Three-dimensional shapelets and an automated classification scheme for dark matter haloes

We extend the two-dimensional Cartesian shapelet formalism to d-dimensions. Concentrating on the three-dimensional case, we derive shapelet-based equations for the mass, centroid, root-mean-square radius, and components of the quadrupole moment and moment of inertia tensors. Using cosmological N-body simulations as an application domain, we show that three-dimensional shapelets can be used to replicate the complex sub-structure of dark matter halos and demonstrate the basis of an automated classification scheme for halo shapes. We investigate the shapelet decomposition process from an algorithmic viewpoint, and consider opportunities for accelerating the computation of shapelet-based representations using graphics processing units (GPUs).Comment: 19 pages, 11 figures, accepted for publication in MNRA

Computing Fast and Reliable Gravitational Waveforms of Binary Neutron Star Merger Remnants

Gravitational waves have been detected from the inspiral of a binary neutron-star, GW170817, which allowed constraints to be placed on the neutron star equation of state. The equation of state can be further constrained if gravitational waves from a post-merger remnant are detected. Post-merger waveforms are currently generated by numerical-relativity simulations, which are computationally expensive. Here we introduce a hierarchical model trained on numerical-relativity simulations, which can generate reliable post-merger spectra in a fraction of a second. Our spectra have mean fitting factors of 0.95, which compares to fitting factors of 0.76 and 0.85 between different numerical-relativity codes that simulate the same physical system. This method is the first step towards generating large template banks of spectra for use in post-merger detection and parameter estimation.Comment: Submitted to PRL. 6 pages, 4 figure

Nuclear Equation of State from Observations of Short Gamma-Ray Burst Remnants

The favoured progenitor model for short $\gamma$-ray bursts (SGRBs) is the merger of two neutron stars that triggers an explosion with a burst of collimated $\gamma$-rays. Following the initial prompt emission, some SGRBs exhibit a plateau phase in their $X$-ray light curves that indicates additional energy injection from a central engine, believed to be a rapidly rotating, highly magnetised neutron star. The collapse of this `protomagnetar' to a black hole is likely to be responsible for a steep decay in $X$-ray flux observed at the end of the plateau. In this letter, we show that these observations can be used to effectively constrain the equation of state of dense matter. In particular, we show that the known distribution of masses in binary neutron star systems, together with fits to the $X$-ray light curves, provide constraints that exclude the softest and stiffest plausible equations of state. We further illustrate how a future gravitational wave observation with Advanced LIGO/Virgo can place tight constraints on the equation of state, by adding into the picture a measurement of the chirp mass of the SGRB progenitor.Comment: accepted for publication in Phys. Rev.

The complement binding-like domains of the murine homing receptor facilitate lectin activity.

The leukocyte homing receptor (HR), the endothelial leukocyte adhesion molecule, and gmp140/platelet activation-dependent granule membrane protein are members of a family of adhesion molecules, termed the lectin cell adhesion molecules (LEC-CAMS) which are unified by a multi-domain structure containing a lectin motif, an epidermal growth factor-like (egf) motif, and variable numbers of a complement binding-like (CB) motif. Previous data have indicated a predominant role for the lectin motif in cell adhesion directed by the LEC-CAMS, although the egf-like domain of the HR may also play a potential role in cell binding. While the role(s) of the CB domains in the LEC-CAMS is currently not understood, they have been hypothesized to act as rigid spacers or stalks for lectin and perhaps, egf domain presentation. In this paper, we analyze the functional characteristics of murine HR-IgG chimeras containing the lectin, lectin plus egf, and lectin plus egf plus CB domains. The Mel 14 mAb, an adhesion blocking antibody which recognizes a conformational determinant in the N-terminus of the HR lectin domain, shows a significantly decreased affinity for a HR construct which lacks the CB motifs, consistent with the possibility that the CB domains are involved with lectin domain structure. In agreement with this conjecture, HR mutants lacking the CB domains show a profound decrease in lectin-specific interaction with the carbohydrate polyphosphomannan ester, suggesting that the changes in Mel 14 affinity for the lectin domain are reflected in lectin functionality. Various assays investigating the interactions between the HR deletion mutants and the peripheral lymph node high endothelium, including cell blocking, immunohistochemical staining, and radioactively labeled ligand binding, all showed that removal of the CB domains results in a lack of HR adhesive function. These results imply that the CB domains of the HR, and, by analogy, the other members of the LEC-CAM family, may play important structural roles involving induction of lectin domain conformation and resultant functionality

A Twin Study of Early-Childhood Asthma in Puerto Ricans

Background:The relative contributions of genetics and environment to asthma in Hispanics or to asthma in children younger than 3 years are not well understood.Objective:To examine the relative contributions of genetics and environment to early-childhood asthma by performing a longitudinal twin study of asthma in Puerto Rican children ≤3 years old.Methods:678 twin infants from the Puerto Rico Neo-Natal Twin Registry were assessed for asthma at age 1 year, with follow-up data obtained for 624 twins at age 3 years. Zygosity was determined by DNA microsatellite profiling. Structural equation modeling was performed for three phenotypes at ages 1 and 3 years: physician-diagnosed asthma, asthma medication use in the past year, and ≥1 hospitalization for asthma in the past year. Models were additionally adjusted for early-life environmental tobacco smoke exposure, sex, and age.Results:The prevalences of physician-diagnosed asthma, asthma medication use, and hospitalization for asthma were 11.6%, 10.8%, 4.9% at age 1 year, and 34.1%, 40.1%, and 8.5% at 3 years, respectively. Shared environmental effects contributed to the majority of variance in susceptibility to physician-diagnosed asthma and asthma medication use in the first year of life (84%-86%), while genetic effects drove variance in all phenotypes (45%-65%) at age 3 years. Early-life environmental tobacco smoke, sex, and age contributed to variance in susceptibility.Conclusion:Our longitudinal study in Puerto Rican twins demonstrates a changing contribution of shared environmental effects to liability for physician-diagnosed asthma and asthma medication use between ages 1 and 3 years. Early-life environmental tobacco smoke reduction could markedly reduce asthma morbidity in young Puerto Rican children. © 2013 Bunyavanich et al

Inhomogeneous Cosmology using General Relativistic Smoothed Particle Hydrodynamics coupled to Numerical Relativity

We perform three-dimensional simulations of homogeneous and inhomogeneous cosmologies via the coupling of a numerical relativity code for spacetime evolution and smoothed particle hydrodynamics (SPH) code. Evolution of a flat dust and radiation dominated Friedmann-Lema\^itre-Roberston-Walker (FLRW) spacetime shows an agreement of exact solutions with residuals on the order $10^{-6}$ and $10^{-3}$ respectively, even at low grid resolutions. We demonstrate evolution of linear perturbations of density, velocity and metric quantities to the FLRW with residuals of only $10^{-2}$ compared to exact solutions. Finally, we demonstrate the evolution of non-linear perturbations of the metric past shell-crossing, such that dark matter halo formation is possible. We show that numerical relativistic smoothed particle hydrodynamics is a viable method for understanding non-linear effects in cosmology.Comment: 15 pages, 12 figures, submitted to PR

Implementing and Sustaining Science Curriculum Reform: A Study of Leadership Practices Among Teachers within a High School Science Department

This study presents a description and analysis of a ninth-grade integrated science curriculum developed and implemented by teachers within a high school science department and subsequently sustained for over 25 years. The Integrated Science Program (ISP) at Lakeside Southwest High School depicted here offers a unique example of longitudinal science education reform. In this study, we examined ISP as an artifact of teacher leadership. Findings affirmed the importance of shared philosophical purpose among teachers, attention to public perceptions, staff stability, the distribution of responsibilities, and instructional coherence. This study also demonstrated how curricular reforms might change over time in response to contextual pressures as was the case with the equity challenges faced by the current teachers of ISP

Mapping the Universe Expansion: Enabling percent-level measurements of the Hubble Constant with a single binary neutron-star merger detection

The joint observation of the gravitational-wave and electromagnetic signal from the binary neutron-star merger GW170817 allowed for a new independent measurement of the Hubble constant $H_0$, albeit with an uncertainty of about 15\% at 1$\sigma$. Observations of similar sources with a network of future detectors will allow for more precise measurements of $H_0$. These, however, are currently largely limited by the intrinsic degeneracy between the luminosity distance and the inclination of the source in the gravitational-wave signal. We show that the higher-order modes in gravitational waves can be used to break this degeneracy in astrophysical parameter estimation in both the inspiral and post-merger phases of a neutron star merger. We show that for systems at distances similar to GW170817, this method enables percent-level measurements of $H_0$ with a single detection. This would permit the study of time variations and spatial anisotropies of $H_0$ with unprecedented precision. We investigate how different network configurations affect measurements of $H_0$, and discuss the implications in terms of science drivers for the proposed 2.5- and third-generation gravitational-wave detectors. Finally, we show that the precision of $H_0$ measured with these future observatories will be solely limited by redshift measurements of electromagnetic counterparts