59 research outputs found
The MAJORANA DEMONSTRATOR: A Search for Neutrinoless Double-beta Decay of Germanium-76
The {\sc Majorana} collaboration is searching for neutrinoless double beta
decay using Ge, which has been shown to have a number of advantages in
terms of sensitivities and backgrounds. The observation of neutrinoless
double-beta decay would show that lepton number is violated and that neutrinos
are Majorana particles and would simultaneously provide information on neutrino
mass. Attaining sensitivities for neutrino masses in the inverted hierarchy
region, meV, will require large, tonne-scale detectors with extremely
low backgrounds, at the level of 1 count/t-y or lower in the region of
the signal. The {\sc Majorana} collaboration, with funding support from DOE
Office of Nuclear Physics and NSF Particle Astrophysics, is constructing the
{\sc Demonstrator}, an array consisting of 40 kg of p-type point-contact
high-purity germanium (HPGe) detectors, of which 30 kg will be enriched
to 87% in Ge. The {\sc Demonstrator} is being constructed in a clean
room laboratory facility at the 4850' level (4300 m.w.e.) of the Sanford
Underground Research Facility (SURF) in Lead, SD. It utilizes a compact graded
shield approach with the inner portion consisting of ultra-clean Cu that is
being electroformed and machined underground. The primary aim of the {\sc
Demonstrator} is to show the feasibility of a future tonne-scale measurement in
terms of backgrounds and scalability.Comment: Proceedings for the MEDEX 2013 Conferenc
Sensitivity Studies for Third-Generation Gravitational Wave Observatories
Advanced gravitational wave detectors, currently under construction, are
expected to directly observe gravitational wave signals of astrophysical
origin. The Einstein Telescope, a third-generation gravitational wave detector,
has been proposed in order to fully open up the emerging field of gravitational
wave astronomy. In this article we describe sensitivity models for the Einstein
Telescope and investigate potential limits imposed by fundamental noise
sources. A special focus is set on evaluating the frequency band below 10Hz
where a complex mixture of seismic, gravity gradient, suspension thermal and
radiation pressure noise dominates. We develop the most accurate sensitivity
model, referred to as ET-D, for a third-generation detector so far, including
the most relevant fundamental noise contributions.Comment: 13 pages, 7 picture
Scientific Potential of Einstein Telescope
Einstein gravitational-wave Telescope (ET) is a design study funded by the
European Commission to explore the technological challenges of and scientific
benefits from building a third generation gravitational wave detector. The
three-year study, which concluded earlier this year, has formulated the
conceptual design of an observatory that can support the implementation of new
technology for the next two to three decades. The goal of this talk is to
introduce the audience to the overall aims and objectives of the project and to
enumerate ET's potential to influence our understanding of fundamental physics,
astrophysics and cosmology.Comment: Conforms to conference proceedings, several author names correcte
Incidence, risk factors and outcomes of checkpoint inhibitor-induced liver injury: a 10-year real-world retrospective cohort study
AbstractsBackground and Aims: Checkpoint inhibitors (CPI) are accounting for increasing number of drug-induced liver injury (DILI) cases. We aimed to determine the incidence rate and risk factors associated with checkpoint inhibitor-induced liver injury (ChILI).Method: Prescription event monitoring was performed on all melanoma and renal cancer patients who received CPI at a tertiary centre between 2011 and 2021. ChILI cases were identified using the definitions, grading and causality assessment methods validated for DILI. We assessed risk factors associated with ChILI in CPInaïve patients using multivariable logistic regression model. Consecutive patients with suspected ChILI from two other tertiary centres were adjudicated and combined for case characterization and outcomes of ChILI.Results: Out of 432 patients received CPI over 10 years, ChILI occurred in 38 (8.8%) with an overall incidence rate of 11.5 per 1,000 patient-months (95% CI 8.2-15.8). Probability of ChILI was highest in combination therapy (32%) with no new events occurred beyond 135 days of treatment. Risk factor analysis showed that combination therapy, female sex, higher baseline alanine transferase level and lower baseline alkaline phosphatase level were independently associated with higher risk of ChILI. In total, 99 patients were adjudicated to have ChILI from three centres.Although Common Terminology Criteria for Adverse Events (CTCAE) classified 20 patients (20.2%) to have ‘life-threatening’ grade 4 hepatitis, ChILI severity was graded as mild in 45 (45.5%) and moderate in the remaining 54 (54.5%) cases.Conclusion: The risk of ChILI in real-world is higher than previously reported. Among patients receiving dual CPI, this risk falls markedly after four and half 7 months. As CTCAE overestimates its clinical severity, case-definition, evaluation and management of ChILI should be revised to harmonise care
International Guidelines for Management of Metastatic Breast Cancer: Combination vs Sequential Single-Agent Chemotherapy
Compared with treatment options for early-stage breast cancer, few data exist regarding the optimal use of chemotherapy for metastatic breast cancer (MBC). The choice of using a combination of cytotoxic chemotherapies vs sequential single agents is controversial. At the 6th European Breast Cancer Conference, the European School of Oncology Metastatic Breast Cancer Task Force convened an open debate on the relative benefits of combination vs sequential therapy. Based on the available data, the Task Force recommends sequential monotherapy as the preferred choice in advanced disease, in the absence of rapid clinical progression, life-threatening visceral metastases, or the need for rapid symptom and/or disease control. Patient- and disease-related factors should be used to choose between combination and sequential single-agent chemotherapy for MBC. Additional research is needed to determine the impact of therapy on patient-rated quality of life and to identify predictive factors that can be used to guide therapy
The third generation of gravitational wave observatories and their science reach
Large gravitational wave interferometric detectors, like Virgo and LIGO, demonstrated the capability to reach their design sensitivity, but to transform these machines into an effective observational instrument for gravitational wave astronomy a large improvement in sensitivity is required. Advanced detectors in the near future and third-generation observatories in more than one decade will open the possibility to perform gravitational wave astronomical observations from the Earth. An overview of the possible science reaches and the technological progress needed to realize a third-generation observatory are discussed in this paper. The status of the project Einstein Telescope (ET), a design study of a third-generation gravitational wave observatory, will be reported
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