Forecasting inflation using dynamic model averaging

We forecast quarterly US inflation based on the generalized Phillips curve using econometric methods which incorporate dynamic model averaging. These methods not only allow for coefficients to change over time, but also allow for the entire forecasting model to change over time. We find that dynamic model averaging leads to substantial forecasting improvements over simple benchmark regressions and more sophisticated approaches such as those using time varying coefficient models. We also provide evidence on which sets of predictors are relevant for forecasting in each period

Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with ⁸⁹Zr-oxine for Medium-Term In Vivo Cell Tracking

Regulatory T cells (Tregs) are a promising candidate cell therapy to treat autoimmune diseases and aid the longevity of transplanted solid organs. Despite increasing numbers of clinical trials using human Treg therapy, important questions pertaining to their in vivo fate, distribution, and function remain unanswered. Treg accumulation in relevant tissues was found to be crucial for Treg therapy efficacy, but existing blood-borne biomarkers are unlikely to accurately reflect the tissue state. Non-invasive Treg tracking by whole-body imaging is a promising alternative and can be achieved by direct radiolabelling of Tregs and following the radiolabelled cells with positron emission tomography (PET). Our goal was to evaluate the radiolabelling of polyclonal Tregs with ⁸⁹Zr to permit their in vivo tracking by PET/CT for longer than one week with current preclinical PET instrumentation. We used [⁸⁹Zr]Zr(oxinate)₄ as the cell-labelling agent and achieved successful radiolabelling efficiency of human Tregs spanning 0.1–11.1 Bq ⁸⁹Zr/Treg cell, which would be compatible with PET tracking beyond one week. We characterized the ⁸⁹Zr-Tregs, assessing their phenotypes, and found that they were not tolerating these intracellular ⁸⁹Zr amounts, as they failed to survive or expand in a ⁸⁹Zr-dose-dependent manner. Even at 0.1 Bq ⁸⁹Zr per Treg cell, while ⁸⁹Zr-Tregs remained functional as determined by a five-day-long effector T cell suppression assay, they failed to expand beyond day 3 in vitro. Moreover, PET imaging revealed signs of ⁸⁹Zr-Treg death after adoptive transfer in vivo. In summary, ⁸⁹Zr labelling of Tregs at intracellular radioisotope amounts compatible with cell tracking over several weeks did not achieve the desired outcomes, as ⁸⁹Zr-Tregs failed to expand and survive. Consequently, we conclude that indirect Treg labelling is likely to be the most effective alternative method to satisfy the requirements of this cell tracking scenario

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment

Supplemental information is available online at: https://www.sciencedirect.com/science/article/pii/S2329050120302515#appsec2 .Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs has been shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical trials. Despite these successes, the in vivo distribution and persistence of adoptively transferred Tregs remained elusive, which hampers clinical translation. Here we isolated human Tregs using a GMP-compatible protocol and lentivirally transduced them with the human sodium iodide symporter to render them traceable in vivo by radionuclide imaging. Engineered human Tregs were characterized for phenotype, survival, suppressive capacity, and reporter function. To study their trafficking behavior, they were subsequently administered to humanized mice with human skin transplants. Traceable Tregs were quantified in skin grafts by non-invasive nano-single-photon emission computed tomography (nanoSPECT)/computed tomography (CT) for up to 40 days, and the results were validated ex vivo. Using this approach, we demonstrated that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1+ innate immune cells. We demonstrated the utility of radionuclide reporter gene-afforded quantitative Treg in vivo tracking, addressing a fundamental need in Treg therapy development and offering a clinically compatible methodology for future Treg therapy imaging in humans.This work was supported by the British Heart Foundation (RG/13/12/30395), the MRC Centre for Transplantation at King's College London (MR/J006742/1), Cancer Research UK (C48390/A21153), and the Wellcome/EPSRC Centre for Medical Engineering (WT203148/Z/16/Z). This research was funded/supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London and/or the NIHR Clinical Research Facility

The T2K Side Muon Range Detector

The T2K experiment is a long baseline neutrino oscillation experiment aiming to observe the appearance of {\nu} e in a {\nu}{\mu} beam. The {\nu}{\mu} beam is produced at the Japan Proton Accelerator Research Complex (J-PARC), observed with the 295 km distant Super- Kamiokande Detector and monitored by a suite of near detectors at 280m from the proton target. The near detectors include a magnetized off-axis detector (ND280) which measures the un-oscillated neutrino flux and neutrino cross sections. The present paper describes the outermost component of ND280 which is a side muon range detector (SMRD) composed of scintillation counters with embedded wavelength shifting fibers and Multi-Pixel Photon Counter read-out. The components, performance and response of the SMRD are presented.Comment: 13 pages, 19 figures v2: fixed several typos; fixed reference

Occlusion of the common femoral artery by cement after total hip arthroplasty: a case report

The incidence of vascular injuries after total hip arthroplasty is extremely low. In this report we describe an unusual injury to the common femoral artery. A 59-year-old Caucasian woman presented with rest pain, numbness and cramps in the operated limb after hip replacement. Cement leakage under the transverse ligament had caused occlusion of the common femoral artery necessitating vascular reconstruction. She had a good functional recovery at follow-up. To the best of our knowledge, this is the first well-documented case reporting this pathomechanism of vascular lesion to the femoral artery. This case report highlights the potential risk of such a limb-threatening complication, and awareness should lead to prevention by meticulous surgical technique (correct technique of pressurization) or to early detection of the lesio

Tracking Performance of the Scintillating Fiber Detector in the K2K Experiment

The K2K long-baseline neutrino oscillation experiment uses a Scintillating Fiber Detector (SciFi) to reconstruct charged particles produced in neutrino interactions in the near detector. We describe the track reconstruction algorithm and the performance of the SciFi after three years of operation.Comment: 24pages,18 figures, and 1 table. Preprint submitted to NI

Differential cross section measurements for the production of a W boson in association with jets in proton-proton collisions at root s=7 TeV

Citation: Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., . . . Collaboration, C. M. S. (2015). Differential cross section measurements for the production of a W boson in association with jets in proton-proton collisions at root s=7 TeV. Physics Letters B, 741, 12-37. doi:10.1016/j.physletb.2014.12.003Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (p(T)) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (H-T), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb (1). The measured cross sections are compared to predictions from Monte Carlo generators, MADGRAPH + PYTHIA and SHERPA, and to next-to-leading-order calculations from BLACKHAT + SHERPA. The differential cross sections are found to be in agreement with the predictions, apart from the p(T) distributions of the leading jets at high p(T) values, the distributions of the H-T at high-H-T and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).Additional Authors: Kiesenhofer, W.;Knunz, V.;Krammer, M.;Kratschmer, I.;Liko, D.;Mikulec, I.;Rabady, D.;Rahbaran, B.;Rohringer, H.;Schofbeck, R.;Strauss, J.;Taurok, A.;Treberer-Treberspurg, W.;Waltenberger, W.;Wulz, C. E.;Mossolov, V.;Shumeiko, N.;SuarezGonzalez, J.;Alderweireldt, S.;Bansal, M.;Bansal, S.;Cornelis, T.;De Wolf, E. A.;Janssen, X.;Knutsson, A.;Luyckx, S.;Ochesanu, S.;Roland, B.;Rougny, R.;Van De Klundert, M.;Van Haevermaet, H.;Van Mechelen, P.;Van Remortel, N.;Van Spilbeeck, A.;Blekman, F.;Blyweert, S.;D'Hondt, J.;Daci, N.;Heracleous, N.;Kalogeropoulos, A.;Keaveney, J.;Kim, T. J.;Lowette, S.;Maes, M.;Olbrechts, A.;Python, Q.;Strom, D.;Tavernier, S.;Van Doninck, W.;Van Mulders, P.;Van Onsem, G. P.;Villella, I.;Caillol, C.;Clerbaux, B.;De Lentdecker, G.;Dobur, D.;Favart, L.;Gay, A. P. R.;Grebenyuk, A.;Leonard, A.;Mohammadi, A.;Pernie, L.;Reis, T.;Seva, T.;Thomas, L.;Vander Velde, C.;Vanlaer, P.;Wang, J.;Adler, V.;Beernaert, K.;Benucci, L.;Cimmino, A.;Costantini, S.;Crucy, S.;Dildick, S.;Fagot, A.;Garcia, G.;Klein, B.;McCartin, J.;Rios, A. A. O.;Ryckbosch, D.;Diblen, S. S.;Sigamani, M.;Strobbe, N.;Thyssen, F.;Tytgat, M.;Yazgan, E.;Zaganidis, N.;Basegmez, S.;Beluffi, C.;Bruno, G.;Castello, R.;Caudron, A.;Ceard, L.;Da Silveira, G. G.;Delaere, C.;du Pree, T.;Favart, D.;Forthomme, L.;Giammanco, A.;Hollar, J.;Jez, P.;Komm, M.;Lemaitre, V.;Liao, J.;Nuttens, C.;Pagano, D.;Perrini, L.;Pin, A.;Piotrzkowski, K.;Popov, A.;Quertenmont, L.;Selvaggi, M.;Marono, M. V.;Garcia, J. M. V.;Beliy, N.;Caebergs, T.;Daubie, E.;Hammad, G. H.;Alda, W. L.;Alves, G. A.;Martins, M. C.;Martins, T. D.;Pol, M. E.;Carvalho, W.;Chinellato, J.;Custodio, A.;Da Costa, E. M.;Damiao, D. D.;Martins, C. D.;De Souza, S. F.;Malbouisson, H.;Malek, M.;Figueiredo, D. M.;Mundim, L.;Nogima, H.;Da Silva, W. L. P.;Santaolalla, J.;Santoro, A.;Sznajder, A.;Manganote, E. J. T.;Pereira, A. V.;Bernardes, C. A.;Dias, F. A.;Tomei, Trfp;Gregores, E. M.;Mercadante, P. G.;Novaes, S. F.;Padula, S. S.;Aleksandrov, A.;Genchev, V.;Iaydjiev, P.;Marinov, A.;Piperov, S.;Rodozov, M.;Sultanov, G.;Vutova, M.;Dimitrov, A.;Glushkov, I.;Hadjiiska, R.;Kozhuharov, V.;Litov, L.;Pavlov, B.;Petkov, P.;Bian, J. G.;Chen, G. M.;Chen, H. S.;Chen, M.;Du, R.;Jiang, C. H.;Liang, D.;Liang, S.;Plestina, R.;Tao, J.;Wang, X.;Wang, Z.;Asawatangtrakuldee, C.;Ban, Y.;Guo, Y.;Li, Q.;Li, W.;Liu, S.;Mao, Y.;Qian, S. J.;Wang, D.;Zhang, L.;Zou, W.;Avila, C.;Sierra, L. F. C.;Florez, C.;Gomez, J. P.;Moreno, B. G.;Sanabria, J. C.;Godinovic, N.;Lelas, D.;Polic, D.;Puljak, I.;Antunovic, Z.;Kovac, M.;Brigljevic, V.;Kadija, K.;Luetic, J.;Mekterovic, D.;Sudic, L.;Attikis, A.;Mavromanolakis, G.;Mousa, J.;Nicolaou, C.;Ptochos, F.;Razis, P. A.;Bodlak, M.;Finger, M.;Finger, M.;Assran, Y.;Kamel, A. E.;Mahmoud, M. A.;Radi, A.;Kadastik, M.;Murumaa, M.;Raidal, M.;Tiko, A.;Eerola, P.;Fedi, G.;Voutilainen, M.;Harkonen, J.;Karimaki, V.;Kinnunen, R.;Kortelainen, M. J.;Lampen, T.;Lassila-Perini, K.;Lehti, S.;Linden, T.;Luukka, P.;Maenpaa, T.;Peltola, T.;Tuominen, E.;Tuominiemi, J.;Tuovinen, E.;Wendland, L.;Tuuva, T.;Besancon, M.;Couderc, F.;Dejardin, M.;Denegri, D.;Fabbro, B.;Faure, J. L.;Favaro, C.;Ferri, F.;Ganjour, S.;Givernaud, A.;Gras, P.;de Monchenault, G. H.;Jarry, P.;Locci, E.;Malcles, J.;Rander, J.;Rosowsky, A.;Titov, M.;Baffioni, S.;Beaudette, F.;Busson, P.;Charlot, C.;Dahms, T.;Dalchenko, M.;Dobrzynski, L.;Filipovic, N.;Florent, A.;de Cassagnac, R. G.;Mastrolorenzo, L.;Mine, P.;Mironov, C.;Naranjo, I. N.;Nguyen, M.;Ochando, C.;Paganini, P.;Salerno, R.;Sauvan, J. B.;Sirois, Y.;Veelken, C.;Yilmaz, Y.;Zabi, A.;Agram, J. L.;Andrea, J.;Aubin, A.;Bloch, D.;Brom, J. M.;Chabert, E. C.;Collard, C.;Conte, E.;Fontaine, J. C.;Gele, D.;Goerlach, U.;Goetzmann, C.;Le Bihan, A. C.;Van Hove, P.;Gadrat, S.;Beauceron, S.;Beaupere, N.;Boudoul, G.;Brochet, S.;Montoya, C. A. C.;Chasserat, J.;Chierici, R.;Contardo, D.;Depasse, P.;El Mamouni, H.;Fan, J.;Fay, J.;Gascon, S.;Gouzevitch, M.;Ille, B.;Kurca, T.;Lethuillier, M.;Mirabito, L.;Perries, S.;Alvarez, J. D. R.;Sabes, D.;Sgandurra, L.;Sordini, V.;Donckt, M.;Verdier, P.;Viret, S.;Xiao, H.;Tsamalaidze, Z.;Autermann, C.;Beranek, S.;Bontenackels, M.;Edelhoff, M.;Feld, L.;Hindrichs, O.;Klein, K.;Ostapchuk, A.;Perieanu, A.;Raupach, F.;Sammet, J.;Schael, S.;Sprenger, D.;Weber, H.;Wittmer, B.;Zhukov, V.;Ata, M.;Dietz-Laursonn, E.;Duchardt, D.;Erdmann, M.;Fischer, R.;Guth, A.;Hebbeker, T.;Heidemann, C.;Hoepfner, K.;Klingebiel, D.;Knutzen, S.;Kreuzer, P.;Merschmeyer, M.;Meyer, A.;Olschewski, M.;Padeken, K.;Papacz, P.;Reithler, H.;Schmitz, S. A.;Sonnenschein, L.;Teyssier, D.;Thuer, S.;Weber, M.;Cherepanov, V.;Erdogan, Y.;Flugge, G.;Geenen, H.;Geisler, M.;Ahmad, W. H.;Hoehle, F.;Kargoll, B.;Kress, T.;Kuessel, Y.;Lingemann, J.;Nowack, A.;Nugent, I. M.;Perchalla, L.;Pooth, O.;Stahl, A.;Asin, I.;Bartosik, N.;Behr, J.;Behrenhoff, W.;Behrens, U.;Bell, A. J.;Bergholz, M.;Bethani, A.;Borras, K.;Burgmeier, A.;Cakir, A.;Calligaris, L.;Campbell, A.;Choudhury, S.;Costanza, F.;Pardos, C. D.;Dooling, S.;Dorland, T.;Eckerlin, G.;Eckstein, D.;Eichhorn, T.;Flucke, G.;Garcia, J. G.;Geiser, A.;Gunnellini, P.;Hauk, J.;Hellwig, G.;Hempel, M.;Horton, D.;Jung, H.;Kasemann, M.;Katsas, P.;Kieseler, J.;Kleinwort, C.;Krucker, D.;Lange, W.;Leonard, J.;Lipka, K.;Lobanov, A.;Lohmann, W.;Lutz, B.;Mankel, R.;Marfin, I.;Melzer-Pellmann, I. A.;Meyer, A. B.;Mnich, J.;Mussgiller, A.;Naumann-Emme, S.;Nayak, A.;Novgorodova, O.;Nowak, F.;Ntomari, E.;Perrey, H.;Pitzl, D.;Placakyte, R.;Raspereza, A.;RibeiroCipriano, P. M.;Ron, E.;Sahin, M. O.;Salfeld-Nebgen, J.;Saxena, P.;Schmidt, R.;Schoerner-Sadenius, T.;Schroder, M.;Spannagel, S.;Trevino, Adrv;Walsh, R.;Wissing, C.;Martin, M. A.;Blobel, V.;Vignali, M. C.;Erfle, J.;Garutti, E.;Goebel, K.;Gorner, M.;Gosselink, M.;Haller, J.;Hoffmann, M.;Hoing, R. S.;Kirschenmann, H.;Klanner, R.;Kogler, R.;Lange, J.;Lapsien, T.;Lenz, T.;Marchesini, I.;Ott, J.;Peiffer, T.;Pietsch, N.;Rathjens, D.;Sander, C.;Schettler, H.;Schleper, P.;Schlieckau, E.;Schmidt, A.;Seidel, M.;Sibille, J.;Sola, V.;Stadie, H.;Steinbruck, G.;Troendle, D.;Usai, E.;Vanelderen, L.;Barth, C.;Baus, C.;Berger, J.;Boser, C.;Butz, E.;Chwalek, T.;De Boer, W.;Descroix, A.;Dierlamm, A.;Feindt, M.;Frensch, F.;Giffels, M.;Hartmann, F.;Hauth, T.;Husemann, U.;Katkov, I.;Kornmayer, A.;Kuznetsova, E.;Pardo, P. L.;Mozer, M. U.;Muller, T.;Nurnberg, A.;Quast, G.;Rabbertz, K.;Ratnikov, F.;Rocker, S.;Simonis, H. J.;Stober, F. M.;Ulrich, R.;Wagner-Kuhr, J.;Wayand, S.;Weiler, T.;Wolf, R.;Anagnostou, G.;Daskalakis, G.;Geralis, T.;Giakoumopoulou, V. A.;Kyriakis, A.;Loukas, D.;Markou, A.;Markou, C.;Psallidas, A.;Topsis-Giotis, I.;Panagiotou, A.;Saoulidou, N.;Stiliaris, E.;Aslanoglou, X.;Evangelou, I.;Flouris, G.;Foudas, C.;Kokkas, P.;Manthos, N.;Papadopoulos, I.;Paradas, E.;Bencze, G.;Hajdu, C.;Hidas, P.;Horvath, D.;Sikler, F.;Veszpremi, V.;Vesztergombi, G.;Zsigmond, A. J.;Beni, N.;Czellar, S.;Karancsi, J.;Molnar, J.;Palinkas, J.;Szillasi, Z.;Raics, P.;Trocsanyi, Z. L.;Ujvari, B.;Swain, S. K.;Beri, S. B.;Bhatnagar, V.;Dhingra, N.;Gupta, R.;Kalsi, A. K.;Kaur, M.;Mittal, M.;Nishu, N.;Singh, J. B.;Kumar, A.;Kumar, A.;Ahuja, S.;Bhardwaj, A.;Choudhary, B. C.;Kumar, A.;Malhotra, S.;Naimuddin, M.;Ranjan, K.;Sharma, V.;Banerjee, S.;Bhattacharya, S.;Chatterjee, K.;Dutta, S.;Gomber, B.;Jain, S.;Jain, S.;Khurana, R.;Modak, A.;Mukherjee, S.;Roy, D.;Sarkar, S.;Sharan, M.;Abdulsalam, A.;Dutta, D.;Kailas, S.;Kumar, V.;Mohanty, A. K.;Pant, L. M.;Shukla, P.;Topkar, A.;Aziz, T.;Banerjee, S.;Chatterjee, R. M.;Dewanjee, R. K.;Dugad, S.;Ganguly, S.;Ghosh, S.;Guchait, M.;Gurtu, A.;Kole, G.;Kumar, S.;Maity, M.;Majumder, G.;Mazumdar, K.;Mohanty, G. B.;Parida, B.;Sudhakar, K.;Wickramage, N.;Bakhshiansohi, H.;Behnamian, H.;Etesami, S. M.;Fahim, A.;Goldouzian, R.;Jafari, A.;Khakzad, M.;Najafabadi, M. M.;Naseri, M.;Mehdiabadi, S. P.;Safarzadeh, B.;Zeinali, M.;Felcini, M.;Grunewald, M.;Abbrescia, M.;Barbone, L.;Calabria, C.;Chhibra, S. S.;Colaleo, A.;Creanza, D.;De Filippis, N.;De Palma, M.;Fiore, L.;Iaselli, G.;Maggi, G.;Maggi, M.;My, S.;Nuzzo, S.;Pompili, A.;Pugliese, G.;Radogna, R.;Selvaggi, G.;Silvestris, L.;Singh, G.;Venditti, R.;Verwilligen, P.;Zito, G.;Abbiendi, G.;Benvenuti, A. C.;Bonacorsi, D.;Braibant-Giacomelli, S.;Brigliadori, L.;Campanini, R.;Capiluppi, P.;Castro, A.;Cavallo, F. R.;Codispoti, G.;Cuffiani, M.;Dallavalle, G. M.;Fabbri, F.;Fanfani, A.;Fasanella, D.;Giacomelli, P.;Grandi, C.;Guiducci, L.;Marcellini, S.;Masetti, G.;Montanari, A.;Navarria, F. L.;Perrotta, A.;Primavera, F.;Rossi, A. M.;Rovelli, T.;Siroli, G. P.;Tosi, N.;Travaglini, R.;Albergo, S.;Cappello, G.;Chiorboli, M.;Costa, S.;Giordano, F.;Potenza, R.;Tricomi, A.;Tuve, C.;Barbagli, G.;Ciulli, V.;Civinini, C.;D'Alessandro, R.;Focardi, E.;Gallo, E.;Gonzi, S.;Gori, V.;Lenzi, P.;Meschini, M.;Paoletti, S.;Sguazzoni, G.;Tropiano, A.;Benussi, L.;Bianco, S.;Fabbri, F.;Piccolo, D.;Ferro, F.;Lo Vetere, M.;Robutti, E.;Tosi, S.;Dinardo, M. E.;Fiorendi, S.;Gennai, S.;Gerosa, R.;Ghezzi, A.;Govoni, P.;Lucchini, M. T.;Malvezzi, S.;Manzoni, R. A.;Martelli, A.;Marzocchi, B.;Menasce, D.;Moroni, L.;Paganoni, M.;Pedrini, D.;Ragazzi, S.;Redaelli, N.;de Fatis, T. T.;Buontempo, S.;Cavallo, N.;Di Guida, S.;Fabozzi, F.;Iorio, A. O. M.;Lista, L.;Meola, S.;Merola, M.;Paolucci, P.;Azzi, P.;Bacchetta, N.;Bellato, M.;Bisello, D.;Branca, A.;Carlin, R.;Checchia, P.;Dall'Osso, M.;Dorigo, T.;Galanti, M.;Gasparini, F.;Gasparini, U.;Giubilato, P.;Gozzelino, A.;Kanishchev, K.;Lacaprara, S.;Margoni, M.;Meneguzzo, A. T.;Pazzini, J.;Pozzobon, N.;Ronchese, P.;Sgaravatto, M.;Tosi, M.;Triossi, A.;Ventura, S.;Zucchetta, A.;Zumerle, G.;Ratti, S. P.;Riccardi, C.;Salvini, P.;Vitulo, P.;Biasini, M.;Bilei, G. M.;Ciangottini, D.;Fano, L.;Lariccia, P.;Mantovani, G.;Menichelli, M.;Romeo, F.;Saha, A.;Santocchia, A.;Spiezia, A.;Androsov, K.;Azzurri, P.;Bagliesi, G.;Bernardini, J.;Boccali, T.;Broccolo, G.;Castaldi, R.;Ciocci, M. A.;Dell'Orso, R.;Donato, S.;Fiori, F.;Foa, L.;Giassi, A.;Grippo, M. T.;Ligabue, F.;Lomtadze, T.;Martini, L.;Messineo, A.;Moon, C. S.;Palla, F.;Rizzi, A.;Savoy-Navarro, A.;Serban, A. T.;Spagnolo, P.;Squillacioti, P.;Tenchini, R.;Tonelli, G.;Venturi, A.;Verdini, P. G.;Vernieri, C.;Barone, L.;Cavallari, F.;Del Re, D.;Diemoza, M.;Grassi, M.;Jorda, C.;Longo, E.;Margaroli, F.;Meridiani, P.;Micheli, F.;Nourbakhsh, S.;Organtini, G.;Paramatti, R.;Rahatlou, S.;Rovelli, C.;Santanastasio, F.;Soffi, L.;Traczyk, P.;Amapane, N.;Arcidiacono, R.;Argiro, S.;Arneodo, M.;Bellan, R.;Biino, C.;Cartiglia, N.;Casasso, S.;Costa, M.;Degano, A.;Demaria, N.;Finco, L.;Mariotti, C.;Maselli, S.;Migliore, E.;Monaco, V.;Musich, M.;Obertino, M. M.;Ortona, G.;Pacher, L.;Pastrone, N.;Pelliccioni, M.;Angioni, G. L. P.;Potenza, A.;Romero, A.;Ruspa, M.;Sacchi, R.;Solano, A.;Staiano, A.;Tamponi, U.;Belforte, S.;Candelise, V.;Casarsa, M.;Cossutti, F.;Della Ricca, G.;Gobbo, B.;LaLicata, C.;Marone, M.;Montanino, D.;Schizzi, A.;Umer, T.;Zanetti, A.;Chang, S.;Kropivnitskaya, A.;Nam, S. K.;Kim, D. H.;Kim, G. N.;Kim, M. S.;Kong, D. J.;Lee, S.;Oh, Y. D.;Park, H.;Sakharov, A.;Son, D. C.;Kim, J. Y.;Song, S.;Choi, S.;Gyun, D.;Hong, B.;Jo, M.;Kim, H.;Kim, Y.;Lee, B.;Lee, K. S.;Park, S. K.;Roh, Y.;Choi, M.;Kim, H.;Kim, J. H.;Park, I. C.;Park, S.;Ryu, G.;Ryu, M. S.;Choi, Y.;Choi, Y. K.;Goh, J.;Kwon, E.;Lee, J.;Seo, H.;Yu, I.;Juodagalvis, A.;Komaragiri, J. R.;Castilla-Valdez, H.;De La Cruz-Burelo, E.;Heredia-de La Cruz, I.;Lopez-Fernandez, R.;Sanchez-Hernandez, A.;Moreno, S. C.;Valencia, F. V.;Pedraza, I.;Ibarguen, H. A. S.;Linares, E. C.;Pineda, A. M.;Krofcheck, D.;Butler, P. H.;Reucroft, S.;Ahmad, A.;Ahmad, M.;Hassan, Q.;Hoorani, H. R.;Khalid, S.;Khan, W. A.;Khurshid, T.;Shah, M. A.;Shoaib, M.;Bialkowska, H.;Bluj, M.;Boimska, B.;Frueboes, T.;Gorski, M.;Kazana, M.;Nawrocki, K.;Romanowska-Rybinska, K.;Szleper, M.;Zalewski, P.;Brona, G.;Bunkowski, K.;Cwiok, M.;Dominik, W.;Doroba, K.;Kalinowski, A.;Konecki, M.;Krolikowski, J.;Misiura, M.;Olszewski, M.;Wolszczak, W.;Bargassa, P.;Silva, Cbde;Faccioli, P.;Parracho, P. G. F.;Gallinaro, M.;Nguyen, F.;Antunes, J. 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I.;Vlimant, J. R.;Wardle, N.;Wohri, H. K.;Zeuner, W. D.;Bertl, W.;Deiters, K.;Erdmann, W.;Horisberger, R.;Ingram, Q.;Kaestli, H. C.;Konig, S.;Kotlinski, D.;Langenegger, U.;Renker, D.;Rohe, T.;Bachmair, F.;Bani, L.;Bianchini, L.;Bortignon, P.;Buchmann, M. A.;Casal, B.;Chanon, N.;Deisher, A.;Dissertori, G.;Dittmar, M.;Donega, M.;Dunser, M.;Eller, P.;Grab, C.;Hits, D.;Lustermann, W.;Mangano, B.;Marini, A. C.;del Arbol, P. M. R.;Meister, D.;Mohr, N.;Nageli, C.;Nef, P.;Nessi-Tedaldi, F.;Pandolfi, F.;Pauss, F.;Peruzzi, M.;Quittnat, M.;Rebane, L.;Ronga, F. J.;Rossini, M.;Starodumov, A.;Takahashi, M.;Theofilatos, K.;Wallny, R.;Weber, H. A.;Amsler, C.;Canelli, M. F.;Chiochia, V.;De Cosa, A.;Hinzmann, A.;Hreus, T.;Rikova, M. I.;Kilminster, B.;Mejias, B. M.;Ngadiuba, J.;Robmann, P.;Snoek, H.;Taroni, S.;Verzetti, M.;Yang, Y.;Cardaci, M.;Chen, K. H.;Ferro, C.;Kuo, C. M.;Lin, W.;Lu, Y. J.;Volpe, R.;Yu, S. S.;Chang, P.;Chang, Y. H.;Chang, Y. W.;Chao, Y.;Chen, K. F.;Chen, P. 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T.;Evans, D.;Holzner, A.;Kelley, R.;Klein, D.;Lebourgeois, M.;Letts, J.;Macneill, I.;Olivito, D.;Padhi, S.;Palmer, C.;Pieri, M.;Sani, M.;Sharma, V.;Simon, S.;Sudano, E.;Tadel, M.;Tu, Y.;Vartak, A.;Welke, C.;Wuerthwein, F.;Yagil, A.;Yoo, J.;Barge, D.;Bradmiller-Feld, J.;Campagnari, C.;Danielson, T.;Dishaw, A.;Flowers, K.;Sevilla, M. F.;Geffert, P.;George, C.;Golf, F.;Gouskos, L.;Incandela, J.;Justus, C.;McColl, N.;Richman, J.;Stuart, D.;To, W.;West, C.;Apresyan, A.;Bornheim, A.;Bunn, J.;Chen, Y.;Di Marco, E.;Duarte, J.;Mott, A.;Newman, H. B.;Pena, C.;Rogan, C.;Spiropulu, M.;Timciuc, V.;Wilkinson, R.;Xie, S.;Zhu, R. Y.;Azzolini, V.;Calamba, A.;Ferguson, T.;Iiyama, Y.;Paulini, M.;Russ, J.;Vogel, H.;Vorobiev, I.;Cumalat, J. P.;Drell, B. R.;Ford, W. T.;Gaz, A.;Lopez, E. L.;Nauenberg, U.;Smith, J. G.;Stenson, K.;Ulmer, K. A.;Wagner, S. R.;Alexander, J.;Chatterjee, A.;Chu, J.;Dittmer, S.;Eggert, N.;Hopkins, W.;Mirman, N.;Kaufman, G. N.;Patterson, J. R.;Ryd, A.;Salvati, E.;Skinnari, L.;Sun, W.;Teo, W. D.;Thom, J.;Thompson, J.;Tucker, J.;Weng, Y.;Winstrom, L.;Wittich, P.;Winn, D.;Abdullin, S.;Albrow, M.;Anderson, J.;Apollinari, G.;Bauerdick, L. A. T.;Beretvas, A.;Berryhill, J.;Bhat, P. C.;Burkett, K.;Butler, J. N.;Cheung, H. W. K.;Chlebana, F.;Cihangir, S.;Elvira, V. D.;Fisk, I.;Freeman, J.;Gao, Y.;Gottschalk, E.;Gray, L.;Green, D.;

Search for vector-like T quarks decaying to top quarks and Higgs bosons in the all-hadronic channel using jet substructure

Citation: Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., . . . Collaboration, C. M. S. (2015). Search for vector-like T quarks decaying to top quarks and Higgs bosons in the all-hadronic channel using jet substructure. Journal of High Energy Physics(6), 48. doi:10.1007/jhep06(2015)080A search is performed for a vector-like heavy T quark that is produced in pairs and that decays to a top quark and a Higgs boson. The data analysed correspond to an integrated luminosity of 19.7 fb(-1) collected with the CMS detector in proton-proton collisions at root s = 8TeV. For T quarks with large mass values the top quarks and Higgs bosons can have significant Lorentz boosts, so that their individual decay products often overlap and merge. Methods are applied to resolve the substructure of such merged jets. Upper limits on the production cross section of a T quark with mass between 500 and 1000 GeV/c(2) are derived. If the T quark decays exclusively to tH, the observed (expected) lower limit on the mass of the T quark is 745 (773) GeV/c(2) at 95% confidence level. For the first time an algorithm is used for tagging boosted Higgs bosons that is based on a combination of jet substructure information and b tagging.Additional Authors: Knunz, V.;Krammer, M.;Kratschmer, I.;Liko, D.;Mikulec, I.;Rabady, D.;Rahbaran, B.;Rohringer, H.;Schofbeck, R.;Strauss, J.;Treberer-Treberspurg, W.;Waltenberger, W.;Wulz, C. E.;Mossolov, V.;Shumeiko, N.;Gonzalez, J. S.;Alderweireldt, S.;Bansal, S.;Cornelis, T.;De Wolf, E. A.;Janssen, X.;Knutsson, A.;Lauwers, J.;Luyckx, S.;Ochesanu, S.;Rougny, R.;Van De Klundert, M.;Van Haevermaet, H.;Van Mechelen, P.;Van Remortel, N.;Van Spilbeeck, A.;Blekman, F.;Blyweert, S.;D'Hondt, J.;Daci, N.;Heracleous, N.;Keaveney, J.;Lowette, S.;Maes, M.;Olbrechts, A.;Python, Q.;Strom, D.;Tavernier, S.;Van Doninck, W.;Van Mulders, P.;Van Onsem, G. P.;Villella, I.;Caillol, C.;Clerbaux, B.;De Lentdecker, G.;Dobur, D.;Favart, L.;Gay, A. P. R.;Grebenyuk, A.;Leonard, A.;Mohammadi, A.;Pernie, L.;Randle-conde, A.;Reis, T.;Seva, T.;Thomas, L.;Velde, C. V.;Vanlaer, P.;Wang, J.;Zenoni, F.;Adler, V.;Beernaert, K.;Benucci, L.;Cimmino, A.;Costantini, S.;Crucy, S.;Dildick, S.;Fagot, A.;Garcia, G.;McCartin, J.;Rios, A. A. O.;Poyraz, D.;Ryckbosch, D.;Diblen, S. S.;Sigamani, M.;Strobbe, N.;Thyssen, F.;Tytgat, M.;Yazgan, E.;Zaganidis, N.;Basegmez, S.;Beluffi, C.;Bruno, G.;Castello, R.;Caudron, A.;Ceard, L.;Da Silveira, G. G.;Delaere, C.;du Pree, T.;Favart, D.;Forthomme, L.;Giammanco, A.;Hollar, J.;Jafari, A.;Jez, P.;Komm, M.;Lemaitre, V.;Nuttens, C.;Perrini, L.;Pin, A.;Piotrzkowski, K.;Popov, A.;Quertenmont, L.;Selvaggi, M.;Marono, M. V.;Garcia, J. M. V.;Beliy, N.;Caebergs, T.;Daubie, E.;Hammad, G. H.;Alda, W. L.;Alves, G. A.;Brito, L.;Martins, M. C.;Martins, T. D.;Molina, J.;Herrera, C. M.;Pol, M. E.;Teles, P. R.;Carvalho, W.;Chinellato, J.;Custodio, A.;Da Costa, E. M.;Damiao, D. D. J.;Martins, C. D. O.;De Souza, S. F.;Malbouisson, H.;Figueiredo, D. M.;Mundim, L.;Nogima, H.;Da Silva, W. L. P.;Santaolalla, J.;Santoro, A.;Sznajder, A.;Manganote, E. J. T.;Pereira, A. V.;Bernardes, C. A.;Dogra, S.;Tomei, Trfp;Gregores, E. M.;Mercadante, P. G.;Novaes, S. F.;Padul, S. S.;Aleksandrov, A.;Genchev, V.;Hadjiiska, R.;Iaydjiev, P.;Marinov, A.;Piperov, S.;Rodozov, M.;Stoykova, S.;Sultanov, G.;Vutova, M.;Dimitrov, A.;Glushkov, I.;Litov, L.;Pavlov, B.;Petkov, P.;Bian, J. G.;Chen, G. M.;Chen, H. S.;Chen, M.;Cheng, T.;Du, R.;Jiang, C. H.;Plestina, R.;Romeo, F.;Tao, J.;Wang, Z.;Asawatangtrakuldee, C.;Ban, Y.;Liu, S.;Mao, Y.;Qian, S. J.;Wang, D.;Xu, Z.;Zhang, L.;Zou, W.;Avila, C.;Cabrera, A.;Sierra, L. F. C.;Florez, C.;Gomez, J. P.;Moreno, B. G.;Sanabria, J. C.;Godinovic, N.;Lelas, D.;Polic, D.;Puljak, I.;Antunovic, Z.;Kovac, M.;Brigljevic, V.;Kadija, K.;Luetic, J.;Mekterovic, D.;Sudic, L.;Attikis, A.;Mavromanolakis, G.;Mousa, J.;Nicolaou, C.;Ptochos, F.;Razis, P. A.;Rykaczewski, H.;Bodlak, M.;Finger, M.;Finger, M.;Assran, Y.;Kamel, A. E.;Mahmoud, M. A.;Radi, A.;Kadastik, M.;Murumaa, M.;Raidal, M.;Tiko, A.;Eerola, P.;Voutilainen, M.;Harkonen, J.;Karimaki, V.;Kinnunen, R.;Kortelainen, M. J.;Lampen, T.;Lassila-Perini, K.;Lehti, S.;Linden, T.;Luukka, P.;Maenpaa, T.;Peltola, T.;Tuominen, E.;Tuominiemi, J.;Tuovinen, E.;Wendland, L.;Talvitie, J.;Tuuva, T.;Besancon, M.;Couderc, F.;Dejardin, M.;Denegri, D.;Fabbro, B.;Faure, J. L.;Favaro, C.;Ferri, F.;Ganjour, S.;Givernaud, A.;Gras, P.;de Monchenault, G. H.;Jarry, P.;Locci, E.;Malcles, J.;Rander, J.;Rosowsky, A.;Titov, M.;Baffioni, S.;Beaudette, F.;Busson, P.;Chapon, E.;Charlot, C.;Dahms, T.;Dalchenko, M.;Dobrzynski, L.;Filipovic, N.;Florent, A.;de Cassagnac, R. G.;Mastrolorenzo, L.;Mine, P.;Naranjo, I. N.;Nguyen, M.;Ochando, C.;Ortona, G.;Paganini, P.;Regnard, S.;Salerno, R.;Sauvan, J. B.;Sirois, Y.;Veelken, C.;Yilmaz, Y.;Zabi, A.;Agram, J. L.;Andrea, J.;Aubin, A.;Bloch, D.;Brom, J. M.;Chabert, E. C.;Collard, C.;Conte, E.;Fontaine, J. C.;Gele, D.;Goerlach, U.;Goetzmann, C.;Le Bihan, A. C.;Skovpen, K.;Van Hove, P.;Gadrat, S.;Beauceron, S.;Beaupere, N.;Bernet, C.;Boudoul, G.;Bouvier, E.;Brochet, S.;Montoya, C. A. C.;Chasserat, J.;Chierici, R.;Contardo, D.;Courbon, B.;Depasse, P.;El Mamouni, H.;Fan, J.;Fay, J.;Gascon, S.;Gouzevitch, M.;Ille, B.;Kurca, T.;Lethuillier, M.;Mirabito, L.;Pequegnot, A. L.;Perries, S.;Alvarez, J. D. R.;Sabes, D.;Sgandurra, L.;Sordini, V.;Donckt, M. V.;Verdier, P.;Viret, S.;Xiao, H.;Tsamalaidze, Z.;Autermann, C.;Beranek, S.;Bontenackels, M.;Edelhoff, M.;Feld, L.;Heister, A.;Klein, K.;Lipinski, M.;Ostapchuk, A.;Preuten, M.;Raupach, F.;Sammet, J.;Schael, S.;Schulte, J. F.;Weber, H.;Wittmer, B.;Zhukov, V.;Ata, M.;Brodski, M.;Dietz-Laursonn, E.;Duchardt, D.;Erdmann, M.;Fischer, R.;Guth, A.;Hebbeker, T.;Heidemann, C.;Hoepfner, K.;Klingebiel, D.;Knutzen, S.;Kreuzer, P.;Merschmeyer, M.;Meyer, A.;Millet, P.;Olschewski, M.;Padeken, K.;Papacz, P.;Reithler, H.;Schmitz, S. A.;Sonnenschein, L.;Teyssier, D.;Thuer, S.;Weber, M.;Cherepanov, V.;Erdogan, Y.;Flugge, G.;Geenen, H.;Geisler, M.;Ahmad, W. H.;Hoehle, F.;Kargoll, B.;Kress, T.;Kuessel, Y.;Kunsken, A.;Lingemann, J.;Nowack, A.;Nugent, I. M.;Pooth, O.;Stahl, A.;Martin, M. A.;Asin, I.;Bartosik, N.;Behr, J.;Behrens, U.;Bell, A. J.;Bethani, A.;Borras, K.;Burgmeier, A.;Cakir, A.;Calligaris, L.;Campbell, A.;Choudhury, S.;Costanza, F.;Pardos, C. D.;Dolinska, G.;Dooling, S.;Dorland, T.;Eckerlin, G.;Eckstein, D.;Eichhorn, T.;Flucke, G.;Garcia, J. G.;Geiser, A.;Gizhko, A.;Gunnellini, P.;Hauk, J.;Hempel, M.;Jung, H.;Kalogeropoulos, A.;Karacheban, O.;Kasemann, M.;Katsas, P.;Kieseler, J.;Kleinwort, C.;Korol, I.;Krucker, D.;Lange, W.;Leonard, J.;Lipka, K.;Lobanov, A.;Lohmann, W.;Lutz, B.;Mankel, R.;Marfin, I.;Melzer-Pellmann, I. A.;Meyer, A. B.;Mittag, G.;Mnich, J.;Mussgiller, A.;Naumann-Emme, S.;Nayak, A.;Ntomari, E.;Perrey, H.;Pitzl, D.;Placakyte, R.;Raspereza, A.;Cipriano, P. M. R.;Roland, B.;Ron, E.;Sahin, M. O.;Salfeld-Nebgen, J.;Saxena, P.;Schoerner-Sadenius, T.;Schroder, M.;Seitz, C.;Spannagel, S.;Trevino, Adrv;Walsh, R.;Wissing, C.;Blobel, V.;Vignali, M. C.;Draeger, A. R.;Erfle, J.;Garutti, E.;Goebel, K.;Gorner, M.;Haller, J.;Hoffmann, M.;Hoing, R. S.;Junkes, A.;Kirschenmann, H.;Klanner, R.;Kogler, R.;Lapsien, T.;Lenz, T.;Marchesini, I.;Marconi, D.;Ott, J.;Peiffer, T.;Perieanu, A.;Pietsch, N.;Poehlsen, J.;Poehlsen, T.;Rathjens, D.;Sander, C.;Schettler, H.;Schleper, P.;Schlieckau, E.;Schmidt, A.;Seidel, M.;Sola, V.;Stadie, H.;Steinbruck, G.;Troendle, D.;Usai, E.;Vanelderen, L.;Vanhoefer, A.;Barth, C.;Baus, C.;Berger, J.;Boser, C.;Butz, E.;Chwalek, T.;De Boer, W.;Descroix, A.;Dierlamm, A.;Feindt, M.;Frensch, F.;Giffels, M.;Gilbert, A.;Hartmann, F.;Hauth, T.;Husemann, U.;Katkov, I.;Kornmayer, A.;Pardo, P. L.;Mozer, M. U.;Muller, T.;Muller, T.;Nurnberg, A.;Quast, G.;Rabbertz, K.;Rocker, S.;Simonis, H. J.;Stober, F. M.;Ulrich, R.;Wagner-Kuhr, J.;Wayand, S.;Weiler, T.;Wolf, R.;Anagnostou, G.;Daskalakis, G.;Geralis, T.;Giakoumopoulou, V. A.;Kyriakis, A.;Loukas, D.;Markou, A.;Markou, C.;Psallidas, A.;Topsis-Giotis, I.;Agapitos, A.;Kesisoglou, S.;Panagiotou, A.;Saoulidou, N.;Stiliaris, E.;Aslanoglou, X.;Evangelou, I.;Flouris, G.;Foudas, C.;Kokkas, P.;Manthos, N.;Papadopoulos, I.;Paradas, E.;Strologas, J.;Bencze, G.;Hajdu, C.;Hidas, P.;Horvath, D.;Sikler, F.;Veszpremi, V.;Vesztergombi, G.;Zsigmond, A. J.;Beni, N.;Czellar, S.;Karancsi, J.;Molnar, J.;Palinkas, J.;Szillasi, Z.;Makovec, A.;Raics, P.;Trocsanyi, Z. L.;Ujvari, B.;Swain, S. K.;Beri, S. B.;Bhatnagar, V.;Gupta, R.;Bhawandeep, U.;Kalsi, A. K.;Kaur, M.;Kumar, R.;Mittal, M.;Nishu, N.;Singh, J. B.;Kumar, A.;Kumar, A.;Ahuja, S.;Bhardwaj, A.;Choudhary, B. C.;Kumar, A.;Malhotra, S.;Naimuddin, M.;Ranjan, K.;Sharma, V.;Banerjee, S.;Bhattacharya, S.;Chatterjee, K.;Dutta, S.;Gomber, B.;Jain, S.;Jain, S.;Khurana, R.;Modak, A.;Mukherjee, S.;Roy, D.;Sarkar, S.;Sharan, M.;Abdulsalam, A.;Dutta, D.;Kumar, V.;Mohanty, A. K.;Pant, L. M.;Shukla, P.;Topkar, A.;Aziz, T.;Banerjee, S.;Bhowmik, S.;Chatterjee, R. M.;Dewanjee, R. K.;Dugad, S.;Ganguly, S.;Ghosh, S.;Guchait, M.;Gurtu, A.;Kole, G.;Kumar, S.;Maity, M.;Majumder, G.;Mazumdar, K.;Mohanty, G. B.;Parida, B.;Sudhakar, K.;Wickramage, N.;Sharma, S.;Bakhshiansohi, H.;Behnamian, H.;Etesami, S. M.;Fahim, A.;Goldouzian, R.;Khakzad, M.;Najafabadi, M. M.;Naseri, M.;Mehdiabadi, S. P.;Hosseinabadi, F. R.;Safarzadeh, B.;Zeinali, M.;Felcini, M.;Grunewald, M.;Abbrescia, M.;Calabria, C.;Chhibra, S. S.;Colaleo, A.;Creanza, D.;Cristella, L.;De Filippis, N.;De Palma, M.;Fiore, L.;Iaselli, G.;Maggi, G.;Maggi, M.;My, S.;Nuzzo, S.;Pompili, A.;Pugliese, G.;Radogna, R.;Selvaggi, G.;Sharma, A.;Silvestris, L.;Venditti, R.;Verwilligen, P.;Abbiendi, G.;Benvenuti, A. C.;Bonacorsi, D.;Braibant-Giacomelli, S.;Brigliadori, L.;Campanini, R.;Capiluppi, P.;Castro, A.;Cavallo, F. R.;Codispoti, G.;Cuffiani, M.;Dallavalle, G. M.;Fabbri, F.;Fanfani, A.;Fasanella, D.;Giacomelli, P.;Grandi, C.;Guiducci, L.;Marcellini, S.;Masetti, G.;Montanari, A.;Navarria, F. L.;Perrotta, A.;Rossi, A. M.;Rovelli, T.;Siroli, G. P.;Tosi, N.;Travaglini, R.;Albergo, S.;Cappello, G.;Chiorboli, M.;Costa, S.;Giordano, F.;Potenza, R.;Tricomi, A.;Tuve, C.;Barbagli, G.;Ciulli, V.;Civinini, C.;D'Alessandro, R.;Focardi, E.;Gallo, E.;Gonzi, S.;Gori, V.;Lenzi, P.;Meschini, M.;Paoletti, S.;Sguazzoni, G.;Tropiano, A.;Benussi, L.;Bianco, S.;Fabbri, F.;Piccolo, D.;Ferretti, R.;Ferro, F.;Lo Vetere, M.;Robutti, E.;Tosi, S.;Dinardo, M. E.;Fiorendi, S.;Gennai, S.;Gerosa, R.;Ghezzi, A.;Govoni, P.;Lucchini, M. T.;Malvezzi, S.;Manzoni, R. A.;Martelli, A.;Marzocchi, B.;Menasce, D.;Moroni, L.;Paganoni, M.;Pedrini, D.;Ragazzi, S.;Redaelli, N.;de Fatis, T. T.;Buontempo, S.;Cavallo, N.;Di Guida, S.;Fabozzi, F.;Iorio, A. O. M.;Lista, L.;Meola, S.;Merola, M.;Paolucci, P.;Azzi, P.;Bacchetta, N.;Bisello, D.;Branca, A.;Carlin, R.;Checchia, P.;Dall'Osso, M.;Dorigo, T.;Dosselli, U.;Gasparini, F.;Gasparini, U.;Gozzelino, A.;Kanishchev, K.;Lacaprara, S.;Margoni, M.;Meneguzzo, A. T.;Pazzini, J.;Pozzobon, N.;Ronchese, P.;Simonetto, F.;Torassa, E.;Tosi, M.;Zotto, P.;Zucchetta, A.;Zumerle, G.;Gabusi, M.;Ratti, S. P.;Re, V.;Riccardi, C.;Salvini, P.;Vitulo, P.;Biasini, M.;Bilei, G. M.;Ciangottini, D.;Fano, L.;Lariccia, P.;Mantovani, G.;Menichelli, M.;Saha, A.;Santocchia, A.;Spiezia, A.;Androsov, K.;Azzurri, P.;Bagliesi, G.;Bernardini, J.;Boccali, T.;Broccolo, G.;Castaldi, R.;Ciocci, M. A.;Dell'Orso, R.;Donato, S.;Fedi, G.;Fiori, F.;Foa, L.;Giassi, A.;Grippo, M. T.;Ligabue, F.;Lomtadze, T.;Martini, L.;Messineo, A.;Moon, C. S.;Palla, F.;Rizzi, A.;Savoy-Navarro, A.;Serban, A. T.;Spagnolo, P.;Squillacioti, P.;Tenchini, R.;Tonelli, G.;Venturi, A.;Verdini, P. G.;Vernieri, C.;Barone, L.;Cavallari, F.;D'Imperio, G.;Del Re, D.;Diemoz, M.;Jorda, C.;Longo, E.;Margaroli, F.;Meridiani, P.;Micheli, F.;Organtini, G.;Paramatti, R.;Rahatlou, S.;Rovelli, C.;Santanastasio, F.;Soffi, L.;Traczyk, P.;Amapane, N.;Arcidiacono, R.;Argiro, S.;Arneodo, M.;Bellan, R.;Biino, C.;Cartiglia, N.;Casasso, S.;Costa, M.;Covarelli, R.;Degano, A.;Demaria, N.;Finco, L.;Mariotti, C.;Maselli, S.;Migliore, E.;Monaco, V.;Musich, M.;Obertino, M.;Pacher, L.;Pastrone, N.;Pelliccioni, M.;Angioni, G. L. P.;Potenza, A.;Romero, A.;Ruspa, M.;Sacchi, R.;Solano, A.;Staiano, A.;Tamponi, U.;Belforte, S.;Candelise, V.;Casarsa, M.;Cossutti, F.;Della Ricca, G.;Gobbo, B.;La Licata, C.;Marone, M.;Schizzi, A.;Umer, T.;Zanetti, A.;Chang, S.;Kropivnitskaya, A.;Nam, S. K.;Kim, D. H.;Kim, G. N.;Kim, M. S.;Kong, D. J.;Lee, S.;Oh, Y. D.;Park, H.;Sakharov, A.;Son, D. C.;Kim, T. J.;Ryu, M. S.;Kim, J. Y.;Moon, D. H.;Song, S.;Choi, S.;Gyun, D.;Hong, B.;Jo, M.;Kim, H.;Kim, Y.;Lee, B.;Lee, K. S.;Park, S. K.;Roh, Y.;Yoo, H. D.;Choi, M.;Kim, J. H.;Park, I. C.;Ryu, G.;Choi, Y.;Choi, Y. K.;Goh, J.;Kim, D.;Kwon, E.;Lee, J.;Yu, I.;Juodagalvis, A.;Komaragiri, J. R.;Ali, Mabm;Linares, E. C.;Castilla-Valdez, H.;De La Cruz-Burelo, E.;Heredia-de La Cruz, I.;Hernandez-Almada, A.;Lopez-Fernandez, R.;Sanchez-Hernandez, A.;Moreno, S. C.;Valencia, F. V.;Pedraza, I.;Ibarguen, H. A. S.;Pineda, A. M.;Krofcheck, D.;Butler, P. H.;Reucroft, S.;Ahmad, A.;Ahmad, M.;Hassan, Q.;Hoorani, H. R.;Khan, W. A.;Khurshid, T.;Shoaib, M.;Bialkowska, H.;Bluj, M.;Boimska, B.;Frueboes, T.;Gorski, M.;Kazana, M.;Nawrocki, K.;Romanowska-Rybinska, K.;Szleper, M.;Zalewski, P.;Brona, G.;Bunkowski, K.;Cwiok, M.;Dominik, W.;Doroba, K.;Kalinowski, A.;Konecki, M.;Krolikowski, J.;Misiura, M.;Olszewski, M.;Bargassa, P.;Silva, Cbde;Faccioli, P.;Parracho, P. G. F.;Gallinaro, M.;Iglesias, L. L.;Nguyen, F.;Antunes, J. R.;Seixas, J.;Varela, J.;Vischia, P.;Bunin, P.;Golutvin, I.;Gorbunov, I.;Karjavin, V.;Konoplyanikov, V.;Kozlov, G.;Lanev, A.;Malakhov, A.;Matveev, V.;Moisenz, P.;Palichik, V.;Perelygin, V.;Savina, M.;Shmatov, S.;Shulha, S.;Skatchkov, N.;Smirnov, V.;Zarubin, A.;Golovtsov, V.;Ivanov, Y.;Kim, V.;Kuznetsova, E.;Levchenko, P.;Murzin, V.;Oreshkin, V.;Smirnov, I.;Sulimov, V.;Uvarov, L.;Vavilov, S.;Vorobyev, A.;Vorobyev, A.;Andreev, Y.;Dermenev, A.;Gninenko, S.;Golubev, N.;Kirsanov, M.;Krasnikov, N.;Pashenkov, A.;Tlisov, D.;Toropin, A.;Epshteyn, V.;Gavrilov, V.;Lychkovskaya, N.;Popov, V.;Pozdnyakov, I.;Safronov, G.;Semenov, S.;Spiridonov, A.;Stolin, V.;Vlasov, E.;Zhokin, A.;Andreev, V.;Azarkin, M.;Dremin, I.;Kirakosyan, M.;Leonidov, A.;Mesyats, G.;Rusakov, S. V.;Vinogradov, A.;Belyaev, A.;Boos, E.;Bunichev, V.;Dubinin, M.;Dudko, L.;Ershov, A.;Gribushin, A.;Klyukhin, V.;Kodolova, O.;Lokhtin, I.;Obraztsov, S.;Savrin, V.;Snigirev, A.;Azhgirey, I.;Bayshev, I.;Bitioukov, S.;Kachanov, V.;Kalinin, A.;Konstantinov, D.;Krychkine, V.;Petrov, V.;Ryutin, R.;Sobol, A.;Tourtchanovitch, L.;Troshin, S.;Tyurin, N.;Uzunian, A.;Volkov, A.;Adzic, P.;Ekmedzic, M.;Milosevic, J.;Rekovic, V.;Maestre, J. A.;Battilana, C.;Calvo, E.;Cerrada, M.;Llatas, M. C.;Colino, N.;De La Cruz, B.;Peris, A. D.;Vazquez, D. D.;Del Valle, A. E.;Bedoya, C. F.;Ramos, J. P. F.;Flix, J.;Fouz, M. C.;Garcia-Abia, P.;Lopez, O. G.;Lopez, S. G.;Hernandez, J. M.;Josa, M. I.;De Martino, E. N.;Yzquierdo, A. P. C.;Pelayo, J. P.;Olmeda, A. Q.;Redondo, I.;Romero, L.;Soares, M. S.;Albajar, C.;de Troconiz, J. F.;Missiroli, M.;Moran, D.;Brun, H.;Cuevas, J.;Menendez, J. F.;Folgueras, S.;Caballero, I. G.;Cifuentes, J. A. B.;Cabrillo, I. J.;Calderon, A.;Campderros, J. D.;Fernandez, M.;Gomez, G.;Graziano, A.;Virto, A. L.;Marco, J.;Marco, R.;Rivero, C. M.;Matorras, F.;Sanchez, F. J. M.;Gomez, J. P.;Rodrigo, T.;Rodriguez-Marrero, A. Y.;Ruiz-Jimeno, A.;Scodellaro, L.;Vila, I.;Cortabitarte, R. V.;Abbaneo, D.;Auffray, E.;Auzinger, G.;Bachtis, M.;Baillon, P.;Ball, A. H.;Barney, D.;Benaglia, A.;Bendavid, J.;Benhabib, L.;Benitez, J. F.;Bloch, P.;Bocci, A.;Bonato, A.;Bondu, O.;Botta, C.;Breuker, H.;Camporesi, T.;Cerminara, G.;Colafranceschi, S.;D'Alfonso, M.;d'Enterria, D.;Dabrowski, A.;David, A.;De Guio, F.;De Roeck, A.;De Visscher, S.;Di Marco, E.;Dobson, M.;Dordevic, M.;Dorney, B.;Dupont-Sagorin, N.;Elliott-Peisert, A.;Franzoni, G.;Funk, W.;Gigi, D.;Gill, K.;Giordano, D.;Girone, M.;Glege, F.;Guida, R.;Gundacker, S.;Guthoff, M.;Hammer, J.;Hansen, M.;Harris, P.;Hegeman, J.;Innocente, V.;Janot, P.;Kousouris, K.;Krajczar, K.;Lecoq, P.;Lourenco, C.;Magini, N.;Malgeri, L.;Mannelli, M.;Marrouche, J.;Masetti, L.;Meijers, F.;Mersi, S.;Meschi, E.;Moortgat, F.;Morovic, S.;Mulders, M.;Orsini, L.;Pape, L.;Perez, E.;Petrilli, A.;Petrucciani, G.;Pfeiffer, A.;Pimia, M.;Piparo, D.;Plagge, M.;Racz, A.;Rolandi, G.;Rovere, M.;Sakulin, H.;Schafer, C.;Schwick, C.;Sharma, A.;Siegrist, P.;Silva, P.;Simon, M.;Sphicas, P.;Spiga, D.;Steggemann, J.;Stieger, B.;Stoye, M.;Takahashi, Y.;Treille, D.;Tsirou, A.;Veres, G. I.;Wardle, N.;Wohri, H. K.;Wollny, H.;Zeuner, W. D.;Bertl, W.;Deiters, K.;Erdmann, W.;Horisberger, R.;Ingram, Q.;Kaestli, H. C.;Kotlinski, D.;Langenegger, U.;Renker, D.;Rohe, T.;Bachmair, F.;Bani, L.;Bianchini, L.;Buchmann, M. A.;Casal, B.;Chanon, N.;Dissertori, G.;Dittmar, M.;Donega, M.;Dunser, M.;Eller, P.;Grab, C.;Hits, D.;Hoss, J.;Lustermann, W.;Mangano, B.;Marini, A. C.;Marionneau, M.;del Arbol, P. M. R.;Masciovecchio, M.;Meister, D.;Mohr, N.;Musella, P.;Nageli, C.;Nessi-Tedaldi, F.;Pandolfi, F.;Pauss, F.;Perrozzi, L.;Peruzzi, M.;Quittnat, M.;Rebane, L.;Rossini, M.;Starodumov, A.;Takahashi, M.;Theofilatos, K.;Wallny, R.;Weber, H. A.;Amsler, C.;Canelli, M. F.;Chiochia, V.;De Cosa, A.;Hinzmann, A.;Hreus, T.;Kilminster, B.;Lange, C.;Ngadiuba, J.;Pinna, D.;Robmann, P.;Ronga, F. J.;Taroni, S.;Verzetti, M.;Yang, Y.;Cardaci, M.;Chen, K. H.;Ferro, C.;Kuo, M.;Lin, W.;Lu, Y. J.;Volpe, R.;Yu, S. S.;Chang, P.;Chang, Y. H.;Chao, Y.;Chen, K. F.;Chen, P. H.;Dietz, C.;Grundler, U.;Hou, W. S.;Liu, Y. F.;Lu, R. S.;Moya, M. M.;Petrakou, E.;Tzeng, Y. M.;Wilken, R.;Asavapibhop, B.;Singh, G.;Srimanobhas, N.;Suwonjandee, N.;Adiguzel, A.;Bakirci, M. N.;Cerci, S.;Dozen, C.;Dumanoglu, I.;Eskut, E.;Girgis, S.;Gokbulut, G.;Guler, Y.;Gurpinar, E.;Hos, I.;Kangal, E. E.;Topaksu, A. K.;Onengut, G.;Ozdemir, K.;Ozturk, S.;Polatoz, A.;Cerci, D. S.;Tali, B.;Topakli, H.;Vergili, M.;Zorbilmez, C.;Akin, I. V.;Bilin, B.;Bilmis, S.;Gamsizkan, H.;Isildak, B.;Karapinar, G.;Ocalan, K.;Sekmen, S.;Surat, U. E.;Yalvac, M.;Zeyrek, M.;Albayrak, E. A.;Gulmez, E.;Kaya, M.;Kaya, O.;Yetkin, T.;Cankocak, K.;Vardarli, F. I.;Levchuk, L.;Sorokin, P.;Brooke, J. J.;Clement, E.;Cussans, D.;Flacher, H.;Goldstein, J.;Grimes, M.;Heath, G. P.;Heath, H. F.;Jacob, J.;Kreczko, L.;Lucas, C.;Meng, Z.;Newbold, D. M.;Paramesvaran, S.;Poll, A.;Sakuma, T.;El Nasr-storey, S. S.;Senkin, S.;Smith, V. J.;Bell, K. W.;Belyaev, A.;Brew, C.;Brown, R. M.;Cockerill, D. J. A.;Coughlan, J. A.;Harder, K.;Harper, S.;Olaiya, E.;Petyt, D.;Shepherd-Themistocleous, C. H.;Thea, A.;Tomalin, I. R.;Williams, T.;Womersley, W. J.;Worm, S. D.;Baber, M.;Bainbridge, R.;Buchmuller, O.;Burton, D.;Colling, D.;Cripps, N.;Dauncey, P.;Davies, G.;Della Negra, M.;Dunne, P.;Elwood, A.;Ferguson, W.;Fulcher, J.;Futyan, D.;Hall, G.;Iles, G.;Jarvis, M.;Karapostoli, G.;Kenzie, M.;Lane, R.;Lucas, R.;Lyons, L.;Magnan, A. M.;Malik, S.;Mathias, B.;Nash, J.;Nikitenko, A.;Pela, J.;Pesaresi, M.;Petridis, K.;Raymond, D. M.;Rogerson, S.;Rose, A.;Seez, C.;Sharp, P.;Tapper, A.;Acosta, M. V.;Virdee, T.;Zenz, S. C.;Cole, J. E.;Hobson, P. R.;Khan, A.;Kyberd, P.;Leggat, D.;Leslie, D.;Reid, I. D.;Symonds, P.;Teodorescu, L.;Turner, M.;Dittmann, J.;Hatakeyama, K.;Kasmi, A.;Liu, H.;Pastika, N.;Scarborough, T.;Wu, Z.;Charaf, O.;Cooper, S. I.;Henderson, C.;Rumerio, P.;Avetisyan, A.;Bose, T.;Fantasia, C.;Lawson, P.;Richardson, C.;Rohlf, J.;John, J. S.;Sulak, L.;Alimena, J.;Berry, E.;Bhattacharya, S.;Christopher, G.;Cutts, D.;Demiragli, Z.;Dhingra, N.;Ferapontov, A.;Garabedian, A.;Heintz, U.;Kukartsev, G.;Laird, E.;Landsberg, G.;Luk, M.;Narain, M.;Segala, M.;Sinthuprasith, T.;Speer, T.;Swanson, J.;Breedon, R.;Breto, G.;Sanchez, M. C. D.;Chauhan, S.;Chertok, M.;Conway, J.;Conway, R.;Cox, P. T.;Erbacher, R.;Gardner, M.;Ko, W.;Lander, R.;Mulhearn, M.;Pellett, D.;Pilot, J.;Ricci-Tam, F.;Shalhout, S.;Smith, J.;Squires, M.;Stolp, D.;Tripathi, M.;Wilbur, S.;Yohay, R.;Cousins, R.;Everaerts, P.;Farrell, C.;Hauser, J.;Ignatenko, M.;Rakness, G.;Takasugi, E.;Valuev, V.;Weber, M.;Burt, K.;Clare, R.;Ellison, J.;Gary, J. W.;Hanson, G.;Heilman, J.;Rikova, M. I.;Jandir, P.;Kennedy, E.;Lacroix, F.;Long, O. R.;Luthra, A.;Malberti, M.;Negrete, M. O.;Shrinivas, A.;Sumowidagdo, S.;Wimpenny, S.;Branson, J. G.;Cerati, G. B.;Cittolin, S.;D'Agnolo, R. T.;Holzner, A.;Kelley, R.;Klein, D.;Letts, J.;Macneill, I.;Olivito, D.;Padhi, S.;Palmer, C.;Pieri, M.;Sani, M.;Sharma, V.;Simon, S.;Tadel, M.;Tu, Y.;Vartak, A.;Welke, C.;Wurthwein, F.;Yagil, A.;Della Porta, G. Z.;Barge, D.;Bradmiller-Feld, J.;Campagnari, C.;Danielson, T.;Dishaw, A.;Dutta, V.;Flowers, K.;Sevilla, M. F.;Geffert, P.;George, C.;Golf, F.;Gouskos, L.;Incandela, J.;Justus, C.;McColl, N.;Mullin, S. D.;Richman, J.;Stuart, D.;To, W.;West, C.;Yoo, J.;Apresyan, A.;Bornheim, A.;Bunn, J.;Chen, Y.;Duarte, J.;Mott, A.;Newman, H. B.;Pena, C.;Pierini, M.;Spiropulu, M.;Vlimant, J. R.;Wilkinson, R.;Xie, S.;Zhu, R. Y.;Azzolini, V.;Calamba, A.;Carlson, B.;Ferguson, T.;Iiyama, Y.;Paulini, M.;Russ, J.;Vogel, H.;Vorobiev, I.;Cumalat, J. P.;Ford, W. T.;Gaz, A.;Krohn, M.;Lopez, E. L.;Nauenberg, U.;Smith, J. G.;Stenson, K.;Wagner, S. R.;Alexander, J.;Chatterjee, A.;Chaves, J.;Chu, J.;Dittmer, S.;Eggert, N.;Mirman, N.;Kaufman, G. N.;Patterson, J. R.;Ryd, A.;Salvati, E.;Skinnari, L.;Sun, W.;Teo, W. D.;Thom, J.;Thompson, J.;Tucker, J.;Weng, Y.;Winstrom, L.;Wittich, P.;Winn, D.;Abdullin, S.;Albrow, M.;Anderson, J.;Apollinari, G.;Bauerdick, L. A. T.;Beretvas, A.;Berryhill, J.;Bhat, P. C.;Bolla, G.;Burkett, K.;Butler, J. N.;Cheung, H. W. K.;Chlebana, F.;Cihangir, S.;Elvira, V. D.;Fisk, I.;Freeman, J.;Gottschalk, E.;Gray, L.;Green, D.;Grunendahl, S.;Gutsche, O.;Hanlon, J.;Hare, D.;Harris, R. M.;Hirschauer, J.;Hooberman, B.;Jindariani, S.;Johnson, M.;Joshi, U.;Klima, B.;Kreis, B.;Kwan,

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells reveals a role for innate immune cells in Treg transplant recruitment

Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs was shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical trials. Despite these successes, the in vivo distribution and persistence of adoptively transferred Tregs remained elusive which hampers clinical translation. Here, we isolated human Tregs using a GMP-compatible protocol and lentivirally transduced them with the human sodium iodide symporter to render them traceable in vivo by radionuclide imaging. Engineered human Tregs were characterized for phenotype, survival, suppressive capacity, and reporter function. To study their trafficking behaviour, they were subsequently administered to humanized mice with human skin transplants. Traceable Tregs were quantified in skin grafts by non-invasive nanoSPECT/CT for up to 40 days and results validated ex vivo. Using this approach, we demonstrated that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1⁺ innate immune cells. We demonstrated the utility of radionuclide reporter gene afforded quantitative Treg in vivo tracking thereby addressing a fundamental need in Treg therapy development and offering clinically compatible methodology for future Treg therapy imaging in humans