Publisher Correction: The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control (BMC Biology, (2021), 19, 1, (41), 10.1186/s12915-021-00975-9)

Following publication of the original article [1], it was reported that the article copyright was incorrect. The correct copyright statement is: © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021. The original article [1] has been corrected

Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort

The objective was to examine whether: (1) statin use was associated with muscle related outcomes at age 60–64, (2) these associations were modifed by 25-hydroxyvitamin D (25(OH)D) status and explained by infammation, body-size or lifestyle in a British birth cohort. Markers of myalgia (intrusive body pain) and myopathy (self-reported and performance-based measures) were examined in 734 men and 822 women (MRC National Survey of Health and Development). Statin use was associated with intrusive body pain, difculty climbing stairs and slower chair rise speed. Some associations were modifed by 25(OH)D e.g. the association with intrusive body pain was evident in the insufcient (13–20ng/l) and defcient(20ng/l (OR=0.8,95% CI 0.5–1.4) (p=0.003 for interaction). Associations were maintained in fully adjusted models of intrusive body pain and difculty climbing stairs, but for chair rise speed they were fully accounted for by infammation, body-size and lifestyle. In a nationally representative British population in early old age, statin use was associated with lower limb muscle-related outcomes, and some were only apparent in those with 25(OH)D status below 20ng/l. Given 25(OH)D is modifable in clinical practice, future studies should consider the links between 25(OH)D status and muscle related outcomes

Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis

We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556–0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD

Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis

<p><i>Background</i>: Cardiac amyloidosis is an infiltrative cardiomyopathy that is challenging to diagnose. We hypothesized that the novel biomarkers hepatocyte growth factor (HGF), galectin-3 (GAL-3), interleukin-6 (IL-6), and vascular endothelial growth factor (VEGF) would be elevated in cardiac amyloidosis and may be able to discriminate from non-cardiac systemic amyloidosis or other cardiomyopathies with similar clinical or morphologic characteristics.</p> <p><i>Methods</i>: Patients were selected from the Vanderbilt Main Heart Registry according to the following groups: (1) amyloid light-chain (AL) cardiac amyloidosis (<i>n</i> = 26); (2) transthyretin (ATTR) cardiac amyloidosis (<i>n</i> = 7); (3) left ventricular hypertrophy (LVH) (<i>n</i> = 45); (4) systolic heart failure (<i>n</i> = 42); and (5) non-cardiac systemic amyloidosis (<i>n</i> = 7). Biomarkers were measured in stored plasma samples. Biomarkers' discrimination performance in predicting AL cardiac amyloidosis (i.e., Concordance index) was reported. A survival analysis was used to explore the relationship between HGF levels and mortality among AL cardiac amyloidosis patients.</p> <p><i>Results</i>: HGF levels were markedly elevated in patients with AL cardiac amyloidosis (median = 622, interquartile range (IQR): 299–1228 pg/mL) compared with the other groups, including those with non-cardiac systemic amyloidosis (median = 134, IQR: 94–163 pg/mL, <i>p</i> < 0.001). HGF was not a specific marker for ATTR amyloidosis. Gal-3 was elevated in all groups with amyloidosis but could not differentiate between those with and without cardiac involvement. There was no difference in IL-6 or VEGF between those with AL cardiac amyloidosis compared to other groups (<i>p</i> = 0.13 and 0.057, respectively).</p> <p><i>Conclusions</i>: HGF may be a specific marker that distinguishes AL cardiac amyloidosis from other cardiomyopathies with similar clinical or morphologic characteristics. Further studies are necessary to determine whether HGF levels predict the likelihood of survival.</p

Swine research [1974]

Facts regarding The Ohio State University Swine Center / R. F. Wilson -- Ohio swine nutrition guide for 1974-75 / H. M. Barnes, D. C. Mahan, J. H. Cline and R. F. Wilson -- The phosphorus shortage and implications for the swine producer during 1974-75 / D. C. Mahan, J. H. Cline and A. P. Grifo, Jr. -- Feedlot performance and carcass capabilities of pigs differing in breed, dietary protein level, and sex / L. E. Watkins, L. A. Swiger and D. C. Mahan -- Effectiveness of additives in paste feed / A. P. Grifo, Jr., H. S. Teague and W. L. Roller -- The effectiveness of dietary selenium on sow reproductive performance and in the prevention of selenium deficiency in the progeny / D. C. Mahan, A. L. Moxon, J. H. Cline and J. E. Jones -- Ohio swine evaluation station test results and ultrasonic comparison / G. A. Isler -- Boar testing to 240 vs. 200 lb. / K. D. Corcoran, D. R. Ricker and G. A. Isle

Ohio swine research and information report, 1972

Areas of swine research--1972 -- High levels of copper in paste feed for growing-finishing pigs / H. S. Teague, A. P. Grifo, Jr. and W. L. Roller -- Effects of vitamin and mineral deletions in swine diets and subsequent feedlot performance / D. C. Mahan and J. H. Cline -- The effect of high environmental temperature on the boar / R. K. Christenson, H. S. Teague, A. P. Grifo, Jr. and W. L. Roller -- The feeding value of triticale for swine / R. F. Wilson -- Influence of supplemental choline on sow performance and early post-farrowing condition of pigs / H. S. Teague, A. P. Grifo, Jr. and R. K. Christenson -- Synchronization of estrus and ovulation in sows following three and six weeks of lactation / R. K. Christenson, H. S. Teague and A. P. Grifo, Jr. -- The influence of physiological levels of histamine and cortisol upon stress susceptibility and muscle quality in pigs / J. H. Perry, V. R. Cahill and H. W. Ockerman -- Breed trends at The Ohio Swine Evaluation Station during the past 12 years / G. A. Isler -- Breeding swine for the future / L. A. Swiger -- Transmissible gastroenteritis of swine / E. H. Bohl -- Internal parasites of swine / J. E. Jones -- Swine waste systems / R. K. Whit