INSOMNIA IN SUBCLINICAL PARANOID PARTICIPANTS

Insomnia has always been thought to be a consequence of schizophrenia and may be predicted by paranoid thoughts. Individuals with a diagnosis of schizophrenia have reported symptoms of insomnia, which can in turn increase psychosis. It is thought that these symptoms can come from decreased daytime activity, reduced cognitive functioning, or distress from psychotic experiences increasing arousal (Waite et al., 2016a; Hodgenkins et al., 2015; Stubbset et al., 2016). However, recent evidence has demonstrated that insomnia can predict later paranoid thoughts. Individuals with comorbid psychotic disorder and insomnia tend to have more severe psychotic experiences such as paranoid thoughts (Freeman et al., 2009; Xianget et al., 2009). The current study explores how insomnia affects an individual who experiences paranoid thoughts. It is expected that insomnia will increase paranoid thoughts in individuals who show varying levels of paranoid ideation ranging from sub-clinical to clinical levels

Using white noise to gate organic transistors for dynamic monitoring of cultured cell layers.

Impedance sensing of biological systems allows for monitoring of cell and tissue properties, including cell-substrate attachment, layer confluence, and the "tightness" of an epithelial tissue. These properties are critical for electrical detection of tissue health and viability in applications such as toxicological screening. Organic transistors based on conducting polymers offer a promising route to efficiently transduce ionic currents to attain high quality impedance spectra, but collection of complete impedance spectra can be time consuming (minutes). By applying uniform white noise at the gate of an organic electrochemical transistor (OECT), and measuring the resulting current noise, we are able to dynamically monitor the impedance and thus integrity of cultured epithelial monolayers. We show that noise sourcing can be used to track rapid monolayer disruption due to compounds which interfere with dynamic polymerization events crucial for maintaining cytoskeletal integrity, and to resolve sub-second alterations to the monolayer integrity

High transconductance organic electrochemical transistors.

The development of transistors with high gain is essential for applications ranging from switching elements and drivers to transducers for chemical and biological sensing. Organic transistors have become well-established based on their distinct advantages, including ease of fabrication, synthetic freedom for chemical functionalization, and the ability to take on unique form factors. These devices, however, are largely viewed as belonging to the low-end of the performance spectrum. Here we present organic electrochemical transistors with a transconductance in the mS range, outperforming transistors from both traditional and emerging semiconductors. The transconductance of these devices remains fairly constant from DC up to a frequency of the order of 1 kHz, a value determined by the process of ion transport between the electrolyte and the channel. These devices, which continue to work even after being crumpled, are predicted to be highly relevant as transducers in biosensing applications

SPI/INTEGRAL observation of the Cygnus region

We present the analysis of the first observations of the Cygnus region by the SPI spectrometer onboard the Integral Gamma Ray Observatory, encompassing ${\sim}$ 600 ks of data. Three sources namely Cyg X-1, Cyg X-3 and EXO 2030+375 were clearly detected. Our data illustrate the temporal variability of Cyg X-1 in the energy range from 20 keV to 300 keV. The spectral analysis shows a remarkable stability of the Cyg X-1 spectra when averaged over one day timescale. The other goal of these observations is SPI inflight calibration and performance verification. The latest objective has been achieved as demonstrated by the results presented in this paper.Comment: 6 pages, 10 figures, accepted for publication in A&A (special INTEGRAL volume

SPI observations of the diffuse 60Fe emission in the Galaxy

Gamma-ray line emission from radioactive decay of 60Fe provides constraints on nucleosynthesis in massive stars and supernovae. The spectrometer SPI on board INTEGRAL has accumulated nearly three years of data on gamma-ray emission from the Galactic plane. We have analyzed these data with suitable instrumental-background models and sky distributions to produce high-resolution spectra of Galactic emission. We detect the gamma-ray lines from 60Fe decay at 1173 and 1333 keV, obtaining an improvement over our earlier measurement of both lines with now 4.9 sigma significance for the combination of the two lines. The average flux per line is (4.4 \pm 0.9) \times 10^{-5} ph cm^{-2} s^{-1} rad^{-1} for the inner Galaxy region. Deriving the Galactic 26Al gamma-ray line flux with using the same set of observations and analysis method, we determine the flux ratio of 60Fe/26Al gamma-rays as 0.148 \pm 0.06. The current theoretical predictions are still consistent with our result.Comment: 10 pages, 7 figures, 2 tables, A&A in pres

A new experiment for the determination of the 18F(p,alpha) reaction rate at nova temperatures

The 18F(p,alpha) reaction was recognized as one of the most important for gamma ray astronomy in novae as it governs the early 511 keV emission. However, its rate remains largely uncertain at nova temperatures. A direct measurement of the cross section over the full range of nova energies is impossible because of its vanishing value at low energy and of the short 18F lifetime. Therefore, in order to better constrain this reaction rate, we have performed an indirect experiment taking advantage of the availability of a high purity and intense radioactive 18F beam at the Louvain La Neuve RIB facility. We present here the first results of the data analysis and discuss the consequences.Comment: Contribution to the Classical Novae Explosions conference, Sitges, Spain, 20-24 May 2002, 5 pages, 3 figure

High-performance transistors for bioelectronics through tuning of channel thickness.

UNLABELLED: Despite recent interest in organic electrochemical transistors (OECTs), sparked by their straightforward fabrication and high performance, the fundamental mechanism behind their operation remains largely unexplored. OECTs use an electrolyte in direct contact with a polymer channel as part of their device structure. Hence, they offer facile integration with biological milieux and are currently used as amplifying transducers for bioelectronics. Ion exchange between electrolyte and channel is believed to take place in OECTs, although the extent of this process and its impact on device characteristics are still unknown. We show that the uptake of ions from an electrolyte into a film of poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate ( PEDOT: PSS) leads to a purely volumetric capacitance of 39 F/cm(3). This results in a dependence of the transconductance on channel thickness, a new degree of freedom that we exploit to demonstrate high-quality recordings of human brain rhythms. Our results bring to the forefront a transistor class in which performance can be tuned independently of device footprint and provide guidelines for the design of materials that will lead to state-of-the-art transistor performance

IRISS (Increasing Resilience in Surveillance Societies) FP7 European Research Project, Deliverable 3.2: Surveillance Impact Report

External research report produced for the European Commission as part of the FP7 IRISS project: Increasing Resilience in Surveillance Socieities, containing European case studies on the varying formats of neighbourhood watch, including the cultural and historical factors which may influence the creation of neighbourhood watch groups in the first instance. Overview of neighbourhood watch in the United Kingdom and analysis of the changing role of the police in relation to community policing and the impact which this has had on the primary purpose of neighbourhood watch organisations.This deliverable was written as part of the IRISS project which received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement No. 285593. Additional co-authors: Alessia Ceresa, Chiara Fonio, Walter Peissl, Robert Rothman, Jaro Sterbik Lamina, Ivan Szekely, Beatrix Vissy, Wolfgang Bonß, Daniel Fischer, Gemma Galdon Clavell, Reinhard Kreissl, Alexander Neumann, Nils Zurawsk

The measurements of light high-energy ions in NINA-2 experiment

The flux of energetic light ions at low altitude is both an important input and output for self-consistent calculations of albedo particles resulting from the interaction of trapped and cosmic ray particles, with the upper atmosphere. In addition, data on the flux of light ions are needed to evaluate radiation damages on space-borne instruments and on space mission crews. In spite of that, sources of data on the flux of energetic ions at LEO are roughly limited to the AP-8 model, CREME/CREME96 codes and the SAMPEX, NOAA/TIROS satellites. The existing and operational European SAC-C/ICARE and PROBA-1/SREM instruments could also be potential sources for proton data at LEO. Although AP-8 and SAMPEX/PSB97 may be publicly accessed through the SPENVIS, they exhibit an order of magnitude difference in low altitude proton fluxes and they do not contain helium fluxes. Therefore, improved light ion radiation models are still needed. <br><br> In this paper we present a procedure to identify and measure the energy of ions that are not stopped in the NINA-2 instrument. Moreover, problems related to particles that cross the instrument in the opposite direction are addressed and shown to be a possible cause of particle misidentification. Measuring fluxes of low abundance elements like energetic helium ions requires a good characterisation of all possible sources of backgrounds in the detector. Hints to determine the several contributions to the background are presented herein and may be applied to extract an order of magnitude of energetic ions fluxes from existing data sets, while waiting for dedicated high performance instruments

Talking About and Preparing for Death Among Older Adults

Experts on end-of-life issues recommend that individuals make preparations – living will, health care proxy, last will and testament, and memorial service – for their eventual death (Bischoff, Sudore, Miao, Boscardin, & Smith, 2013). While these experts further encourage a broader process of advance care planning, which includes conversations with loved ones, many individuals are reticent to engage in such end-of-life conversations (Brinkman-Stoppelenburg, Rietjens, & Heide, 2014). The purpose of this study was to investigate relationships between older adults’ comfort having end-of-life discussions with family members, death preparation, and comfort with their end-of-life plans. Community-dwelling older adults (N = 354) participated in an interview survey about end-of-life issues. Comfort with having end-of-life discussions with family was associated with greater death preparation and comfort with end-of-life plans. Death preparation mediated the relationship between comfort with end-of-life discussions and comfort with end-of-life plans. Overall, the results are consistent with the notion that individuals who are more comfortable discussing their end-of-life plans with loved ones engage in greater death preparation and thereby feel a greater sense of contentment with their plans for death