Ferromagnetism in (In,Mn)As Diluted Magnetic Semiconductor Thin Films Grown by Metalorganic Vapor Phase Epitaxy

In1-xMnxAs diluted magnetic semiconductor (DMS) thin films have been grown using metalorganic vapor phase epitaxy (MOVPE). Tricarbonyl(methylcyclopentadienyl)manganese was used as the Mn source. Nominally single-phase, epitaxial films were achieved with Mn content as high as x=0.14 using growth temperatures Tg>475 C. For lower growth temperatures and higher Mn concentrations, nanometer scale MnAs precipitates were detected within the In1-xMnxAs matrix. Magnetic properties of the films were investigated using a superconducting quantum interference device (SQUID) magnetometer. Room-temperature ferromagnetic order was observed in a sample with x=0.1. Magnetization measurements indicated a Curie temperature of 333 K and a room-temperature saturation magnetization of 49 emu/cm^3. The remnant magnetization and the coercive field were small, with values of 10 emu/cm^3 and 400 Oe, respectively. A mechanism for this high-temperature ferromagnetism is discussed in light of the recent theory based on the formation of small clusters of a few magnetic atoms.Comment: 5 pages, 5 figures, accepted for publication in JVST

Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy

Pathogenic variants in A Disintegrin And Metalloproteinase (ADAM) 22, the postsynaptic cell membrane receptor for the glycoprotein leucine-rich repeat glioma-inactivated protein 1 (LGI1), have been recently associated with recessive developmental and epileptic encephalopathy. However, so far, only two affected individuals have been described and many features of this disorder are unknown. We refine the phenotype and report 19 additional individuals harboring compound heterozygous or homozygous inactivating ADAM22 variants, of whom 18 had clinical data available. Additionally, we provide follow-up data from two previously reported cases. All affected individuals exhibited infantile-onset, treatment-resistant epilepsy. Additional clinical features included moderate to profound global developmental delay/intellectual disability (20/20), hypotonia (12/20), delayed motor development (19/20). Brain MRI findings included cerebral atrophy (13/20), supported by post-mortem histological examination in patient-derived brain tissue, cerebellar vermis atrophy (5/20), and callosal hypoplasia (4/20). Functional studies in transfected cell lines confirmed the deleteriousness of all identified variants and indicated at least three distinct pathological mechanisms: defective cell membrane expression (1), impaired LGI1-binding (2), and/or impaired interaction with the postsynaptic density protein PSD-95 (3). We reveal novel clinical and molecular hallmarks of ADAM22 deficiency and provide knowledge that might inform clinical management and early diagnostics

Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy

Pathogenic variants in A Disintegrin And Metalloproteinase (ADAM) 22, the postsynaptic cell membrane receptor for the glycoprotein leucine-rich repeat glioma-inactivated protein 1 (LGI1), have been recently associated with recessive developmental and epileptic encephalopathy. However, so far, only two affected individuals have been described and many features of this disorder are unknown. We refine the phenotype and report 19 additional individuals harbouring compound heterozygous or homozygous inactivating ADAM22 variants, of whom 18 had clinical data available. Additionally, we provide follow-up data from two previously reported cases. All affected individuals exhibited infantile-onset, treatment-resistant epilepsy. Additional clinical features included moderate to profound global developmental delay/intellectual disability (20/20), hypotonia (12/20) and delayed motor development (19/20). Brain MRI findings included cerebral atrophy (13/20), supported by post-mortem histological examination in patient-derived brain tissue, cerebellar vermis atrophy (5/20), and callosal hypoplasia (4/20). Functional studies in transfected cell lines confirmed the deleteriousness of all identified variants and indicated at least three distinct pathological mechanisms: (i) defective cell membrane expression; (ii) impaired LGI1-binding; and/or (iii) impaired interaction with the postsynaptic density protein PSD-95. We reveal novel clinical and molecular hallmarks of ADAM22 deficiency and provide knowledge that might inform clinical management and early diagnostics. Van der Knoop et al. describe the clinical features of 21 individuals with biallelic pathogenic variants in ADAM22 and confirm the deleteriousness of the variants with functional studies. Clinical hallmarks of this rare disorder comprise progressive encephalopathy and infantile-onset refractory epilepsy.Peer reviewe

Semiconductor Spintronics

Spintronics refers commonly to phenomena in which the spin of electrons in a solid state environment plays the determining role. In a more narrow sense spintronics is an emerging research field of electronics: spintronics devices are based on a spin control of electronics, or on an electrical and optical control of spin or magnetism. This review presents selected themes of semiconductor spintronics, introducing important concepts in spin transport, spin injection, Silsbee-Johnson spin-charge coupling, and spindependent tunneling, as well as spin relaxation and spin dynamics. The most fundamental spin-dependent nteraction in nonmagnetic semiconductors is spin-orbit coupling. Depending on the crystal symmetries of the material, as well as on the structural properties of semiconductor based heterostructures, the spin-orbit coupling takes on different functional forms, giving a nice playground of effective spin-orbit Hamiltonians. The effective Hamiltonians for the most relevant classes of materials and heterostructures are derived here from realistic electronic band structure descriptions. Most semiconductor device systems are still theoretical concepts, waiting for experimental demonstrations. A review of selected proposed, and a few demonstrated devices is presented, with detailed description of two important classes: magnetic resonant tunnel structures and bipolar magnetic diodes and transistors. In most cases the presentation is of tutorial style, introducing the essential theoretical formalism at an accessible level, with case-study-like illustrations of actual experimental results, as well as with brief reviews of relevant recent achievements in the field.Comment: tutorial review; 342 pages, 132 figure

Brancherapport Preventie '98-'01

Uitgave van VWS. Te bestellen bij: Sdu Uitgevers, Postbus 20014, 2500 EA Den Haag, telefoon (070) 378 98 80.Rapport is ook te downloaden van http://www.minvws.nl/images/branche-preventie-98-01_tcm10-19587.pdf<br>Het 'Brancherapport Preventie '98-'01' maakt deel uit van het 'Brancherapport Volksgezondheid' dat bestaat uit de deelrapporten 'Preventie', 'Cure', 'Care', 'GGZ-MZ' en 'Welzijn en Sport'. Op verzoek van het ministerie van VWS heeft het RIVM in samenwerking met organisaties uit het preventieveld het deelrapport preventie opgesteld. Doel van het 'Brancherapport Preventie' is aan de hand van feiten en cijfers een beeld te geven over de ontwikkelingen in de preventiesector in het afgelopen jaar en de drie jaren ervoor (1998-2001). Alle brancherapporten zijn vergelijkbaar opgebouwd en geven informatie over vraag, aanbod, gebruik/capaciteit, financiering en kwaliteit van activiteiten op het betreffende terrein. De informatie is daarmee beter toegankelijk en op hoofdlijnen tussen sectoren vergelijkbaar. De brancherapporten '98-'01 zijn samen met de Zorgnota en de begroting in november 2002 aan de Tweede Kamer aangeboden om hen te informeren over de stand van zaken in de verschillende sectoren. Het 'Brancherapport Preventie' bevat brede, feitelijke en objectieve informatie over de preventiesector en is hierdoor ook voor partijen in het veld bruikbaar bij ontwikkeling en uitvoering van beleid. In de toekomst zullen de brancherapporten tegelijkertijd met andere verantwoordingsdocumenten van VWS uitkomen. Het eerstvolgende 'Brancherapport Preventie' zal uitkomen in mei 2004.VW