Influência da obesidade sobre a expressão protéica do sistema B-adrenérgico miocárdico

A obesidade induzida por dieta hiperlipídica insaturada, por 15 semanas, não promove alterações na expressão protéica dos receptores B-adrenérgicos, β-1 e β-2 e proteína Gsα

Процесс анализа угроз, влияющих на экономическую устойчивость предприятия

На основании проведенного исследования были выявлены факторы возникновения угроз, их группировка по степени воздействию на экономическую устойчивость предприятий и рассмотрена формализация процесса анализа угроз экономической устойчивости предприятий. В условиях рыночной экономики невозможно управлять предприятием без учета влияния угроз, а для эффективного управления важно не только знать об их присутствии, а и правильно идентифицировать конкретную угрозу.На підставі проведеного дослідження були виявлені чинники виникнення загроз, їх угруповання по степені впливу на економічну стійкість підприємств і розглянута формалізація процесу аналізу загроз економічної стійкості підприємств. В умовах ринкової економіки неможливо керувати підприємством без вивчення впливу загроз, а для ефективного керування важливо не тільки знати про їх присутність, а і правильно ідентифікувати конкретну загрозу.On the basis of the conducted research the factors of origin of threats were exposed, their gourmet on a degree to influence on economic stability of enterprises and formalization of process of analysis of threats of economic stability of enterprises is considered. In the conditions of market economy it is impossible to manage an enterprise without taking into account influencing of threats, and for the effective management it is important not only to know about their presence, and to identify the concrete threat correctly

Characterisation of a new family of carboxyl esterases with an OsmC domain

Proteins in the serine esterase family are widely distributed in bacterial phyla and display activity against a range of biologically produced and chemically synthesized esters. A serine esterase from the psychrophilic bacterium Pseudoalteromonas arctica with a C-terminal OsmC-like domain was recently characterized; here we report on the identification and characterization of further putative esterases with OsmC-like domains constituting a new esterase family that is found in a variety of bacterial species from different environmental niches. All of these proteins contained the Ser-Asp-His motif common to serine esterases and a highly conserved pentapeptide nucleophilic elbow motif. We produced these proteins heterologously in Escherichia coli and demonstrated their activity against a range of esterase substrates. Two of the esterases characterized have activity of over two orders of magnitude higher than other members of the family, and are active over a wide temperature range. We determined the crystal structure of the esterase domain of the protein from Rhodothermus marinus and show that it conforms to the classical α/β hydrolase fold with an extended ‘lid’ region, which occludes the active site of the protein in the crystal. The expansion of characterized members of the esterase family and demonstration of activity over a wide-range of temperatures could be of use in biotechnological applications such as the pharmaceutical, detergent, bioremediation and dairy industries

Experience gained in applying IEC 80001-1 principles to a medical IT network supporting a clinical information system.

IEC 80001-1:2010 [1] recognises that medical devices are incorporated into IT-networks to achieve desirable benefits1. The standard defines the roles, responsibilities and activities that are necessary for the risk management of IT-networks incorporating medical devices to address safety, effectiveness and data and system security. It applies throughout the life cycle of IT-networks incorporating medical devices and applies to responsible organizations, medical device manufacturers and providers of other information technology. IEC 80001-1:2010 draws on processes set out in ISO 14971:2007 [2] intended to be used by equipment manufacturers to identify hazards associated with medical devices. It also draws on ISO/IEC 20000-1:2011 [3] which specifies the requirements for an IT service provider to meet when implementing an IT service management system

Assessing a Hospital’s Medical IT Network Risk Management Practice with 80001-1

Medical device interoperability has been identified as a key way of decreasing healthcare costs while improving patient care.1 This has lead to a shift toward placing more medical devices onto information technology (IT) networks. However, placing medical devices onto an IT network may lead to additional risks to safety, effectiveness and security of the devices, the network, and the data. ANSI/AAMI/IEC 80001-1 addresses the roles, responsibilities, and activities that need to be carried out when managing these risks. In this article, we describe an exercise undertaken to assess the medical IT network risk management practice implemented within a hospital to control risk associated with a clinical information system (CIS). The level of compliance with the 80001-1 standard was determined using an assessment framework developed by the Regulated Software Research Centre (RSRC). The purpose of this exercise was to test and inform the development of an assessment method that is part of the assessment framework for this standard. The exercise also sought to identify how the management of such an existing CIS project meets the requirements of 80001-1

Using IEC80001-1 to assess a hospital’s Medical IT- Network risk management practice

Medical device interoperability has been identified as a key way of decreasing healthcare costs while improving patient care [1]. This has lead to a shift towards placing more medical devices onto IT networks. However, placing medical devices onto an IT network may lead to additional risks to the safety, effectiveness and security. IEC 80001-1 addresses the roles, responsibilities and activities that need to be carried out when managing these risks. In this article, we describe an exercise undertaken to assess a Clinical Information Systems level of compliance with the IEC 80001-1 standard using an assessment framework developed by the Regulated Software Research Centre (RSRC). The purpose of this exercise was, to test and inform the development of an assessment method which is part of the assessment framework for this standard, and also, to identify how the management of such an existing Clinical Information Systems (CIS) project meets the requirements of IEC 80001-1

Fundamentals of information theory and coding design

In a clear, concise, and modular format, this book introduces the fundamental concepts and mathematics of information and coding theory. The authors emphasize how a code is designed and discuss the main properties and characteristics of different coding algorithms along with strategies for selecting the appropriate codes to meet specific requirements. They provide comprehensive coverage of source and channel coding, address arithmetic, BCH, and Reed-Solomon codes and explore some more advanced topics such as PPM compression and turbo codes. Worked examples and sets of basic and advanced exercises in each chapter reinforce the text's clear explanations of all concepts and methodologies