How do elementary school boys characterize their reading favorites and behaviors?

The purpose of this study was to determine if there is a boy crisis in our schools. It also looked at what the boys are interested in and what are they reading. The study investigated the latest research on young boys struggling to read, and their comparison to young girls. The study provided evidence of their favorite books and authors. It furnished information on the boys\u27 computer and television time. The study showed how the boys selected books and where they located new books. Percentages were presented about their personal libraries. Overall, the study investigated how to make classrooms and libraries boy-friendly. In order to accomplish this goal educators have to re-examine, and re-shape the boys environment and the structure of the curriculum

The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats

A novel factor of interest for growth/plasticity in the brain is pregnane xenobiotic receptor (PXR). PXR is a liver factor known for its role in xenobiotic clearance and cholesterol metabolism. It is expressed in the brain, suggesting a potential role for plasticity, particularly involving cholesterol-based steroids and neurosteroids. Mating induces synthesis of neurosteroids in the midbrain Ventral Tegmental Area (VTA) of female rodents, as well as other “plastic” regions of the brain, including the hippocampus, that may be involved in the consolidation of the mating experience. Reducing PXR in the VTA attenuates mating-induced biosynthesis of the neurosteroid, 5α-pregnan-3α-ol-20-one (3α,5α-THP). The 18 kDA translocator protein (TSPO) is one rate-limiting factor for 3α,5α-THP neurosteroidogenesis. The hypothesis tested was that PXR is an upstream factor of TSPO for neurosteroidogenesis of 3α,5α-THP in the VTA for lordosis, independent of peripheral glands. First, proestrous rats were administered a TSPO blocker (PK11195) and/or 3α,5α-THP following infusions of PXR antisense oligonucleotides (AS-ODNs) or vehicle to the VTA. Inhibiting TSPO with PK11195 reduced 3α,5α-THP levels in the midbrain and lordosis, an effect that could be reversed with 3α,5α-THP administration, but not AS-ODN+3α,5α-THP. Second, proestrous, ovariectomized (OVX), or ovariectomized/adrenalectomized (OVX/ADX) rats were infused with a TSPO enhancer (FGIN 1-27) subsequent to AS-ODNs or vehicle to the VTA. PXR AS-ODNs blocked actions of FGIN 1–27 for lordosis and 3α,5α-THP levels among proestrous > OVX > OVX/ADX rats. Thus, PXR may be upstream of TSPO, involved in neurosteroidogenesis of 3α,5α-THP in the brain for plasticity. This novel finding of a liver factor involved in behavioral/neural plasticity substantiates future studies investigating factors known for their prominent actions in the peripheral organs, such as the liver, for modulating brain function and its augmentation

Fulfilling the promise of applied developmental science: Is it time to reconsider our approach?

The promise of applied developmental science is that we can use scientific methods to promote positive human development and improve the lives of children and families. However, the present political environment in the United States makes the creation of research-informed federal policy difficult, even when the evidence supporting a given policy is unequivocal. In this essay, we hope to begin a conversation about how we, as applied developmental scientists, may modify our approach in order to best fulfill the promise of applied developmental science. To begin this conversation, we discuss the potential for establishing long-term partnerships with smaller entities, including state and municipal governments and non-governmental organizations to narrow the gap between what we know about children and families and the policies and programs that impact them. This \u27bottom-up\u27 approach has a long lineage in applied developmental science, and is currently enjoying a renaissance through the burgeoning interest in researcher-practitioner partnerships. Whether implicitly or explicitly, these partnerships often incorporate a systems perspective on children\u27s development; here, we review why embracing a systems perspective may increase the likelihood of crafting policies and programs that can improve the lives of children and families

Dimensions of Maternal Parenting and Infants’ Autonomic Functioning Interactively Predict Early Internalizing Behavior Problems

Developmental pathways to childhood internalizing behavior problems are complex, with both environmental and child-level factors contributing to their emergence. The authors use data from a prospective longitudinal study (n = 206) to examine the associations between dimensions of caregiving experiences in the first year of life and anxious/depressed and withdrawn behaviors in early childhood. Additionally, the authors examine the extent to which these associations were moderated by infants’ autonomic functioning in the first year of life indexed using measures of respiratory sinus arrhythmia (RSA) and heart period (HP). Findings suggest that higher levels of maternal sensitivity in infancy are associated with fewer anxious/depressed and withdrawn behaviors at age 3 years. Negative intrusiveness was found to be positively associated with children’s anxious/depressed behaviors but not withdrawn behaviors. Further, moderation analyses suggested that the link between negative intrusive parenting during infancy and subsequent anxious/depressed behaviors is exacerbated for infants with average or low baseline HP and that positive engaging parenting during infancy was negatively related to withdrawn behaviors for infants demonstrating average to high levels baseline HP. Interestingly, RSA was not found to moderate the associations between parenting in infancy and later internalizing behavior problems suggesting that, during infancy, overall autonomic functioning may have greater implications for the development of internalizing behaviors than do parasympathetic influences alone. Implications of these findings and future directions for research are discussed

An empirical analysis of the nine Internet Gaming Disorder criteria

Internet Gaming Disorder (IGD) has received increased scientific attention since May 2013, and its assessment can be conducted using the nine criteria suggested by American Psychiatric Association (APA). This study examined the role of each IGD criterion using a conditional inference tree model. Methods: A total of 3,377 gamers (82.7% male, mean age 20 years, SD = 4.3 years) were recruited to the present study. In addition to collecting sociodemographic information, participants filled out the Internet Gaming Disorder Scale–Short-Form (IGDS9-SF) based on the DSM-5 criteria. Results: The conditional inference tree model revealed that endorsement of ‘withdrawal’ (criterion 2) and ‘loss of control’ (criterion 4) increased the likelihood of IGD by 77.77% (95%CI: 62.09–93.45) while endorsing ‘withdrawal’, ‘loss of control’ and ‘negative consequences’ (criterion 9) increased the likelihood of IGD by 26.66% (95%CI: 4.28–49.04). Finally, not endorsing ‘withdrawal’ but endorsing ‘preoccupation’ (criterion 1) increased the probability of IGD by 7.14% (95%CI: 1.63–12.65). Conclusions: Overall, these results suggest that not all IGD criteria carry the same diagnostic weight as each criterion can play a different role in the development of IGD. It is envisaged that these findings will help improve the assessment of IGD in the future

An Ecological Systems Perspective on Individual Differences in Children\u27s Performance on Measures of Executive Function

The predictive validity of performance on cognitive-behavioral measures of executive function (EF) suggests that these measures index children\u27s underlying capacity for self-regulation. In this paper, we apply ecological systems theory to critically evaluate this assertion. We argue that as typically administered, standard measures of EF do not index children\u27s underlying, trait-like capacity for EF, but rather assess their state-like EF performance at a given point in time and in a particular (and often quite peculiar) context. This underscores the importance of disentangling intra-individual (i.e., state-like) and inter-individual (trait-like) differences in performance on these measures and understanding how factors at various levels of organization may contribute to both. To this end, we offer an approach that combines the collection of repeated measures of EF with a multilevel modeling framework, and conclude by discussing the application of this approach to the study of educational interventions designed to foster children\u27s EF

Dynein structure and power stroke

Dynein ATPases are microtubule motors that are critical to diverse processes such as vesicle transport and the beating of sperm tails; however, their mechanism of force generation is unknown. Each dynein comprises a head, from which a stalk and a stem emerge. Here we use electron microscopy and image processing to reveal new structural details of dynein c, an isoform from Chlamydomonas reinhardtii flagella, at the start and end of its power stroke. Both stem and stalk are flexible, and the stem connects to the head by means of a linker approximately 10 nm long that we propose lies across the head. With both ADP and vanadate bound, the stem and stalk emerge from the head 10 nm apart. However, without nucleotide they emerge much closer together owing to a change in linker orientation, and the coiled-coil stalk becomes stiffer. The net result is a shortening of the molecule coupled to an approximately 15-nm displacement of the tip of the stalk. These changes indicate a mechanism for the dynein power stroke

Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors

Our previous studies demonstrated arsenic trioxide- (ATO-) induced selective tumor vascular disruption and augmentation of thermal or radiotherapy effect against solid tumors. These results suggested that a trimodality approach of radiation, ATO, and local hyperthermia may have potent therapeutic efficacy against solid tumors. Here, we report the antitumor effect of hypofractionated radiation followed by ATO administration and local 42.5 °C hyperthermia and the effects of cisplatin and thermoradiotherapy. We found that the therapeutic efficacy of ATO-based thermoradiotherapy was equal or greater than that of cisplatin-based thermoradiotherapy, and marked evidence of in vivo apoptosis and tumor necrosis were observed in ATO-treated tumors. We conclude that ATO-based thermoradiotherapy is a powerful means to control tumor growth by using vascular disruption to augment the effects of thermal and radiation therapy

Fathers’ sensitive parenting and the development of early executive functioning.

Using data from a diverse sample of 620 families residing in rural, predominately low-income communities, this study examined longitudinal links between fathers’ sensitive parenting in infancy and toddlerhood and children’s early executive functioning, as well as the contribution of maternal sensitive parenting. After accounting for the quality of concurrent and prior parental care, children’s early cognitive ability, and other child and family factors, fathers’ and mothers’ sensitive and supportive parenting during play at 24-months predicted children’s executive functioning at 3-years of age. In contrast, paternal parenting quality during play at 7-months did not make an independent contribution above that of maternal care, but the links between maternal sensitive and supportive parenting and executive functioning seemed to operate in similar ways during infancy and toddlerhood. These findings add to prior work on early experience and children’s executive functioning, suggesting that both fathers and mothers play a distinct and complementary role in the development of these self-regulatory skills