Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study.

Troponin C (TnC) is an important regulatory molecule in cardiomyocytes. Calcium binding to site II in TnC initiates a series of molecular events that result in muscle contraction. The most direct change upon Ca(2+) binding is an opening motion of the molecule that exposes a hydrophobic patch on the surface allowing for Troponin I to bind. Molecular dynamics simulations were used to elucidate the dynamics of this crucial protein in three different states: apo, Ca(2+)-bound, and Ca(2+)-TnI-bound. Dynamics between the states are compared, and the Ca(2+)-bound system is investigated for opening motions. On the basis of the simulations, NMR chemical shifts and order parameters are calculated and compared with experimental observables. Agreement indicates that the simulations sample the relevant dynamics of the system. Brownian dynamics simulations are used to investigate the calcium association of TnC. We find that calcium binding gives rise to correlative motions involving the EF hand and collective motions conducive of formation of the TnI-binding interface. We furthermore indicate the essential role of electrostatic steering in facilitating diffusion-limited binding of Ca(2+)

Precise predictions for V + 2 jet backgrounds in searches for invisible Higgs decays

We present next-to-leading order QCD and electroweak (EW) theory predictions for V + 2 jet production, with V = Z, W$^{±}$, considering both the QCD and EW production modes and their interference. We focus on phase-space regions where V + 2 jet production is dominated by vector-boson fusion, and where these processes yield the dominant irreducible backgrounds in searches for invisible Higgs boson decays. Predictions at parton level are provided together with detailed prescriptions for their implementation in experimental analyses based on the reweighting of Monte Carlo samples. The key idea is that, exploiting accurate data for W + 2 jet production in combination with a theory-driven extrapolation to the Z + 2 jet process can lead to a determination of the irreducible background at the few-percent level. Particular attention is devoted to the estimate of the residual theoretical uncertainties due to unknown higher-order QCD and EW effects and their correlation between the different V + 2 jet processes, which is key to improve the sensitivity to invisible Higgs decays

Description of an 8 MW reference wind turbine

An 8 MW wind turbine is described in terms of mass distribution, dimensions, power curve, thrust curve, maximum design load and tower configuration. This turbine has been described as part of the EU FP7 project LEANWIND in order to facilitate research into logistics and naval architecture efficiencies for future offshore wind installations. The design of this 8 MW reference wind turbine has been checked and validated by the design consultancy DNV-GL. This turbine description is intended to bridge the gap between the NREL 5 MW and DTU 10 MW reference turbines and thus contribute to the standardisation of research and development activities in the offshore wind energy industry

NLO QCD+EW predictions for 2ℓ\ell2v diboson signatures at the LHC

We present next-to-leading order (NLO) calculations including QCD and electroweak (EW) corrections for 2$\ell$2ν diboson signatures with two opposite-charge leptons and two neutrinos. Specifically, we study the processes $pp \to e^+\mu^-\nu_e\overline{\nu}_{\mu}$ and $pp \to e^+e^-\nu\overline{\nu}$, including all relevant off-shell diboson channels, $W^+W^-, ZZ, \gamma Z$, as well as non-resonant contributions. Photon-induced processes are computed at NLO EW, and we discuss subtle differences related to the definition and the renormalisation of the coupling α for processes with initial- and final-state photons. All calculations are performed within the automated Munich/Sherpa+OpenLoops frameworks, and we provide numerical predictions for the LHC at 13 TeV. The behaviour of the corrections is investigated with emphasis on the high-energy regime, where NLO EW effects can amount to tens of percent due to large Sudakov logarithms. The interplay between $W$ $W$and $ZZ$ contributions to the same-flavour channel, $pp \to e^+e^-\nu\overline{\nu}$, is discussed in detail, and a quantitative analysis of photon-induced contributions is presented. Finally, we consider approximations that account for all sources of large logarithms, at high and low energy, by combining virtual EW corrections with a YFS soft-photon resummation or a QED parton shower

6.P. Workshop: Responding to violence and abuse across the life-course

Much research on the mental health effects of violence focus on domestic violence as experienced in adulthood. The mental health impacts are often gauged using cross-sectional studies and focus on current associations between violence and health. This workshop presents a range of analyses - drawing on data from New Zealand, Germany and the UK - that address the ways in which violence and abuse manifest at different life stages, including in childhood, among working-age adults, and in later life. The presentations highlight differences across the life course, as well as commonalities. They provide evidence of the long-term, even life long, shadow that violence and abuse can cast over people's health, and provide evidence of the extensive costs for society. Health impacts are shown to be broad, not only anxiety and depression, but substance dependence, chronic physical health conditions, and related health risks such as obesity. This workshop comprises four presentations that each consider violence and abuse prevalent at a particular stage of life, and provide evidence to inform the sensitive tailoring of responses from and for families, schools, health and social services, workplace human resource employees, and care and residential homes. The format of the workshop comprises brief presentations, with a focus on extended audience discussions. We invite engagement from people from a range of disciplines interested in how different forms of violence and abuse present at different life stages, the impacts on health, and the ways in which society should respond. This workshop is submitted on behalf of the EUPHA Public Mental Health Section

Surgical intervention for hydrocephalus in infancy; etiology, age and treatment data in a Dutch cohort

Contains fulltext : 217415.pdf (Publisher’s version ) (Open Access

NNLO QCD + NLO EW with Matrix+OpenLoops: precise predictions for vector-boson pair production

We present the first combination of NNLO QCD and NLO EW corrections for vector-boson pair production at the LHC. We consider all final states with two, three and four charged leptons, including resonant and non-resonant diagrams, spin correlations and off-shell effects. Detailed predictions are discussed for three representative channels corresponding to W+W−, W±Z and Z Z production. Both QCD and EW corrections are very significant, and the details of their combination can play a crucial role to achieve the level of precision demanded by experimental analyses. In this context we point out nontrivial issues that arise at large transverse momenta, where the EW corrections are strongly enhanced by Sudakov logarithms and the QCD corrections can feature so-called giant K -factors. Our calculations have been carried out in the Matrix+OpenLoops framework and can be extended to the production of an arbitrary colour singlet in hadronic collisions, provided that the required two-loop QCD amplitudes are available. Combined NNLO QCD and NLO EW predictions for the full set of massive diboson processes will be made publicly available in the next release of Matrix and will be instrumental in advancing precision diboson studies and new-physics searches at the LHC and future hadron colliders