Mangiferin: A Promising Anticancer Bioactive

Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, i.e., oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of Mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of Mangiferin

New generalized fuzzy metrics and fixed point theorem in fuzzy metric space

In this paper, in fuzzy metric spaces (in the sense of Kramosil and Michalek (Kibernetika 11:336-344, 1957)) we introduce the concept of a generalized fuzzy metric which is the extension of a fuzzy metric. First, inspired by the ideas of Grabiec (Fuzzy Sets Syst. 125:385-389, 1989), we define a new G-contraction of Banach type with respect to this generalized fuzzy metric, which is a generalization of the contraction of Banach type (introduced by M Grabiec). Next, inspired by the ideas of Gregori and Sapena (Fuzzy Sets Syst. 125:245-252, 2002), we define a new GV-contraction of Banach type with respect to this generalized fuzzy metric, which is a generalization of the contraction of Banach type (introduced by V Gregori and A Sapena). Moreover, we provide the condition guaranteeing the existence of a fixed point for these single-valued contractions. Next, we show that the generalized pseudodistance J:X×X→[0,∞) (introduced by Włodarczyk and Plebaniak (Appl. Math. Lett. 24:325-328, 2011)) may generate some generalized fuzzy metric NJ on X. The paper includes also the comparison of our results with those existing in the literature

Generalized Cauchy means

Given two means M and N, the operator MM,NMM,N assigning to a given mean μ the mean MM,N(μ)(x,y)=M(μ(x,N(x,y)),μ(N(x,y),y)) was defined in Berrone and Moro (Aequationes Math 60:1–14, 2000) in connection with Cauchy means: the Cauchy mean generated by the pair f, g of continuous and strictly monotonic functions is the unique solution μ to the fixed point equation MA(f),A(g)(μ)=μ, where A(f) and A(g) are the quasiarithmetic means respectively generated by f and g. In this article, the operator MM,NMM,N is studied under less restrictive conditions and a general fixed point theorem is derived from an explicit formula for the iterates MnM,NMM,Nn . The concept of class of generalized Cauchy means associated to a given family of mixing pairs of means is introduced and some distinguished families of pairs are presented. The question of equality in these classes of means remains a challenging open problem.Fil: Berrone, Lucio Renato. Universidad Nacional de Rosario. Facultad de Ciencias Exactas, Ingeniería y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Reducible means and reducible inequalities

It is well-known that if a real valued function acting on a convex set satisfies the $n$-variable Jensen inequality, for some natural number $n\geq 2$, then, for all $k\in\{1,\dots, n\}$, it fulfills the $k$-variable Jensen inequality as well. In other words, the arithmetic mean and the Jensen inequality (as a convexity property) are both reducible. Motivated by this phenomenon, we investigate this property concerning more general means and convexity notions. We introduce a wide class of means which generalize the well-known means for arbitrary linear spaces and enjoy a so-called reducibility property. Finally, we give a sufficient condition for the reducibility of the $(M,N)$-convexity property of functions and also for H\"older--Minkowski type inequalities

Reducing the polynomial-like iterative equations order and a generalized Zoltan Boros' problem

We present a technique for reducing the order of polynomial-like iterative equations; in particular, we answer a question asked by Wenmeng Zhang and Weinian Zhang. Our method involves the asymptotic behaviour of the sequence of consecutive iterates of the unknown function at a given point. As an application we solve a generalized problem of Zoltán Boros posed during the 50th ISFE