Plectoeratidus subarcticus, n.gen., n.sp., a new agglutinated foraminifer from the Upper Cretaceous of the western Barents Sea

We describe the new foraminiferal genus and species Plectoeratidus subarcticus n.gen. n.sp., from the Upper Cretaceous deep-water deposits of the Kviting and Kveite formations in the western Barents Sea. The genus is characterised by its planispiral-biserial-uniserial chamber arrangement, terminal aperture and lateral compression. The biometric analysis of test ontogenesis has been applied to document its dimorphism attributed to megalospheric and microspheric generations. This taxon may represent an evolutionary transition between the Cretaceous genera Spiroplectammina or Bolivinopsis and the Cenozoic genus Eratidus. The taxon appears to be endemic to the flysch-type agglutinated foraminiferal assemblages in the Norwegian Sea area

Triassic and Jurassic possible planktonic foraminifera and the assemblages recovered from the Ogrodzieniec Glauconitic Marls Formation (uppermost Callovian and lowermost Oxfordian, Jurassic) of the Polish Basin

Abstract. In the 1960s and 1970s Werner Fuchs of the Austrian Geological Survey (Vienna) described a significant number of new foraminiferal taxa that he considered ancestral to the planktonic foraminifera. All these taxa are well-curated in the collections of the Austrian Geological Survey and have been studied by one of us (Malcolm B. Hart). Some of these taxa, from the Triassic and lowermost Jurassic strata of Austria and northern Italy, are poorly preserved, possibly the result of having an original aragonitic wall structure. None of these taxa possess characters which give the appearance of a planktonic mode of life, although some of them (e.g. Oberhauserella, Praegubkinella) may well have been ancestral to the holoplanktonic foraminifera that appeared in the Toarcian and younger strata. Other taxa in the collections of the Austrian Geological Survey (part of GeoSphere Austria), from the Jurassic of Poland, are preserved as glauconitic steinkerns and are either unidentifiable as foraminifera or suspect in terms of their stratigraphical and evolutionary significance

Internet-based psychoeducation for bipolar disorder: a qualitative analysis of feasibility, acceptability and impact

<p>Background: In a recent exploratory randomised trial we found that a novel, internet-based psychoeducation programme for bipolar disorder (Beating Bipolar) was relatively easy to deliver and had a modest effect on psychological quality of life. We sought to explore the experiences of participants with respect to feasibility, acceptability and impact of Beating Bipolar.</p> <p>Methods: Participants were invited to take part in a semi-structured interview. Thematic analysis techniques were employed; to explore and describe participants’ experiences, the data were analysed for emerging themes which were identified and coded.</p> <p>Results: The programme was feasible to deliver and acceptable to participants where they felt comfortable using a computer. It was found to impact upon insight into illness, health behaviour, personal routines and positive attitudes towards medication. Many participants regarded the programme as likely to be most beneficial for those recently diagnosed.</p> <p>Conclusions: An online psychoeducation package for bipolar disorder, such as Beating Bipolar, is feasible and acceptable to patients, has a positive impact on self-management behaviours and may be particularly suited to early intervention. Alternative (non-internet) formats should also be made available to patients.</p&gt

Triassic and Jurassic possible planktonic foraminifera and the assemblages recovered from the Ogrodzieniec Glauconitic Marls Formation (uppermost Callovian and lowermost Oxfordian, Jurassic) of the Polish Basin

In the 1960s and 1970s Werner Fuchs of the Austrian Geological Survey (Vienna) described a significant number of new foraminiferal taxa that he considered ancestral to the planktonic foraminifera. All these taxa are well-curated in the collections of the Austrian Geological Survey and have been studied by one of us (Malcolm B. Hart). Some of these taxa, from the Triassic and lowermost Jurassic strata of Austria and northern Italy, are poorly preserved, possibly the result of having an original aragonitic wall structure. None of these taxa possess characters which give the appearance of a planktonic mode of life, although some of them (e.g. Oberhauserella, Praegubkinella) may well have been ancestral to the holoplanktonic foraminifera that appeared in the Toarcian and younger strata. Other taxa in the collections of the Austrian Geological Survey (part of GeoSphere Austria), from the Jurassic of Poland, are preserved as glauconitic steinkerns and are either unidentifiable as foraminifera or suspect in terms of their stratigraphical and evolutionary significance.</p

Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma

in esophageal squamous cell carcinom

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step

Long non-coding RNAs (lncRNAs) are a novel class of regulatory genes that play critical roles in various processes ranging from normal development to human diseases such as cancer progression. Recent studies have shown that lncRNAs regulate the gene expression by chromatin remodelling, transcription, splicing and RNA decay control, enhancer function, and epigenetic regulation. However, little is known about translation regulation by lncRNAs. We identified a translational regulatory lncRNA (treRNA) through genome-wide computational analysis. We found that treRNA is upregulated in paired clinical breast cancer primary and lymph-node metastasis samples, and that its expression stimulates tumour invasion in vitro and metastasis in vivo. Interestingly, we found that treRNA downregulates the expression of the epithelial marker E-cadherin by suppressing the translation of its mRNA. We identified a novel ribonucleoprotein (RNP) complex, consisting of RNA-binding proteins (hnRNP K, FXR1, and FXR2), PUF60 and SF3B3, that is required for this treRNA functions. Translational suppression by treRNA is dependent on the 3'UTR of the E-cadherin mRNA. Taken together, our study indicates a novel mechanism of gene regulation by lncRNAs in cancer progression

Expression of Osteopontin in oesophageal squamous cell carcinoma

Osteopontin is a multifunctional 34 kDa extracellular matrix protein with a cell-binding domain. It is involved cell adhesion and cell migration and is therefore considered to influence tumorigenesis and/or metastasis. The purpose of the present study was to evaluate the clinical significance of Osteopontin expression in oesophageal squamous cell carcinoma (ESCC). In the present study, we immunohistochemically investigated the relationship between Osteopontin expression and clinicopathological factors including prognosis in surgical specimens of primary tumours in 175 patients with ESCC. Osteopontin was expressed in 48% of 175 patients. Osteopontin expression was significantly correlated with lymph node metastasis, lymphatic invasion, and stage (P=0.0015, 0.037 and 0.033, respectively). Tumours with expressing Osteopontin exhibited more lymph node metastasis, lymphatic invasion and advanced stage than the tumour with negative Osteopontin expression. Five-year survival rate was better in patients with negative Osteopontin expression than in those with positive Osteopontin expression (P=0.035). However, multivariate analysis revealed that Osteopontin expression was not an independent prognostic factor. As our findings suggest that Osteopontin may play an important role in progress of ESCC, the evaluation of Osteopontin expression is useful for predicting the malignant properties of ESCC

Cognitive and Psychological Reactions of the General Population Three Months After the 2011 Tohoku Earthquake and Tsunami

BACKGROUND: The largest earthquake on record in Japan (magnitude 9.0) occurred on March 11, 2011, and the subsequent tsunami devastated the Pacific coast of Northern Japan. These further triggered the Fukushima I nuclear power plant accidents. Such a hugely complex disaster inevitably has negative psychological effects on general populations as well as on the direct victims. While previous disaster studies enrolled descriptive approaches focusing on direct victims, the structure of the psychological adjustment process of people from the general population has remained uncertain. The current study attempted to establish a path model that sufficiently reflects the early psychological adaptation process of the general population to large-scale natural disasters. METHODS AND FINDINGS: Participants from the primary disaster area (n = 1083) and other areas (n = 2372) voluntarily participated in an online questionnaire study. By constructing path models using a structural equation model procedure (SEM), we examined the structural relationship among psychological constructs known related to disasters. As post-traumatic stress symptoms (PTS) were significantly more present in people in the primarily affected area than in those in secondary- or non-affected areas, the path models were constructed for the primary victims. The parsimoniously depicted model with the best fit was achieved for the psychological-adjustment centered model with quality of life (QoL) as a final outcome. CONCLUSION: The paths to QoL via negative routes (from negative cognitive appraisal, PTS, and general stress) were dominant, suggesting the importance of clinical intervention for reducing negative cognitive appraisal, and for caring for general stress and PTS to maintain QoL at an early stage of psychological adaptation to a disaster. The model also depicted the presence of a positive route where positive cognitive appraisal facilitates post-traumatic growth (PTG) to achieve a higher QoL, suggesting the potential importance of positive psychological preventive care for unexpected natural disasters

Agglutination of benthic foraminifera in relation to mesoscale bathymetric features in the abyssal NE Atlantic (Porcupine Abyssal Plain)

Abyssal hills, small topographic features rising above the abyssal seafloor (< 1000 m altitude), have distinct environmental characteristics compared to abyssal plains, notably the presence of coarser-grained sediments. As a result, they are a major source of habitat heterogeneity in the deep sea. The aim of this study was to investigate whether there is a link between abyssal hills and the test characteristics of selected agglutinated benthic foraminiferal species. We analysed 1) the overall morphometry, and 2) the granulometric and chemical (elemental) characteristics of the agglutinated tests of ten common foraminiferal species (Adercotryma glomerata, Ammobaculites agglutinans, Cribrostomoides subglobosus, Lagenammina sp.1, Nodulina dentaliniformis, Portatrochammina murrayi, three Reophax sp. and Recurvoides sp. 9) at four sites (two on top of abyssal hills and two on the adjacent plain) in the area of the Porcupine Abyssal Plain Sustained Observatory, northeast Atlantic. The foraminiferal test data were compared with the particle size distribution and elemental composition of sediments from the study sites in order to explore possible grain size and mineral selectivity. We found differences in the visual appearance of the tests (i.e. the degree of irregularity in their shape), which was confirmed by morphometric analyses, related to seafloor topography. The agglutinated foraminifera selected different sized particles on hills and plains, reflecting the distinct granulometric characteristics of these settings. These characteristics (incorporation of coarse particles, test morphometry) could provide evidence for the recognition of ancient abyssal hill environments, as well as other palaeoceanographic settings that were characterised by enhanced current flow. Furthermore, analyses of sediment samples from the hill and plain sites using wavelength dispersive X-ray fluorescence (WD-XRF) yielded different elemental profiles from the plains, probably a result of winnowing on the hills, although all samples were carbonate-rich. In contrast, the majority of the agglutinated tests were rich in silica, suggesting a preferential selection for quartz

Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety

<p>Abstract</p> <p>Background</p> <p>Hepatocyte growth factor (HGF) stimulates hepatocyte proliferation, and also acts as an anti-apoptotic factor. Therefore, HGF is a potential therapeutic agent for treatment of fatal liver diseases. We performed a translational medicine protocol with recombinant human HGF (rh-HGF), including a phase I/II study of patients with fulminant hepatitis (FH) or late-onset hepatic failure (LOHF), in order to examine the safety, pharmacokinetics, and clinical efficacy of this molecule.</p> <p>Methods</p> <p>Potential adverse effects identified through preclinical safety tests with rh-HGF include a decrease in blood pressure (BP) and an increase in urinary excretion of albumin. Therefore, we further investigated the effect of rh-HGF on circulatory status and renal toxicity in preclinical animal studies. In a clinical trial, 20 patients with FH or LOHF were evaluated for participation in this clinical trial, and four patients were enrolled. Subjects received rh-HGF (0.6 mg/m²/day) intravenously for 12 to 14 days.</p> <p>Results</p> <p>We established an infusion method to avoid rapid BP reduction in miniature swine, and confirmed reversibility of renal toxicity in rats. Although administration of rh-HGF moderately decreased BP in the participating subjects, this BP reduction did not require cessation of rh-HGF or any vasopressor therapy; BP returned to resting levels after the completion of rh-HGF infusion. Repeated doses of rh-HGF did not induce renal toxicity, and severe adverse events were not observed. Two patients survived, however, there was no evidence that rh-HGF was effective for the treatment of FH or LOHF.</p> <p>Conclusions</p> <p>Intravenous rh-HGF at a dose of 0.6 mg/m²was well tolerated in patients with FH or LOHF; therefore, it is desirable to conduct further investigations to determine the efficacy of rh-HGF at an increased dose.</p