Agglomeration externalities, innovation and regional growth: Theoretical perspectives and meta-analysis

Technological change and innovation and are central to the quest for regional development. In the globally-connected knowledge-driven economy, the relevance of agglomeration forces that rely on proximity continues to increase, paradoxically despite declining real costs of information, communication and transportation. Globally, the proportion of the population living in cities continues to grow and sprawling cities remain the engines of regional economic transformation. The growth of cities results from a complex chain that starts with scale, density and geography, which then combine with industrial structure characterised by its extent of specialisation, competition and diversity, to yield innovation and productivity growth that encourages employment expansion, and further urban growth through inward migration. This paper revisits the central part of this virtuous circle, namely the Marshall-Arrow-Romer externalities (specialisation), Jacobs externalities (diversity) and Porter externalities (competition) that have provided alternative explanations for innovation and urban growth. The paper evaluates the statistical robustness of evidence for such externalities presented in 31 scientific articles, all building on the seminal work of Glaeser et al. (1992). We aim to explain variation in estimation results using study characteristics by means of ordered probit analysis. Among the results, we find that the impact of diversity depends on how it is measured and that diversity is important for the high-tech sector. High population density increases the chance of finding positive effects of specialisation on growth. More recent data find more positive results for both specialization and diversity, suggesting that agglomeration externalities become more important over time. Finally, primary study results depend on whether or not the externalities are considered jointly and on other features of the regression model specification

When The Silv\u27ry Moon Is Shining On The Goldn Harvest Sheaves

https://digitalcommons.library.umaine.edu/mmb-vp/4831/thumbnail.jp

When You Sang The Palms to Me

https://digitalcommons.library.umaine.edu/mmb-vp/4668/thumbnail.jp

Southern Rose

https://digitalcommons.library.umaine.edu/mmb-vp/5048/thumbnail.jp

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways

The new model of fitting the spectral energy distributions of Mkn 421 and Mkn 501

The spectral energy distribution (SED) of TeV blazars has a double-humped shape that is usually interpreted as Synchrotron Self Compton (SSC) model. The one zone SSC model is used broadly but cannot fit the high energy tail of SED very well. It need bulk Lorentz factor which is conflict with the observation. Furthermore one zone SSC model can not explain the entire spectrum. In the paper, we propose a new model that the high energy emission is produced by the accelerated protons in the blob with a small size and high magnetic field, the low energy radiation comes from the electrons in the expanded blob. Because the high and low energy photons are not produced at the same time, the requirement of large Doppler factor from pair production is relaxed. We present the fitting results of the SEDs for Mkn 501 during April 1997 and Mkn 421 during March 2001 respectively.Comment: 5 pages, 1 figures, 1table. accepted for publication in Sciences in China --

When the tale comes true: multiple populations and wide binaries in the Orion Nebula Cluster

The high-quality OmegaCAM photometry of the 3x3 deg around the Orion Nebula Cluster (ONC) in r, and i filters by Beccari et al.(2017) revealed three well-separated pre-main sequences in the color-magnitude diagram (CMD). The objects belonging to the individual sequences are concentrated towards the center of the ONC. The authors concluded that there are two competitive scenarios: a population of unresolved binaries and triples with an exotic mass ratio distribution, or three stellar populations with different ages. We use Gaia DR2 in combination with the photometric OmegaCAM catalog to test and confirm the presence of the putative three stellar populations. We also study multiple stellar systems in the ONC for the first time using Gaia DR2. We confirm that the second and third sequence members are more centrally concentrated towards the center of the ONC. In addition we find an indication that the parallax and proper motion distributions are different among the members of the stellar sequences. The age difference among stellar populations is estimated to be 1-2 Myr. We use Gaia measurements to identify and remove as many unresolved multiple system candidates as possible. Nevertheless we are still able to recover two well-separated sequences with evidence for the third one, supporting the existence of the three stellar populations. We were able to identify a substantial number of wide binary objects (separation between 1000-3000 au). This challenges previously inferred values that suggested no wide binary stars exist in the ONC. Our inferred wide-binary fraction is approx 5%. We confirm the three populations correspond to three separated episodes of star formation. Based on this result, we conclude that star formation is not happening in a single burst in this region. (abridged)Comment: Astronomy and Astrophysics (A&A) accepted. 12 pages, 9 figures + appendix. New version with language corrections and new ID values in Tab.A.

Nonlinear evolution of the magnetized Kelvin-Helmholtz instability: from fluid to kinetic modeling

The nonlinear evolution of collisionless plasmas is typically a multi-scale process where the energy is injected at large, fluid scales and dissipated at small, kinetic scales. Accurately modelling the global evolution requires to take into account the main micro-scale physical processes of interest. This is why comparison of different plasma models is today an imperative task aiming at understanding cross-scale processes in plasmas. We report here the first comparative study of the evolution of a magnetized shear flow, through a variety of different plasma models by using magnetohydrodynamic, Hall-MHD, two-fluid, hybrid kinetic and full kinetic codes. Kinetic relaxation effects are discussed to emphasize the need for kinetic equilibriums to study the dynamics of collisionless plasmas in non trivial configurations. Discrepancies between models are studied both in the linear and in the nonlinear regime of the magnetized Kelvin-Helmholtz instability, to highlight the effects of small scale processes on the nonlinear evolution of collisionless plasmas. We illustrate how the evolution of a magnetized shear flow depends on the relative orientation of the fluid vorticity with respect to the magnetic field direction during the linear evolution when kinetic effects are taken into account. Even if we found that small scale processes differ between the different models, we show that the feedback from small, kinetic scales to large, fluid scales is negligable in the nonlinear regime. This study show that the kinetic modeling validates the use of a fluid approach at large scales, which encourages the development and use of fluid codes to study the nonlinear evolution of magnetized fluid flows, even in the colisionless regime