Diffusion of finite-size particles in confined geometries

The diffusion of finite-size hard-core interacting particles in two- or three-dimensional confined domains is considered in the limit that the confinement dimensions become comparable to the particle’s dimensions. The result is a nonlinear diffusion equation for the one-particle probability density function, with an overall collective diffusion that depends on both the excluded-volume and the narrow confinement. By including both these effects the equation is able to interpolate between severe confinement (for example, single-file diffusion) and unconfined diffusion. Numerical solutions of both the effective nonlinear diffusion equation and the stochastic particle system are presented and compared. As an application, the case of diffusion under a ratchet potential is considered, and the change in transport properties due to excluded-volume and confinement effects is examined

ALICE potential for heavy-flavour physics

The Large Hadron Collider (LHC), where lead nuclei will collide at the unprecedented c.m.s. energy of 5.5 TeV per nucleon-nucleon pair, will offer new and unique opportunities for the study of the properties of strongly interacting matter at high energy density over extended volumes. We will briefly explain why heavy-flavour particles are well-suited tools for such a study and we will describe how the ALICE experiment is preparing to make use of these tools.Comment: 6 pages, 3 figures, prepared for the Proceedings of "Strange Quark Matter 2007", Levoca, Slovaki

Explorative investigation of the anti-glycative effect of a rapeseed by-product extract

Formation of Advanced Glycation End-products (AGEs) in biological systems are increased during hyperglycaemia due to higher levels of circulating glucose, as well as carbonyl reactive species. AGEs are causative factors of common chronic diseases. Since synthetic AGE-inhibitors exert unwanted side effects and polyphenols act as potent antiglycative agents, vegetables (fruits, seeds and related by-products) are good candidates for searching natural inhibitors. The aim of this research is to explore the suitability of a polyphenol-rich rapeseed cake extract (RCext) to decrease the formation of AGEs in an in vitro model. Total Phenolic Content, antioxidant, anti-glycative activity, specific inhibition of AGEs (pentosidine and argypyrimidine), and methylglyoxal trapping capacity of the RCext were evaluated. The metabolomic profile of the extract was also analysed through GC-MS. Different phenols, amino acids, carbohydrates, organic acids and fatty acids are identified in the RCE by GC-MS. Results confirm the high concentration of polyphenols correlated with the antioxidant capacity and anti-glycative activity in a dose dependent manner. Rapeseed cake extract (3.7 mg mL−1) significantly reduced the formation of free fluorescent AGEs and pentosidine up to 34.85%. The anti-glycative activity of the extract is likely to be due to the high concentration of sinapinic acid in its metabolic profile, and the mechanism of action is mediated by methylglyoxal trapping. Results show a promising potential for using rapeseed cake extract as a food supplement to ameliorate the formation of AGEs. Rapeseed cake extract should therefore be considered a potential candidate for the prevention of glycation-associated complications of age-related pathologie

Book review: Clinical endocrinology and diagnostic imaging

Prague: Charles University, Karolinum Press, 2014; 372 pagesISBN 978-80-246-2058-9, paperback price: R138.9

Jets in 200 GeV p+p and d+Au collisions from the STAR experiment at RHIC

Full jet reconstruction in heavy-ion collisions is a promising tool for the quantitative study of properties of the dense medium produced at RHIC. Measurements of d+Au collisions are important to disentangle initial state nuclear effects from medium-induced kT broadening and jet quenching. Study of jet production and properties in d+Au in combination with similar studies in p+p is an important baseline measurement needed to better understand heavy-ion results. We present mid-rapidity inclusive jet pT spectra and di-jet correlations (kT) in 200 GeV p+p and d+Au collisions from the 2007-2008 RHIC run. We discuss the methods used to correct the data for detector effects and for background in d+Au collisions.Comment: 4 pages, 5 figures. To appear in Hot Quarks 2010 conference proceeding

A Hybrid Differential Evolution Approach to Designing Deep Convolutional Neural Networks for Image Classification

Convolutional Neural Networks (CNNs) have demonstrated their superiority in image classification, and evolutionary computation (EC) methods have recently been surging to automatically design the architectures of CNNs to save the tedious work of manually designing CNNs. In this paper, a new hybrid differential evolution (DE) algorithm with a newly added crossover operator is proposed to evolve the architectures of CNNs of any lengths, which is named DECNN. There are three new ideas in the proposed DECNN method. Firstly, an existing effective encoding scheme is refined to cater for variable-length CNN architectures; Secondly, the new mutation and crossover operators are developed for variable-length DE to optimise the hyperparameters of CNNs; Finally, the new second crossover is introduced to evolve the depth of the CNN architectures. The proposed algorithm is tested on six widely-used benchmark datasets and the results are compared to 12 state-of-the-art methods, which shows the proposed method is vigorously competitive to the state-of-the-art algorithms. Furthermore, the proposed method is also compared with a method using particle swarm optimisation with a similar encoding strategy named IPPSO, and the proposed DECNN outperforms IPPSO in terms of the accuracy.Comment: Accepted by The Australasian Joint Conference on Artificial Intelligence 201

Overview on jet results from STAR

Full jet reconstruction allows access to the parton kinematics over a large energy domain and can be used to constrain the mechanisms of energy loss in heavy-ion collisions. Such measurements are challenging at RHIC, due to the high-multiplicity environments created in heavy-ion collisions. In these proceedings, we report an overview of the results on full jet reconstruction obtained by the STAR experiment. Jet measurements in 200 GeV p+p show that jets are calibrated pQCD probes and provide a baseline for jet measurements in Au+Au collisions. Inclusive differential jet production cross sections and ratios are reported for central 200 GeV Au+Au collisions and compared to p+p. We also present measurements of fully reconstructed di-jets at mid-rapidity, and compare spectra and fragmentation functions in p+p and central Au+Au collisions.Comment: Proceedings for the 26th WWND conferenc

Selection of the Most Suitable Decomposition Filter for the Measurement of Fluctuating Harmonics

The proliferation of nonlinear loads in both industrial and residential distribution grids leads to undesirable nonsinusoidal and fluctuating harmonic pollution on voltage and current waveforms. New analysis tools, such as wavelets, are being used to overcome the problems posed by the use of the Fourier transform when analyzing complex waveforms. Nevertheless, the selection of the wavelet basis must be done carefully to minimize spectral leakage due to the nonexact frequency discrimination. In this context, this paper proposes an objective method for comparing different wavelet families for the measurement of harmonic contents. This methodology is applicable for determining the best filter among the 53 preselected structures according to the following requirements: frequency selectivity, computational complexity, convolution results, and observed spectral leakage. With all these considerations, the Butterworth infinite-impulse response filter of order 29 was found to be the best wavelet decomposition structure to achieve an effective harmonic analysis up to the 50th order

New version of the Pediatric Evaluation of Disability Inventory (PEDI-CAT): translation, cultural adaptation to Brazil and analyses of psychometric properties

BACKGROUND: The Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT), developed with innovative measurement methodologies, evaluates functioning of children and youth, from 0 to 21 years, with different health conditions. It is a revision of an earlier instrument (PEDI) that has been used in national and international clinical practice and research. It was felt to be necessary to make this new version (PEDI-CAT) available in Brazil. OBJECTIVES: Translate and culturally adapt the PEDI-CAT to the Brazilian-Portuguese language and test its psychometric properties. METHOD: This methodological study was developed through the following stages: (1) translation, (2) synthesis, (3) back-translation, (4) revision by an expert committee, (5) testing of the pre-final version, and (6) evaluation of the psychometric properties. The 276 translated PEDI-CAT items were divided into three age groups (0-7, 8-14, and 15-21 years). RESULTS: The PEDI-CAT translation followed all six stages. The adaptations incorporated cultural and socioeconomic class specificities. The PEDI-CAT/Brazil showed good indices of inter-examiner (intraclass correlation coefficient-ICC=0.83-0.89) and test-retest (ICC=0.96-0.97) reliability, good internal consistency (0.99) and small standard error of measurement in all three age groups (0.12-0.17). Factor analyses grouped the items from the three functional skills domains into one factor, and items from the responsibility scale into three factors, supporting the adequacy of these factor solutions to the conceptual structure of the instrument and the developmental model. CONCLUSION: The PEDI-CAT/Brazil is a theoretically consistent, culturally appropriate, and reliable instrument. Its availability in Brazil will contribute to the evaluation and measurement of functional outcomes from clinical interventions, longitudinal follow-up, and rehabilitation research

Weight gain in patients after therapy for hyperthyroidism

Objective. To determine the prevalence of obesity following therapy for hyperthyroidism and to assess the contributing factors associated with an undesirable weight gain.Design. A retrospective analysis was undertaken of clinical records for 160 hyperthyroid patients attending an endocrine clinic in Bloemfontein (1994 - 2001).Results. Of the 160 patients, 143 had Graves' disease and 17 patients had multinodular goitre. Most of our patients (N = 147) were treated with radioiodine, 10 patients with carbimazole and 3 patients had thyroidectomy. The median weight gain 6 months after therapy was 5.0 kg, after 12 months 9.0 kg, and after 24 months 12 kg, whereafter body mass stabilised. Before therapy 27.5% of patients had a body mass index (BMI) of < 22 kg/m2, 29.4% were overweight (BMI > 25 kg/m2) and 19.3% were obese (BMI > 30 kg/m2). Two years after treatment only 8.7% of patients had a BMI of < 22 kg/m2, 27.5% had a BMI > 25 kg/m2, and 51.3% had become obese. The main factors associated with weight gain 24 months after therapy were poor control of thyroid function on replacement therapy, diagnosis of Graves' disease and need for thyroxine replacement.Conclusion. This study has shown a large increase (32%) in the prevalence of obesity following treatment for hyperthyroidism. The main weight gain was during the first 2 years after therapy. The main factors contributing to excessive weight gain were need for replacement therapy and poor control of thyroid function