Involvement of Mhc Loci in immune responses that are not Ir-gene-controlled

Twenty-nine randomly chosen, soluble antigens, many of them highly complex, were used to immunize mice of two strains, C3H and B10.RIII. Lymphnode cells from the immunized mice were restimulated in vitro with the priming antigens and the proliferative response of the cells was determined. Both strains were responders to 28 of 29 antigens. Eight antigens were then used to immunize 11 congenic strains carrying different H-2 haplotypes, and the T-cell proliferative responses of these strains were determined. Again, all the strains responded to seven of the eight antigens. These experiments were then repeated, but this time -antibodies specific for the A (AA) or E (EE) molecules were added to the culture to block the in vitro responsiveness. In all but one of the responses, inhibition with both A-specific and E-specific antibodies was observed. The response to one antigen (Blastoinyces) was exceptional in that some strains were nonresponders to this antigen. Furthermore, the response in the responder strains was blocked with A-specific, but not with E-specific, antibodies. The study demonstrates that responses to antigens not controlled by Irr genes nevertheless require participation of class II Mhc molecules. In contrast to Ir gene-controlled responses involving either the A- or the E-molecule controlling loci (but never both), the responses not Ir-controlled involve participation of both A- and E-controlling loci. The lack of Ir-gene control is probably the result of complexity of the responses to multiple determinants. There is thus no principal difference between responses controlled and those not controlled by Ir genes: both types involve the recognition of the antigen, in the context of Mhc molecules

Resource-sensitive synchronization inference by abduction

We present an analysis which takes as its input a sequential program, augmented with annotations indicating potential parallelization opportunities, and a sequential proof, written in separation logic, and produces a correctly-synchronized parallelized program and proof of that program. Unlike previous work, ours is not an independence analysis; we insert synchronization constructs to preserve relevant dependencies found in the sequential program that may otherwise be violated by a naive translation. Separation logic allows us to parallelize fine-grained patterns of resource-usage, moving beyond straightforward points-to analysis. Our analysis works by using the sequential proof to discover dependencies between different parts of the program. It leverages these discovered dependencies to guide the insertion of synchronization primitives into the parallelized program, and to ensure that the resulting parallelized program satisfies the same specification as the original sequential program, and exhibits the same sequential behaviour. Our analysis is built using frame inference and abduction, two techniques supported by an increasing number of separation logic tools

Mass correlation between light and heavy reaction products in multinucleon transfer 197Au+130Te collisions

We studied multinucleon transfer reactions in the 197Au+130Te system at Elab=1.07 GeV by employing the PRISMA magnetic spectrometer coupled to a coincident detector. For each light fragment we constructed, in coincidence, the distribution in mass of the heavy partner of the reaction. With a Monte Carlo method, starting from the binary character of the reaction, we simulated the de-excitation process of the produced heavy fragments to be able to understand their final mass distribution. The total cross sections for pure neutron transfer channels have also been extracted and compared with calculations performed with the grazing code

Experimental study of the collision 11Be + 64Zn around the Coulomb barrier

In this paper details of the experimental procedure and data analysis of the collision of 11Be+64Zn around the Coulomb barrier are described and discussed in the framework of different theoretical approaches. In a previous work [ A. Di Pietro et al. Phys. Rev. Lett. 105 022701 (2010)], the elastic scattering angular distribution of the collisions 9, 10Be+64Zn as well as the angular distribution for the quasielastic scattering and transfer/breakup cross sections for the 11Be+64Zn reaction were briefly reported. The suppression of the quasielastic angular distribution in the Coulomb-nuclear interference angular region observed in the collision of the 11Be halo nucleus with respect to the other two beryllium isotopes was interpreted as being caused by a long-range absorption owing to the long decay length of the 11Be wave function. In this paper, new continuum-discretized coupled-channel calculations of the 11Be+64Zn reaction are reported in the attempt to interpret the effect of coupling with the breakup channels on the measured cross sections. The calculations show that the observed suppression of the Coulomb-nuclear interference peak is caused by a combined effect of Coulomb and nuclear couplings to the breakup channels

Evidence of strong effects of the 11Be halo structure on reaction processes at energies around the Coulomb barrier

The collision induced by the three Beryllium isotopes, 9, 10, 11Be, on 64Zn target were investigated at Ec.m. ≈ 1.4 the Coulomb barrier. Elastic scattering angular distributions were measured for the 9, 10Be collisions whereas, in the 11Be case the quasielastic scattering angular distribution was obtained. A strong damping of the quasielastic cross-section was observed in the 11Be case, especially in the angular range around the Coulomb-nuclear interference peak. In this latter case a large total-reaction cross-section is found, more than a factor of two larger than the ones extracted in the reactions induced by the non-halo Beryllium isotopes. A large contribution to the total-reaction cross-section in the 11Be case could be attributed to transfer and/or break-up events

Elastic Scattering and Reaction Mechanisms of the Halo Nucleus 11Be around the Coulomb Barrier

Collisions induced by 9, 10, 11Be on a 64Zn target at the same c.m. energy were studied. For the first time, strong effects of the 11Be halo structure on elastic-scattering and reaction mechanisms at energies near the Coulomb barrier are evidenced experimentally. The elastic-scattering cross section of the 11Be halo nucleus shows unusual behavior in the Coulomb-nuclear interference peak angular region. The extracted total-reaction cross section for the 11Be collision is more than double the ones measured in the collisions induced by 9, 10Be. It is shown that such a strong enhancement of the total-reaction cross section with 11Be is due to transfer and breakup processes

Structure of 24Mg excited states and their influence on nucleosynthesis

The main idea of the two presented experiments is to study the decay of resonances in 24Mg at excitation energies above the 12C+12C decay thresh- old, in the astrophysical energy region of interest. The measurement of the 12C(16O,α)24Mg* reaction was performed at INFN-LNS in Catania. Only the α+20Ne decay channel of 24Mg is presented here, because it was a motivation for conducting a new experiment, a study of the 4He(20Ne,4He)20Ne reaction, performed at INFN-LNL in Legnaro. Some preliminary results of this measurement are also presented