efforts should be placed on supporting access to these services for women that are newer to sex work, and those working in entertainment venues or public places. Outreach workers appear to support access to HIV prevention information and supplies and facilitate linkages to HIV testing for sex workers