5,146 research outputs found

    BIRDS AT AIRPORTS

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    Birds are a serious hazard to aviation. A bird or a flock of birds that suddenly rises from a runway or surrounding area may collide with incoming or departing aircraft and cause the aircraft to crash, possibly resulting in the loss of human life. Bird collision with aircraft is commonly known as “bird strike.” Damage caused to aircraft usually results from collision of one or more birds with the engines and/or fuselage. Although most bird strikes do not result in crashes, they do involve expensive structural and mechanical damage to aircraft. The incidence of this problem worldwide makes bird strike a serious economic problem

    Alien Registration- Godin, Leo C J. (Westbrook, Cumberland County)

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    https://digitalmaine.com/alien_docs/20051/thumbnail.jp

    Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs

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    Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown. Herein we address these topics for the M1 muscarinic acetylcholine receptor, a key molecular target for novel cognition enhancers, by employing Spatial Intensity Distribution Analysis. This method can measure fluorescent particle concentration and assess oligomerization states of proteins within defined regions of living cells. Imaging and analysis of the basolateral surface of cells expressing some 50 molecules.microm-2 of the human muscarinic M1 receptor identified an ~75/25 mixture of receptor monomers and dimers/oligomers. Both sustained and shorter-term treatment with the selective M1 antagonist pirenzepine resulted in a large shift in the distribution of receptor species to favor the dimeric/oligomeric state. Although sustained treatment with pirenzepine also resulted in marked upregulation of the receptor, simple mass-action effects were not the basis for ligand-induced stabilization of receptor dimers/oligomers. The related antagonist telenzepine also produced stabilization and enrichment of the M1 receptor dimer population but the receptor subtype non-selective antagonists atropine and N-methylscopolamine did not. In contrast, neither pirenzepine nor telenzepine altered the quaternary organization of the related M3 muscarinic receptor. These data provide unique insights into the selective capacity of receptor ligands to promote and/or stabilize receptor dimers/oligomers and demonstrate that the dynamics of ligand regulation of the quaternary organization of G protein-coupled receptors is markedly more complex than previously appreciated. This may have major implications for receptor function and behavior

    Efficient Hole Trapping in Carbon Dot/Oxygen-Modified Carbon Nitride Heterojunction Photocatalysts for Enhanced Methanol Production from CO₂ under Neutral Conditions

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    Artificial photosynthesis of alcohols from CO 2 is a promising route to provide sustainable fuels. The performance is still unsatisfactory mainly due to the rapid charge relaxation compared to the sluggish photoreactions and the oxidation of alcohol products. Here, we demonstrate that CO 2 is reduced to methanol with 100% selectivity using water as the only electron donor on a carbon nitride-like polymer (FAT) decorated with carbon dots. The quantum efficiency of 5.9% (λ = 420 nm) is 300% higher than the previously reported carbon nitride junction. Using transient absorption spectroscopy, we observed that holes in FAT can be extracted by the carbon dots with nearly 75% efficiency before they become unreactive by trapping. Extraction of holes resulted in a greater density of photoelectrons, indicative of reduced recombination of shorter-lived reactive electrons. This work offers a unique strategy to promote photocatalysis by increasing the amount of reactive photogenerated charges via structure engineering and extraction before energy losses by deep trapping

    An Incremental Learning Method to Support the Annotation of Workflows with Data-to-Data Relations

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    Workflow formalisations are often focused on the representation of a process with the primary objective to support execution. However, there are scenarios where what needs to be represented is the effect of the process on the data artefacts involved, for example when reasoning over the corresponding data policies. This can be achieved by annotating the workflow with the semantic relations that occur between these data artefacts. However, manually producing such annotations is difficult and time consuming. In this paper we introduce a method based on recommendations to support users in this task. Our approach is centred on an incremental rule association mining technique that allows to compensate the cold start problem due to the lack of a training set of annotated workflows. We discuss the implementation of a tool relying on this approach and how its application on an existing repository of workflows effectively enable the generation of such annotations

    Electrostatic Patch Effect in Cylindrical Geometry. I. Potential and Energy between Slightly Non-Coaxial Cylinders

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    We study the effect of any uneven voltage distribution on two close cylindrical conductors with parallel axes that are slightly shifted in the radial and by any length in the axial direction. The investigation is especially motivated by certain precision measurements, such as the Satellite Test of the Equivalence Principle (STEP). By energy conservation, the force can be found as the energy gradient in the vector of the shift, which requires determining potential distribution and energy in the gap. The boundary value problem for the potential is solved, and energy is thus found to the second order in the small transverse shift, and to lowest order in the gap to cylinder radius ratio. The energy consists of three parts: the usual capacitor part due to the uniform potential difference, the one coming from the interaction between the voltage patches and the uniform voltage difference, and the energy of patch interaction, entirely independent of the uniform voltage. Patch effect forces and torques in the cylindrical configuration are derived and analyzed in the next two parts of this work.Comment: 26 pages, 1 Figure. Submitted to Classical and Quantum Gravit

    Physics-based characterization of soft marine sediments using vector sensors

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    In a 2007 experiment conducted in the northern North Sea, observations of a low-frequency seismo-acoustic wave field with a linear horizontal array of vector sensors located on the seafloor revealed a strong, narrow peak around 38 Hz in the power spectra and a presence of multi-mode horizontally and vertically polarized interface waves with phase speeds between 45 and 350 m/s. Dispersion curves of the interface waves exhibit piece-wise linear dependences between the logarithm of phase speed and logarithm of frequency with distinct slopes at large and small phase speeds, which suggests a seabed with a power-law shear speed dependence in two distinct sediment layers. The power spectrum peak is interpreted as a manifestation of a seismo-acoustic resonance. A simple geoacoustic model with a few free parameters is derived that quantitatively reproduces the key features of the observations. This article's approach to the inverse problem is guided by a theoretical analysis of interface wave dispersion and resonance reflection of compressional waves in soft marine sediments containing two or more layers of different composition. Combining data from various channels of the vector sensors is critical for separating waves of different polarizations and helps to identify various arrivals, check consistency of inversions, and evaluate sediment density
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