Responses to Weight Loss Treatment Among Obese Individuals with and without BED: A Matched-study Meta-analysis

The moderating influence of binge eating status on obese individuals’ responses to weight loss treatment was evaluated with a meta-analysis of 36 tests of weight loss treatment (n=792) that were matched to control key background variables. After controlling for pre-treatment weight, treatment produced more weight loss in samples of obese non- BED compared with obese BED participants. Weight loss treatment produced large posttreatment reductions in depression in both obese BED and non-BED samples. The results indicate that BED status moderated post-treatment weight loss among people in weight treatment programs. Obese BED (average weight loss= 1.3 kg) samples lost negligible weight compared to obese non-BED (average weight loss= 10.5 kg) samples. BED status did not moderate psychological responses to treatment: both BED and non-BED samples experienced large post-treatment reductions in depression. The clinical implications of these findings are discussed

Reducing Maternal and Child Health Disparities among Latino Immigrants in South Carolina Through a Tailored, Culturally Appropriate and Participant-Driven Initiative

Newly arrived Latino immigrants in South Carolina (SC), especially Latina mothers, experience many health related barriers including a general lack of health services information. The PASOs program, which means “steps” in Spanish, uses education, outreach, partnerships and advocacy to empower Latino families to utilize available health care services throughout SC. PASOs is a community-based program conducted by college trained bilingual/bicultural facilitators with the support from community health care workers (promotores de salud). Participants (n=523) were expectant mothers with an average age of 27 (SD=6) years, mostly from Mexico (69%), with an average of 9 (SD=4) years of education and 7 (SD=5) years living in the US. Repeated measures analyses from pre-test to post-test indicated significant knowledge improvement (p<0.005) regarding the importance of prenatal care, signs of preterm delivery, benefits of breastfeeding, and the importance of folic acid intake during periconception. By the end of the course, the majority of the Latinas (93%; p<0.0001) were able to name a birth control method they planned to use following their current pregnancy. Results of this study emphasize the benefits associated with the implementation of a culturally-appropriate program with newly arrived Latino immigrants, including an increase on preconception, pregnancy, and post-pregnancy knowledge

Geographic variation in dispersal distance facilitates range expansion of a lake shore plant in response to climate change

AimGeographic variation in dispersal abilities is widespread and likely to affect species’ range dynamics in response to climate change. However, distribution models that predict climate‐induced range shifts do not account for spatial variation in dispersal. We developed an eco‐genetic model to investigate how variation in dispersal distances across a species’ range could interact with climate‐induced selection and alter predicted range dynamics in a species with documented variation in dispersal traits.LocationWe investigated the range of an annual plant, Cakile edentula var. lacustris, which occupies beaches spanning a 555 km latitudinal gradient along the Laurentian Great Lakes.MethodsWe built a hybrid model that combines climatic niche modelling, based on decadal climate projections, with an individual‐based model that allows for evolutionary processes to act upon a heritable dispersal kernel. We evaluated how spatial variation in dispersal distance and dispersal evolution influenced range dynamics, spatial and temporal variation in dispersal, and the distribution of neutral genetic variation. The model was parametrized with data on C. edentula’s distribution, life history and dispersal characteristics.ResultsGeographic variation in dispersal distance, adaptive dispersal evolution and dispersal distance increased the potential for local populations of C. edentula to keep pace with changing climatic conditions through range shifts. Dispersal distances always increased at the expanding and contracting range edges when dispersal was allowed to evolve. Furthermore, scenarios where dispersal distances were initially lower at the range edges resulted in the largest evolutionary changes over 105 years (>1.5 km increase in mean distance at northern edge). Adaptive dispersal evolution always reduced neutral genetic diversity across the species’ range.Main conclusionsVariation in dispersal abilities across C. edentula’s range and adaptive evolution led to different predicted outcomes in range dynamics during climate change illustrating the importance of including spatial variation in dispersal into species distribution models.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151269/1/ddi12951.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151269/2/ddi12951_am.pd

Ischemic Colitis Secondary to Ergotamine Use: A Case Study

A 48-year-old woman with a history of chronic migraines, initially admitted for inpatient management of intractable migraine headaches, developed new onset abdominal pain, hypotension, and diarrhea on hospital day number ten. In our institution's headache unit, patients are treated by a multidisciplinary approach, including individualized drug therapy based on diagnosis and previous response to therapy. Given the patient's hypotension and clinical appearance, she was transferred to the intensive care unit and treated for septic shock and metabolic acidosis. A bedside colonscopy revealed diffuse ischemic colitis. Final pathology after colon resection showed widespread, transmural necrosis of the colonic wall. We review the pathophysiology of ergotamine use and its potential association with ischemic colitis

Negotiating daughterhood and strangerhood: retrospective accounts of serial migration

Most considerations of daughtering and mothering take for granted that the subjectivities of mothers and daughters are negotiated in contexts of physical proximity throughout daughters’ childhoods. Yet many mothers and daughters spend periods separated from each other, sometimes across national borders. Globally, an increasing number of children experience life in transnational families. This paper examines the retrospective narratives of four women who were serial migrants as children (whose parents migrated before they did) . It focuses on their accounts of the reunion with their mothers and how these fit with the ways in which they construct their mother-daughter relationships. We take a psychosocial approach by using a psychoanalytically-informed reading of these narratives to acknowledge the complexities of the attachments produced in the context of migration and to attend to the multi-layered psychodynamics of the resulting relationships. The paper argues that serial migration positioned many of the daughters in a conflictual emotional landscape from which they had to negotiate ‘strangerhood’ in the context of sadness at leaving people to whom they were attached in order to join their mothers (or parents). As a result, many were resistant to being positioned as daughters, doing daughtering and being mothered in their new homes

Book reviews

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44489/1/10745_2005_Article_BF01531641.pd

Frontiers in data analytics for adaptation research: Topic modeling

Rapid growth over the past two decades in digitized textual information represents untapped potential for methodological innovations in the adaptation governance literature that draw on machine learning approaches already being applied in other areas of computational social sciences. This Focus Article explores the potential for text mining techniques, specifically topic modeling, to leverage this data for large‐scale analysis of the content of adaptation policy documents. We provide an overview of the assumptions and procedures that underlie the use of topic modeling, and discuss key areas in the adaptation governance literature where topic modeling could provide valuable insights. We demonstrate the diversity of potential applications for topic modeling with two examples that examine: (a) how adaptation is being talked about by political leaders in United Nations Framework Convention on Climate Change; and (b) how adaptation is being discussed by decision‐makers and public administrators in Canadian municipalities using documents collected from 25 city council archives. This article is categorized under: Vulnerability and Adaptation to Climate Change > Institutions for Adaptatio

Validation of Coupled Atmosphere-Fire Behavior Models

Recent advances in numerical modeling and computer power have made it feasible to simulate the dynamical interaction and feedback between the heat and turbulence induced by wildfires and the local atmospheric wind and temperature fields. At Los Alamos National Laboratory, the authors have developed a modeling system that includes this interaction by coupling a high resolution atmospheric dynamics model, HIGRAD, with a fire behavior model, BEHAVE, to predict the spread of wildfires. The HIGRAD/BEHAVE model is run at very high resolution to properly resolve the fire/atmosphere interaction. At present, these coupled wildfire model simulations are computationally intensive. The additional complexity of these models require sophisticated methods for assuring their reliability in real world applications. With this in mind, a substantial part of the research effort is directed at model validation. Several instrumented prescribed fires have been conducted with multi-agency support and participation from chaparral, marsh, and scrub environments in coastal areas of Florida and inland California. In this paper, the authors first describe the data required to initialize the components of the wildfire modeling system. Then they present results from one of the Florida fires, and discuss a strategy for further testing and improvement of coupled weather/wildfire models

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells

Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus. Here, we examined entry of CRCoV into human rectal tumor cells (HRT-18G cell line) by analyzing co-localization of single virus particles with cellular markers in the presence or absence of chemical inhibitors of pathways potentially involved in virus entry. We also targeted these pathways using siRNA. The results show that the virus hijacks caveolin-dependent endocytosis to enter cells via endocytic internalization

Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes

Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity. A fraction of Stx3 is localized to late endosomes/lysosomes, although how it traffics there and its function in these organelles is unknown. Here we report that Stx3 undergoes monoubiquitination in a conserved polybasic domain. Stx3 present at the basolateral—but not the apical—plasma membrane is rapidly endocytosed, targeted to endosomes, internalized into intraluminal vesicles (ILVs), and excreted in exosomes. A nonubiquitinatable mutant of Stx3 (Stx3-5R) fails to enter this pathway and leads to the inability of the apical exosomal cargo protein GPRC5B to enter the ILV/exosomal pathway. This suggests that ubiquitination of Stx3 leads to removal from the basolateral membrane to achieve apical polarity, that Stx3 plays a role in the recruitment of cargo to exosomes, and that the Stx3-5R mutant acts as a dominant-negative inhibitor. Human cytomegalovirus (HCMV) acquires its membrane in an intracellular compartment and we show that Stx3-5R strongly reduces the number of excreted infectious viral particles. Altogether these results suggest that Stx3 functions in the transport of specific proteins to apical exosomes and that HCMV exploits this pathway for virion excretion