Mocarts: a lightweight radiation transport simulator for easy handling of complex sensing geometries

In functional neuroimaging (fNIRS), elaborated sensing geometries pairing multiple light sources and detectors arranged over the tissue surface are needed. A variety of software tools for probing forward models of radiation transport in tissue exist, but their handling of sensing geometries and specification of complex tissue architectures is, most times, cumbersome. In this work, we introduce a lightweight simulator, Monte Carlo Radiation Transport Simulator (MOCARTS) that attends these demands for simplifying specification of tissue architectures and complex sensing geometries. An object-oriented architecture facilitates such goal. The simulator core is evolved from the Monte Carlo Multi-Layer (mcml) tool but extended to support multi-channel simulations. Verification against mcml yields negligible error (RMSE~4-10e-9) over a photon trajectory. Full simulations show concurrent validity of the proposed tool. Finally, the ability of the new software to simulate multi-channel sensing geometries and to define biological tissue models in an intuitive nested-hierarchy way are exemplified

Efficiency Evaluation of Fully Integrated On-board EV Battery Chargers with Nine-Phase Machines

A fully integrated on-board battery charger for future electric vehicles (EVs) has been recently introduced. It re-utilizes all the propulsion components of an EV in charging/vehicle-to-grid (V2G) modes, it does not require any additional components or hardware reconfiguration, and charging/V2G modes are realized with zero electromagnetic torque production. Both fast (three-phase) and slow (single-phase) charging are possible, with unity power factor operation at the grid side. The solution is based on the use of a triple three-phase machine and a nine-phase inverter/rectifier. This paper reports on the results of efficiency evaluation for the said system. Testing is performed using both a nine-phase induction machine and a nine-phase permanent magnet (PM) machine for a range of operating conditions in charging/V2G modes, with both three-phase and single-phase grid connection. Additionally, the impact of converter interleaving on the losses and efficiency is also studied. Losses are separated for different subsystems, thus providing an insight into the importance of optimization of different EV power train components from the efficiency point of view. Promising efficiencies, in the order of 90%, are achieved although none of the system components have been optimized

An Integrated On-Board Battery Charger with a Nine-Phase PM Machine

A fully integrated on-board battery charger for electrical vehicles (EVs) has been developed recently using a nine-phase machine. All the components used for propulsion are employed in the charging process, no additional components are required, and there is no need for hardware reconfiguration between charging and propulsion modes of operation. The proposed solution can be connected directly to single-phase or three-phase grid to perform charging, so that the expensive off-board charger infrastructure is not needed. The only requirement is to use a nine-phase machine in combination with a nine-phase inverter in the powertrain of the EV. This however inevitably brings in further advantages in the propulsion mode, such as increased fault tolerance and the current subdivision into more phases. The benefits of the topology, originally developed for an induction machine, make it interesting for further investigation. Therefore, the performance of the charger is examined here using a permanent magnet synchronous machine (PMSM). The results show that the charger topology is applicable to other types of synchronous machines and is, even more importantly, independent of the angular spatial shift between the individual three-phase windings of the nine-phase machine’s stator. The results are comparable with those obtained using an induction machine and confirm the viability of the solution in conjunction with the PMSM as a propulsion motor

Lubrication performance of an ammonium cation-based ionic liquid used as an additive in a polar oil.

This paper studies the tribological behavior of the ionic liquid methyltrioctylammonium bis(trifluoromethylsulfonyl)imide ([N 1888 ][NTf 2 ]) as additive at different concentrations (1.25, 2.50, 3.75 and 5.00 wt%) in a polar base oil (diester). A tribometer using a ball-on-disk reciprocating configuration under fully flooded lubrication was used at a frequency of 15 Hz, at three different loads (40, 80 and 120 N), stroke length of 4 mm, and duration of 45 min. Worn surface on the disk was studied by confocal microscopy, SEM and XPS. Main results showed similar coefficient of friction for all lubricant samples; but different wear results were found at different loads, probably related with the chemical states found for fluorine on the worn surface and the temperature-dependent adsorption-desorption processes

Collaborative Gaze Channelling for Improved Cooperation During Robotic Assisted Surgery

The use of multiple robots for performing complex tasks is becoming a common practice for many robot applications. When different operators are involved, effective cooperation with anticipated manoeuvres is important for seamless, synergistic control of all the end-effectors. In this paper, the concept of Collaborative Gaze Channelling (CGC) is presented for improved control of surgical robots for a shared task. Through eye tracking, the fixations of each operator are monitored and presented in a shared surgical workspace. CGC permits remote or physically separated collaborators to share their intention by visualising the eye gaze of their counterparts, and thus recovers, to a certain extent, the information of mutual intent that we rely upon in a vis-à-vis working setting. In this study, the efficiency of surgical manipulation with and without CGC for controlling a pair of bimanual surgical robots is evaluated by analysing the level of coordination of two independent operators. Fitts' law is used to compare the quality of movement with or without CGC. A total of 40 subjects have been recruited for this study and the results show that the proposed CGC framework exhibits significant improvement (p<0.05) on all the motion indices used for quality assessment. This study demonstrates that visual guidance is an implicit yet effective way of communication during collaborative tasks for robotic surgery. Detailed experimental validation results demonstrate the potential clinical value of the proposed CGC framework. © 2012 Biomedical Engineering Society.link_to_subscribed_fulltex

Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer

Background Apalutamide, a competitive inhibitor of the androgen receptor, is under development for the treatment of prostate cancer. We evaluated the efficacy of apalutamide in men with nonmetastatic castration-resistant prostate cancer who were at high risk for the development of metastasis. Methods We conducted a double-blind, placebo-controlled, phase 3 trial involving men with nonmetastatic castration-resistant prostate cancer and a prostate-specific antigen doubling time of 10 months or less. Patients were randomly assigned, in a 2:1 ratio, to receive apalutamide (240 mg per day) or placebo. All the patients continued to receive androgen-deprivation therapy. The primary end point was metastasis-free survival, which was defined as the time from randomization to the first detection of distant metastasis on imaging or death. Results A total of 1207 men underwent randomization (806 to the apalutamide group and 401 to the placebo group). In the planned primary analysis, which was performed after 378 events had occurred, median metastasis-free survival was 40.5 months in the apalutamide group as compared with 16.2 months in the placebo group (hazard ratio for metastasis or death, 0.28; 95% confidence interval [CI], 0.23 to 0.35;