166 research outputs found
Constant entropy sampling and release waves of shock compressions
We present several equilibrium methods that allow to compute isentropic
processes, either during the compression or the release of the material. These
methods are applied to compute the isentropic release of a shocked monoatomic
liquid at high pressure and temperature. Moreover, equilibrium results of
isentropic release are compared to the direct nonequilibrium simulation of the
same process. We show that due to the viscosity of the liquid but also to
nonequilibrium effects, the release of the system is not strictly isentropic
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Comparative Law Research on the Personal Data Protection Law in Various Countries
In the JST Moonshot R&D Project (Goal 9), "Legal Principles of Decentralized Management" (proposed by Tatsuhiko Yamamoto, professor at Keio University), we discuss the benefits and challenges that arise from social implementation of personal AI from a legal perspective. It is analyzed from Personal AI is AI that manages personal data on behalf of the individual based on the individual's privacy preferences. This can be seen as a tool to back up the right to information self-determination (the right to control one's own information).
This research is a comparative study of personal information protection legislation in the EU, Germany, France, Switzerland, the United States, Canada, South Korea, Taiwan, Thailand, and China. We asked report authors from each country to investigate how mechanisms for individual involvement (right to request deletion, right to access, consent, right to data portability) are stipulated in personal information protection laws. We examined the significance and challenges of the right to information self-determination, paying particular attention to the relationship between the Constitution and the Personal Information Protection Act
HCN emission from translucent gas and UV-illuminated cloud edges revealed by wide-field IRAM 30m maps of Orion B GMC: Revisiting its role as tracer of the dense gas reservoir for star formation
We present 5 deg^2 (~250 pc^2) HCN, HNC, HCO+, and CO J=1-0 maps of the Orion
B GMC, complemented with existing wide-field [CI] 492 GHz maps, as well as new
pointed observations of rotationally excited HCN, HNC, H13CN, and HN13C lines.
We detect anomalous HCN J=1-0 hyperfine structure line emission almost
everywhere in the cloud. About 70% of the total HCN J=1-0 luminosity arises
from gas at A_V < 8 mag. The HCN/CO J=1-0 line intensity ratio shows a bimodal
behavior with an inflection point at A_V < 3 mag typical of translucent gas and
UV-illuminated cloud edges. We find that most of the HCN J=1-0 emission arises
from extended gas with n(H2) < 10^4 cm^-3, even lower density gas if the
ionization fraction is > 10^-5 and electron excitation dominates. This result
explains the low-A_V branch of the HCN/CO J=1-0 intensity ratio distribution.
Indeed, the highest HCN/CO ratios (~0.1) at A_V < 3 mag correspond to regions
of high [CI] 492 GHz/CO J=1-0 intensity ratios (>1) characteristic of
low-density PDRs. Enhanced FUV radiation favors the formation and excitation of
HCN on large scales, not only in dense star-forming clumps. The low surface
brightness HCN and HCO+ J=1-0 emission scale with I_FIR (a proxy of the stellar
FUV radiation field) in a similar way. Together with CO J=1-0, these lines
respond to increasing I_FIR up to G0~20. On the other hand, the bright HCN
J=1-0 emission from dense gas in star-forming clumps weakly responds to I_FIR
once the FUV radiation field becomes too intense (G0>1500). The different power
law scalings (produced by different chemistries, densities, and line excitation
regimes) in a single but spatially resolved GMC resemble the variety of
Kennicutt-Schmidt law indexes found in galaxy averages. As a corollary for
extragalactic studies, we conclude that high HCN/CO J=1-0 line intensity ratios
do not always imply the presence of dense gas.Comment: accepted for publication in A&A. 24 pages, 18 figures, plus Appendix.
Abridged Abstract. English language not edite
Topological data analysis reveals genotype-phenotype relationships in primary ciliary dyskinesia
Background: Primary ciliary dyskinesia (PCD) is a heterogeneous inherited disorder caused by mutations in approximately 50 cilia-related genes. PCD genotype-phenotype relationships have mostly arisen from small case series because existing statistical approaches to investigate relationships have been unsuitable for rare diseases. /
Methods: We applied a topological data analysis (TDA) approach to investigate genotype-phenotype relationships in PCD. Data from separate training and validation cohorts included 396 genetically defined individuals carrying pathogenic variants in PCD genes. To develop the TDA models, twelve clinical and diagnostic variables were included. TDA-driven hypotheses were subsequently tested using traditional statistics. /
Results: Disease severity at diagnosis measured by FEV1 z-score was (i) significantly worse in individuals with CCDC39 mutations compared to other gene mutations and (ii) better in those with DNAH11 mutations; the latter also reported less neonatal respiratory distress. Patients without neonatal respiratory distress had better preserved FEV1 at diagnosis. Individuals with DNAH5 mutations were phenotypically diverse. Cilia ultrastructure and beat pattern defects correlated closely to specific causative gene groups, confirming these tests can be used to support a genetic diagnosis. /
Conclusions: This large scale multi-national study presents PCD as a syndrome with overlapping symptoms and variation in phenotype, according to genotype. TDA modelling confirmed genotype-phenotype relationships reported by smaller studies (e.g. FEV1 worse with CCDC39 mutations), and identified new relationships, including FEV1 preservation with DNAH11 mutations and diversity of severity with DNAH5 mutations
Infection control, genetic assessment of drug resistance and drug susceptibility testing in the current management of multidrug/extensively-resistant tuberculosis (M/XDR-TB) in Europe: A tuberculosis network European Trialsgroup (TBNET) study
Aim Europe has the highest documented caseload and greatest increase in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) of all World Health Organization (WHO) regions. This survey examines how recommendations for M/XDR-TB management are being implemented. Methods TBNET is a pan-European clinical research collaboration for tuberculosis. An email survey of TBNET members collected data in relation to infection control, access to molecular tests and basic microbiology with drug sensitivity testing. Results 68/105 responses gave valid information and were from countries within the WHO European Region. Inpatient beds matched demand, but single rooms with negative pressure were only available in low incidence countries; ultraviolet decontamination was used in 5 sites, all with >10 patients with M/XDR-TB per year. Molecular tests for mutations associated with rifampicin resistance were widely available (88%), even in lower income and especially in high incidence countries. Molecular tests for other first line and second line drugs were less accessible (76 and 52% respectively). A third of physicians considered that drug susceptibility results were delayed by > 2 months. Conclusion Infection control for inpatients with M/XDR-TB remains a problem in high incidence countries. Rifampicin resistance is readily detected, but tests to plan regimens tailored to the drug susceptibilities of the strain of Mycobacterium tuberculosis are significantly delayed, allowing for further drug resistance to develop
Late cardiomyopathy in childhood acute myeloid leukemia survivors: a study from the L.E.A. program
HCN emission from translucent gas and UV-illuminated cloud edges revealed by wide-field IRAM 30m maps of Orion B GMC: Revisiting its role as tracer of the dense gas reservoir for star formation
35 pags., 28 figs., 14 tabs.We present 5 deg^2 (~250 pc^2) HCN, HNC, HCO+, and CO J=1-0 maps of the Orion
B GMC, complemented with existing wide-field [CI] 492 GHz maps, as well as new
pointed observations of rotationally excited HCN, HNC, H13CN, and HN13C lines.
We detect anomalous HCN J=1-0 hyperfine structure line emission almost
everywhere in the cloud. About 70% of the total HCN J=1-0 luminosity arises
from gas at A_V < 8 mag. The HCN/CO J=1-0 line intensity ratio shows a bimodal
behavior with an inflection point at A_V < 3 mag typical of translucent gas and
UV-illuminated cloud edges. We find that most of the HCN J=1-0 emission arises
from extended gas with n(H2) ~< 10^4 cm^-3, even lower density gas if the
ionization fraction is > 10^-5 and electron excitation dominates. This result
explains the low-A_V branch of the HCN/CO J=1-0 intensity ratio distribution.
Indeed, the highest HCN/CO ratios (~0.1) at A_V < 3 mag correspond to regions
of high [CI] 492 GHz/CO J=1-0 intensity ratios (>1) characteristic of
low-density PDRs. Enhanced FUV radiation favors the formation and excitation of
HCN on large scales, not only in dense star-forming clumps. The low surface
brightness HCN and HCO+ J=1-0 emission scale with I_FIR (a proxy of the stellar
FUV radiation field) in a similar way. Together with CO J=1-0, these lines
respond to increasing I_FIR up to G0~20. On the other hand, the bright HCN
J=1-0 emission from dense gas in star-forming clumps weakly responds to I_FIR
once the FUV radiation field becomes too intense (G0>1500). The different power
law scalings (produced by different chemistries, densities, and line excitation
regimes) in a single but spatially resolved GMC resemble the variety of
Kennicutt-Schmidt law indexes found in galaxy averages. As a corollary for
extragalactic studies, we conclude that high HCN/CO J=1-0 line intensity ratios
do not always imply the presence of dense gas.M.G.S.M. and J.R.G. thank the Spanish MICINN for funding support under grant PID2019-106110GB-I00. This work was supported by the French Agence Nationale de la Recherche through the DAOISM grant ANR-21-CE31–0010, and by the Programme National “Physique et Chimie du Milieu Interstellaire”
(PCMI) of CNRS/INSU with INC/INP, co-funded by CEA and CNES. Part of this research was carried out at the Jet Propulsion Laboratory, California Institute
of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004).Peer reviewe
Diagnostic criteria and follow-up in neuroendocrine cell hyperplasia of infancy: a case series
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