Risk factors for chronic non communicable diseases in Mombasa, Kenya: Epidemiological study using WHO stepwise approach

Objective: To describe the prevalence and distribution patterns of the major common risk factors for non communicable diseases among the people living in Mombasa, Kenya. Methods: Using the WHO STEPwise approach, risk factors for non communicable diseases were analyzed for 305 people aged between 13 to 67 years. The study sample was arrived at through convenient stratification of the population according to age and setting followed by random selection of the participants. Results: The most common individual risk factors registered were physical inactivity, hypertension and overweight/obesity accounting for 42%, 24% and 11% of the sample respectively. Participants who possessed a single risk factor profile were 42% and those who had multiple risk factors were approximately 17%. Hypertension and physical inactivity were the most common multiple risk factor pattern possessed by 7.5% of the participants who had at least one of the investigated risk factors for CNCDs. Socio-demographic characteristics including male gender, increasing age, being a student and low socio-economic status were found to be positive predictors of CNCDs Conclusion: The burden of CNCDs risk factors is unequally distributed among Mombasa residents. The poorest quintile posses the worst risk factor profile compared to their privileged counterparts. The implementation of WHO STEPwise approach was feasible since it revealed a comprehensive picture of the at-risk groups thus forming a vital baseline framework for target-specific and cost-effective CNCDs control and prevention interventions. Keywords: Chronic non communicable diseases, Risk factors, Health promotion, Epidemiology, Mombas

X-ray Temperature and Mass Measurements to the Virial Radius of Abell 1413 with Suzaku

We present X-ray observations of the northern outskirts of the relaxed galaxy cluster A1413 with Suzaku, whose XIS instrument has the low intrinsic background needed to make measurements of these low surface brightness regions. We excise 15 point sources superimposed on the image above a flux of $1\times 10^{-14}$ \fluxunit (2--10keV) using XMM-Newton and Suzaku images of the cluster. We quantify all known systematic errors as part of our analysis, and show our statistical errors encompasses them for the most part. Our results extend previous measurements with Chandra and XMM-Newton, and show a significant temperature drop to about 3keV at the virial radius, $r_{200}$. Our entropy profile in the outer region ($> 0.5 r_{200}$) joins smoothly onto that of XMM-Newton, and shows a flatter slope compared with simple models, similar to a few other clusters observed at the virial radius. The integrated mass of the cluster at the virial radius is approximately $7.5\times10^{14}M_{\odot}$ and varies by about 30% depending on the particular method used to measure it.Comment: 32pages, 9 figures, accepted for publication in PAS

X-ray Spectroscopy of the Core of the Perseus Cluster with Suzaku: Elemental Abundances in the Intracluster Medium

The results from Suzaku observations of the central region of the Perseus cluster are presented. Deep exposures with the X-ray Imaging Spectrometer provide high quality X-ray spectra from the intracluster medium. X-ray lines from helium-like Cr and Mn have been detected significantly for the first time in clusters. In addition, elemental abundances of Ne, Mg, Si, S, Ar, Ca, Fe, and Ni are accurately measured within 10' (or 220 kpc) from the cluster center. The relative abundance ratios are found to be within a range of 0.8-1.5 times the solar value. These abundance ratios are compared with previous measurements, those in extremely metal-poor stars in the Galaxy, and theoretical models.Comment: 10 pages, 3 figures, accepted for ApJ

X-ray observations of the galaxy cluster Abell 2029 to the virial radius

We present Suzaku observations of the galaxy cluster Abell 2029, which exploit Suzaku's low particle background to probe the ICM to radii beyond those possible with previous observations (reaching out to the virial radius), and with better azimuthal coverage. We find significant anisotropies in the temperature and entropy profiles, with a region of lower temperature and entropy occurring to the south east, possibly the result of accretion activity in this direction. Away from this cold feature, the thermodynamic properties are consistent with an entropy profile which rises, but less steeply than the predictions of purely gravitational hierarchical structure formation. Excess emission in the northern direction can be explained due to the overlap of the emission from the outskirts of Abell 2029 and nearby Abell 2033 (which is at slightly higher redshift). These observations suggest that the assumptions of spherical symmetry and hydrostatic equilibrium break down in the outskirts of galaxy clusters, which poses challenges for modelling cluster masses at large radii and presents opportunities for studying the formation and accretion history of clusters.Comment: 15 pages, 14 figures. Accepted for publication in the Monthly Notices of the Royal Astronomical Societ

Suzaku X-ray Imaging of the Extended Lobe in the Giant Radio Galaxy NGC6251 Associated with the Fermi-LAT Source 2FGLJ1629.4+8236

We report the results of a Suzaku X-ray imaging study of NGC6251, a nearby giant radio galaxy with intermediate FR I/II radio properties. Our pointing direction was centered on the gamma -ray emission peak recently discovered with Fermi-LAT around the position of the north-west radio lobe 15 arcmin offset from the nucleus. After subtracting two "off-source" pointings adjacent to the radio lobe, and removing possible contaminants in the XIS field of view, we found significant residual X-ray emission most likely diffuse in nature. The spectrum of the excess X-ray emission is well fit by a power law with photon index \Gamma = 1.90 +- 0.15 and a 0.5 - 8 keV flux of 4 x 10^{-13} erg cm^{-2} s^{-1}. We interpret this diffuse X-ray emission component as being due to inverse-Compton up-scattering of the cosmic microwave background photons by ultrarelativistic electrons within the lobe, with only a minor contribution from the beamed emission of the large-scale jet. Utilizing archival radio data for the source, we demonstrate by means of broad-band spectral modeling that the -ray flux of the Fermi-LAT source 2FGL J1629.4+8236 may well be accounted for by the high-energy tail of the inverse-Compton continuum of the lobe. Thus, this claimed association of gamma-rays from the north-west lobe of NGC6251, together with the recent Fermi-LAT imaging of the extended lobes of Centaurus A, indicates that particles may be efficiently (re-)accelerated up to ultrarelativistic energies within extended radio lobes of nearby radio galaxies in general.Comment: 19 pages, 4 figures, accepted for publication in the Ap

Consilient Discrepancy: Porosity and Atmosphere in Cinema and Architecture

Cinema constitutes a way of looking at the world, at a world – its aspect, its appearance; but it also presents how that world looks, its prospect – by the prospective glance it throws back toward us. The “look” of a film – its mood, ambiance or atmosphere – eclipses formal and aesthetics registers. It is fundamentally world-forming, and therefore both cosmogonic and ethical: cosmogonic because it produces a world in the midst of, and as, the temporality that devolves through its passage; and ethical because the world it brings about is an inhabited world, a conjugation of people and place that constructs particular ways of being-there-together. The premise here is that atmosphere, ambiance and mood have never been vague categories for cinema and need not be for architecture: rather, that they are in fact producible through deliberate organizational strategies – kinematic and narrative in film, tectonic and material in architecture – according to what might be called “consilient discrepancy” – the coexistence of disseveral systems in unaligned multiplicity that, while never fusing, resonate to produce emergent conditions. Cinema offers architecture an accessible and instructive instance of such consilient discrepancy, because, in it, atmosphere is more fully captured and the conditions that create it more evidently analyzable. To that extent, cinema provides architecture with comparative grounds for engaging with atmosphere through a properly tectonic practice that can potentially enrich the design and experience of architecture. Consilient discrepancy is evident across multiple registers in film. It can function at the level of narrative, space and time and thus puts into question verisimilitude, causality, situational and durational veracity. An example of this is the constitutive disjunctions of Jean-Luc Godard’s jump cut montage where sampled film sequences, film and photographic stills, texts and citations, ambient sound, spoken word and music, build into complex assemblages of sense (Histoire(s) du Cinema, 1998). It is evident in Nicholas Roeg’s multiple, simultaneous temporalities where past and future events interpenetrate and mutually condition the narrative present (Bad Timing, 1980). Similarly, we can find it in Michelangelo Antonioni’s sequence shots that traverse multiple timeframes across the same space – a technique that enables past and present to communicate and amplify the affective, foundational value of the unseen and off-frame (The Passenger, 1975). Another example would be David Lynch’s labyrinthine existential settings, constituted of interminable slippages between indeterminable and infinitely potentialized spaces of dreams, imagination, memory and reality (Mulholland Drive, 2001). Likewise, we could cite Michael Hanake’s persistent displacement of causality and verisimilitude through ambiguous narrative viewpoints (Caché, 2005), and Roy Andersson’s radically liminal settings and characters whose lives constitute larval pre- and/or posthuman states of existence (A Pigeon Sat on a Branch Reflecting on Existence, 2014). This paper will foreground two foundational characteristics of atmosphere in cinema, as evident in the works just cited, and explore their applicability to architecture. The first characteristic is the consilient discrepancy outlined here by way of introduction, and the second, related characteristic, is a spatiality of porosity and occlusion. The provisional aim of comparing cinema and architecture according to this tectonic logic is to go beyond typical ways of understanding cinema’s formal engagement with architecture. For this purpose, a detailed analysis of Béla Tarr’s film Werckmeister Harmonies (2000) will serve as a case study for how the medium of cinema generates atmosphere, ambiance and mood through visual language. This will be followed by a similarly detailed consideration of concomitant qualities created in two recent works by the architects Flores Prats, the Mills Museum and Casal Balaguer. Functioning as exemplars of how cinematic qualities can be made manifest in architecture, these precedents will further substantiate the cinematic–architectonic proposition ventured in this paper

Exceeding the Limits of Static Cold Storage in Limb Transplantation Using Subnormothermic Machine Perfusion

Background For 50 years, static cold storage (SCS) has been the gold standard for solid organ preservation in transplantation. Although logistically convenient, this preservation method presents important constraints in terms of duration and cold ischemia-induced lesions. We aimed to develop a machine perfusion (MP) protocol for recovery of vascularized composite allografts (VCA) after static cold preservation and determine its effects in a rat limb transplantation model. Methods Partial hindlimbs were procured from Lewis rats and subjected to SCS in Histidine-Tryptophan-Ketoglutarate solution for 0, 12, 18, 24, and 48 hours. They were then either transplanted (Txp), subjected to subnormothermic machine perfusion (SNMP) for 3 hours with a modified Steen solution, or to SNMP + Txp. Perfusion parameters were assessed for blood gas and electrolytes measurement, and flow rate and arterial pressures were monitored continuously. Histology was assessed at the end of perfusion. For select SCS durations, graft survival and clinical outcomes after transplantation were compared between groups at 21 days. Results Transplantation of limbs preserved for 0, 12, 18, and 24-hour SCS resulted in similar survival rates at postoperative day 21. Grafts cold-stored for 48 hours presented delayed graft failure (p = 0.0032). SNMP of limbs after 12-hour SCS recovered the vascular resistance, potassium, and lactate levels to values similar to limbs that were not subjected to SCS. However, 18-hour SCS grafts developed significant edema during SNMP recovery. Transplantation of grafts that had undergone a mixed preservation method (12-hour SCS + SNMP + Txp) resulted in better clinical outcomes based on skin clinical scores at day 21 post-transplantation when compared to the SCS + Txp group (p = 0.01613). Conclusion To date, VCA MP is still limited to animal models and no protocols are yet developed for graft recovery. Our study suggests that ex vivo SNMP could help increase the preservation duration and limit cold ischemia-induced injury in VCA transplantation.</p