214 research outputs found
30P Nowa fizyczna metoda wczesnego diagnozowania i monitorowania leczenia chorych z rozpoznaniem nowotworu
Pole magnetyczne o indukcji B > 10 tesli znajduje zastosowanie w analizie indukowanej dwójłomności kołowej surowicy krwi. Analiza oddziaływania silnego pola magnetycznego i elektromagnetycznego pola wiązki świetlnej z surowicą krwi wykazała, że w silnym polu magnetycznym ujawnia się wyraźnie ilościowa różnica magneto-optycznych efektów obserwowanych dla surowic dawców krwi chorych z nowotworami. Dokonano analizy 110 surowic krwi. Pomiary wykonano w silnym impulsowym (B ≅ 30 tesli). Próbki surowicy 23 dawców krwi zostały poddane badaniom mającym na celu określenie naturalnej aktywności optycznej. Surowice te stanowiły punkt odniesienia do analiz surowic chorych onkologicznych. Analizowano surowice chorych z rozpoznaniem raka prostaty, jelita grubego, raka jajnika, w którym w trakcie leczenia oznacza się poziom markerów nowotworowych. Druga grupa chorych to pacjenci z mierzalnymi guzami gruczołu piersiowego, mięsaka, czerniaka, szpiczaka. Dokonano pomiarów magneto-optycznych współczynników a, b, c oraz naturalnej aktywności optycznej α0 surowic.Wykazano wyraźną współzależność między stanem chorego, a wartością współczynnika b oraz jego korelacją ze wzrostem poziomu markerów nowotworowych lub wielkością ognisk przerzutowych. Prowadzone po raz pierwszy badania magnatyczno-optycznej dwójłomności kołowej surowicy są szybką metodą analityczną. Mogą w przyszłości mieć zastosowanie w diagnostyce i monitorowaniu leczenia nowotworów
1,8-Diamidocarbazoles: an easily tuneable family of fluorescent anion sensors and transporters
The synthesis, structure and anion recognition properties of an extensive, rationally designed series of bisamide derivatives of 1,8-diaminocarbazole and 1,8-diamino-3,6-dichlorocarbazole are described. Despite simple structures and the presence of only three hydrogen bond donors, such compounds are remarkably strong and selective receptors for oxyanions in DMSO + 0.5%H2O. Owing to their carbazole fluorophore, they are also sensitive turn-on fluorescent sensors for H2PO4− and AcO−, with a more than 15-fold increase in fluorescence intensity upon binding. Despite relatively weak chloride affinity, some of the diamidocarbazoles have also been shown, for the first time, to be very active chloride transporters through lipid bilayers. The binding, sensing and transport properties of these receptors can be easily modulated by the usually overlooked variations in the length and degree of branching of their alkyl side arms. Overall, this study demonstrates that the 1,8-diamidocarbazole binding unit is a very promising and synthetically versatile platform for the development of fluorescent sensors and transporters for anions.Polish National Science Centre for grant OPUS
(2011/01/B/ST5/03900). The study was carried out at the
Biological and Chemical Research Centre, University of Warsaw,
established within a project co-financed by the European Union
through the European Regional Development Fund under the
Operational Programme Innovative Economy 2007–2013. R. Q.
thanks financial support provided by Consejería de Educación –
Junta de Castilla y León (Project BU092U16
Applying the product lines paradigm to the quantitative analysis of collective adaptive systems
Phase separation in a lattice model of a superconductor with pair hopping
We have studied the extended Hubbard model with pair hopping in the atomic
limit for arbitrary electron density and chemical potential. The Hamiltonian
considered consists of (i) the effective on-site interaction U and (ii) the
intersite charge exchange interactions I, determining the hopping of electron
pairs between nearest-neighbour sites. The model can be treated as a simple
effective model of a superconductor with very short coherence length in which
electrons are localized and only electron pairs have possibility of
transferring. The phase diagrams and thermodynamic properties of this model
have been determined within the variational approach, which treats the on-site
interaction term exactly and the intersite interactions within the mean-field
approximation. We have also obtained rigorous results for a linear chain (d=1)
in the ground state. Moreover, at T=0 some results derived within the random
phase approximation (and the spin-wave approximation) for d=2 and d=3 lattices
and within the low density expansions for d=3 lattices are presented. Our
investigation of the general case (as a function of the electron concentration
and as a function of the chemical potential) shows that, depending on the
values of interaction parameters, the system can exhibit not only the
homogeneous phases: superconducting (SS) and nonordered (NO), but also the
phase separated states (PS: SS-NO). The system considered exhibits interesting
multicritical behaviour including tricritical points.Comment: 15 pages, 9 figures; pdf-ReVTeX, final version, corrected typos;
submitted to Journal of Physics: Condensed Matte
70 Wyniki leczenia chorych na raka sutka w stadium rozsiewu w materiale Wielkopolskiego Centrum Onkologii
WstępLeczenie chorych na raka sutka w stadium rozsiewu (M1) ma charakter paliatywny. Metody leczenia obejmują radioterapię, chemioterapię, hormonoterapię w monoterapii lub jako leczenie skojarzone. Wyniki leczenia są najczęściej złe. Przedstawiamy wyniki leczenia chorych na raka sutka w stadium rozsiewu leczonych w Wielkopolskim Centrum Onkologii.Materiał i metody95 chorych na raka sutka w stadium M1 leczono w latach 1983–1987 w Wielkopolskim Centrum Onkologii. Wiek chorych wahał się od 29 do 74 lat, średnio 51,5 lat. W grupie 65 chorych pierwszym umiejscowieniem przerzutów był kościec, w dalszej kolejności płuca i wątroba. Większość chorych leczona była cytostatykami lub hormonami, u części zastosowano paliatywną radioterapię. Wyniki leczenia opracowano na podstawie historii chorób i przeprowadzonej katamnezie. Grupę badaną poddano 5-letniej obserwacji.Wyniki8 chorych (8,4%) przeżyło 5 lat od momentu rozpoczęcia leczenia zmian przerzutowych. Średni okres przeżycia w całej grupie wyniósł 13,5 miesiąca.WnioskiPomimo złego rokowania leczeniem systemowym udaje się przedłużyć życie części chorych na raka sutka, u których wystąpiły przerzuty odległe
79. The effectivness of pain treatment with Strontium 89 in patient with osseous metastases
Aimof this study was to assessment of 89 Sr therapy as pain treatment modality in the group of patients with multiple bone metastases.Material and methodsFrom January 2000 to October 2000 in our center were treated 41 patients; 17 – prostate cancer and 24 – breast cancer patients. All patients had applied only one dose of 150 MBq of 89 Sr. Before and follow-up each patient has been evaluated; performance status according to the Karnofsky Scale and paro intensity according the VAS scale. We did not observe any clinical important haematological side effects. The ionisation dosemetric monitoring of the sources and the radioactive refuse were recorded. The radioactive refuse was storage in special container when the activity decreased to the background.ResultsWe noted relief of paro as follow:-“complete” 18 of 41 patients (8-prostate cancer, 10 – breast cancer),-“partial” 12 of 41 patients (3- prostate cancer, 9- breast cancer),-“no effect” 11 of 41 patients (6-prostate cancer, 5- breast cancer).ConclusionsWe suggest that therapy of painful multiple bone metastases with application of 89 Sr is effective nd safe
Thermal properties of large main-belt asteroids observed by Herschel PACS
Non-resolved thermal infrared observations enable studies of thermal and
physical properties of asteroid surfaces provided the shape and rotational
properties of the target are well determined via thermo-physical models. We
used calibration-programme Herschel PACS data (70, 100, 160 m) and
state-of-the-art shape models derived from adaptive-optics observations and/or
optical light curves to constrain for the first time the thermal inertia of
twelve large main-belt asteroids. We also modelled previously
well-characterised targets such as (1) Ceres or (4) Vesta as they constitute
important benchmarks. Using the scale as a free parameter, most targets
required a re-scaling 5\% consistent with what would be expected given
the absolute calibration error bars. This constitutes a good cross-validation
of the scaled shape models, although some targets required larger re-scaling to
reproduce the IR data. We obtained low thermal inertias typical of large main
belt asteroids studied before, which continues to give support to the notion
that these surfaces are covered by fine-grained insulating regolith. Although
the wavelengths at which PACS observed are longwards of the emission peak for
main-belt asteroids, they proved to be extremely valuable to constrain size and
thermal inertia and not too sensitive to surface roughness. Finally, we also
propose a graphical approach to help examine how different values of the
exponent used for scaling the thermal inertia as a function of heliocentric
distance (i.e. temperature) affect our interpretation of the results.Comment: Accepted for publication in Astronomy & Astrophysics (preprint
version
Origins of the Ambient Solar Wind: Implications for Space Weather
The Sun's outer atmosphere is heated to temperatures of millions of degrees,
and solar plasma flows out into interplanetary space at supersonic speeds. This
paper reviews our current understanding of these interrelated problems: coronal
heating and the acceleration of the ambient solar wind. We also discuss where
the community stands in its ability to forecast how variations in the solar
wind (i.e., fast and slow wind streams) impact the Earth. Although the last few
decades have seen significant progress in observations and modeling, we still
do not have a complete understanding of the relevant physical processes, nor do
we have a quantitatively precise census of which coronal structures contribute
to specific types of solar wind. Fast streams are known to be connected to the
central regions of large coronal holes. Slow streams, however, appear to come
from a wide range of sources, including streamers, pseudostreamers, coronal
loops, active regions, and coronal hole boundaries. Complicating our
understanding even more is the fact that processes such as turbulence,
stream-stream interactions, and Coulomb collisions can make it difficult to
unambiguously map a parcel measured at 1 AU back down to its coronal source. We
also review recent progress -- in theoretical modeling, observational data
analysis, and forecasting techniques that sit at the interface between data and
theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue
connected with a 2016 ISSI workshop on "The Scientific Foundations of Space
Weather." 44 pages, 9 figure
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