190 research outputs found

    Biola Hour Highlights, 1975 - 11

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    Free for the Taking by Joseph R. Cooke What is Demon Possession? by Henry W. Holloman Psalm 139 by Al Sanders II Corinthians by Richard Chase Revelation No.151 by Lloyd Anderson October Panel by Richard Chase, Charles Feinberg, and Samuel Sutherlandhttps://digitalcommons.biola.edu/bhhs/1021/thumbnail.jp

    Failure in Internally Pressurized Bent Tubes

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    The analysis and modeling of tube-hydroformed components is more complicated than that employed for sheet-metal panels, due to the lengthier process sequence and variable strain path - from flat-rolled sheet to tube; from straight tube to bent tube; and from bent tube to hydroformed component. These additional process steps make it difficult to determine whether post mortem analyses of tube failure during hydroforming can, and should, be conducted with the same tools and databases as used for simple stampings. To provide a partial answer, the properties of commercially fabricated welded straight tubes were evaluated using a free-expansion internal pressure test and compared with those of free-expansion internal pressure tests on bent tubes. The results demonstrated that the behavior of the bent tube was consistent with the mechanical properties of the as-received tube, provided due notice was accorded to the complex strain history of the bent tube. However, due to the strain-path changes occurring at the failure location, conventional approaches for monitoring strain history would yield (apparently) anomalous results

    Rescue of replication failure by Fanconi anaemia proteins

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    Chromosomal aberrations are often associated with incomplete genome duplication, for instance at common fragile sites, or as a consequence of chemical alterations in the DNA template that block replication forks. Studies of the cancer-prone disease Fanconi anaemia (FA) have provided important insights into the resolution of replication problems. The repair of interstrand DNA crosslinks induced by chemotherapy drugs is coupled with DNA replication and controlled by FA proteins. We discuss here the recent discovery of new FA-associated proteins and the development of new tractable repair systems that have dramatically improved our understanding of crosslink repair. We focus also on how FA proteins protect against replication failure in the context of fragile sites and on the identification of reactive metabolites that account for the development of Fanconi anaemia symptoms

    History of narcolepsy at Stanford University

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