Are benthic fluxes important for the availability of Si in the Gulf of Finland?

We estimated the efflux of dissolved silicon (DSi) from sediments in the Gulf of Finland and compared it to sedimentation fluxes, burial of Si and existing data on Si loading and stocks, reassessing the reliability of existing Si budgets. Benthic fluxes of DSi measured in situ and in vitro were several times higher than estimates from diffusion calculations. The spatial variability in the open Gulf of Finland was relatively small, while both very high and low fluxes were measured from coastal areas. Fluxes were highest in late summer and lowest in early spring. In our re-assessed budget we present a new lower estimate for Si burial in the sediments, ca. 6 Gmol a(-1) and show that more than half of the sedimentation flux of Si is released back into the water column. Changes in the efficiency of internal DSi recycling may thus affect the prevalence of siliceous phytoplankton within the ecosystem, and the diatom spring bloom may be regulated by the functioning of this internal recycling pump. We also show that the seasonal variation in benthic DSi fluxes and dissolved phosphate fluxes is similar, and that a tentative connection between hypoLxia and high DSi efflux exists. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe

Global governance: fit for purpose?

This report from the SNS Democracy Council provides a thorough assessment of whether the current system of global governance is fit for purpose. Do current international organizations hold the power required to develop, implement, and enforce global policies? Do these institutions wield this power with sufficient effectiveness to reduce transboundary problems? And do they possess legitimacy as governing bodies in the eyes of citizens and elites? This report explores these themes in a comparative perspective, mapping and analyzing patterns across a broad range of international organizations in areas such as development, finance, health, human rights, security, and trade. As an illustration, the report also offers an in-depth analysis of power, effectiveness, and legitimacy in respect of global climate governance.Security and Global AffairsInstitutions, Decisions and Collective Behaviou

The elite–citizen gap in international organization legitimacy

Scholars and policy makers debate whether elites and citizens hold different views of the legitimacy of international organizations (IOs). Until now, sparse data has limited our ability to establish such gaps and to formulate theories for explaining them. This article offers the first systematic comparative analysis of elite and citizen perceptions of the legitimacy of IOs. It examines legitimacy beliefs toward six key IOs, drawing on uniquely coordinated survey evidence from Brazil, Germany, the Philippines, Russia, and the United States. We find a notable elite–citizen gap for all six IOs, four of the five countries, and all of six different elite types. Developing an individual-level approach to legitimacy beliefs, we argue that this gap is driven by systematic differences between elites and citizens in characteristics that matter for attitudes toward IOs. Our findings suggest that deep-seated differences between elites and general publics may present major challenges for democratic and effective international cooperation.Riksbankens Jubileumsfond (Grant M15-0048:1)Security and Global AffairsInstitutions, Decisions and Collective Behaviou

False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine.

Alzheimer's disease is commonly regarded as a loss of memory for past events. However, patients with Alzheimer's disease seem not only to forget events but also to express false confidence in remembering events that have never happened. How and why false recognition occurs in such patients is currently unknown, and treatments targeting this specific mnemonic abnormality have not been attempted. Here, we used a modified object recognition paradigm to show that the tgCRND8 mouse-which overexpresses amyloid β and develops amyloid plaques similar to those in the brains of patients with Alzheimer's disease-exhibits false recognition. Furthermore, we found that false recognition did not occur when tgCRND8 mice were kept in a dark, quiet chamber during the delay, paralleling previous findings in patients with mild cognitive impairment, which is often considered to be prodromal Alzheimer's disease. Additionally, false recognition did not occur when mice were treated with the partial N-methyl-d-aspartic acid receptor antagonist memantine. In a subsequent experiment, we found abnormally enhanced N-methyl-d-aspartic acid receptor-dependent long-term depression in these mice, which could be normalized by treatment with memantine. We suggest that Alzheimer's disease typical amyloid β pathology leads to aberrant synaptic plasticity, thereby making memory representations more susceptible to interfering sensory input, thus increasing the likelihood of false recognition. Parallels between these findings and those from the literature on Alzheimer's disease and mild cognitive impairment suggest a mechanism underlying false recognition in these patients. The false recognition phenomenon may provide a novel paradigm for the discovery of potential therapies to treat the mnemonic dysfunction characteristic of this disease