Heavy-flavor dynamics in nucleus-nucleus collisions: from RHIC to LHC

The stochastic dynamics of c and b quarks in the fireball created in nucleus-nucleus collisions at RHIC and LHC is studied employing a relativistic Langevin equation, based on a picture of multiple uncorrelated random collisions with the medium. Heavy-quark transport coefficients are evaluated within a pQCD approach, with a proper HTL resummation of medium effects for soft scatterings. The Langevin equation is embedded in a multi-step setup developed to study heavy-flavor observables in pp and AA collisions, starting from a NLO pQCD calculation of initial heavy-quark yields, complemented in the nuclear case by shadowing corrections, k_T-broadening and nuclear geometry effects. Then, only for AA collisions, the Langevin equation is solved numerically in a background medium described by relativistic hydrodynamics. Finally, the propagated heavy quarks are made hadronize and decay into electrons. Results for the nuclear modification factor R_AA of heavy-flavor hadrons and electrons from their semi-leptonic decays are provided, both for RHIC and LHC beam energies.Comment: 4 pages, 2 figures (3 eps files); submitted for publication in the proceedings of "Quark Matter 2011", 23-28 May 2011, Annecy (France

Swimming into peptidomimetic chemical space using pepMMsMIMIC

pepMMsMIMIC is a novel web-oriented peptidomimetic compound virtual screening tool based on a multi-conformers three-dimensional (3D)-similarity search strategy. Key to the development of pepMMsMIMIC has been the creation of a library of 17 million conformers calculated from 3.9 million commercially available chemicals collected in the MMsINC® database. Using as input the 3D structure of a peptide bound to a protein, pepMMsMIMIC suggests which chemical structures are able to mimic the protein–protein recognition of this natural peptide using both pharmacophore and shape similarity techniques. We hope that the accessibility of pepMMsMIMIC (freely available at http://mms.dsfarm.unipd.it/pepMMsMIMIC) will encourage medicinal chemists to de-peptidize protein–protein recognition processes of biological interest, thus increasing the potential of in silico peptidomimetic compound screening of known small molecules to expedite drug development

Urea‑functionalized amorphous calcium phosphate nanofertilizers: optimizing the synthetic strategy towards environmental sustainability and manufacturing costs

This work has been performed thanks to the funding by Fondazione CARIPLO (Project No. 2016-0648: Romancing the stone: size-controlled HYdroxyaPATItes for sustainable Agriculture – HYPATIA). JMDL acknowledges Spanish Ministry of Science, Innovation and Universities of Spain (MCIU/AEI/FEDER, UE) for funding through the projects NanoVIT (RTI-2018-095794-A-C22) and NanoSmart (RYC-2016-21042). GBRR also acknowledges the Spanish MICIU for her postdoctoral contract within the Juan de la Cierva Program (JdC-2017). Financial support for this work was also provided by the Marie Skłodowska-Curie Standard Fellowships (888972-PSust- MOF, F.J.C.) within the European Union research and innovation framework programme (2014-2020). We thank Prof. Jan Skov Pedersen (Aarhus University, DK) for technical and scientific assistance on SAXS experiments.Nanosized fertilizers are the new frontier of nanotechnology towards a sustainable agriculture. Here, an efficient N-nanofertilizer is obtained by post-synthetic modification (PSM) of nitrate-doped amorphous calcium phosphate (ACP) nanoparticles (NPs) with urea. The unwasteful PSM protocol leads to N-payloads as large as 8.1 w/w%, is well replicated by using inexpensive technical-grade reagents for cost-effective up-scaling and moderately favours urea release slowdown. Using the PSM approach, the N amount is ca. 3 times larger than that obtained in an equivalent one-pot synthesis where urea and nitrate are jointly added during the NPs preparation. In vivo tests on cucumber plants in hydroponic conditions show that N-doped ACP NPs, with half absolute N-content than in conventional urea treatment, promote the formation of an equivalent amount of root and shoot biomass, without nitrogen depletion. The high nitrogen use efficiency (up to 69%) and a cost-effective preparation method support the sustainable real usage of N-doped ACP as a nanofertilizer.Fondazione Cariplo 2016-0648Spanish Ministry of Science, Innovation and Universities of Spain (MCIU/AEI/FEDER, UE) RTI-2018-095794-A-C22 RYC-2016-21042Marie Sklodowska-Curie Standard Fellowships within the European Union research and innovation framework programme (2014-2020) 888972-PSustMOFSpanish MICIU within the Juan de la Cierva Program (JdC-2017

Foraging niche separation of social wasps in an invaded area: Implications for their management

Foraging niche separation may be a mechanism to promote coexistence of two competing species by concentrating intraspecific competition relative to interspecific competition. The present study investigated foraging behaviour and microhabitat use of two coexisting species of invasive social wasps, Vespula germanica and Vespula vulgaris, when foraging for two different food resources. Also, we tested the attractiveness of traps baited with a synthetic lure for those two species. We found that V. germanica wasps prefer to forage at ground level regardless of the resource, while V. vulgaris prefers protein resources at the shrubland level given a choice between a protein bait at ground or at shrubland level. However, when baited with the synthetic lure, the species caught was not affected by the height at which traps were placed. That is, in a no choice scenario, the traps were sufficiently attractive to lure both species of wasps to both microhabitats (ground and shrubland levels). Thus, our results support the existence of spatial niche differentiation at least in protein foraging and suggest that the synthetic lure evaluated could be used to trap both species of Vespula wasps present in Argentina. These results could help to improve management strategies of these social wasps in an invaded area.Estación Experimental Agropecuaria BarilocheFil: Masciocchi, Maite. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituo de Investigaciones Forestales y Agropecuarias Bariloche. Grupo de Ecología de Poblaciones de Insectos; ArgentinaFil: Unelius, Carl Rikard. Linnaeus University. Faculty of Health and Life Sciences; SueciaFil: Buteler, Micaela. Universidad Nacional del Comahue. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones en Biodiversidad y Medio Ambiente; Argentin

Strain effects on magnetic compensation and spin reorientation transition of Co/Gd synthetic ferrimagnets

Synthetic ferrimagnets are an attractive materials class for spintronics as they provide access to all-optical switching of magnetization and, at the same time, allow for ultrafast domain wall motion at angular momentum compensation. In this work, we systematically study the effects of strain on the perpendicular magnetic anisotropy and magnetization compensation of Co/Gd and Co/Gd/Co/Gd synthetic ferrimagnets. Firstly, the spin reorientation transition of a bilayer system is investigated in wedge type samples, where we report an increase in the perpendicular magnetic anisotropy in the presence of in-plane strain. Using a model for magnetostatics and spin reorientation transition in this type of system, we confirm that the observed changes in anisotropy field are mainly due to the Co magnetoelastic anisotropy. Secondly, the magnetization compensation of a quadlayer is studied. We find that magnetization compensation of this synthetic ferrimagnetic system is not altered by external strain. This confirms the resilience of this material system against strain that may be induced during the integration process, making Co/Gd ferrimagnets suitable candidates for spintronics applications.Synthetic ferrimagnets are an attractive materials class for spintronics as they provide access to all-optical switching of magnetization and, at the same time, allow for ultrafast domain wall motion at angular momentum compensation. In this work, we systematically study the effects of strain on the perpendicular magnetic anisotropy and magnetizationcompensation of Co/Gd and Co/Gd/Co/Gd synthetic ferrimagnets. Firstly, the spin reorientation transition of a bilayer system is investigated in wedge type samples, where we report an increase in the perpendicular magnetic anisotropy in the presence of in-plane strain. Using a model for magnetostatics and spin reorientation transition in this type ofsystem, we confirm that the observed changes in anisotropy field are mainly due to the Co magnetoelastic anisotropy. Secondly, the magnetization compensation of a quadlayer is studied. We find that magnetization compensation of this synthetic ferrimagnetic system is not altered by external strain. This confirms the resilience of this material systemagainst strain that may be induced during the integration process, making Co/Gd ferrimagnets suitable candidates for spintronics applications

Outcomes After Stereotactic Body Radiation Therapy as a Bridging Modality to Liver Transplantation for Hepatocellular Carcinoma

Purpose: For patients with hepatocellular carcinoma awaiting liver transplantation (LT), stereotactic body radiation therapy (SBRT) has emerged as a bridging treatment to ensure patients maintain priority status and eligibility per Milan criteria. In this study, we aimed to determine the efficacy and safety of SBRT in such situations. Methods and Materials: A retrospective analysis was conducted of the outcomes of 27 patients treated with SBRT who were listed for LT at 1 institution. Among these, 20 patients with 26 tumors went on to LT and were the focus of this study. Operative reports and postoperative charts were evaluated for potential radiation-related complications. The explant pathology findings were correlated with equivalent dose in 2 Gy fractions and tumor size. Results: Median pretreatment tumor size was 3.05 cm. Median total dose of radiation was 50 Gy delivered in 5 fractions. Pathologic complete response (pCR) was achieved in 16 tumors (62%). Median interval from end of SBRT to transplant was 287 days. Of the 21 tumors imaged before transplant, 16 or 76% demonstrated a clinical complete response based on modified Response Evaluation Criteria in Solid Tumors criteria. There was no significant correlation between pCR rate and increasing tumor size (odds ratio [OR], 0.95; 95% confidence interval, 0.595-1.53) or pCR rate and equivalent dose in 2 Gy fractions (OR, 1.03; 95% confidence interval, 0.984-1.07.) No patients experienced radiation-related operative or postoperative complications. Of the 27 patients who were listed for transplant, the dropout rate was 22%. Two of the 5 patients with Child-Pugh score 10 died of liver failure. Conclusions: These data demonstrate that SBRT as a bridging modality is a feasible option, with a pCR rate comparable to that of other bridging modalities and no additional radiation-related operative or postoperative complications. There was no dose dependence nor size dependence for pCR rate, which may indicate that for the tumor sizes in this study, the radiation doses delivered were sufficiently high

Urea-Doped Calcium Phosphate Nanoparticles as Sustainable Nitrogen Nanofertilizers for Viticulture: Implications on Yield and Quality of Pinot Gris Grapevines

In recent years, the application of nanotechnology for the development of new “smart fertilizers” is regarded as one of the most promising solutions for boosting a more sustainable and modern grapevine cultivation. Despite showing interesting potential benefits over conventional fertilization practices, the use of nanofertilizers in viticulture is still underexplored. In this work, we investigated the effectiveness of non-toxic calcium phosphate nanoparticles (Ca3(PO4)2∙nH2O) doped with urea (U-ACP) as a nitrogen source for grapevine fertilization. Plant tests were performed for two years (2019–2020) on potted adult Pinot gris cv. vines grown under semi-controlled conditions. Four fertilization treatments were compared: N1: commercial granular fertilization (45 kg N ha−1); N2: U-ACP applied in fertigation (36 kg N ha−1); N3: foliar application of U-ACP (36 kg N ha−1); C: control, receiving no N fertilization. Plant nitrogen status (SPAD), yield parameters as well as those of berry quality were analyzed. Results here presented clearly show the capability of vine plants to recognize and use the nitrogen supplied with U-ACP nanoparticles either when applied foliarly or to the soil. Moreover, all of the quali–quantitative parameters measured in vine plants fed with nanoparticles were perfectly comparable to those of plants grown in conventional condition, despite the restrained dosage of nitrogen applied with the nanoparticles. Therefore, these results provide both clear evidence of the efficacy of U-ACP nanoparticles as a nitrogen source and the basis for the development of alternative nitrogen fertilization strategies, optimizing the dosage/benefit ratio and being particularly interesting in a context of a more sustainable and modern viticulture.PSR 2014/2020 Regione Autonoma Friuli Venezia Giulia—Misure 16.1.1, DGR 1313/2018, DC 398/AGFOR 2020—GESOVIT PROJECTFondazione Cariplo, Italy, Grant n. 2016-0648, project: Romancing the stone: size controlled HYdroxyaPATItes for sustainable Agriculture (HYPATIA

Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma in Patients With Child-Pugh B or C Cirrhosis

Purpose: Our purpose was to report outcomes in patients with Child-Pugh B or C (CP B/C) hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT). Methods and Materials: Patients with HCC suitable for SBRT were prospectively enrolled in the study from 2012 to 2018. Outcomes in patients with CP B/C were analyzed. Cox proportional hazard models were used to compare survival outcomes between baseline CP score and post-SBRT CP score. Results: Twenty-three patients with CP B/C with a total of 29 HCC tumors were treated with SBRT. Eighty-seven percent of patients were CP B8-C10. Median tumor size was 3.1 cm (range, 1-10 cm). Median dose delivered was 40 Gy in a median of 5 fractions. Eighteen of 23 patients (78.3%) had been previously treated with transarterial chemoembolization. Median follow-up was 14.5 months. Rates of 6- and 12-month local control were 100% and 92.3%, respectively. Six- and 12-month survival rates were 73.9% and 56.5%, respectively. Median survival was 14.5 months overall and 9.2, 22.5, 14.5, and 14.4 months for patients with CP B7, B8, B9, and C10, respectively. No patients exhibited symptoms of classic radiation-induced liver disease. However, 10 patients had CP score progression, with 4 patients (17%) having a \u3e /=2-point increase in CP score by 6 months (or time of censor). There were 7 liver-related deaths, and based on independent review by a hepatologist, 1 of these deaths may have been attributable to SBRT-related liver injury. Fifteen of 23 patients were listed for liver transplant (LT) at the time of SBRT and 9 went on to receive LT with a pathologic complete response rate of 63.6%. Median survival, excluding patients who received LT, was 7.3 months. Conclusions: SBRT is a reasonable treatment option for carefully selected patients with CP B7-C10. In our small cohort, there was no detectable difference between local control or overall survival and baseline CP score