Weak-field Hall effect and static polarizability of Bloch electrons

A theory of the weak field Hall effect of Bloch electrons based on the analysis of the forces acting on electrons is presented. It is argued that the electric current is composed of two contributions, that driven by the electric field along current flow and the non-dissipative contribution originated in demagnetization currents. The Hall resistance as a function of the electron concentration for the tight-binding model of a crystal with square lattice and body-centered cubic lattice is described in detail. For comparison the effect of strong magnetic fields is also discussed

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

Understanding how avian influenza viruses adapt to human hosts is critical for the monitoring and prevention of future pandemics. Host specificity is determined by multiple sites in different viral proteins, and mutation of only a limited number of these sites can lead to inter-species transmission. Several of these sites have been identified in the viral polymerase, the best characterised being position 627 in the PB2 subunit. Efficient viral replication at the relatively low temperature of the human respiratory tract requires lysine 627 rather than the glutamic acid variant found systematically in avian viruses. However, the molecular mechanism by which any of these host specific sites determine host range are unknown, although adaptation to host factors is frequently evoked. We used ESPRIT, a library screening method, to identify a new PB2 domain that contains a high density of putative host specific sites, including residue 627. The X-ray structure of this domain (denoted the 627-domain) exhibits a novel fold with the side-chain of Lys627 solvent exposed. The structure of the K627E mutated domain shows no structural differences but the charge reversal disrupts a striking basic patch on the domain surface. Five other recently proposed host determining sites of PB2 are also located on the 627-domain surface. The structure of the complete C-terminal region of PB2 comprising the 627-domain and the previously identified NLS-domain, which binds the host nuclear import factor importin alpha, was also determined. The two domains are found to pack together with a largely hydrophilic interface. These data enable a three-dimensional mapping of approximately half of PB2 sites implicated in cross-species transfer onto a single structural unit. Their surface location is consistent with roles in interactions with other viral proteins or host factors. The identification and structural characterization of these well-defined PB2 domains will help design experiments to elucidate the effects of mutations on polymerase–host factor interactions

Gut thinking: the gut microbiome and mental health beyond the head

Background: In recent decades, dominant models of mental illness have become increasingly focused on the head, with mental disorders being figured as brain disorders. However, research into the active role that the microbiome-gut-brain axis plays in affecting mood and behaviour may lead to the conclusion that mental health is more than an internalised problem of individual brains. Objective: This article explores the implications of shifting understandings about mental health that have come about through research into links between the gut microbiome and mental health problems such as depression and anxiety. It aims to analyse the different ways that the lines between mind and body and mental and physical health are re-shaped by this research, which is starting to inform clinical and public understanding. Design: As mental health has become a pressing issue of political and public concern it has become increasingly constructed in socio-cultural and personal terms beyond clinical spaces, requiring a conceptual response that exceeds biomedical inquiry. This article argues that an interdisciplinary critical medical humanities approach is well positioned to analyse the impact of microbiome-gut-brain research on conceptions of mind. Results: The entanglement of mind and matter evinced by microbiome-gut-brain axis research potentially provides a different way to conceptualise the physical and social concomitants of mental distress. Conclusion: Mental health is not narrowly located in the head but is assimilated by the physical body and intermingled with the natural world, requiring different methods of research to unfold the meanings and implications of gut thinking for conceptions of human selfhood

Marital status distribution of the U.K. military: Does it differ from the general population?

UK media suggest UK military personnel have high divorce rates; to date, these claims are not substantiated. Marital status distribution of the general population and military were compared using data from the Office for National Statistics marital projections (2008) and a military cohort study (2007 – 2009), respectively. Data from the military cohort study was collected via questionnaire with a response rate of 56% for the overall cohort questionnaire and 99.5% for the martial status question. Overall, military personnel (59.4%) were more likely to be married than the general population (49.3%) and less likely to be divorced (3.7%) than the general population (10.0%). Military females and military personnel married under 30 years of age are more likely to report divorce. Military welfare services might target these groups with programs assisting marital relationships

The Propagation of Magneto-Centrifugally Launched Jets: I

We present simulations of the propagation of magnetized jets. This work differs from previous studies in that the cross-sectional distributions of the jets's state variables are derived from analytical models for magneto-centrifugal launching. The source is a magnetized rotator whose properties are specfied as boundary conditions. The jets in these simulations are considerably more complex than the ``top-hat''constant density etc. profiles used in previous work. We find that density and magnetic field stratification (with radius) in the jet leads to new behavior including the separation of an inner jet core from a low density collar. We find this {\it jet within a jet} structure, along with the magnetic stresses, leads to propagation behaviors not observed in previous simulation studies. Our methodology allows us to compare MHD jets from different types of sources whose properties could ultimately be derived from the behavior of the propagating jets.Comment: 42 pages, accepted by the Ap

Using self-definition to predict the influence of procedural justice on organizational, interpersonal, and job/task-oriented citizenship behaviors

An integrative self-definition model is proposed to improve our understanding of how procedural justice affects different outcome modalities in organizational behavior. Specifically, it is examined whether the strength of different levels of self-definition (collective, relational, and individual) each uniquely interact with procedural justice to predict organizational, interpersonal, and job/task-oriented citizenship behaviors, respectively. Results from experimental and (both single and multisource) field data consistently revealed stronger procedural justice effects (1) on organizational-oriented citizenship behavior among those who define themselves strongly in terms of organizational characteristics, (2) on interpersonal-oriented citizenship behavior among those who define themselves strongly in terms of their interpersonal relationships, and (3) on job/task-oriented citizenship behavior among those who define themselves weakly in terms of their distinctiveness or uniqueness. We discuss the relevance of these results with respect to how employees can be motivated most effectively in organizational settings

RASSF1A and the rs2073498 Cancer Associated SNP

RASSF1A is one of the most frequently inactivated tumor suppressors yet identified in human cancer. It is pro-apoptotic and appears to function as a scaffolding protein that interacts with a variety of other tumor suppressors to modulate their function. It can also complex with the Ras oncoprotein and may serve to integrate pro-growth and pro-death signaling pathways. A SNP has been identified that is present in approximately 29% of European populations [rs2073498, A(133)S]. Several studies have now presented evidence that this SNP is associated with an enhanced risk of developing breast cancer. We have used a proteomics based approach to identify multiple differences in the pattern of protein/protein interactions mediated by the wild type compared to the SNP variant protein. We have also identified a significant difference in biological activity between wild type and SNP variant protein. However, we have found only a very modest association of the SNP with breast cancer predisposition

Human group formation in online guilds and offline gangs driven by common team dynamic

Quantifying human group dynamics represents a unique challenge. Unlike animals and other biological systems, humans form groups in both real (offline) and virtual (online) spaces -- from potentially dangerous street gangs populated mostly by disaffected male youths, through to the massive global guilds in online role-playing games for which membership currently exceeds tens of millions of people from all possible backgrounds, age-groups and genders. We have compiled and analyzed data for these two seemingly unrelated offline and online human activities, and have uncovered an unexpected quantitative link between them. Although their overall dynamics differ visibly, we find that a common team-based model can accurately reproduce the quantitative features of each simply by adjusting the average tolerance level and attribute range for each population. By contrast, we find no evidence to support a version of the model based on like-seeking-like (i.e. kinship or `homophily')

Research and development progress report 128

Report presenting experimental results for the washing of brine from beds of small plastic and glass beads, and from beds of ice particles prepared by partial freezing of brine. The data are analyzed in terms of a longitudinal-dispersion model which describes the blending of water and brine at the moving wash-water "front"