2,846 research outputs found
Field-induced magnetic ordering in the Haldane system PbNi2V2O8
The Haldane system PbNi2V2O8 was investigated by the temperature dependent
magnetization M(T) measurements at fields higher than H_c, with H_c the
critical fields necessary to close the Haldane gap. It is revealed that M(T)
for H > H_c exhibits a cusp-like minimum at T_{min}, below which M(T) increases
with decreasing T having a convex curve. These features have been observed for
both and , with c-axis being parallel to the chain.
These data indicate the occurrence of field-induced magnetic ordering around
T_{min}. Phase boundaries for and do not cross each
other, consistent with the theoretical calculation for negative single-ion
anisotropy D.Comment: 3 figures, submitted to Phys. Rev.
Designing molecules to bypass the singlet-triplet bottleneck in the electroluminescence of organic light-emitting-diode materials
Electroluminescence in organic light emitting diode (OLED) materials occurs
via the recombination of excitonic electrons-hole pairs Only the singlet
excitons of commonly used OLED materials, e.g., Aluminum trihydroxyquinoline
(AlQ), decay radiatively, limiting the external quantum efficiency to a
maximum 25%. Thus 75% of the energy is lost due to the triplet bottleneck for
radiative recombination. We consider molecules derived from AlQ which
bypass the triplet bottleneck by designing structures which contain strong
spin-orbit coupling. As a first stage of this work, groundstate energies and
vertical excitation energies of Al-arsenoquinolines and Al-boroarsenoquinolines
are calculated. It is found that the substitution of N by As leads to very
favourable results, while the boron substitution leads to no advantage.Comment: 4 pages, 4 figue
Magnetic phase diagram of antiferroquadrupole ordering in HoB2C2
The magnetic phase diagram for antiferro-quadrupole (AFQ) ordering in
tetragonal HoBC has been investigated by measurements of elastic
constants , and in fields along the basal -
plane as well as the principal [001]-axis. The hybrid magnet (GAMA) in Tsukuba
Magnetic Laboratory was employed for high field measurements up to 30 T. The
AFQ phase is no longer observed above 26.3 T along the principal [001] axis in
contrast to the relatively small critical field of 3.9 T in fields applied
along the basal [110] axis. The quadrupolar intersite interaction of
and/or is consistent with the anisotropy in the magnetic phase diagram
of the AFQ phase in HoBC.Comment: Phys. Rev. B. (2005) in press. approx 8 pages, 10 figure
A non-perturbative approach to halo breakup
The theory of weakly bound cluster breakup, like halo nucleus breakup, needs
an accurate treatment of the transitions from bound to continuum states induced
by the nuclear and Coulomb potentials. When the transition probability is not
very small, a non-perturbative framework might be necessary. Nuclear excitation
dominates at small impact parameters whereas the Coulomb potential being long
range acts over a larger impact parameter interval. In this article, we propose
an effective breakup amplitude which meets a number of requirements necessary
for an accurate quantitative description of the breakup reaction mechanism.
Furthermore our treatment gives some insight on the interplay between time
dependent perturbation theory and sudden approximation and it allows to include
the nuclear and Coulomb potentials to all orders within an eikonal-like
framework.Comment: 22 Latex pages, 1 table, 8 eps figures. Accepted for publication on
Nucl. Phys.
11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity. \ud
RESEARCH DESIGN AND METHODS: Rodent and human cell cultures, whole-tissue explants, and animal models were used to determine the impact of glucocorticoids and selective 11beta-HSD1 inhibition upon insulin signaling and action. \ud
RESULTS: Dexamethasone decreased insulin-stimulated glucose uptake, decreased IRS1 mRNA and protein expression, and increased inactivating pSer insulin receptor substrate (IRS)-1. 11beta-HSD1 activity and expression were observed in human and rodent myotubes and muscle explants. Activity was predominantly oxo-reductase, generating active glucocorticoid. A1 (selective 11beta-HSD1 inhibitor) abolished enzyme activity and blocked the increase in pSer IRS1 and reduction in total IRS1 protein after treatment with 11DHC but not corticosterone. In C57Bl6/J mice, the selective 11beta-HSD1 inhibitor, A2, decreased fasting blood glucose levels and improved insulin sensitivity. In KK mice treated with A2, skeletal muscle pSer IRS1 decreased and pThr Akt/PKB increased. In addition, A2 decreased both lipogenic and lipolytic gene expression.\ud
CONCLUSIONS: Prereceptor facilitation of glucocorticoid action via 11beta-HSD1 increases pSer IRS1 and may be crucial in mediating insulin resistance in skeletal muscle. Selective 11beta-HSD1 inhibition decreases pSer IRS1, increases pThr Akt/PKB, and decreases lipogenic and lipolytic gene expression that may represent an important mechanism underpinning their insulin-sensitizing action
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