Global Maps of Science based on the new Web-of-Science Categories

In August 2011, Thomson Reuters launched version 5 of the Science and Social Science Citation Index in the Web of Science (WoS). Among other things, the 222 ISI Subject Categories (SCs) for these two databases in version 4 of WoS were renamed and extended to 225 WoS Categories (WCs). A new set of 151 Subject Categories (SCs) was added, but at a higher level of aggregation. Since we previously used the ISI SCs as the baseline for a global map in Pajek (Rafols et al., 2010) and brought this facility online (at http://www.leydesdorff.net/overlaytoolkit), we recalibrated this map for the new WC categories using the Journal Citation Reports 2010. In the new installation, the base maps can also be made using VOSviewer (Van Eck & Waltman, 2010).Comment: Scientometrics, in pres

Just how difficult can it be counting up R&D funding for emerging technologies (and is tech mining with proxy measures going to be any better?)

Decision makers considering policy or strategy related to the development of emerging technologies expect high quality data on the support for different technological options. A natural starting point would be R&D funding statistics. This paper explores the limitations of such aggregated data in relation to the substance and quantification of funding for emerging technologies. Using biotechnology as an illustrative case, we test the utility of a novel taxonomy to demonstrate the endemic weaknesses in the availability and quality of data from public and private sources. Using the same taxonomy, we consider the extent to which tech-mining presents an alternative, or potentially complementary, way to determine support for emerging technologies using proxy measures such as patents and scientific publications

Conversion of Adjustable Gastric Banding to Roux-en-Y Gastric Bypass in One or Two Steps: What Is the Best Approach? Analysis of a Multicenter Database Concerning 832 Patients

Background: Roux-en-Y gastric bypass (RYGB) is often the preferred conversion procedure for laparoscopic adjustable gastric banding (LAGB) poor responders. However, there is controversy whether it is better to convert in one or two stages. This study aims to compare the outcomes of one and two-stage conversions of LAGB to RYGB. Methods: Retrospective review of a multicenter prospectively collected database. Data on conversion in one and two stages was compared. Results: Eight hundred thirty-two patients underwent LAGB conversion to RYGB in seven specialized bariatric centers. Six hundred seventy-three (81%) were converted in one-stage. Patients in the two-stage group were more likely to have experienced technical complications, such as slippage or erosions (86% vs. 37%, p = 0.0001) and to have had a higher body mass index (BMI) (41.6 vs. 39.9 Kg/m2, p = 0.005). There were no differences in postoperative complications and mortality rates between the one-stage and two-stage groups (13.5% vs. 10.8%, and 0.7% vs. 0.0% respectively, p = ns). Mean final BMI and %total weight loss (%TWL) for the one-stage and the two-stage groups were 31.6 vs. 32.4 Kg/m2 (p = ns) and 30.4 vs. 26.8 (p = 0.017) after a mean follow-up of 33 months. Follow-up at 1, 3, and 5 years was 98%, 75%, and 54%, respectively. Conclusions: One-stage conversion of LAGB to RYGB is safe and effective. Two-stage conversion carries low morbidity and mortality in the case of band slippage, erosion, or higher BMI patients. These findings suggest the importance of patient selection when choosing the appropriate conversion approachinfo:eu-repo/semantics/publishedVersio

Adjustable Gastric Banding Conversion to One Anastomosis Gastric Bypass: Data Analysis of a Multicenter Database

Introduction: One anastomosis gastric bypass (OAGB) has been proposed as a rescue technique for laparoscopic adjustable gastric banding (LAGB) poor responders. Aim: We sought to analyze, complications, mortality, and medium-term weight loss results after LAGB conversion to OAGB. Methods: Data analysis of an international multicenter database. Results: One hundred eighty-nine LAGB-to-OAGB operations were retrospectively analyzed. Eighty-seven (46.0%) were converted in one stage. Patients operated on in two stages had a higher preoperative body mass index (BMI) (37.9 vs. 41.3 kg/m2, p = 0.0007) and were more likely to have encountered technical complications, such as slippage or erosions (36% vs. 78%, p < 0.0001). Postoperative complications occurred in 4.8% of the patients (4.6% and 4.9% in the one-stage and the two-stage group, respectively). Leak rate, bleeding episodes, and mortality were 2.6%, 0.5%, and 0.5%, respectively. The final BMI was 30.2 at a mean follow-up of 31.4 months. Follow-up at 1, 3, and 5 years was 100%, 88%, and 70%, respectively. Conclusion: Conversion from LAGB to OAGB is safe and effective. The one-stage approach appears to be the preferred option in non-complicate cases, while the two-step approach is mostly done for more complicated cases.info:eu-repo/semantics/publishedVersio

A Semantic-Driven Model for Ranking Digital Learning Objects Based on Diversity in the User Comments

This paper presents a computational model for measuring diversity in terms of variety, balance and disparity. This model is informed by the Stirling’s framework for understanding diversity from social science and underpinned by semantic techniques from computer science. A case study in learning is used to illustrate the application of the model. It is driven by the desire to broaden learners’ perspectives in an increasingly diverse and inclusive society. For example, interpreting body language in a job interview may be influenced by the different background of observers. With the explosion of digital objects on social platforms, selecting the appropriate ones for learning can be challenging and time consuming. The case study uses over 2000 annotated comments from 51 YouTube videos on job interviews. Diversity indicators are produced based on the comments for each video, which in turn facilitate the ranking of the videos according to the degree of diversity in the comments for the selected domain

LYACOLORE: synthetic datasets for current and future Lyman-alpha forest BAO surveys

The statistical power of Lyman-α forest Baryon Acoustic Oscillation (BAO) measurements is set to increase significantly in the coming years as new instruments such as the Dark Energy Spectroscopic Instrument deliver progressively more constraining data. Generating mock datasets for such measurements will be important for validating analysis pipelines and evaluating the effects of systematics. With such studies in mind, we present LyaCoLoRe: a package for producing synthetic Lyman-α forest survey datasets for BAO analyses. LyaCoLoRe transforms initial Gaussian random field skewers into skewers of transmitted flux fraction via a number of fast approximations. In this work we explain the methods of producing mock datasets used in LyaCoLoRe, and then measure correlation functions on a suite of realisations of such data. We demonstrate that we are able to recover the correct BAO signal, as well as large-scale bias parameters similar to literature values. Finally, we briefly describe methods to add further astrophysical effects to our skewers—high column density systems and metal absorbers—which act as potential complications for BAO analyses

Cortisol como inhibidor de la entrada de LDL-Ox y de la remoción de colesterol en macrófagos THP1

El rol de los glucocorticoides en el desarrollo de la ateroesclerosis es discutido mostrando diferentes efectos en humanos y en modelos experimentales de animales. La ateroescleroisis es el resultado de una respuesta inflamatoria crónica frente a un endotelio injuriado, donde una entrada descontrolada de LDL-Ox (lipoproteínas de baja densidad oxidadas) en macrófagos desencadena su transformación en células espumosas (foams cells), el mayor componente de las estrías grasas en la placa arterosclerótica. Existe poca evidencia del efecto directo de los glucocorticoides sobre los macrófagos espumosos.Facultad de Ciencias Médica

The Impact of Boundary Spanning Scholarly Publications and Patents

Human knowledge and innovation are recorded in two media: scholarly publication and patents. These records not only document a new scientific insight or new method developed, but they also carefully cite prior work upon which the innovation is built.We quantify the impact of information flow across fields using two large citation dataset: one spanning over a century of scholarly work in the natural sciences, social sciences and humanities, and second spanning a quarter century of United States patents.We find that a publication's citing across disciplines is tied to its subsequent impact. In the case of patents and natural science publications, those that are cited at least once are cited slightly more when they draw on research outside of their area. In contrast, in the social sciences, citing within one's own field tends to be positively correlated with impact

Changing Directions: Steering science, technology and innovation towards the Sustainable Development Goals

Science, technology and innovation are failing to address the world’s most urgent sustainability challenges, according to a major new report from the STRINGS project. ‘Changing Directions: Steering science, technology and innovation towards the Sustainable Development Goals’ is the final report of an in-depth study involving collaborators from across the globe. It highlights a glaring mismatch between the priorities of the world’s scientific communities and the United Nations’ Sustainable Development Goals, which were set up to drive change across all areas of social justice and environmental issues