COTORRA: COntext-aware Testbed fOR Robotic Applications

Edge & Fog computing have received considerable attention as promising candidates for the evolution of robotic systems. In this letter, we propose COTORRA, an Edge & Fog driven robotic testbed that combines context information with robot sensor data to validate innovative concepts for robotic systems prior to being applied in a production environment. In lab/university, we established COTORRA as an easy applicable and modular testbed on top of heterogeneous network infrastructure. COTORRA is open for pluggable robotic applications. To verify its feasibility and assess its performance, we ran set of experiments that show how autonomous navigation applications can achieve target latencies bellow 15ms or perform an inter-domain (DLT) federation within 19 seconds.Comment: 4 pages, 4 figures, submitted to IEEE Communications Letter

Evaluación de curva de potencia en plataforma de ensayo para aerogeneradores de baja potencia

El presente trabajo expone los resultados del ensayo de curva de potencia de un aerogenerador de baja potencia, en configuración para carga de baterías, según lo metodología definida por la norma IEC 61400-12, anexo H. Las mediciones implicadas en este ensayo se realizaron entre mayo y agosto de 2013 en el Laboratorio de Ensayos de Aerogeneradores del INTI en la ciudad se Cutral-Có (Neuquén). El aerogenerador, cuyos resultados se exponen, es uno de los equipos de fabricación nacional que están siendo ensayados por INTI en el marco de un programa nacional de fortalecimiento sectorial. Se presentan las curvas de potencia para tres niveles de carga de banco de baterías, la energía anual producida y la intensidad de turbulencia, entre otras mediciones realizadas durante el periodo en el que se extendieron las pruebas.This paper presents the results of power curve measurements of a battery charging small wind turbine. The measurement method used is defined by IEC 61400-12, Annex H standard. The testing process was performed between May and August 2013 in INTI Wind Energy Laboratory, in Cutral-Có city. The wind turbine under test, is one of the several Argentinian devices being tested by INTI, under a national sectorial supporting program. Power curve for three different battery bank voltages, turbulence intensity, annual energy production, among other testing results are shown throughout this work.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics

Antipsychotic drugs remain the current standard for schizophrenia treatment. Although they directly recognize the orthosteric binding site of numerous monoaminergic G protein-coupled receptors (GPCRs), these drugs, and particularly second-generation antipsychotics such as clozapine, all have in common a very high affinity for the serotonin 5-HT receptor (5-HTR). Using classical pharmacology and targeted signaling pathway assays, previous findings suggest that clozapine and other atypical antipsychotics behave principally as 5-HTR neutral antagonists and/or inverse agonists. However, more recent findings showed that antipsychotics may also behave as pathway-specific agonists. Reversible phosphorylation is a common element in multiple signaling networks. Combining a quantitative phosphoproteomic method with signaling network analysis, we tested the effect of clozapine treatment on the overall level of protein phosphorylation and signal transduction cascades in vitro in mammalian cell lines induced to express either the human 5-HTR or the H452Y variant of the gene encoding the 5-HTR receptor. This naturally occurring variation within the 5-HTR gene was selected because it has been repeatedly associated with schizophrenia patients who do not respond to clozapine treatment. Our data show that short time exposure (5 or 10 min) to clozapine (10 M) led to phosphorylation of numerous signaling components of pathways involved in processes such as endocytosis, ErbB signaling, insulin signaling or estrogen signaling. Cells induced to express the H452Y variant showed a different basal phosphoproteome, with increases in the phosphorylation of mTOR signaling components as a translationally relevant example. However, the effect of clozapine on the functional landscape of the phosphoproteome was significantly reduced in cells expressing the 5-HTR-H452Y construct. Together, these findings suggest that clozapine behaves as an agonist inducing phosphorylation of numerous pathways downstream of the 5-HTR, and that the single nucleotide polymorphism encoding 5-HTR-H452Y affects these clozapine-induced phosphorylation-dependent signaling networks

Evaluación del uso apropiado de medicamentos en atención primaria. ¿Cómo se puede mejorar?

IntroducciónEl proceso de medicación de un paciente abarca la identificación de su problema de salud, la prescripción para esa indicación por parte del médico, la dispensación farmacéutica y el consumo del fármaco. Los estudios de utilización de medicamentos analizan dicho proceso con el de detectar los factores que alteran el uso correcto de los fármacos.ObjetivoEvaluar la calidad de la prescripción de ciertos medicamentos en atención primaria en función de la indicación para la que fueron prescritos, detectando aquellas características de los pacientes, médicos prescriptores, centros de atención primaria y áreas de salud que influyen en su uso inapropiado.MétodoEstudio prescripción-indicación basado en la estimación de modelos multinivel con bases de datos individualizadas de las prescripciones, que contienen características de las prescripciones, pacientes, médicos, centros de salud y áreas de salud de pertenencia. Estos modelos suponen un avance en este tipo de estudios ya que permiten analizar de forma conjunta la información de distintos niveles y estimar sus respectivas «cuotas de responsabilidad» en la inadecuación de la prescripción.DiscusiónAdemás de su interés metodológico, que puede guiar estudios posteriores, el principal interés del trabajo estriba en su carácter pionero en la utilización masiva de microdatos poblacionales para evaluar la calidad de la prescripción, que proceden de las historias clínicas informatizadas de atención primaria.IntroductionThe process of medicating a patient embraces the identification of the health problem, the doctor’ s prescription to treat this indication, the dispensing of the medicine and its consumption. The studies of use of medicine analyse this process in order to detect those factors that impinge on the correct use of medicines.ObjectiveTo evaluate the quality of the prescription of certain primary care medicines as a function of the indication for which they were prescribed, detecting those features of the patients, prescribing doctors, primary care centre and health district that affect their inappropriate use.MethodPrescription-indication study based on the calculation of multiple-level models with individualised data bases for the prescriptions. These include characteristics of the prescriptions, patients, doctors, health centres and the health district involved. These models are a step forward in this kind of study, in that they enable analysis of the information from different levels at the same time as calculation of the respective «degrees of responsibility» for inadequacies of prescription.DiscussionApart from its methodological originality, which may serve for subsequent studies, the main interest of this study lies in the pioneering nature of its massive use of population micro-data to evaluate prescription quality. These data are taken from the computerised clinical records in primary care

A combined optical/infrared spectral diagnostic analysis of the HH1 jet

Complete flux-calibrated spectra covering the spectral range from 6000 A to 2.5 um have been obtained along the HH1 jet and analysed in order to explore the potential of a combined optical/near-IR diagnostic applied to jets from young stellar objects. Important physical parameters have been derived along the jet using various diagnostic line ratios. This multi-line analysis shows, in each spatially unresolved knot, the presence of zones at different excitation conditions, as expected from the cooling layers behind a shock front. In particular, a density stratification in the jet is evident from ratios of various lines of different critical density. In particular, [FeII] lines originate in a cooling layer located at larger distances from the shock front than that generating the optical lines, where the compression is higher and the temperature is declining. The derived parameters were used to measure the mass flux along the jet, adopting different procedures, the advantages and limitations of which are discussed. dM/dt is high in the initial part of the flow but decreases by about an order of magnitude further out. Conversely, the mass flux associated with the warm molecular material is low and does not show appreciable variations along the jet. We suggest that part of the mass flux in the external regions is not revealed in optical and IR lines because it is associated with a colder atomic component, which may be traced by the far-IR [O I]63 um line. Finally, we find that the gas-phase abundance of refractory species is lower than the solar value suggesting that a significant fraction of dust grains may still be present in the jet beam.Comment: Accepted on Astronomy & Astrophysic

Caspase-8 inhibition represses initial human monocyte activation in septic shock model

In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic potential of directly targeting innate immune cell activation to limit the cytokine storm and downstream phases. We initially investigated whether caspase-8 could be an appropriate target given it has recently been shown to be involved in microglial activation. We found that LPS caused a mild increase in caspase-8 activity and that the caspase-8 inhibitor IETD-fmk partially decreased monocyte activation. Furthermore, caspase-8 inhibition induced necroptotic cell death of activated monocytes. Despite inducing necroptosis, caspase-8 inhibition reduced LPS-induced expression and release of IL-1β and IL-10. Thus, blocking monocyte activation has positive effects on both the pro and anti-inflammatory phases of septic shock. We also found that in primary mouse monocytes, caspase-8 inhibition did not reduce LPS-induced activation or induce necroptosis. On the other hand, broad caspase inhibitors, which have already been shown to improve survival in mouse models of sepsis, achieved both. Thus, given that monocyte activation can be regulated in humans via the inhibition of a single caspase, we propose that the therapeutic use of caspase-8 inhibitors could represent a more selective alternative that blocks both phases of septic shock at the source.Unión Europea, Ministerio de Economía y Competitividad SAF2012-39029Unión Europea, Ministerio de Economía y Competitividad SAF2015-64171REspaña,Junta de Andalucía P10-CTS-649

AEMET- γSREPS

El futuro de la predicción del tiempo se fundamentará en sistema(s) de predicción por conjuntos (SPC) que describan cada vez más detalladamente la atmósfera y sus interrelaciones con el resto de componentes del Sistema Climático: suelo, océanos, hielos y biosfera. Más detalladamente porque los modelos de predicción del tiempo representarán la atmósfera a escalas horizontales (y verticales) cada vez más pequeñas, desde muy pocos kilómetros a unos pocos metros. ¿Y por qué más detalladamente? Pues porque hay procesos de mesoescala (de 1 a 20 km en jerga de meteorólogos y modelizadores) que sólo se simulan adecuadamente con modelos detallados. Y que se simulen adecuadamente es determinante para poder hacer una buena predicción de eventos meteorológicos relevantes como por ejemplo precipitaciones intensas y/o copiosas que producen inundaciones. Y las incertidumbres inherentes a esas escalas y, por ende, su predecibilidad, sólo se podrán tener en cuenta con las predicciones de carácter probabilista basadas en SPC y no con una sola predicción determinista. En ese camino se enmarcan los actuales SPC de área limitada (una zona más o menos rectangular de la Tierra), de alta resolución (1-4 km), convection permitting (sin parametrizar la convección), anidados en modelos globales (todo el planeta), como el AEMET-γSREPS de AEMET