Reputation Management: Corporate Image and Communication

Reputation was, is, and always will be of immense importance to organisations, whether commercial, governmental or not-for-profit. To reach their goals, stay competitive and prosper, good reputation paves the organisational path to acceptance and approval by stakeholders. Even organisations operating in difficult ethical environments - perhaps self-created - need to sustain a positive reputation where possible. Argenti & Druckenmiller argue that, “organisations increasingly recognize the importance of corporate reputation to achieve business goals and stay competitive” (Argenti & Druckenmiller 2004, p.368). While there are many recent examples of organisations whose leadership and business practice behaviours have destroyed their reputation, such as Enron, Arthur Andersen, Tyco and WorldCom, the positive case for reputation is that it has fostered continued expansion of old stagers like Johnson & Johnson and Philips and innovators such as Cisco Systems, who top recent rankings of the most respected organisations in the US and Europe. What is evident is that reputation does not occur by chance. It relates to leadership, management, and organisational operations, the quality of products and services, and - crucially - relationships with stakeholders. It is also connected to communication activities and feedback mechanisms. This chapter will consider the definitions and nature of reputation and its management, best practice and evaluation. It will also discuss the boundaries between branding, image and reputation

A comparison between the pharmacological responsiveness of sensory nerve endings and sympathetic ganglion cells

The effects of a number of agonists, antagonists and local anaesthetics on electrical activity in fibres of the rabbit saphenous nerve in situ, and. on the surface potential of the isolated superior cervical ganglion of the rat have been studied.Acetylcholine, carbachol, methacholine, pilocarpine, Mcl A343, nicotine, tetramethylammonium, dimethylphenylpiperazinium, histamine, 5- hydroxytryptamine, bradykinin and angiotensin induced an afferent discharge in fibres of the rabbit saphenous nerve on intra- arterial injection into the skin. The same compounds depolarized the isolated . ganglion, although the rank orders of potency differed somewhat in the two preparations. The use of the appropriate agonists and. antagonists showed. that the cholinoceptive sites could be subdivided. into muscarinic and nicotinic receptors, the latter predominating in both tissues.Adrenaline and noradrenaline first augmented and then depressed. the acetylcholine -induced. discharge in the saphenous nerve; these effects were mediated via a- adrenoreceptors. Isoprenaline produced a prolonged small. increase in the acetylcholine -induced. discharge and this effect was mediated via ß- adrenoreceptors. In the isolated ganglion, adrenaline and. noradrenaline produced. a weak, a- receptormediated, hyperpolarization.Drugs possessing a nicotinic action gave rise to a secondary hyperpolarization of the ganglion cells which followed the initial depolarization on washing the tissue. Some evidence was obtained suggesting that this hyperpolarization was not a rebound phenomenon consequent upon the initial depolarization, but was due to the release of catecholamine within the ganglion. Drugs with a muscarinic action gave rise to a late post-washing depolarization which appeared to be mediated via muscarinic receptors.Guanethidine blocked. the action of acetylcholine on the saphenous nerve and. on the ganglion, but only in the former preparation did the effect resemble the adrenergic neurone blocking action of the drug in being reversed by d.examphetamine.No evidence was forthcoming to support the concept of the existence of a synaptic gap associated. with sensory endings: natural touch responses were still present at a time when drug - induced discharges had, been extinguished by antagonistic agents.A brief study was made of the effect of local anaesthetics and. drugs with local anaesthetic properties upon both preparations. It is suggested. that the rabbit saphenous nerve preparation may provide an additional means of assessing the potency and. durability of local anaesthetic agents.The results are discussed. in relation to the effects of the drugs on other non-myelinated neuronal membranes

Masticatory biomechanics of red and grey squirrels ( Sciurus vulgaris and Sciurus carolinensis ) modelled with multibody dynamics analysis

The process of feeding in mammals is achieved by moving the mandible relative to the cranium to bring the teeth into and out of occlusion. This process is especially complex in rodents which have a highly specialized configuration of jaw adductor muscles. Here, we used the computational technique of multi-body dynamics analysis (MDA) to model feeding in the red (Sciurus vulgaris) and grey squirrel (Sciurus carolinensis) and determine the relative contribution of each jaw-closing muscle in the generation of bite forces. The MDA model simulated incisor biting at different gapes. A series of ‘virtual ablation experiments' were performed at each gape, whereby the activation of each bilateral pair of muscles was set to zero. The maximum bite force was found to increase at wider gapes. As predicted, the superficial and anterior deep masseter were the largest contributors to bite force, but the temporalis had only a small contribution. Further analysis indicated that the temporalis may play a more important role in jaw stabilization than in the generation of bite force. This study demonstrated the ability of MDA to elucidate details of red and grey squirrel feeding biomechanics providing a complement to data gathered via in vivo experimentation

The Changing Workplace: A Survey of Employees’ Views and Experiences. The National Workplace Surveys 2009, Vol.2 Employees

Abstract included in text

Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation

Background: Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal models of axial pain are not widely available. Accordingly, we developed a mouse model of acute cervical muscle inflammation and assessed the functional properties of superficial dorsal horn (SDH) neurons.<p></p> Results: Male C57/Bl6 mice (P24-P40) were deeply anaesthetised (urethane 2.2?g/kg i.p) and the rectus capitis major muscle (RCM) injected with 40??l of 2% carrageenan. Sham animals received vehicle injection and controls remained anaesthetised for 2?hrs. Mice in each group were sacrificed at 2?hrs for analysis. c-Fos staining was used to determine the location of activated neurons. c-Fos labelling in carrageenan-injected mice was concentrated within ipsilateral (87% and 63% of labelled neurons in C1 and C2 segments, respectively) and contralateral laminae I - II with some expression in lateral lamina V. c-Fos expression remained below detectable levels in control and sham animals. In additional experiments, whole cell recordings were obtained from visualised SDH neurons in transverse slices in the ipsilateral C1 and C2 spinal segments. Resting membrane potential and input resistance were not altered. Mean spontaneous EPSC amplitude was reduced by ~20% in neurons from carrageenan-injected mice versus control and sham animals (20.63???1.05 vs. 24.64???0.91 and 25.87???1.32 pA, respectively). The amplitude (238???33 vs. 494???96 and 593???167 pA) and inactivation time constant (12.9???1.5 vs. 22.1???3.6 and 15.3???1.4?ms) of the rapid A type potassium current (IAr), the dominant subthreshold current in SDH neurons, were reduced in carrageenan-injected mice.<p></p> Conclusions: Excitatory synaptic drive onto, and important intrinsic properties (i.e., IAr) within SDH neurons are reduced two hours after acute muscle inflammation. We propose this time point represents an important transition period between peripheral and central sensitisation with reduced excitatory drive providing an initial neuroprotective mechanism during the early stages of the progression towards central sensitisation

PCR-Directed Formation of Viral Hybridsin Vitro

AbstractWhen constructing viruses that have desired hybrid phenotypes, anticipated difficulties include the nonviability of many, possibly most, of the hybrid genomes that can be constructed by incorporation of DNA fragments. Therefore, many different hybrid genomes may have to be constructed in order to find one that is viable. To perform this combinatorial work in a single experiment, we have used bacteriophage T7-infected cell extracts to transfer DNAin vitro.In an extract, we have incubated T7 DNA, together with DNA obtained by polymerase chain reaction (PCR) amplification of the gene (gene 17) for the tail fiber of the T7-related bacteriophage, T3. Afterin vitropackaging of DNA in the extract, hybrid progeny bacteriophage were detected by probing with a T3-specific oligonucleotide; hybrids are found at a frequency of 0.1%. By determination of the nucleotide sequence of the entire gene 17 of 14 independently isolated hybrids, both right and left ends of the PCR fragment are found to be truncated in all hybrids. For all 14 hybrids, the right end is in the same location; the left end is found at 3 different locations. The nonrandom location of the ends is explained by selection among different inserts for viability; that is, most of the hybrid genomes are nonviable. Some hybrids acquire from T3 the desirable phenotype of nonadherence to agarose gels during agarose gel electrophoresis

Pharmacist-led management of chronic pain in primary care:results from a randomised controlled exploratory trial

To compare the effectiveness of pharmacist medication review, with or without pharmacist prescribing, with standard care, for patients with chronic pain

Antidepressant exposure in pregnancy and child sensorimotor and visuospatial development

Motor development underlies many aspects of education and learning. There has been uncertainty about the impact of exposure of antidepressant medication in pregnancy on child motor outcomes. This paper examines whether exposure to antidepressants in utero increases the risk of poorer motor development in two areas: sensorimotor and visuospatial processing. Data were obtained from 195 women and children across 3 groups: women with untreated depression in pregnancy, women treated with antidepressants and control women. Data were collected across pregnancy, postpartum and until 4 years for mother and child. Maternal depression was established at baseline with the Structured Clinical Interview for DSM-IV. Antidepressant exposure, including type, dose and timing, was measured through repeated self-report across pregnancy and the postpartum, medical records at delivery and in cord blood samples collected at delivery. Child sensorimotor and visuospatial outcomes were assessed at 4 years of age with four subtests from the NEPSY-II. Our study found for sensorimotor development, visuomotor precision completion time was associated with better performance for antidepressant exposed children compared to those with mothers with untreated depression. Yet another measure of sensorimotor development, motor manual sequences, was poorer in those exposed to antidepressants. One subtest for visuospatial processing, block construction, was associated with poorer performance in antidepressant-exposed children who had poor neonatal adaptation and those exposed to a higher dose of antidepressant. These findings suggest an inconsistent association between sensorimotor development and antidepressant use in pregnancy. However, the findings for visuospatial processing would support further exploration of antidepressant associated poor neonatal adaption and later motor development

A short empirical note on perfectionism and flourishing

Flourishing describes an optimal state of mental health characterized by emotional, psychological, and social well-being. In a recent publication, Flett and Hewitt (2015) suggested that perfectionism prevents people from flourishing. Perfectionism, however, is a multidimensional personality characteristic, and its various dimensions show different relationships with indicators of subjective well-being. In the first empirical study of perfectionism and flourishing, we examined the relationships of multidimensional perfectionism (self-oriented, other-oriented, and socially prescribed perfectionism) and self-reported flourishing in the past two weeks. Results from the sample of 388 university students revealed that only socially prescribed perfectionism showed a negative relationship with flourishing, whereas self-oriented perfectionism showed a positive relationship. These results were unchanged when positive and negative affect were controlled statistically. Our findings indicate that not all dimensions of perfectionism undermine flourishing and that it is important to differentiate perfectionistic strivings and concerns when regarding the perfectionism–flourishing relationship

Detection of Tyrosinase Autoantibodies in Patients With Vitiligo Using 35S-Labeled Recombinant Human Tyrosinase in a Radioimmunoassay

Tyrosinase antibodies recently have been reported to occur frequently in patients with vitligo. We describe the detection of tyrosinase antibodies in vitiligo patients using in vitro 35S-labeled human tyrosinase in a radioimmunoassay. Of 46 vitiligo sera examined in the assay, five (10.9%) were found to be positive for tyrosinase antibodies. In contrast, 20 control sera and sera from 10 patients with Hashimoto's thyroiditis were negative. Four of the sera positive in the radioimmunoassay were also positive in an ELISA using mushroom tyrosinase as antigen. Absorption studies indicated that pre-incubation with mushroom tyrosinase absorbed out the immunoreactivity of the positive sera in the radioimmunoassay, suggesting cross-reactivity, but this absorption was never complete, indicating that there are tyrosinase antibodies in human sera that do not react with the mushroom protein. There was no obvious association between the presence of tyrosinase antibodies and the age of the patients (range: 22–62 y), their duration of disease (range: 5–20 y), or the type of vitiligo (one segmental, one symmetricallperiorificial, three symmetrical), although the three patients with the highest antibody levels also had an associated autoimmune disorder (one with Graves' disease; two with autoimmune hypothyroidism). The results confirm that tyrosinase autoantibodies are present in the sera of vitiligo patients but at a low frequency. The technique described is sensitive and quantitative and allows the detection of confirmational epitopes. It will be useful in longitudinal studies to determine the relation between the clinical features of vitiligo and tyrosinase antibody levels