Strategies for Reducing Adverse Outcomes for Criminal Justice-Involved Populations

In the United States, we spend $81 billion taxpayer dollars annually on the costs of incarceration according to the Bureau of Justice Statistics, but including other costs may increase that estimate to$181 billion. Data from Worcester suggest that the cost of incarcerating individuals in the Piedmont neighborhood of Worcester eclipse the entire annual budget of the Division of Public Health in Worcester. With a hard line on petty crime, lack of substance use disorder treatment in jail and prison, concentrated policing and racial profiling in low income communities of color and poor reentry support services, mass incarceration is destined to continue. The opioid crisis in Massachusetts has affirmed that individuals with a history of incarceration and opioid use disorder are at greatest risk for nonfatal and fatal overdose. Furthermore, homelessness and serious mental illness increase that risk dramatically. In turn, the Governor and Secretary of Health and Human Services in concert with the Massachusetts Medicaid Program, the Department of Public Health and the Trial courts have undertaken a multi-pronged strategy to mitigate those risks. This panel will present three interventions to improve those outcomes. Three panelists will describe and present findings on three studies completed and in process to reduce the health risks for justice-involved persons in Massachusetts. Dr. Ferguson will describe an implementation science study of four correctional systems which embarked on medication assisted therapies for opioid use disorder which has helped to inform current mixed methods research to study a pilot of medication assisted treatment in seven Massachusetts jails; Dr. Pivovarova will describe her study of health status for individuals participating in Drug Court, a diversionary program that mandates substance use disorder treatment in the community for individuals arrested for drug related offenses; and Ms. Dupuis will describe the MassHealth funded Behavioral Health Justice Involved project to provide returning citizens with navigators to assist them in linking to community-based treatment and to address social determinants of health such as housing and employment. During the presentations, attendees will be asked to formulate questions or reflections for discussion. These will be collected and prioritized by the moderator of the session for further discussion

Nanoclay Modification of Shape Memory Polyurethane

Effect of nanoclay modification on the properties of polytetramethylene oxide-based polyurethane was examined. Nanoclay was dispersed in polyurethane wherein the clay content was varied from 1 to 5 wt.%. The nanocomposites were characterized by thermal, FTIR, XRD and thermo-mechanical analyses and their shape memory properties were evaluated. Morphology was examined by TEM analysis. Bending test was adopted for the evaluation of shape memory property. Increase in clay content resulted an increase in transition temperature. Tensile strength and modulus increased proportional to nanoclay content. The elongation decreased with clay content. Intercalated structure of clay in the PU matrix was observed from XRD studies, which was confirmed by TEM analysis. Modulus ratio showed a decreasing trend with nanoclay content. This resulted in decreased shape recovery characteristics. Highest shape recovery of 92% was observed for PU with 1 wt.% clay content. Moderate nanoclay leveling is conducive to deriving mechanically stronger PU without loss of shape memory characteristics

Gender Disparities in Out-of-Hospital Cardiac Arrests

Background Despite advances in resuscitation science and public health, out-of-hospital cardiac arrest (OOHCA) has an average survival rate of only 12% nationwide, compared to 24.8% of patients who suffer from cardiac arrest while in hospital. Additionally, gender is an important element of human health, and there is a clear pattern for gender-specific survivability in cardiac arrest. This study examined differences in presentations, treatment, management, and outcomes. Aim The primary focus of this study was to shed light on differences in presentations, treatments, and outcomes between men and women suffering from an out-of-hospital cardiac arrest and the accompanying contributing factors. Methods All emergency medical services-related data, including age, date, initial rhythm, chemical interventions (i.e., epinephrine, dextrose), blood glucose levels, defibrillations, endotracheal tube (ETT) attempts, final airway management, achievement of return of spontaneous circulation (ROSC), and the conclusion of the case up to the emergency department, were recorded using a standardized emergency medical services (EMS) charting record by the highest-ranking EMS provider on the ambulance. The reports were retrospectively collected and analyzed. Conclusion The study examined demographics, treatments rendered, and outcomes in OOHCA cases that occurred in a major United States (US) city in 2016. Several significant differences in care were noted between men and women. In general, women received less respiratory, chemical, and electrical interventions than men; however, statistically significant differences were only observed in the number of attempts of endotracheal intubations, number of doses of epinephrine per encounter, and number of defibrillations per encounter. In spite of generally receiving less care, women appeared to respond more favorably to cardiac arrest interventions, as demonstrated by higher rates of ROSC. Despite this, women were also found to be eight years older at the time of arrest. Future studies are needed to determine causality in discrepancies between the genders in addition to investigating differences in treatment in other areas of the United States

Optimal Scene Time to Achieve Favorable Outcomes in Out-of-hospital Cardiac Arrest: How Long Is Too Long?

Despite advances in resuscitation science and public health, out-of-hospital cardiac arrest (OOHCA) cases have an average survival rate of only 12% nationwide, compared to 24.8% of cases occurring in hospital. Many factors, including resuscitation interventions, contribute to positive patient outcomes and have, therefore, been studied in attempts to optimize emergency medical services (EMS) protocols to achieve higher rates of return of spontaneous circulation (ROSC) in the field. However, no consensus has been met regarding the appropriate amount of time for EMS to spend on scene

Revealing hidden species diversity in closely related species using nuclear SNPs, SSRs and DNA sequences - a case study in the tree genus Milicia

Background: Species delimitation in closely related plant taxa can be challenging because (i) reproductive barriers are not always congruent with morphological differentiation, (ii) use of plastid sequences might lead to misinterpretation, (iii) rare species might not be sampled. We revisited molecular-based species delimitation in the African genus Milicia, currently divided into M. regia (West Africa) and M. excelsa (from West to East Africa). We used 435 samples collected in West, Central and East Africa. We genotyped SNP and SSR loci to identify genetic clusters, and sequenced two plastid regions (psbA-trnH, trnC-ycf6) and a nuclear gene (At103) to confirm species’ divergence and compare species delimitation methods. We also examined whether ecological niche differentiation was congruent with sampled genetic structure. Results: West African M. regia, West African and East African M. excelsa samples constituted three well distinct genetic clusters according to SNPs and SSRs. In Central Africa, two genetic clusters were consistently inferred by both types of markers, while a few scattered samples, sympatric with the preceding clusters but exhibiting leaf traits of M. regia, were grouped with the West African M. regia cluster based on SNPs or formed a distinct cluster based on SSRs. SSR results were confirmed by sequence data from the nuclear region At103 which revealed three distinct ‘Fields For Recombination’ corresponding to (i) West African M. regia, (ii) Central African samples with leaf traits of M. regia, and (iii) all M. excelsa samples. None of the plastid sequences provide indication of distinct clades of the three species-like units. Niche modelling techniques yielded a significant correlation between niche overlap and genetic distance. Conclusions: Our genetic data suggest that three species of Milicia could be recognized. It is surprising that the occurrence of two species in Central Africa was not reported for this well-known timber tree. Globally, our work highlights the importance of collecting samples in a systematic way and the need for combining different nuclear markers when dealing with species complexes. Recognizing cryptic species is particularly crucial for economically exploited species because some hidden taxa might actually be endangered as they are merged with more abundant species

THE SUSCEPTIBILITY OF RECENT ISOLATES OF Schistosoma mansoni TO PRAZIQUANTEL

Introduction: Schistosomiasis is a chronic disease caused by trematode flatworms of the genus Schistosoma and its control is dependent on a single drug, praziquantel (PZQ), but concerns over PZQ resistance have renewed interest in evaluating the in vitro susceptibility of recent isolates of Schistosoma mansoni to PZQ in comparison with well-established strains in the laboratory. Material and methods: The in vitro activity of PZQ (6.5-0.003 µg/mL) was evaluated in terms of mortality, reduced motor activity and ultrastructural alterations against S. mansoni. Results: After 3 h of incubation, PZQ, at 6.5 µg/mL, caused 100% mortality of all adult worms in the three types of recent isolates, while PZQ was inactive at concentrations of 0.08-0.003 µg/mL after 3 h of incubation. The results show that the SLM and Sotave isolates basically presented the same pattern of susceptibility, differing only in the concentration of 6.5 µg/mL, where deaths occurred from the range of 1.5 h in Sotave and just in the 3 h range of SLM. Additionally, this article presents ultrastructural evidence of rapid severe PZQ-induced surface membrane damage in S. mansoni after treatment with the drug, such as disintegration, sloughing, and erosion of the surface. Conclusion: According to these results, PZQ is very effective to induce tegument destruction of recent isolates of S. mansoni

The Variations in the Level of Angiotensin II Between Subjects in Ajloun City and the Dead Sea Impact Hypertension Parameters

Introduction: Jordan has a unique array of diversity among which having the deepest level in the world, the Dead Sea and an area with high attitudes in Ajloun City which gives us a great chance to study the biological effects on hypertension and possible impacts in selecting the appropriate treatment. Study objectives: to explore the impacts of variations of attitudes in hypertension and the level of beta blockers through studying the level of angiotensin II among study participants and to investigate if the patterns of anti-hypertensive treatments are impacted. Methods and subjects: a cross-sectional study design was carried out among participants from the two different areas. From each area, a total of 500 participants were recruited and surveyed through a questionnaire. Blood pressure was measured for all participants and blood samples were withdrawn to carry out the testing of angiotensin II. Data were analyzed statistically based on the appropriate software including excel and SPSS. The relationships were examined according to independent T-Test. Significance was considered according to p0.05). On the other hand, heart parameters including SBP, DBP, MBP, pulse, and PCV all of which were significantly higher in Ajloun than in the Dead Sea (p=0.001) for all selected variables. The level of angiotensin II was 12.08 ± 5.19 pg/ml in Ajloun and this was higher than that of the Dead Sea (8.84 ± 4.65 pg/ml). The difference in the mean of angiotensin II was statistically significant (p=0.039). Conclusion: the results of the present study showed that living in high altitude compared with the lowest area in the world (the Dead Sea) exposes persons for the risks of hypertension and other cardiovascular diseases. Our findings may lead to better therapeutic strategies particularly when to prescribe angiotensin II based therapies

Lying Behavior, Family Functioning and Adjustment in Early Adolescence

Item does not contain fulltextCommunication between children and parents has been the subject of several studies, examining the effects of, for example, disclosure and secrecy on adolescents' social relationships and adjustment. Less attention has paid to adolescent deception. We developed and tested a new instrument on lying behavior in a sample of 671 parent-adolescent couples. Analyses on the psychometric properties showed that this instrument had one principal component, and high internal consistency, item-total correlations and inter-item correlations. Lying was moderately associated with other indicators of parent-child communication, the quality of the parent-child relationship, and with parenting practices. In addition, frequent lying was moderately related to behavioral problems and emotional problems.10 p