Infección por SARS-CoV-2 y obesidad

La pandemia por coronavirus 2019 (COVID-19) ha tenido diferentes efectos. Uno de ellos fue concentrar la atención de múltiples investigadores y clínicos para dedicarse a estudiar y tratar de entender los retos de esta infección en diferentes poblaciones, que se han determinado en riesgo de presentar una manifestación más grave de la infección. La obesidad ha sido recientemente identificada como una de las comorbilidades de mayor riesgo junto con la insuficiencia cardíaca, con una probabilidad siete veces mayor para el requerimiento de ventilación mecánica invasiva. La obesidad es un factor en la gravedad de la enfermedad del SARS-CoV-2, que tiene un mayor impacto en pacientes con un índice de masa corporal (IMC) ?35 kg/m2 . Los pacientes con obesidad, especialmente aquellos con grado severo, deben tomar medidas adicionales para evitar el contagio con SARS-CoV-2, mediante el cumplimiento de las medidas de prevención durante la pandemia actual, si se quiere, de forma más rigurosa

On the Rotation of Post-T Tauri Stars in Associations

Nearby associations are excellent objects for the study of the initial spin up phase during the PMS evolution. An empirical approach is adopted here to infer their rotations properties and relations to X-ray emission. Three nearby associations are considered. The TW Hya association with an age of 8 Myr, the Beta Pictoris moving group with 12 Myr and a combination of Tucana and Horologium associations (30 Myr). Two low and high rotation modes are considered for each association with stellar masses less than 1.5M and greater than 1.5M respectively. We infer representative equatorial rotation velocities Vo from the observed distribution of projected rotational velocities vsini. A spin up is found for the high rotation mode, whereas in the low rotation mode the Vo do not increase significantly. This insufficient increase of Vo is probably the cause of a decrease of the total mean specific angular momentum for the low mass stars between 8 and 30 Myr. However, for the high mass stars, where a sufficient spin up is present, the specific angular momentum is practically conserved in this same time interval. By supposing that the distribution of masses of these three associations follows a universal mass function, we estimate the number of members of these associations that remain to be detected. The analysis of rotation and stellar masses using luminosity X-rays indicators present similar properties, as the dependence on stellar mass and rotation, at least for the younger associations, to those obtained for T Tauri stars in the ONC. A strong desaturation effect appears at 30 Myr. This effect seems to be provoked by the minimum configuration of the stellar convection layers, attained for the first time for the higher mass stars at 30 Myr. The desaturation appears to be independent of rotation at this stage.Comment: 37 pages, 10 figures, 4 tables. Accepted by the Astronomical Journa

Coping Strategies Used by Female Victims of the Colombian Armed Conflict: The Women in the Colombian Conflict (MUCOCO) Program

The effects of armed conflict on women in post-conflict situations are an area of analysis for social disciplines. This study will analyze the situation in Colombia, currently involved in a peace restoration process. The aim is to verify the efficacy of a coping and emotion regulation program analyzing victimization as well as the coping strategies employed in response to these violent acts. The program focuses on 62 women contacted through the Ruta Pacífica de las Mujeres, a nongovernmental organization. The program had a positive effect on women, reporting lower levels of posttraumatic stress, more functional coping strategies, and less use of dysfunctional strategies. All emotional cognitive and social indicators improved. Women felt emotionally better, perceiving greater social support and more trust in institutions. Survivors had more self-confidence to achieve their goals and solve their problems. The implications in a context of peace reconstruction and search for social cohesion are discussed.project (Proyectos CUD 2017) funded by the Oficina de Cooperación al Desarrollo (Development Cooperation Office) of the Universidad del País Vasco/Euskal Herriko Unibertsitatea (University of the Basque Country, Spain) and the University of Burgos funding for the research group SIQoL (Y133GI)

Factors associated with viremia in people living with HIV on antiretroviral therapy in Guatemala

INTRODUCTION: Viral suppression prevents HIV transmission and disease progression, but socio-economic and clinical factors can hinder the goal of suppression. We evaluated factors associated with viral non suppression (VNS) and persistent viremia (PV) in people living with HIV (PLHIV) receiving antiretroviral therapy (ART) in Guatemala. METHODS: We conducted a cross sectional analysis using data from an ongoing cohort of PLHIV attending the largest HIV clinic in Guatemala. Univariable and multivariable analyses were conducted between PLHIV with viral suppression and detectable viremia. VNS was defined as most recent HIV RNA ≥ 200 copies/ml and PV as two consecutive HIV RNA ≥ 200 copies/ml. RESULTS: Of 664 participants, 13.3% had VNS and 7.1% had PV. In univariable analysis disaggregated by gender, low income, poor education, perceived difficulty attending healthcare, and alcohol use were associated with VNS in men while low CD4 at diagnosis, multiple prior ART regimens and treatment interruptions were significant in both genders. Multiple prior ART regimens (adjusted Odds Ratio (aOR) 2.82, [95% confidence interval (CI) 1.59, 4.99], p \u3c 0.01), treatment interruptions (aOR 4.51, [95% CI 2.13, 9.58], p \u3c 0.01), excessive alcohol consumption (aOR 2.56, [95% CI 1.18, 5.54], p \u3c 0.05) perceived difficulty attending healthcare (aOR 2.07, [ 95% CI 1.25, 3.42], p \u3c 0.01) and low CD4 at diagnosis (aOR 2.34, 95% [CI 1.30, 4.20], p \u3c 0.01) were independently associated with VNS on multivariable regression. CONCLUSIONS: We conclude that socio-economic and clinical factors influence viral suppression in our cohort and vary between men and women. Gender specific approaches are necessary to achieve the 90% suppression goal

Sensor Interface for Cardiac Rehabilitation Monitoring: Pilot Clinical Study

In this paper, is presented a pilot clinical study of a monitoring system designed for cardiac rehabilitation (CR). The system allows measuring three main metrics: cardiovascular, spatiotemporal gait and difficulty in physical activity parameters. In this study, the sensor interface was used with two volunteer patients from the phase II of CR. During the experiment, the monitoring system was used to report the parameters and store the information from the patients without interrupting the session. It was found that there is no difference between the data from the interface and the measurements that are normally taken by physiatrists. Additionally, the system allows the continuous measurement and visualization of the status of the patient, which might prove useful for physiatrists. This work presents an exploratory experiment for an on-line assessment method for CR sessions, which in turn, opens the possibility of implementing different biofeedback methods to improve the rehabilitation effects of CR

Formalizing Bitcoin Crashes with Universally Composable Security

Bitcoin has introduced an open and decentralized consensus mechanism which in combination with an append-only ledger allows building so-called blockchain systems, often instantiated as permissionless cryptocurrencies. Bitcoin is surprisingly successful and its market capitalization has reached about 168 billion USD as of July 2020. Due to its high economic value, it became a lucrative target and the growing community has discovered various attacks, proposed promising improvements, and introduced contingency plans for handling catastrophic failures. Nonetheless, existing analysis and contingency plans are not formalized and are tailored only to handle a small specific subset of diverse attacks, and as such, they cannot resist unexpected emergency cases and it is hard to reason about their effectiveness and impact on the system. In this work, we provide a formalized framework to help evaluate a variety of attacks and their mitigations. The framework is based upon the universal composability (UC) framework to describe the attacker\u27s power and the system\u27s security goals. We propose the system in the context of Bitcoin and to the best of our knowledge, no similar work has been proposed previously. Besides, we demonstrate and evaluate our model with different case studies from the real world. Finally, we signal remaining challenges for the contingency plans and their formalization

A comparison of multiple Rosetta data sets and 3D model calculations of 67P/Churyumov-Gerasimenko coma around equinox (May 2015)

We have used the latest available shape model for gas and dust simulations of the inner coma of comet 67P/Churyumov-Gerasimenko for the period around May 2015 (equinox). We compare results from a purely insolation-driven model with a complementary set of observations made by ROSINA, VIRTIS, MIRO, and OSIRIS within the same period. The observations include - for the first time - inverted MIRO measurements of gas density, temperature and bulk velocity to constrain the model. The comparisons show that, as in November 2014 (Marschall et al., 2016), insolation-driven activity does not provide an adequate fit to the data. Both VIRTIS and MIRO observations indicate that emissions from the Hatmehit and Imhotep regions of the nucleus are strongly depleted in total gas, H2O, and dust emissions in this case. The MIRO inversion provides a challenging constraint to the models as a consequence of the terminator orbit and nucleus pointing of the spacecraft. Nonetheless a consistent picture with a dominance of outgassing from the Hapi region, even at equinox, is clearly evident. An inhomogeneous model consistent with models proposed for the November 2014 time-frame was constructed and provides a better fit to the data. As far as we are aware this is the first time comae data from four Rosetta instruments have been used to constrain within one self-contained model the emission distribution at the nucleus surface and study the dynamics of the gas and dust outflow

Modelación del arroz en Latinoamérica: estado del arte y base de datos para parametrización.

El arroz en Latinoamérica y el Caribe (LAC) es un cultivo de gran importancia social y económica. El consumo de arroz en LAC ha aumentado significativamente durante los últimos años, registrando un promedio actual de 30 kg persona-1 año-1. La particularidad del arroz producido en LAC está en una alta calidad de grano y una producción que se realiza en su mayoría bajo sistemas mecanizados con siembra directa. En LAC, el arroz es producido bajo riego y secano dentro de diferentes eco-regiones (templado, tropical húmedo, tropical seco). La seguridad alimentaria y el cambio climático constituyen un reto para la producción de arroz en LAC, elevando la necesidad de aumentar, pero a su vez estabilizar los rendimientos y la calidad del grano. La modelación de cultivos permite evaluar potenciales estrategias de adaptación. Estas herramientas permiten conocer, de forma anticipada, el comportamiento de las variedades de arroz bajo diferentes ambientes (combinaciones de suelo, clima, manejo y sus interacciones). Esto permite proyectar no solo los cambios en rendimiento y manejo del cultivo, pero también entender los procesos eco-fisiológicos que causan dichos cambios. El objetivo del presente trabajo es recopilar información relevante sobre el cultivo de arroz en LAC, para su uso para calibración y/o validación de los modelos de simulación de crecimiento de cultivos. La información recabada incluye (1) generalidades sobre estudios de modelación existentes en LAC; (2) datos de crecimiento y desarrollo de variedades en ensayos experimentales; y (3) datos generales (a nivel nacional) de manejo del cultivo en LAC. A través de una revisión de literatura se encontraron estudios de modelación publicados para cuatro países de Latinoamérica: Brasil, Venezuela, Chile y Cuba. Se colectaron y organizaron datos de un total de 65 ensayos eco-fisiológicos para calibración y evaluación de modelos mecanísticos para dos países: Brasil y Colombia. Estas bases de datos incluyen información básica de clima y suelos, así como de crecimiento y desarrollo del cultivo para 2 variedades en Colombia; y para 3 variedades en Brasil. Adicionalmente, de acuerdo a información disponible a través del Fondo Latinoamericano de Arroz de Riego (FLAR) se determinó que existe información en otros países de la región. Esta información fue identificada como parte de este trabajo, y podría en el futuro formar parte de una segunda base de datos, que complemente la presentada en este informe. Toda esta información, así como los datos de manejo a nivel nacional recolectados a través de FLAR, constituyen un importante primer paso para estudiar los impactos del cambio climático en el cultivo de arroz en LAC.bitstream/item/176093/1/CNPAF-2018-abh.pdfEUR 29026 E

Factors influencing terrestriality in primates of the Americas and Madagascar

Among mammals, the order Primates is exceptional in having a high taxonomic richness in which the taxa are arboreal, semiterrestrial, or terrestrial. Although habitual terrestriality is pervasive among the apes and African and Asian monkeys (catarrhines), it is largely absent among monkeys of the Americas (platyrrhines), as well as galagos, lemurs, and lorises (strepsirrhines), which are mostly arboreal. Numerous ecological drivers and species-specific factors are suggested to set the conditions for an evolutionary shift from arboreality to terrestriality, and current environmental conditions may provide analogous scenarios to those transitional periods. Therefore, we investigated predominantly arboreal, diurnal primate genera from the Americas and Madagascar that lack fully terrestrial taxa, to determine whether ecological drivers (habitat canopy cover, predation risk, maximum temperature, precipitation, primate species richness, human population density, and distance to roads) or species-specific traits (body mass, group size, and degree of frugivory) associate with increased terrestriality. We collated 150,961 observation hours across 2,227 months from 47 species at 20 sites in Madagascar and 48 sites in the Americas. Multiple factors were associated with ground use in these otherwise arboreal species, including increased temperature, a decrease in canopy cover, a dietary shift away from frugivory, and larger group size. These factors mostly explain intraspecific differences in terrestriality. As humanity modifies habitats and causes climate change, our results suggest that species already inhabiting hot, sparsely canopied sites, and exhibiting more generalized diets, are more likely to shift toward greater ground use.Fil: Eppley, Timothy M.. San Diego Zoo Wildlife Alliance; Estados Unidos. Portland State University; Estados UnidosFil: Hoeks, Selwyn. Radboud Universiteit Nijmegen; Países BajosFil: Chapman, Colin A.. University of KwaZulu-Natal; Sudáfrica. Wilson Center; Estados Unidos. Northwest University; China. The George Washington University; Estados UnidosFil: Ganzhorn, Jörg U.. Universitat Hamburg; AlemaniaFil: Hall, Katie. Sedgwick County Zoo; Estados UnidosFil: Owen, Megan A.. San Diego Zoo Wildlife Alliance; Estados UnidosFil: Adams, Dara B.. Humboldt State University; Estados Unidos. Ohio State University; Estados UnidosFil: Allgas, Néstor. Asociación Neotropical Primate Conservation Perú; PerúFil: Amato, Katherine R.. Northwestern University; Estados UnidosFil: Andriamahaihavana, McAntonin. Université D'antananarivo; MadagascarFil: Aristizabal, John F.. Universidad Autónoma de Ciudad Juárez; México. Universidad de los Andes; ColombiaFil: Baden, Andrea L.. City University of New York; Estados Unidos. New York Consortium In Evolutionary Primatology; Estados UnidosFil: Balestri, Michela. Oxford Brookes University (oxford Brookes University);Fil: Barnett, Adrian A.. University Of Roehampton; Reino Unido. Universidade Federal de Pernambuco; BrasilFil: Bicca Marques, Júlio César. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Bowler, Mark. University Of Suffolk; Reino Unido. San Diego Zoo Wildlife Alliance; Estados UnidosFil: Boyle, Sarah A.. Rhodes College; Estados UnidosFil: Brown, Meredith. University of Calgary; CanadáFil: Caillaud, Damien. University of California at Davis; Estados UnidosFil: Calegaro Marques, Cláudia. Universidade Federal do Rio Grande do Sul; BrasilFil: Campbell, Christina J.. California State University Northridge (calif. State Univ. Northridge);Fil: Campera, Marco. Oxford Brookes University (oxford Brookes University);Fil: Campos, Fernando A.. University of Texas at San Antonio; Estados UnidosFil: Cardoso, Tatiane S.. Museu Paraense Emílio Goeldi; BrasilFil: Carretero Pinzón, Xyomara. Proyecto Zocay; ColombiaFil: Champion, Jane. University of Calgary; CanadáFil: Chaves, Óscar M.. Universidad de Costa Rica; Costa RicaFil: Chen Kraus, Chloe. University of Yale; Estados UnidosFil: Colquhoun, Ian C.. Western University; CanadáFil: Dean, Brittany. University of Calgary; CanadáFil: Kowalewski, Miguel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); Argentin

The case for investment in tobacco control: lessons from four countries in the Americas

Objective. To synthesize learnings from four national tobacco control investment cases conducted in the Ameri- cas (Colombia, Costa Rica, El Salvador, Suriname) under the World Health Organization Framework Convention on Tobacco Control (WHO FCTC) 2030 project, to describe results and how national health authorities have used the cases, and to discuss implications for the role of investment cases in advancing tobacco control. Methods. We draw on findings from four national investment cases that included 1) a cost-of-illness analysis calculating the health and economic burden of tobacco use, 2) a return-on-investment analysis of implement- ing key tobacco control demand reduction measures, and 3) a subsidiary analysis of one tobacco control topic of national interest (e.g., equity implications of cigarette taxation). Co-authors reported how cases have been used to advance tobacco control. Results. In Colombia, Costa Rica, El Salvador, and Suriname, tobacco use causes social and economic losses equivalent to between 1.0 to 1.8 percent of GDP. Across these countries, implementing WHO FCTC demand reduction measures would save an average of 11 400 lives per year over the next 15 years. Benefits of the mea- sures would far outweigh the costs of implementation and enforcement. Governments are using the cases to advance tobacco control, including to improve tobacco control laws and their enforcement, strengthen tobacco taxation, prioritize tobacco control planning, coordinate a multisectoral response, and engage political leaders. Conclusions. National investment cases can help to strengthen tobacco control in countries, including by increasing public and political support for implementation of the WHO FCTC and by informing effective plan- ning, legislation, coordination and financing