Species sensitivity of early face and eye processing

The final publication is available at Elsevier via http://dx.doi.org/10.1016/j.neuroimage.2010.07.031. © 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Humans are better at recognizing human faces than faces of other species. However, it is unclear whether this species sensitivity can be seen at early perceptual stages of face processing and whether it involves species sensitivity for important facial features like the eyes. These questions were addressed by comparing the modulations of the N170 ERP component to faces, eyes and eyeless faces of humans, apes, cats and dogs, presented upright and inverted. Although all faces and isolated eyes yielded larger responses than the control object category (houses), the N170 was shorter and smaller to human than animal faces and larger to human than animal eyes. Most importantly, while the classic inversion effect was found for human faces, animal faces yielded no inversion effect or an opposite inversion effect, as seen for objects, suggesting a different neural process involved for humans faces compared to faces of other species. Thus, in addition to its general face and eye categorical sensitivity, the N170 appears particularly sensitive to the human species for both faces and eyes. The results are discussed in the context of a recent model of the N170 response involving face and eye sensitive neurons (Itier et al., 2007) where the eyes play a central role in face perception. The data support the intuitive idea that eyes are what make animal head fronts look face-like and that proficiency for the human species involves visual expertise for the human eyes

Direct contact and authoritarianism as moderators between extended contact and reduced prejudice: Lower threat and greater trust as mediators

Using a representative sample of Dutch adults (N = 1238), we investigated the moderating influence of direct contact and authoritarianism on the potential of extended contact to reduce prejudice. As expected, direct contact and authoritarianism moderated the effect of extended contact on prejudice. Moreover, the third-order moderation effect was also significant, revealing that extended contact has the strongest effect among high authoritarians with low levels of direct contact. We identified trust and perceived threat as the mediating processes underlying these moderation effects. The present study thus attests to the theoretical and practical relevance of reducing prejudice via extended contact. The discussion focuses on the role of extended contact in relation to direct contact and authoritarianism as well as on the importance of trust in intergroup contexts

Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins

The human serine proteases granzymes A and B are expressed in cytotoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. Recombinant granzyme A and granzyme B proteins were produced in bacteria, purified and then used to raise specific mouse monoclonal antibodies. Seven monoclonal antibodies (mAb) were raised against granzyme A, which all recognized the same or overlapping epitopes. They reacted specifically in an immunoblot of interleukin-2 (IL-2) stimulated PBMNC with a disulfide-linked homodimer of 43 kDa consisting of 28 kDa subunits. Seven mAb against granzyme B were obtained, which could be divided into two groups, each recognizing a different epitope. On an immunoblot, all mAb reacted with a monomer of 33 kDa protein. By immunohistochemistry, these mAb could be used to detect granzymes A and B expression in activated CTL and NK cells. The availability of these mAb may facilitate studies on the role of human cytotoxic cells in various immune reactions and may contribute to a better understanding of the role of granzmes A and B in the cytotoxic response in vivo

Hydrophobic drug/toxin binding sites in voltage-dependent K+ and Na+ channels

In the Na(v)channel family the lipophilic drugs/toxins binding sites and the presence of fenestrations in the channel pore wall are well defined and categorized. No such classification exists in the much larger K(v)channel family, although certain lipophilic compounds seem to deviate from binding to well-known hydrophilic binding sites. By mapping different compound binding sites onto 3D structures of Kv channels, there appear to be three distinct lipid-exposed binding sites preserved in K(v)channels: the front and back side of the pore domain, and S2-S3/S3-S4 clefts. One or a combination of these sites is most likely the orthologous equivalent of neurotoxin site 5 in Na(v)channels. This review describes the different lipophilic binding sites and location of pore wall fenestrations within the K(v)channel family and compares it to the knowledge of Na(v)channels

Is sexism a gender issue? A motivated social cognition perspective on men’s and women’s sexist attitudes toward own and other gender

The present research investigated the antecedents of ambivalent sexism (i.e., hostile and benevolent forms) in both men and women toward own and other gender. In two heterogeneous adult samples (Study 1: N = 179 and Study 2: N = 222), it as revealed that gender itself was only a minor predictor of sexist attitudes compared to the substantial impact of individual differences in general motivated cognition (i.e., Need for closure). Analyses further showed that the relationship between Need for closure and sexism was mediated by social attitudes (i.e., right-wing authoritarianism and social dominance orientation), which were differently related to benevolent and hostile forms of sexism. In the discussion it is argued that sexism primarily stems from individual differences in motivated cognitive style, which relates to peoples? perspective on the social world, rather than from group differences between men and women

Weak lensing in scalar-tensor theories of gravity

This article investigates the signatures of various models of dark energy on weak gravitational lensing, including the complementarity of the linear and non-linear regimes. It investigates quintessence models and their extension to scalar-tensor gravity. The various effects induced by this simplest extension of general relativity are discussed. It is shown that, given the constraints in the Solar System, models such as a quadratic nonminimal coupling do not leave any signatures that can be detected while other models, such as a runaway dilaton, which include attraction toward general relativity can let an imprint of about 10%.Comment: 25 pages, 29 figure

A model with simultaneous first and second order phase transitions

We introduce a two dimensional nonlinear XY model with a second order phase transition driven by spin waves, together with a first order phase transition in the bond variables between two bond ordered phases, one with local ferromagnetic order and another with local antiferromagnetic order. We also prove that at the transition temperature the bond-ordered phases coexist with a disordered phase as predicted by Domany, Schick and Swendsen. This last result generalizes the result of Shlosman and van Enter (cond-mat/0205455). We argue that these phenomena are quite general and should occur for a large class of potentials.Comment: 7 pages, 7 figures using pstricks and pst-coi

Submicron Systems Architecture: Semiannual Technical Report

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Submicron Systems Architecture Project : Semiannual Technical Report

The Mosaic C is an experimental fine-grain multicomputer based on single-chip nodes. The Mosaic C chip includes 64KB of fast dynamic RAM, processor, packet interface, ROM for bootstrap and self-test, and a two-dimensional selftimed router. The chip architecture provides low-overhead and low-latency handling of message packets, and high memory and network bandwidth. Sixty-four Mosaic chips are packaged by tape-automated bonding (TAB) in an 8 x 8 array on circuit boards that can, in turn, be arrayed in two dimensions to build arbitrarily large machines. These 8 x 8 boards are now in prototype production under a subcontract with Hewlett-Packard. We are planning to construct a 16K-node Mosaic C system from 256 of these boards. The suite of Mosaic C hardware also includes host-interface boards and high-speed communication cables. The hardware developments and activities of the past eight months are described in section 2.1. The programming system that we are developing for the Mosaic C is based on the same message-passing, reactive-process, computational model that we have used with earlier multicomputers, but the model is implemented for the Mosaic in a way that supports finegrain concurrency. A process executes only in response to receiving a message, and may in execution send messages, create new processes, and modify its persistent variables before it either exits or becomes dormant in preparation for receiving another message. These computations are expressed in an object-oriented programming notation, a derivative of C++ called C+-. The computational model and the C+- programming notation are described in section 2.2. The Mosaic C runtime system, which is written in C+-, provides automatic process placement and highly distributed management of system resources. The Mosaic C runtime system is described in section 2.3

Three-phase point in a binary hard-core lattice model?

Using Monte Carlo simulation, Van Duijneveldt and Lekkerkerker [Phys. Rev. Lett. 71, 4264 (1993)] found gas-liquid-solid behaviour in a simple two-dimensional lattice model with two types of hard particles. The same model is studied here by means of numerical transfer matrix calculations, focusing on the finite size scaling of the gaps between the largest few eigenvalues. No evidence for a gas-liquid transition is found. We discuss the relation of the model with a solvable RSOS model of which the states obey the same exclusion rules. Finally, a detailed analysis of the relation with the dilute three-state Potts model strongly supports the tricritical point rather than a three-phase point.Comment: 17 pages, LaTeX2e, 13 EPS figure