Coronal Variability in the Young Cluster NGC 2516

NGC 2516 has been observed by Chandra several times in order to correct the plate scale of the spacecraft's focal plane instruments. Because of this, Chandra has observed NGC 2516 with all four imaging arrangements available. In addition, NGC 2516 has been observed as part of the High Resolution Camera (HRC) guaranteed time program and is scheduled for return plate scale calibration visits. This makes it the best cluster to study for long-term variability. NGC 2516 is about 140 Myr old and less than 400 pc away. In our first paper, we discussed the detection of 150 X-ray sources (42% of which are identified as cluster members) in the calibration data taken during the orbital activation phase of the Chandra mission. In our second paper, we combined all the extant data sets and detected 284 sources, more than half of which are considered likely cluster members. In this our third paper, we further explore techniques of combining Advanced CCD Imaging Spectrometer (ACIS) and HRC Chandra data for timing analysis. We have been able to combine almost 70 ks of observation time, spread over five epochs, to study variability in this cluster on multiple timescales. We find that while stochastic variability rates are about the same for all objects in the sample, the timescale for detecting variability is shorter for late-type stars. Both stochastic and flare variability rates seen in NGC 2516 are similar to those seen in younger clusters IC 348, NGC 1333, and M42

Chandra Orion Ultradeep Project: Observations and Source Lists

We present a description of the data reduction methods and the derived catalog of more than 1600 X-ray point sources from the exceptionally deep January 2003 Chandra X-ray Observatory observation of the Orion Nebula Cluster and embedded populations around OMC-1. The observation was obtained with Chandra's Advanced CCD Imaging Spectrometer (ACIS) and has been nicknamed the Chandra Orion Ultradeep Project (COUP). With an 838 ks exposure made over a continuous period of 13.2 days, the COUP observation provides the most uniform and comprehensive dataset on the X-ray emission of normal stars ever obtained in the history of X-ray astronomy.Comment: 52 pages, 11 figures, 12 tables. Accepted for publication in ApJS, special issue dedicated to Chandra Orion Ultradeep Project. A version with high quality figures can be found at http://www.astro.psu.edu/users/gkosta/COUP_Methodology.pd

The Einstein Observatory catalog of IPC x ray sources. Volume 1E: Documentation

The Einstein Observatory (HEAO-2, launched November 13, 1978) achieved radically improved sensitivity over previous x-ray missions through the use of focusing optics, which simultaneously afforded greatly reduced background and produced true images. During its 2.5-yr mission, the Einstein X-Ray Telescope was pointed toward some 5,000 celestial targets, most of which were detected, and discovered several thousand additional 'serendipitous' sources in the observed fields. This catalog contains contour diagrams and source data, obtained with the imaging proportional counter in the 0.16 to 3.5 keV energy band, and describes methods for recovering upper limits for any sky position within the observed images. The main catalog consists of six volumes (numbered 2 through 7) of right ascension ordered pages, each containing data for one observation. Along with the primary documentation describing how the catalog was constructed, volume 1 contains a complete source list, results for merged fields, a reference system to published papers, and data useful for calculating upper limits and fluxes

Stellar Activity on the Young Suns of Orion: COUP Observations of K5-7 Pre-Main Sequence Stars

In January 2003, the Chandra Orion Ultradeep Project (COUP) detected about 1400 young stars during a 13.2 day observation of the Orion Nebula Cluster (ONC). This paper studies a well-defined sample of 28 solar-mass COUP sources to characterize the magnetic activity of analogs of the young Sun and thereby to improve understanding of the effects of solar X-rays on the solar nebula during the era of planet formation. We find that active young Suns spend 70% of their time in a characteristic state with relatively constant flux and magnetically confined plasma with temperatures kT_2 = 2.1 * kT_1. During characteristic periods, the 0.5-8 keV X-ray luminosity is about 0.03% of the bolometric luminosity. One or two powerful flares per week with peak luminosities logL_x ~ 30-32 erg/s are typically superposed on this characteristic emission accompanied by heating of the hot plasma component from ~2.4 keV to ~7 keV at the flare peak. The energy distribution of flares superposed on the characteristic emission level follows the relationship dN/dE ~ E^-1.7. The flare rates are consistent with the production of sufficiently energetic protons to spawn a spallogenic origin of some important short-lived radionuclides found in ancient meteorites. The X-rays can ionize gas in the circumstellar disk at a rate of 6 10^-9 ionizations per second at 1 AU from the central star, orders of magnitude above cosmic ray ionization rates. The estimated energetic particle fluences are sufficient to a account for many isotopic anomalies observed in meteoritic inclusions.Comment: 49 pages, 12 figures. Accepted for publication in the Astrophysical Journal Supplements, COUP Special Issue (Oct 2005). For version with higher quality figures, see http://www.astro.psu.edu/coup/Suns.htm

High Resolution X-ray Spectroscopy of the Post-T Tauri Star PZ Tel

We present an analysis of the Chandra High Energy Transmission Grating Spectrometer observation of the rapidly rotating P_(rot)=0.94 d post T Tauri (~20 Myr old) star PZ Telescopii, in the Tucana association. Using two different methods we have derived the coronal emission measure distribution, em(T), and chemical abundances. The em(T) peaks at log T = 6.9 and exhibits a significant emission measure at temperatures log T > 7. The coronal abundances are generally ~0.5 times the solar photospheric values that are presumed fairly representative of the composition of the underlying star. A minimum in abundance is seen at a first ionization potential (FIP) of 7-8 eV, with evidence for higher abundances at both lower and higher FIP, similar to patterns seen in other active stars. From an analysis of the He-like triplet of Mg XI we have estimated electron densities of ~10^(12)-10^(13) cm^(-3). All the coronal properties found for PZ Tel are much more similar to those of AB Dor, which is slightly older than PZ Tel, than to those of the younger T Tauri star TW Hya. These results support earlier conclusions that the soft X-ray emission of TW Hya is likely dominated by accretion activity rather than by a magnetically-heated corona. Our results also suggest that the coronae of pre-main sequence stars rapidly become similar to those of older active main-sequence stars soon after the accretion stage has ended.Comment: 15 pages, 8 Postscript figures, accepted for publication in Astrophysical Journa

The association of acrocentric chromosomes in 1000 normal human male metaphase cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65834/1/j.1469-1809.1967.tb00544.x.pd

Effect of oral prednisolone on symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection: a randomized clinical trial

Importance: Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. Objective: To assess the effects of oral corticosteroids for acute lower respiratory tract infection in adults without asthma. Design, Setting, and Participants: Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014) conducted in 54 family practices in England among 401 adults with acute cough and at least 1 lower respiratory tract symptom not requiring immediate antibiotic treatment and with no history of chronic pulmonary disease or use of asthma medication in the past 5 years. Interventions: Two 20-mg prednisolone tablets (n = 199) or matched placebo (n = 202) once daily for 5 days. Main Outcomes and Measures: The primary outcomes were duration of moderately bad or worse cough (0 to 28 days; minimal clinically important difference, 3.79 days) and mean severity of symptoms on days 2 to 4 (scored from 0 [not affected] to 6 [as bad as it could be]; minimal clinically important difference, 1.66 units). Secondary outcomes were duration and severity of acute lower respiratory tract infection symptoms, duration of abnormal peak flow, antibiotic use, and adverse events. Results: Among 401 randomized patients, 2 withdrew immediately after randomization, and 1 duplicate patient was identified. Among the 398 patients with baseline data (mean age, 47 [SD, 16.0] years; 63% women; 17% smokers; 77% phlegm; 70% shortness of breath; 47% wheezing; 46% chest pain; 42% abnormal peak flow), 334 (84%) provided cough duration and 369 (93%) symptom severity data. Median cough duration was 5 days (interquartile range [IQR], 3-8 days) in the prednisolone group and 5 days (IQR, 3-10 days) in the placebo group (adjusted hazard ratio, 1.11; 95% CI, 0.89-1.39; P = .36 at an α = .05). Mean symptom severity was 1.99 points in the prednisolone group and 2.16 points in the placebo group (adjusted difference, −0.20; 95% CI, −0.40 to 0.00; P = .05 at an α = .001). No significant treatment effects were observed for duration or severity of other acute lower respiratory tract infection symptoms, duration of abnormal peak flow, antibiotic use, or nonserious adverse events. There were no serious adverse events. Conclusions and Relevance: Oral corticosteroids should not be used for acute lower respiratory tract infection symptoms in adults without asthma because they do not reduce symptom duration or severity

Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma

Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17.1%). Furthermore, somatic loss of chromosome Y (LOY) was detected in about 40% of male subjects, while mosaic LOY was detected in DNA isolated from peripheral blood in 9.6% of them, and was the only recurrent CNV in constitutional DNA samples. LOY in constitutional DNA, but not in tumor DNA was associated with older age. Amongst Y-linked genes that were downregulated due to LOY, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked homologs whose deficiency is involved in ccRCC progression. Our findings establish somatic LOY as a highly recurrent genetic defect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factors, and suggest that different mechanisms may underlie the somatic and mosaic LOY observed in tumors and peripheral blood, respectively

The Einstein Observatory catalog of IPC x ray sources. Volume 7E: Right ascension range 20h 00m to 23h 59m

The Einstein Observatory (HEAO-2, launched November 13, 1978) achieved radically improved sensitivity over previous x-ray missions through the use of focusing optics which simultaneously afforded greatly reduced background and produced true images. During its 2.5-yr mission, the Einstein X-Ray Telescope was pointed toward some 5,000 celestial targets, most of which were detected, and discovered several thousand additional 'serendipitous' sources in the observed fields. This catalog contains contour diagrams and source data, obtained with the imaging proportional counter in the 0.16 to 3.5 keV energy band, and describes methods for recovering upper limits for any sky position within the observed images. The main catalog consists of six volumes (numbered 2 through 7) of right ascension ordered pages, each containing data for one observation. Along with the primary documentation describing how the catalog was constructed, volume 1 contains a complete source list, results for merged fields, a reference system to published papers, and data useful for calculating upper limits and fluxes