Bantam System Technology Project Ground System Requirements Document

The Low Cost Booster Project (LCBP), also known as Bantam, is an element of the Advanced Space Transportation Program focused on Low Cost Booster Technologies. During FY 99 flight demonstrations are planned to demonstrate the feasibility of producing a booster capable of inserting a 150 kg payload into low earth orbit. The ground support system is an element of the full launch system. The ground support system provides for integration of the payload with the launch vehicle, preparation of the vehicle for launch (including maintenance, integration and test of the vehicle flight software), monitor and control of the launch sequence, range safety during launch, and collection of telemetry during the flight up to payload release. The ground support system is intended to make the maximum possible use of Government Off-the-Shelf (GOTS) or Commercial Off-the-Shelf (COTS) hardware and software to obtain the best value in terms of development operations support and ultimate life cycle cost for the launch system

Bantam System Technology Project

This report focuses on determining a best value, low risk, low cost and highly reliable Data and Command System for support of the launch of low cost vehicles which are to carry small payloads into low earth orbit. The ground-based DCS is considered as a component of the overall ground and flight support system which includes the DCS, flight computer, mission planning system and simulator. Interfaces between the DCS and these other component systems are considered. Consideration is also given to the operational aspects of the mission and of the DCS selected. This project involved: defining requirements, defining an efficient operations concept, defining a DCS architecture which satisfies the requirements and concept, conducting a market survey of commercial and government off-the-shelf DCS candidate systems and rating the candidate systems against the requirements/concept. The primary conclusions are that several low cost, off-the-shelf DCS solutions exist and these can be employed to provide for very low cost operations and low recurring maintenance cost. The primary recommendation is that the DCS design/specification should be integrated within the ground and flight support system design as early as possible to ensure ease of interoperability and efficient allocation of automation functions among the component systems

Muon Catalyzed Fusion in 3 K Solid Deuterium

Muon catalyzed fusion in deuterium has traditionally been studied in gaseous and liquid targets. The TRIUMF solid-hydrogen-layer target system has been used to study the fusion reaction rates in the solid phase of D_2 at a target temperature of 3 K. Products of two distinct branches of the reaction were observed; neutrons by a liquid organic scintillator, and protons by a silicon detector located inside the target system. The effective molecular formation rate from the upper hyperfine state of $\mu d$ and the hyperfine transition rate have been measured: $\tilde{\lambda}_(3/2)=2.71(7)_{stat.}(32)_{syst.} \mu/s$, and $\tilde{\lambda}_{(3/2)(1/2)} =34.2(8)_{stat.}(1)_{syst.} \mu /s$. The molecular formation rate is consistent with other recent measurements, but not with the theory for isolated molecules. The discrepancy may be due to incomplete thermalization, an effect which was investigated by Monte Carlo calculations. Information on branching ratio parameters for the s and p wave d+d nuclear interaction has been extracted.Comment: 19 pages, 11 figures, submitted to PRA Feb 20, 199

Cryogenic and room temperature strength of sapphire jointed by hydroxide-catalysis bonding

Hydroxide-catalysis bonding is a precision technique used for jointing components in opto-mechanical systems and has been implemented in the construction of quasi-monolithic silica suspensions in gravitational wave detectors. Future detectors are likely to operate at cryogenic temperatures which will lead to a change in test mass and suspension material. One candidate material is mono-crystalline sapphire. Here results are presented showing the influence of various bonding solutions on the strength of the hydroxide-catalysis bonds formed between sapphire samples, measured both at room temperature and at 77 K, and it is demonstrated that sodium silicate solution is the most promising in terms of strength, producing bonds with a mean strength of 63 MPa. In addition the results show that the strengths of bonds were undiminished when tested at cryogenic temperatures

The tumor suppressor miR-642a-5p targets Wilms tumor 1 gene and cell-cycle progression in prostate cancer

RNA-based therapeutics are emerging as innovative options for cancer treatment, with microRNAs being attractive targets for therapy development. We previously implicated microRNA-642a-5p (miR-642a-5p) as a tumor suppressor in prostate cancer (PCa), and here we characterize its mode of action, using 22Rv1 PCa cells. In an in vivo xenograft tumor model, miR-642a-5p induced a significant decrease in tumor growth, compared to negative control. Using RNA-Sequencing, we identified gene targets of miR-642a-5p which were enriched for gene sets controlling cell cycle; downregulated genes included Wilms Tumor 1 gene (WT1), NUAK1, RASSF3 and SKP2; and upregulated genes included IGFBP3 and GPS2. Analysis of PCa patient datasets showed a higher expression of WT1, NUAK1, RASSF3 and SKP2; and a lower expression of GPS2 and IGFBP3 in PCa tissue compared to non-malignant prostate tissue. We confirmed the prostatic oncogene WT1, as a direct target of miR-642a-5p, and treatment of 22Rv1 and LNCaP PCa cells with WT1 siRNA or a small molecule inhibitor of WT1 reduced cell proliferation. Taken together, these data provide insight into the molecular mechanisms by which miR-642a-5p acts as a tumor suppressor in PCa, an effect partially mediated by regulating genes involved in cell cycle control; and restoration of miR-642-5p in PCa could represent a novel therapeutic approach

The structure and dynamics of a bright point as seen with Hinode, SoHO and TRACE

Our aim is to determine the plasma properties of a coronal bright point and compare its magnetic topology extrapolated from magnetogram data with its appearance in X-ray images. We analyse spectroscopic data obtained with EIS/Hinode, Ca II H and G-band images from SOT/Hinode, UV images from TRACE, X-ray images from XRT/Hinode and high-resolution/high-cadence magnetogram data from MDI/SoHO. The BP comprises several coronal loops as seen in the X-ray images, while the chromospheric structure consists of tens of small bright points as seen in Ca II H. An excellent correlation exists between the Ca II BPs and increases in the magnetic field, implying that the Ca II H passband is a good indicator for the concentration of magnetic flux. Doppler velocities between 6 and 15 km/s are derived from the Fe XII and Fe XIII lines for the BP region, while for Fe XIV and Si VII they are in the range from -15 to +15 km/s. The coronal electron density is 3.7x10^9 cm^-3. An excellent correlation is found between the positive magnetic flux and the X-ray light-curves. The remarkable agreement between the extrapolated magnetic field configuration and some of the loops composing the BP as seen in the X-ray images suggests that a large fraction of the magnetic field in the bright point is close to potential. The close correlation between the positive magnetic flux and the X-ray emission suggests that energy released by magnetic reconnection is stimulated by flux emergence or cancellation.Comment: 10 pages with 11 figures. Accepted in Astronomy and Astrophysic