Integrated optical bimodal waveguide biosensors : principles and applications

Altres ajuts: the ICN2 is funded by the CERCA program/Generalitat de Catalunya.Integrated optical biosensors have become one of the most compelling technologies for the achievement of highly sensitive, multianalyte, portable and easy to use point-of-care (POC) devices with tremendous impact in healthcare and environmental protection, among other application fields. In this context, bimodal waveguide (BiMW) interferometers have emerged over the last years as a powerful biosensor technology providing the benefits of extreme sensitivity under a label-free scheme, reliability and robustness within a highly compact footprint that can be integrated and multiplexed in lab-on-a-chip (LOC) platforms. In this review, we provide an overview of the state-of-the-art about integrated optical BiMW biosensors from the theoretical fundamentals to their practical implementation. Furthermore, we explore recent advances such as novel designs, integration in specific LOC systems and its application in real biosensing scenarios. Final remarks and perspectives on the potential impact of these biosensor interferometric structures are also provided, as well as some limitations that must be addressed in next steps

Novel sensing algorithm for linear read-out of bimodal waveguide interferometric biosensors

Altres ajuts: the ICN2 was supported by the CERCA programme of the Generalitat de Catalunya.Biosensors employing photonics integrated circuits, and specifically those that rely on interferometric evanescent wave working principles, have outstanding performances due to the extreme sensitivity exhibited in one-step and direct assay, without the need of amplification. Within the interferometric configurations, the Bimodal Waveguide (BiMW) interferometric sensor stands out due to its demonstrated sensitivity for real-life applications and the simplicity of its design. To overcome the ambiguities that arise from the periodic nature of interferometric read-outs, a new all-optical modulation and the subsequent trigonometry-based algorithm have been proposed and applied to the BiMW biosensor. This new algorithm has been successfully employed for the selective identification and quantification of the external Spike (S) protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Our biosensing results from this simple, quick, and user-friendly method demonstrate high sensitivity and specificity and pave the way towards a point-of-care device for general use

Caractérisation et sélection sanitaire de la variété d'orange 'Navelina'

Rappel de l'origine de cette 'Navel' et des méthodes utilisées pour la caractériser morphologiquement (arbre et fruit) et biométriquement. Comparaison avec 'Washington Navel'. Mesures prises pour assurer la sélection sanitaire à court terme et à moyen terme (nucellaires)

An analysis and proposal for the work of social workers in psychopedagogical services in schools in the Valencian Autonomous Community

Los Trabajadores Sociales de Educación de la provincia de Alicante nos planteamos la necesidad de actualizar las funciones que la normativa de la, denominada en su día, Conselleria de Educación y Ciencia nos marca, dentro de los Servicios Psicopedagógicos Escolares (SPE) y Gabinetes Psicopedagógicos Municipales (GPM) de la Comunidad Autónoma Valenciana. Los motivos vienen determinados por considerar una normativa obsoleta (Orden 10 de marzo de 1995), una realidad social y educativa cambiante que determinan nuevas demandas hacia el trabajador social de educación, y la configuración de un perfil profesional que nos diferencie de otros profesionales que también intervienen en el ámbito socio-educativo. Este documento es el resultado del trabajo realizado inicialmente por un grupo de trabajadores sociales de educación (a partir de ahora TRASO) de la Provincia de Alicante y consensuado, finalmente, en el I Encuentro de Trabajadores Sociales de Educación de la Comunidad Autónoma Valenciana en diciembre de 2016.As social workers in education in the province of Alicante we consider it necessary to update our roles as described in the regulations of the Regional Council of Education and Science, within the School Psychopedagogical Services and the Municipal Educational Psychopedagogical Services of the Autonomous Community of Valencia. We propose these changes because the regulations are outdated (1995), and because of the need to reflect the changing educational and social reality. In addition, the work of social workers in the educational field has changed, and social workers need their own professional profile that is differentiated from that of other professionals who work in the field of education. This document is the result of the work of a group of social workers in the educational field in the province of Alicante. It was approved by the first meeting of social workers in the educational field in the Autonomous Community of Valencia in December of 2016

Comparative Analysis of the Volatile Fraction of Fruit Juice from Different Citrus Species

The volatile composition of fruit from four Citrus varieties (Powell Navel orange, Clemenules mandarine, and Fortune mandarine and Chandler pummelo) covering four different species has been studied. Over one hundred compounds were profiled after HS-SPME-GC-MS analysis, including 27 esters, 23 aldehydes, 21 alcohols, 13 monoterpene hydrocarbons, 10 ketones, 5 sesquiterpene hydrocarbons, 4 monoterpene cyclic ethers, 4 furans, and 2 aromatic hydrocarbons, which were all confirmed with standards. The differences in the volatile profile among juices of these varieties were essentially quantitative and only a few compounds were found exclusively in a single variety, mainly in Chandler. The volatile profile however was able to differentiate all four varieties and revealed complex interactions between them including the participation in the same biosynthetic pathway. Some compounds (6 esters, 2 ketones, 1 furan and 2 aromatic hydrocarbons) had never been reported earlier in Citrus juices. This volatile profiling platform for Citrus juice by HS-SPME-GC-MS and the interrelationship detected among the volatiles can be used as a roadmap for future breeding or biotechnological applications

Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease

Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with noncardiovascular death in CKD populations are lacking. The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a subpopulation of the National Observatory of Atherosclerosis in Nephrology (NEFRONA) study (n ¼ 2185 CKD patients). After 48 months of follow-up, 62 cardiovascular deaths and 108 non-cardiovascular deaths were recorded. We identified a high non-cardiovascular death risk combination of SNPs corresponding to individuals carrying the most frequent allele (G) at rs562020, the rare allele (C) at rs2283368 and homozygotes for the rare allele (G) at rs2320762 (rs562020 GG/AG þ rs2283368 CC/CT þ rs2320762 GG). Among the patients with the three SNPs genotyped (n ¼ 1016), 75 (7.4%) showed this combination. Furthermore, 95 (9.3%) patients showed a low-risk combination carrying all the opposite genotypes (rs562020 AA þ rs2283368 TT þ rs2320762 GT/TT). All the other combinations [n ¼ 846 (83.3%)] were considered as normal risk. Using competing risk regression analysis, we confirmed that the proposed combinations are independently associated with a higher fhazard ratio [HR] 3.28 [confidence interval (CI) 1.51-7.12]g and lower [HR 6 × 10- (95% CI 3.3 × 10--1.1 × 10-)] risk of suffering a non-cardiovascular death in the CKD population of the NEFRONA cohort compared with patients with the normal-risk combination. Determination of three SNPs of the Klotho gene could help in the prediction of non-cardiovascular death in CKD

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Valle-Inclan y su obra Actas

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai