Examination of the material removal mechanisms during the lapping process of advanced ceramic rolling elements

Two types of HIPed Si3N4 bearing ball blanks with different surface hardness and fracture toughness were lapped under various loads, speeds, and lubricants using a novel eccentric lapping machine. The lapped surfaces were examined by optical microscope and SEM. The experimental results show that the material removal rate for type I ball blanks were 3-4-fold of type 2 in most cases. Different lapping fluids affected the material removal rate at lower lapping loads, but they had much less influence on the material removal rate at higher lapping loads. The SEM micrographs reveal that the grain pullout prevailed on the lapped surface of type I ball blanks, and the surface of type 2 featured bulk material removal by microcracking. Under extreme high lapping load, surface cracks and damages were found, and SEM with EDX disclosed steel from the lapping plate had transferred to the ceramic ball surface. The preliminary conclusion is that the material removal mechanism during the lapping process of silicon nitride balls using this eccentric lapping machine is mainly mechanical abrasive wear. Lawn and Wilshaw's indentation model on brittle materials is used to explain the difference in material removal rate for the two types of ball blanks

Concomitant occurrence of FXTAS and clinically defined sporadic inclusion body myositis: report of two cases.

This report describes unique presentations of inclusion body myositis (IBM) in two unrelated patients, one male and one female, with genetically and histologically confirmed fragile X-associated tremor/ataxia syndrome (FXTAS). We summarize overlapping symptoms between two disorders, clinical course, and histopathological analyses of the two patients with FXTAS and sporadic IBM, clinically defined per diagnostic criteria of the European Neuromuscular Centre. In case 1, a post-mortem analysis of available brain and muscle tissues is also described. Histopathological features (rimmed vacuoles) consistent with clinically defined IBM were detected in both presented cases. Postmortem testing in case 1 revealed the presence of an FMR1 premutation allele of 60 CGG repeats in both brain and skeletal muscle samples. Case 2 was a premutation carrier with 71 CGG repeats who had a son with FXS. Given that FXTAS is associated with immune-mediated disorders among premutation carriers, it is likely that the pathogeneses of IBM and FXTAS are linked. This is, to our knowledge, the first report of these two conditions presenting together, which expands our understanding of clinical symptoms and unusual presentations in patients with FXTAS. Following detection of a premutation allele of the FMR1 gene, FXTAS patients with severe muscle pain should be assessed for IBM

A three-dimensional structured/unstructured hybrid Navier-Stokes method for turbine blade rows

A three-dimensional viscous structured/unstructured hybrid scheme has been developed for numerical computation of high Reynolds number turbomachinery flows. The procedure allows an efficient structured solver to be employed in the densely clustered, high aspect-ratio grid around the viscous regions near solid surfaces, while employing an unstructured solver elsewhere in the flow domain to add flexibility in mesh generation. Test results for an inviscid flow over an external transonic wing and a Navier-Stokes flow for an internal annular cascade are presented

Three-dimensional viscous flow analysis inside a turbine volute

A three-dimensional numerical method has been developed to analyze the complex flow field inside a turbine volute. Comparisons are made between solutions with different boundary conditions

Large Eddy Simulation of Transonic Flow Field in NASA Rotor 37

The current paper reports on numerical investigations on the flow characteristics in a transonic axial compressor, NASA Rotor 37. The flow field was used previously as a CFD blind test case conducted by American Society of Mechanical Engineers in 1994. Since the CFD blind-test exercise, many numerical studies on the flow field in the NASA Rotor 37 have been reported. Although steady improvements have been reported in both numerical procedure and turbulence closure, it is believed that all the important aspects of the flow field have not been fully explained with numerical studies based on the Reynolds Averaged Navier-Stokes (RANS) solution. Experimental data show large dip in total pressure distribution near the hub at downstream of the rotor at 100% rotor speed. Most original numerical solutions from the blind test exercise did not predict this total pressure deficit correctly. This total pressure deficit at the rotor exit was attributed to a hub corner flow separation by the author. Several subsequent numerical studies with different turbulence closure model also calculated this dip in total pressure rise. Also, several studies attributed this total pressure deficit to a small leakage flow coming from the hub in the test article. As the experimental study cannot be repeated, either explanation cannot be validated. The primary purpose of the current investigation is to investigate the transonic flow field with both RANS and a Large Eddy Simulation (LES). The RANS approach gives similar results presented at the original blind test exercise. Although the RANS calculates higher overall total pressure rise, the total pressure deficit near the hub is calculated correctly. The numerical solution shows that the total pressure deficit is due to a hub corner flow separation. The calculated pressure rise from the LES agrees better with the measured total pressure rise especially near the casing area where the passage shock interacts with the tip clearance vortex and flow becomes unsteady due to this interaction. The LES simulation also calculates the total pressure rise deficit near the hub and it agrees well with the measured data

Reliable microsatellite genotyping of the Eurasian badger (Meles meles) using faecal DNA

The potential link between badgers and bovine tuberculosis has made it vital to develop accurate techniques to census badgers. Here we investigate the potential of using genetic profiles obtained from faecal DNA as a basis for population size estimation. After trialling several methods we obtained a high amplification success rate (89%) by storing faeces in 70% ethanol and using the guanidine thiocyanate/silica method for extraction. Using 70% ethanol as a storage agent had the advantage of it being an antiseptic. In order to obtain reliable genotypes with fewer amplification reactions than the standard multiple-tubes approach, we devised a comparative approach in which genetic profiles were compared and replication directed at similar, but not identical, genotypes. This modified method achieved a reduction in polymerase chain reactions comparable with the maximumlikelihood model when just using reliability criteria, and was slightly better when using reliability criteria with the additional proviso that alleles must be observed twice to be considered reliable. Our comparative approach would be best suited for studies that include multiple faeces from each individual. We utilized our approach in a well-studied population of badgers from which individuals had been sampled and reliable genotypes obtained. In a study of 53 faeces sampled from three social groups over 10 days, we found that direct enumeration could not be used to estimate population size, but that the application of mark–recapture models has the potential to provide more accurate results

Three-Dimensional Flow Analysis Inside Consortium Impeller at Design and Off-Design Conditions

Three-dimensional flow fields inside the Consortium impeller were analyzed with a Navier-Stokes code. The numerical results at the design and off-design conditions are compared with the experimental data

Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review

Inhibition of DNA methyltransferases (DNMTs) has emerged as a novel treatment strategy in solid tumors. Aberrant hypermethylation in promoters of critical tumor suppressor genes is the basis for the idea that treatment with hypomethylating agents may lead to the restoration of a “normal” epigenome and produce clinically meaningful therapeutic outcomes. The aim of this review article is to summarize the current state of knowledge of DNMT inhibitors in the treatment of genitourinary malignancies. The efficacy of these agents in genitourinary malignancies was reported in a number of studies and suggests a role of induced DNA hypomethylation in overcoming resistance to conventional cytotoxic treatments. The clinical significance of these findings should be further investigated

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice.

The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of obesity. Therefore, we assessed whether KCs and RHMs, or both, represent the major liver inflammatory cell type in obesity. We used a combination of in vivo macrophage tracking methodologies and adoptive transfer techniques in which KCs and RHMs are differentially labeled with fluorescent markers. With these approaches, the inflammatory phenotype of these distinct macrophage populations was determined under lean and obese conditions. In vivo macrophage tracking revealed an approximately sixfold higher number of RHMs in obese mice than in lean mice, whereas the number of KCs was comparable. In addition, RHMs comprised smaller size and immature, monocyte-derived cells compared with KCs. Furthermore, RHMs from obese mice were more inflamed and expressed higher levels of tumor necrosis factor-α and interleukin-6 than RHMs from lean mice. A comparison of the MCP-1/C-C chemokine receptor type 2 (CCR2) chemokine system between the two cell types showed that the ligand (MCP-1) is more highly expressed in KCs than in RHMs, whereas CCR2 expression is approximately fivefold greater in RHMs. We conclude that KCs can participate in obesity-induced inflammation by causing the recruitment of RHMs, which are distinct from KCs and are not precursors to KCs. These RHMs then enhance the severity of obesity-induced inflammation and hepatic insulin resistance