ART. XXXI.???A Practical Treatise on the Causes, Symptoms, and Treatment of Spermatorrh??a:

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Total hip arthroplasty through the direct anterior approach with and without the use of a traction table: a matched-control, retrospective, single-surgeon study.

Hip surgeons performing total hip arthroplasty (THA) through the direct anterior approach (DAA) commonly use a traction table to facilitate exposure. Even though performing THA through DAA without a traction table could be technically more demanding, this technique offers the advantage of intraoperative leg length comparison. Therefore, this study aimed to compare clinical outcomes, complication rates, component positioning, and leg length discrepancy (LLD) after THA through the DAA performed with or without a traction table. A single-surgeon continuous series of 75 patients who underwent DAA THA performed with a traction table was matched for gender, age, and BMI with 75 patients who underwent DAA THA performed without a traction table (male, 62; female, 88, with an average age of 68 years old). Clinical and radiological outcomes, intra- and postoperative complications, and LLD were retrospectively assessed. No statistically significant difference was detected in surgical time, hospital stay, Harris Hip Score (HHS), complication rates, and implant positioning between the two groups. Leg length restoration was significantly more accurate in the group performed without a traction table (2.4 ± 2 mm vs. 3.7 ± 3.1 mm; p value ≤ 0.05). No LLD > 10 mm was reported in the group performed without a traction table, whereas two cases (2.7%) were reported in those performed with a traction table. Performing THA through DAA without a traction table was associated with a significantly more accurate leg length restoration without a significant increase in the rates of intra- and postoperative complications

Orléans – Lycée Saint-Euverte

Date de l'opération : 1989 (SU) Inventeur(s) : Lallemand Véronique ; Petit Dominique ; Primat J Suite à la mise en œuvre du projet d'extension du lycée technique Saint-Euverte dans un zone de vestiges potentiels [ (Fig. n°1 : Localisation des fouilles effectuées en ville de 1984 à1991), site H], une surveillance de travaux puis une fouille de sauvetage urgent ont été engagées en 1989. Cette intervention a mis en évidence une occupation du site dès la période gallo-romaine précoce qui se matér..

Ethane-beta-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent Rats

Intermittent ethanol abuse or ‘binge drinking’ during adolescence induces neuronal damage, which may be associated with cognitive dysfunction. To investigate the neurochemical processes involved, rats were administered either 1 g/kg or 2 g/kg ethanol in a ‘binge drinking’ regime. After only 3 weeks, significant activation of phagocytic cells in the peripheral (alveolar macrophages) and the hippocampal brain region (microglia cells) was present,as exemplified by increases in the release of pro-inflammatory cytokines in the macrophages and of iNOS in the microglia. This was associated with neuronal loss in the hippocampus CA1 region. Daily supplementation with a taurine prodrug, ethane-β-sultam, 0.028 g/kg, during the intermittent ethanol loading regime, supressed the release of the pro-inflammatory cytokines and of reactive nitrogen species, as well as neuronal loss, particularly in the rats administered the lower dose of ethanol, 1 g/kg. Plasma, macrophage and hippocampal taurine levels increased marginally after ethane-β-sultam supplementation. The ‘binge drinking’ ethanol rats administered 1 g/kg ethanol showed increased latencies to those of the control rats in their acquisition of spacial navigation in the Morris Water Maze, which was normalised to that of the controls values after ethane-β-sultam administration. Such results confirm that the administration of ethane-β-sultam to binge drinking rats reduces neuroinflammation in both the periphery and the brain, suppresses neuronal loss, and improved working memory of rats in a water maze study

Premiers résultats des plongées Nautile de la campagne SUBPSO 1 sur la zone de collision "ride des Loyauté arc des Nouvelles-Hébrides" (Sud-Ouest Pacifique)

International audienceFour dives were conducted over the collision zone "Loyalty ridge/New Hebrides arc". On the Loyalty ridge, basaltic and rhyolitic breccias overlain by reef limestones were observed. An andesitic volcaniclastic sequence outcrops on the western flank of the New Hebrides arc. Near the trench, the Loyalty ridge has been sliced by normal faults along which the reef limestones collapsed of at least 4,000m. The unusual existence ofSW verging anticlines on the outer wall, 1,000m above the trench, was confirmed. These folds affect rocks ofthe lowerpartofthe ridge flank.Quatre plongées, réalisées sur la zone de collision «ride des Loyauté/arc des NouvellesHébrides », ont permis d'observer: (1) sur la ride des Loyauté, en mur externe de la fosse, des formations volcano-détritiques basaltiques et rhyolitiques, coiffées par des calcaires récifaux, le toutintensément fracturé; (2) sur le flanc occidental de l'arc néo-hébridais, en mur interne de la fosse, une série volcano-détritique andésitique. A l'approche de la fosse, des failles normales ont découpé la ride des Loyauté, amenant les calcaires récifaux jusqu'à des profondeurs de plus de 4000m. Enfin, la présence inhabituelle de plis déjetés vers le SW sur le mur externe, 1000 m au-dessus de la fosse, a été confirmée; ils semblent s'être développés aux dépens de matériel de la partie inférieure du flanc de la ride

Machine Learning Can Predict the Timing and Size of Analog Earthquakes

Despite the growing spatiotemporal density of geophysical observations at subduction zones, predicting the timing and size of future earthquakes remains a challenge. Here we simulate multiple seismic cycles in a laboratory‐scale subduction zone. The model creates both partial and full margin ruptures, simulating magnitude M_w 6.2–8.3 earthquakes with a coefficient of variation in recurrence intervals of 0.5, similar to real subduction zones. We show that the common procedure of estimating the next earthquake size from slip‐deficit is unreliable. On the contrary, machine learning predicts well the timing and size of laboratory earthquakes by reconstructing and properly interpreting the spatiotemporally complex loading history of the system. These results promise substantial progress in real earthquake forecasting, as they suggest that the complex motion recorded by geodesists at subduction zones might be diagnostic of earthquake imminence

Premiers résultats des plongées de la campagne SUBPSO 1 dans la zone de collision des rides d'Entrecasteaux et de l'arc des Nouvelles-Hébrides

International audienceGeological cross-sections,constructed from observations and samples collected during seven dives of theFrench submersible Nautile,reveal that the inner wall of the New Hebrides trench, in front of the North d'Entrecasteaux ridge and the Bougainville guyot,is primarily composed of volcanic and volcaniclastic rocks, most likely shed from the arc. Observations indicate that the bedding of thearc-slope rocks,which generally slopes trench ward in this collision zone,dips steeply (40-80°) arcward near the contact of the colliding features. In this particular area, arc-slope rocks are generally highly fractured and sheared, an exception being rocks forming the ridge east of the Bougainville guyot.Arc-slope rocks are deeply incised by erosional channels and show numerous fresh slump scars. These scars confirm the importance of mass wasting along the deformation front. No evidence for fluid venting,such as clams and mud volcanoes,was observed during the dives.Les coupes géologiques réalisées à partir de sept plongées du Nautile ont montré que le mur interne de la fosse des Nouvelles-hébrides,en face de la ride Nord d'Entrecasteaux et du guyot Bougainville,est essentiellement constitué par des formations volcaniques et volcano-détritiques provenant probablement de l'arc. Ces formations, généralement inclinées vers la fosse, ont,au contact de la ride et du guyot,rebroussées vers le haut et pentées de 40 à 80°vers l'arc. A ces niveaux,les roches sont intensément fracturées et cisaillées à l'exception de celles constituant le bourrelet qui surplombe le toit du guyot Bougainville.Le mur interne présente enfin une morphologie remarquable comprenant des loupes d'arrachement gravitaire,des chenaux d'érosion, des canyons et,localement,des marmites de géant.Ces figures confirment l'importance de l'érosion gravitaire le long du front de déformation.Aucune manifestation de sorties de fluides n'a été observée lors de ces plongées

Prehistory of Transit Searches

Nowadays the more powerful method to detect extrasolar planets is the transit method. We review the planet transits which were anticipated, searched, and the first ones which were observed all through history. Indeed transits of planets in front of their star were first investigated and studied in the solar system. The first observations of sunspots were sometimes mistaken for transits of unknown planets. The first scientific observation and study of a transit in the solar system was the observation of Mercury transit by Pierre Gassendi in 1631. Because observations of Venus transits could give a way to determine the distance Sun-Earth, transits of Venus were overwhelmingly observed. Some objects which actually do not exist were searched by their hypothetical transits on the Sun, as some examples a Venus satellite and an infra-mercurial planet. We evoke the possibly first use of the hypothesis of an exoplanet transit to explain some periodic variations of the luminosity of a star, namely the star Algol, during the eighteen century. Then we review the predictions of detection of exoplanets by their transits, those predictions being sometimes ancient, and made by astronomers as well as popular science writers. However, these very interesting predictions were never published in peer-reviewed journals specialized in astronomical discoveries and results. A possible transit of the planet beta Pic b was observed in 1981. Shall we see another transit expected for the same planet during 2018? Today, some studies of transits which are connected to hypothetical extraterrestrial civilisations are published in astronomical refereed journals. Some studies which would be classified not long ago as science fiction are now considered as scientific ones.Comment: Submiited to Handbook of Exoplanets (Springer

Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.

Cystic fibrosis (CF) lung disease is characterized by persistent inflammation. Antiinflammatory drugs, such as corticosteroids and ibuprofen, have proved to slow the decline of pulmonary function although their use is limited because of frequent adverse events. We hypothesized that colchicine could be an alternative treatment because of its antiinflammatory properties and upregulatory effect on cystic fibrosis transmembrane regulator (CFTR) closely related proteins. We herein present results obtained in an open study of eight CF children treated with colchicine for at least 6 months. Clinical status was better in all patients and respiratory function tests significantly improved in five. Median duration of antibiotherapy decreased significantly. These preliminary results support our hypothesis of a beneficial effect of colchicine in CF patients and stress the need for a controlled therapeutic trial