Algon: a framework for supporting comparison of distributed algorithm performance

Programmers often need to use distributed algorithms to add non-functional behaviour such as mutual exclusion, deadlock detection and termination, to a distributed application. They find the selection and implementation of these algorithms daunting. Consequently, they have no idea which algorithm will be best for their particular application. To address this difficulty the Algon framework provides a set of pre-coded distributed algorithms for programmers to choose from, and provides a special performance display tool to support choice between algorithms. The performance tool is discussed. The developer of a distributed application will be able to observe the performance of each of the available algorithms according to a set of of widely accepted and easily-understandable performance metrics and compare and contrast the behaviour of the algorithms to support an informed choice. The strength of the Algon framework is that it does not require a working knowledge of algorithmic theory or functionality in order for the developer to use the algorithms

Magnetoresistance and collective Coulomb blockade in super-lattices of ferromagnetic CoFe nanoparticles

We report on transport properties of millimetric super-lattices of CoFe nanoparticles surrounded by organic ligands. R(T)s follow R(T) = R_0.exp(T/T_0)^0.5 with T_0 ranging from 13 to 256 K. At low temperature I(V)s follow I=K[(V-V_T)/V_T]^ksi with ksi ranging 3.5 to 5.2. I(V) superpose on a universal curve when shifted by a voltage proportional to the temperature. Between 1.8 and 10 K a high-field magnetoresistance with large amplitude and a strong voltage-dependence is observed. Its amplitude only depends on the magnetic field/temperature ratio. Its origin is attributed to the presence of paramagnetic states present at the surface or between the nanoparticles. Below 1.8 K, this high-field magnetoresistance abruptly disappears and inverse tunnelling magnetoresistance is observed, the amplitude of which does not exceed 1%. At this low temperature, some samples display in their I(V) characteristics abrupt and hysteretic transitions between the Coulomb blockade regime and the conductive regime. The increase of the current during these transitions can be as high as a factor 30. The electrical noise increases when the sample is near the transition. The application of a magnetic field decreases the voltage at which these transitions occur so magnetic-field induced transitions are also observed. Depending on the applied voltage, the temperature and the amplitude of the magnetic field, the magnetic-field induced transitions are either reversible or irreversible. These abrupt and hysteretic transitions are also observed in resistance-temperature measurements. They could be the soliton avalanches predicted by Sverdlov et al. [Phys. Rev. B 64, 041302 (R), 2001] or could also be interpreted as a true phase transition between a Coulomb glass phase to a liquid phase of electrons

Evolution of the mass, size, and star formation rate in high-redshift merging galaxies MIRAGE - A new sample of simulations with detailed stellar feedback

We aim at addressing the questions related to galaxy mass assembly through major and minor wet merging processes in the redshift range 1<z<2. A consequent fraction of Milky Way like galaxies are thought to have undergone an unstable clumpy phase at this early stage. Using the adaptive mesh refinement code RAMSES, with a recent physically-motivated implementation of stellar feedback, we build the Merging and Isolated high-Redshift Adaptive mesh refinement Galaxies (MIRAGE) sample. It is composed of 20 mergers and 3 isolated idealized disks simulations with global physical properties in accordance with the 1<z<2 mass complete sample MASSIV. The numerical hydrodynamical resolution reaches 7 parsecs in the smallest Eulerian cells. Our simulations include: star formation, metal line cooling, metallicity advection, and a recent implementation of stellar feedback which encompasses OB-type stars radiative pressure, photo-ionization heating, and supernovae. The initial conditions are set to match the z~2 observations, thanks to a new public code DICE. The numerical resolution allows us to follow the formation and evolution of giant clumps formed in-situ from Jeans instabilities triggered by high initial gas fraction. The star formation history of isolated disks shows stochastic star formation rate, which proceeds from the complex behavior of the giant clumps. Our minor and major gas-rich merger simulations do not trigger starbursts, suggesting a saturation of the star formation in a turbulent and clumpy interstellar medium fed by substantial accretion from the circum-galactic medium. Our simulations are close to the normal regime of the disk-like star formation on a Schmidt-Kennicutt diagram. The mass-size relation and its rate of evolution matches observations, suggesting that the inside-out growth mechanisms of the stellar disk do not necessarily require to be achieved through a cold accretion.Comment: 18 pages, 12 figures. Accepted in A&

Biochemical and clinical response after umbilical cord blood transplant in a boy with early childhood-onset beta-mannosidosis.

BACKGROUND: Deficiency in the enzyme β-mannosidase was described over three decades ago. Although rare in occurrence, the presentation of childhood-onset β-mannosidase deficiency consists of hypotonia in the newborn period followed by global development delay, behavior problems, and intellectual disability. No effective pharmacologic treatments have been available. METHODS: We report 2-year outcomes following the first umbilical cord blood transplant in a 4-year-old boy with early childhood-onset disease. RESULTS: We show restoration of leukocyte β-mannosidase activity which remained normal at 2 years posttransplant, and a simultaneous increase in plasma β-mannosidase activity and dramatic decrease in urine-free oligosaccharides were also observed. MRI of the brain remained stable. Neurocognitive evaluation revealed test point gains, although the magnitude of improvement was less than expected for age, causing lower IQ scores that represent a wider developmental gap between the patient and unaffected peers. CONCLUSION: Our findings suggest that hematopoietic cell transplant can correct the biochemical defect in β-mannosidosis, although preservation of the neurocognitive trajectory may be a challenge

The 3rd IBIS/ISGRI soft gamma-ray survey catalog

In this paper we report on the third soft gamma-ray source catalog obtained with the IBIS/ISGRI gamma-ray imager on board the INTEGRAL satellite. The scientific dataset is based on more than 40 Ms of high quality observations performed during the first three and a half years of Core Program and public IBIS/ISGRI observations. Compared to previous IBIS/ISGRI surveys, this catalog includes a substantially increased coverage of extragalactic fields, and comprises more than 400 high-energy sources detected in the energy range 17-100 keV, including both transients and faint persistent objects which can only be revealed with longer exposure times.Comment: Accepted for publication in ApJ Suppl.; 11 pages; 4 figures Minor changes to conten

Governor Patrick Signs Bill to Control Health Care Costs

Surveys of foliar endophytes from the Acadian forest region over the past three decades have identified numerous phylogenetically diverse fungi producing natural products toxic to forest pests and diseases. The life histories of some conifer endophytes can be restricted to plant foliage or may include saprotrophic phases on other plants tissues or even alternate hosts. Considering the potentially broad host preferences of conifer endophytes we explored fungi isolated from understory species and their metabolites as part of an ongoing investigation of fungal biodiversity from the Acadian forest. We report a hitherto unidentified Xylariomycetidae species isolated from symptomatic Labrador tea (Rhododendron groenlandicum) leaves and mountain laurel (Kalmia latifolia) collected in coastal southern New Brunswick, Canada. Morphological and phylogenetic evidence demonstrated the unknown species was a novel Synnemapestaloides (Sporocadaceae) species, described here as Syn. ericacearum. A preliminary screening assay indicated that the culture filtrate extract of the new species was potently antifungal towards the biotrophic pathogen Microbotryum violaceum, warranting an investigation of its natural products. Two natural products possessing a rare 1,3-benzodioxin-4-one scaffold, synnemadoxins A-B (1-2), and their postulated precursor, synnemadiacid A (3), were characterized as new structures and assessed for antimicrobial activity. All isolated compounds elicited in vitro inhibitory antifungal activity towards M. violaceum at 2.3 μg mL-1 and moderate antibiotic activity. Further, the characterization of synnemadoxins A-B provided a perspective on the biosynthesis of some related 1,3-benzodioxin-4-ones produced by other fungi within the Xylariales

Shape-Selection of Thermodynamically Stabilized Colloidal Pd and Pt Nanoparticles Controlled via Support Effects

Colloidal chemistry, in combination with nanoparticle (NP)/support epitaxial interactions is used here to synthesize shape-selected and thermodynamically stable metallic NPs over a broad range of NP sizes. The morphology of three-dimensional palladium and platinum NPs supported on TiO₂(110) was investigated using scanning tunneling microscopy. Well-defined Pd and Pt NPs were synthesized via inverse micelle encapsulation. The initially spherical NPs were found to become faceted and form an epitaxial relationship with the support after high-temperature annealing (e.g., 1100 °C). Shape selection was achieved for almost all Pd NPs, namely, a truncated octahedron shape with (111) top and interfacial facets. The Pt NPs were however found to adopt a variety of shapes. The epitaxial relationship of the NPs with the support was evidenced by the alignment of the cluster’s edges with TiO₂(110)-[001] atomic rows and was found to be responsible for the shape control. The ability of synthesizing thermally stable shape-selected metal NPs demonstrated here is expected to be of relevance for applications in the field of catalysis, since the activity and selectivity of NP catalysts has been shown to strongly depend on the NP shape

INTEGRAL detection of hard X-rays from NGC 6334: Nonthermal emission from colliding winds or an AGN?

We report the detection of hard X-ray emission from the field of the star-forming region NGC 6334 with the the International Gamma-Ray Astrophysics Laboratory INTEGRAL. The JEM-X monitor and ISGRI imager aboard INTEGRAL and Chandra ACIS imager were used to construct 3-80 keV images and spectra of NGC 6334. The 3-10 keV and 10-35 keV images made with JEM-X show a complex structure of extended emission from NGC 6334. The ISGRI source detected in the energy ranges 20-40 keV and 40-80 keV coincides with the NGC 6334 ridge. The 20-60 keV flux from the source is (1.8+-0.37)*10(-11) erg cm(-2) s(-1). Spectral analysis of the source revealed a hard power-law component with a photon index about 1. The observed X-ray fluxes are in agreement with extrapolations of X-ray imaging observations of NGC 6334 by Chandra ACIS and ASCA GIS. The X-ray data are consistent with two very different physical models. A probable scenario is emission from a heavily absorbed, compact and hard Chandra source that is associated with the AGN candidate radio source NGC 6334B. Another possible model is the extended Chandra source of nonthermal emission from NGC 6334 that can also account for the hard X-ray emission observed by INTEGRAL. The origin of the emission in this scenario is due to electron acceleration in energetic outflows from massive early type stars. The possibility of emission from a young supernova remnant, as suggested by earlier infrared observations of NGC 6334, is constrained by the non-detection of 44Ti lines.Comment: 8 pages, 8 figures, Astronomy and Astrophysics (in press