Tuberculosis de la sínfisis del pubis : a propósito de un caso clínico.

Se presenta un caso muy infrecuente de tuberculosis osteoarticular de localización en la sínfisis del pubis. Destaca la dificultad de su diagnóstico por lo inespecífico de su clínica, por el desconocimiento de enfermedad pulmonar o lesión primaria tuberculosa, y la dificultad para aislar al propio bacilo tuberculoso. Establecemos los diagnósticos diferenciales más importantes con los que se puede confundir esta patología antes de llegar a un diagnóstico certero y se valoran los síntomas, signos y hallazgos radiológicos más frecuentes que contribuyen al diagnóstico, así como el tratamiento específico empleado.We presen t a cas e o f an infrecuen t locatio n o f osteoarticula r tuber - culosis a t th e pubi x xymphisis. This patolog y is difficult t o determine , specil y if ther e doe s no t exit a pulmonar y o r primar y TBC lesion . Also , th e difficult t o obtai n a positiv e microbiolog y cultur e increase s th e dela y i n diagnosis. We establis h all posibl e differencia l diagnoses. Whic h ca n lea d t o confusio n i n this typ e o f pathology . A carefu l evaluatio n o f most commo n simptoms, sign s an d radiologien e fínding s ar e described , a s wel l as, th e specifi c treatmen t employe d i n this particuler e case

Non-relativistic leptogenesis

Bödeker D, Wörmann M. Non-relativistic leptogenesis. Journal of Cosmology and Astroparticle Physics. 2014;2014(02):016.In many phenomenologically interesting models of thermal leptogenesis the heavy neutrinos are non-relativistic when they decay and produce the baryon asymmetry of the Universe. We propose a non-relativistic approximation for the corresponding rate equations in the non-resonant case, and a systematic way for computing relativistic corrections. We determine the leading order coefficients in these equations, and the first relativistic corrections. The non-relativistic approximation works remarkably well. It appears to be consistent with results obtained using a Boltzmann equation taking into account the momentum distribution of the heavy neutrinos, while being much simpler. We also compute radiative corrections to some of the coefficients in the rate equations. Their effect is of order 1% in the regime favored by neutrino oscillation data. We obtain the correct leading order lepton number washout rate in this regime, which leads to large (~ 20%) effects compared to previous computations

Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS

Adrenomedullin (ADM) is upregulated independently by hypoxia and LPS, two key factors in the pathogenesis of acute lung injury (ALI). This study evaluates the expression of ADM in ALI using experimental models combining both stimuli: an in vivo model of rats treated with LPS and acute normobaric hypoxia (9% O2) and an in vitro model of rat lung cell lines cultured with LPS and exposed to hypoxia (1% O2). ADM expression was analyzed by in situ hybridization, Northern blot, Western blot, and RIA analyses. In the rat lung, combination of hypoxia and LPS treatments overcomes ADM induction occurring after each treatment alone. With in situ techniques, the synergistic effect of both stimuli mainly correlates with ADM expression in inflammatory cells within blood vessels and, to a lesser extent, to cells in the lung parenchyma and bronchiolar epithelial cells. In the in vitro model, hypoxia and hypoxia LPS treatments caused a similar strong induction of ADM expression and secretion in epithelial and endothelial cell lines. In alveolar macrophages, however, LPS-induced ADM expression and secretion were further increased by the concomitant exposure to hypoxia, thus paralleling the in vivo response. In conclusion, ADM expression is highly induced in a variety of key lung cell types in this rat model of ALI by combination of hypoxia and LPS, suggesting an essential role for this mediator in this syndrom

Effects of acute hypoxia and lipopolysaccharide on nitric oxide synthase-2 expression in acute lung injury

The potential role of nitric oxide synthase-2 (NOS2) in acute lung injury (ALI) has gained increasing attention. This study evaluates the effects of hypoxia, an important feature of ALI, on NOS2 expression in a rat model of ALI caused by exposure to hypoxia and LPS. Exposure to hypoxia alone had no effect on the expression of NOS2 in rat lungs. LPS treatment resulted in a significant increase in NOS2 in the lungs, which was further enhanced by concomitant exposure to hypoxia. Immunohistochemical analysis and in situ hybridization showed no changes in the expression of NOS2 in lung resident cells under any conditions. The increase in NOS2 levels is mainly due to the influx of NOS2-expressing inflammatory cells. By morphologic analysis, these inflammatory cells were identified as neutrophils, lymphocytes, and monocytes. In vitro experiments of lung epithelial and endothelial cell lines showed no detectable expression of NOS2 with any of the treatments. In a macrophage cell line, LPS-induced NOS2 expression was not affected by the concomitant exposure to hypoxia. In conclusion, LPS increases NOS2 expression in rat lungs through the recruitment of NOS2-producing leukocytes. Simultaneous exposure to LPS and hypoxia results in a greater influx of inflammatory cells that further enhances NOS2 expression

On the full Boltzmann equations for Leptogenesis

We consider the full Boltzmann equations for standard and soft leptogenesis, instead of the usual integrated Boltzmann equations which assume kinetic equilibrium for all species. Decays and inverse decays may be inefficient for thermalising the heavy-(s)neutrino distribution function, leading to significant deviations from kinetic equilibrium. We analyse the impact of using the full kinetic equations in the case of a previously generated lepton asymmetry, and find that the washout of this initial asymmetry due to the interactions of the right-handed neutrino is larger than when calculated via the integrated equations. We also solve the full Boltzmann equations for soft leptogenesis, where the lepton asymmetry induced by the soft SUSY-breaking terms in sneutrino decays is a purely thermal effect, since at T=0 the asymmetry in leptons cancels the one in sleptons. In this case, we obtain that in the weak washout regime (K ~< 1) the final lepton asymmetry can change up to a factor four with respect to previous estimates.Comment: 34 pages, 6 figures, to be published in JCA

Full Boltzmann equations for leptogenesis including scattering

We study the evolution of a cosmological baryon asymmetry produced via leptogenesis by means of the full classical Boltzmann equations, without the assumption of kinetic equilibrium and including all quantum statistical factors. Beginning with the full mode equations we derive the usual equations of motion for the right-handed neutrino number density and integrated lepton asymmetry, and show explicitly the impact of each assumption on these quantities. For the first time, we investigate also the effects of scattering of the right-handed neutrino with the top quark to leading order in the Yukawa couplings by means of the full Boltzmann equations. We find that in our full Boltzmann treatment the final lepton asymmetry can be suppressed by as much as a factor of 1.5 in the weak wash-out regime (K<1), compared to the usual integrated approach which assumes kinetic equilibrium and neglects quantum statistics. This suppression is in contrast with the enhancement seen in some previous studies that considered only decay and inverse decay of the right-handed neutrino. However, this suppression quickly decreases as we increase K. In the strong wash-out regime (K>1), the full Boltzmann treatment and the integrated approach give nearly identical final lepton asymmetries (within 10 % of each other at K>3). Finally, we show that the opposing effects of quantum statistics on decays/inverse decays and the scattering processes tend to reduce the net importance of scattering on leptogenesis in the full treatment compared to the integrated approach.Comment: 39 pages, 8 figures, typos corrected, replaced to match published versio

Neutrino masses from higher than d=5 effective operators

We discuss the generation of small neutrino masses from effective operators higher than dimension five, which open new possibilities for low scale see-saw mechanisms. In order to forbid the radiative generation of neutrino mass by lower dimensional operators, extra fields are required, which are charged under a new symmetry. We discuss this mechanism in the framework of a two Higgs doublet model. We demonstrate that the tree level generation of neutrino mass from higher dimensional operators often leads to inverse see-saw scenarios in which small lepton number violating terms are naturally suppressed by the new physics scale. Furthermore, we systematically discuss tree level generalizations of the standard see-saw scenarios from higher dimensional operators. Finally, we point out that higher dimensional operators can also be generated at the loop level. In this case, we obtain the TeV scale as new physics scale even with order one couplings.Comment: 22 pages, 3 figures, 2 tables. Some references adde

Leptogenesis from Soft Supersymmetry Breaking (Soft Leptogenesis)

Soft leptogenesis is a scenario in which the cosmic baryon asymmetry is produced from a lepton asymmetry generated in the decays of heavy sneutrinos (the partners of the singlet neutrinos of the seesaw) and where the relevant sources of CP violation are the complex phases of soft supersymmetry-breaking terms. We explain the motivations for soft leptogenesis, and review its basic ingredients: the different CP-violating contributions, the crucial role played by thermal corrections, and the enhancement of the efficiency from lepton flavour effects. We also discuss the high temperature regime $T > 10^7$ GeV in which the cosmic baryon asymmetry originates from an initial asymmetry of an anomalous $R$-charge, and soft leptogenesis reembodies in $R$-genesis.Comment: References updated. Some minor corrections to match the published versio

In vitro mutagenicity assessment of fried meat-based food from mass catering companies

The current article aimed to evaluate the in vitro mutagenicity of ten fried meat-based food extracts obtained from different catering companies from Navarra (Spain). A miniaturized 6-well version of the Ames test in Salmonella typhimurium TA98, and the in vitro micronucleus test (OECD TG 487) in TK6 cells were performed. None of the ten extracts of fried meat-based food induced gene mutations in S. typhimurium TA98 with or without metabolic activation, but five induced chromosomal aberrations after 24 h treatment of TK6 without metabolic activation. More studies are needed to check the biological relevance of these in vitro studies