Open access repositories in the Asia-Oceania region: Experiences and guidelines from three academic institutions

In recent years open access models have transcended traditional modes of publishing, thus enabling freer access to research. This paper takes a trans-regional approach to open access publishing in the Asia and Oceania region focussing on individual institutions in three countries – Charles Darwin University (Australia), University of Hong Kong and the University of Malaya, reflecting on how each one is rising, in its own individual way, to meet the range of challenges that its research communities are facing. Specifically, it focuses on open access and institutional repository development, and traces their development at each of the aforementioned institutions. This paper is based on interviews conducted with staff involved with the development of the repository, and the open access collection in particular, at each of the three institutions. It synthesises open access developments and reviews the role the library has played in each institution in the development of open access across the academic and research community; and the success that has been achieved to date. It highlights any common factors between the approaches taken by each institution, as well as any significant differences of note. The findings reveal that each of the three institutions is at a different stage of development with the University of Hong Kong repository ranked at the top within Asia. Each has used a slightly different approach toward open access, and used different software to develop their repository. The authors have collated the overall experiences of each institution in open access publishing and repository development. They have highlighted the successes and failures that each has experienced and formulated a set of guidelines that may help those embarking on establishing an open access repository.postprin

Research Support in Australian Academic Libraries: Services, Resources, and Relationships

In the last decade Australian academic libraries have increasingly aligned their research support services with assessment criteria used in the national research evaluation exercise (Excellence for Research in Australia). The same period has seen growing interest in research impact outside of traditional measures, such as bibliometrics. Social media has provided opportunities for research dissemination and new tools, altmetrics, to measure these activities have emerged. This article reports on research into the extent and nature of research support services at Australian academic libraries, how the services are managed, and the factors that influence their development and delivery. Quantitative and qualitative research methods were used to compare the findings with an earlier study and to provide a deeper understanding of research support in Australia. Three key themes, services, staff and resourcing, and relationships, are discussed in relation to the management and challenges faced in providing research support

MR-derived renal morphology and renal function in patients with atherosclerotic renovascular disease

Appropriate selection of patients with atherosclerotic renovascular disease (ARVD) for revascularization might be improved if accurate non-invasive investigations were used to assess severity of pre-existing parenchymal damage. The purpose of this study was to evaluate the associations between magnetic resonance imaging (MRI)-measured renal morphological parameters and single-kidney glomerular filtration rate (GFR) in ARVD. Three-dimensional (3D)-MRI was performed on 35 ARVD patients. Renal bipolar length (BL), parenchymal volume, parenchymal (PT), and cortical thicknesses (CT) were measured in 65 kidneys. Thirteen kidneys were supplied by normal vessels, 13 had insignificant (<50%) renal artery stenosis (RAS), 33 significant (≥50%) RAS, and six complete vessel occlusion. All patients underwent radioisotopic measurement of single-kidney GFR (isoSK-GFR). Overall, 3D parameters such as parenchymal volume were better correlates of isoSK-GFR (r=0.86, P<0.001) than BL (r=0.78, P<0.001), PT (r=0.63, P<0.001) or CT (r=0.60, P<0.001). Kidneys with ≥50% RAS did show significant reduction in mean CT compared to those supplied by normal vessel (5.67±1.63 vs 7.28±1.80 mm, P=0.002; 22.1% reduction) and an even greater loss of parenchymal volume (120.65±47.15 vs 179.24±86.90 ml, P<0.001; 32.7% reduction) with no significant reduction in BL. In a proportion of ≥50% RAS kidneys, a disproportionately high parenchymal volume to isoSK-GFR was observed supporting a concept of ‘hibernating parenchyma’. 3D parameters of parenchymal volume are stronger correlates of isoSK-GFR than two-dimensional measures of BL, PT or CT. 3D morphological evaluation together with isoSK-GFR might be useful in aiding patient selection for renal revascularization. Kidneys with increased parenchymal volume to SK-GFR might represent a subgroup with the potential to respond beneficially to angioplasty

Crystal structure, Hirshfeld surface analysis and computational study of bis(2-{[(2,6-dichlorobenzylidene)hydrazinylidene]methyl}phenolato)cobalt(II) and of the copper(II) analogue

The title homoleptic Schiff base complexes, [M(C14H9Cl2N2O)2], for M = CoII,(I), and CuII, (II), present distinct coordination geometries despite the Schiff base dianion coordinating via the phenolato-O and imine-N atoms in each case. For (I), the coordination geometry is based on a trigonal bipyramid whereas for (II), a square-planar geometry is found (Cu site symmetry 1). In the crystal of (I), discernible supramolecular layers in the ac plane are sustained by chlorobenzene-C—HO(coordinated), chlorobenzene-C—H(fusedbenzene ring) as well as (fused-benzene, chlorobenzene)–(chlorobenzene) interactions [inter-centroid separations = 3.6460 (17) and 3.6580 (16) A˚ , respectively]. The layers inter-digitate along the b-axis direction and are linked by dichlorobenzene-C—H(fused-benzene ring) and – interactions between fused-benzene rings and between chlorobenzene rings [inter-centroid separations = 3.6916 (16) and 3.7968 (19) A˚ , respectively] . Flat, supramolecular layers are also found in the crystal of (II), being stabilized by – interactions formed between fused-benzene rings and between chlorobenzene rings [intercentroid separations = 3.8889 (15) and 3.8889 (15) A˚ , respectively]; these stack parallel to [101] without directional interactions between them. The analysis of the respective calculated Hirshfeld surfaces indicate diminished roles for HH contacts [26.2% (I) and 30.5% (II)] owing to significant contributions by ClH/HCl contacts [25.8% (I) and 24.9% (II)]. Minor contributions by ClCl [2.2%] and CuCl [1.9%] contacts are indicated in the crystals of (I) and (II), respectively. The interaction energies largely arise from dispersion terms; the aforementioned CuCl contact in (II) gives rise to the most stabilizing interaction in the crystal of (II)

Concerted reductive coupling of an alkyl chloride at Pt(IV)

Oxidation of a doubly cyclometallated platinum(II) complex results in two isomeric platinum(IV) complexes. Whereas the trans isomer is robust, being manipulable in air at room temperature, the cis isomer decomposes at −20 °C and above. Reductive coupling of an alkyl chloride at the cis isomer gives a new species which can be reoxidised. The independence of this coupling on additional halide rules out the reverse of an SN2 reaction, leaving a concerted process as the only sensible reaction pathway

UNMANNED AERIAL VEHICLE (UAV)

ABSTRACT Unmanned aerial vehicles (UAV) are the logical successors to modern aircraft and advancements in automated technology. The current generation of UAV&apos;s is focused on wartime capabilities and reconnaissance, leaving an existing market untapped by UAV technology: the commercial field. There are hundreds of applications for UAV technology in the civilian market, from emergency response applications and media outlets to communication technicians and horticulturalists. The vehicle can even act as a path guider in normal case and as a fire extinguisher in emergency. This project will help generate interests as well as innovations in the fields of unmanned vehicles, thereby working towards a practical and obtainable solution to save lives and mitigate the risk of property damage

Preoperative predictors for residual tumor after surgery in patients with ovarian carcinoma

Objectives: Suboptimal debulking (>1 cm residual tumor) results in poor survival rates for patients with an advanced stage of ovarian cancer. The purpose of this study was to develop a prediction model, based on simple preoperative parameters, for patients with an advanced stage of ovarian cancer who are at risk of suboptimal cytoreduction despite maximal surgical effort. Methods: Retrospective analysis of 187 consecutive patients with a suspected clinical diagnosis of advanced-stage ovarian cancer undergoing upfront debulking between January 1998 and December 2003. Preoperative parameters were Karnofsky performance status, ascites and serum concentrations of CA 125, hemoglobin, albumin, LDH and blood platelets. The main outcome parameter was residual tumor >1 cm. Univariate and multivariate logistic regression was employed for testing possible prediction models. A clinically applicable graphic model (nomogram) for this prediction was to be developed. Results: Serum concentrations of CA 125 and blood platelets in the group with residual tumor >1 cm were higher in comparison to the optimally cytoreduced group (p 1 cm based on serum levels of CA 125 and albumin was established. Conclusion: Postoperative residual tumor despite maximal surgical effort can be predicted by preoperative CA 125 and serum albumin levels. With a nomogram based on these two parameters, probability of postoperative residual tumor in each individual patient can be predicted. This proposed nomogram may be valuable in daily routine practice for counseling and to select treatment modality. Copyrigh

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

he antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F-subtype (ARE-ABCFs), which are widely distributed throughout Gram-positive bacteria and bind the ribosome to alleviate translational inhibition from antibiotics that target the large ribosomal subunit. Here, we present single-particle cryo-EM structures of ARE-ABCF-ribosome complexes from three Gram-positive pathogens: Enterococcus faecalis LsaA, Staphylococcus haemolyticus VgaALC and Listeria monocytogenes VgaL. Supported by extensive mutagenesis analysis, these structures enable a general model for antibiotic resistance mediated by these ARE-ABCFs to be proposed. In this model, ABCF binding to the antibiotic-stalled ribosome mediates antibiotic release via mechanistically diverse long-range conformational relays that converge on a few conserved ribosomal RNA nucleotides located at the peptidyltransferase center. These insights are important for the future development of antibiotics that overcome such target protection resistance mechanisms