154 research outputs found
FastVentricle: Cardiac Segmentation with ENet
Cardiac Magnetic Resonance (CMR) imaging is commonly used to assess cardiac
structure and function. One disadvantage of CMR is that post-processing of
exams is tedious. Without automation, precise assessment of cardiac function
via CMR typically requires an annotator to spend tens of minutes per case
manually contouring ventricular structures. Automatic contouring can lower the
required time per patient by generating contour suggestions that can be lightly
modified by the annotator. Fully convolutional networks (FCNs), a variant of
convolutional neural networks, have been used to rapidly advance the
state-of-the-art in automated segmentation, which makes FCNs a natural choice
for ventricular segmentation. However, FCNs are limited by their computational
cost, which increases the monetary cost and degrades the user experience of
production systems. To combat this shortcoming, we have developed the
FastVentricle architecture, an FCN architecture for ventricular segmentation
based on the recently developed ENet architecture. FastVentricle is 4x faster
and runs with 6x less memory than the previous state-of-the-art ventricular
segmentation architecture while still maintaining excellent clinical accuracy.Comment: 11 pages, 6 figures, Accepted to Functional Imaging and Modeling of
the Heart (FIMH) 201
Single ion implantation for single donor devices using Geiger mode detectors
Electronic devices that are designed to use the properties of single atoms
such as donors or defects have become a reality with recent demonstrations of
donor spectroscopy, single photon emission sources, and magnetic imaging using
defect centers in diamond. Improving single ion detector sensitivity is linked
to improving control over the straggle of the ion as well as providing more
flexibility in lay-out integration with the active region of the single donor
device construction zone by allowing ion sensing at potentially greater
distances. Using a remotely located passively gated single ion Geiger mode
avalanche diode (SIGMA) detector we have demonstrated 100% detection efficiency
at a distance of >75 um from the center of the collecting junction. This
detection efficiency is achieved with sensitivity to ~600 or fewer
electron-hole pairs produced by the implanted ion. Ion detectors with this
sensitivity and integrated with a thin dielectric, for example 5 nm gate oxide,
using low energy Sb implantation would have an end of range straggle of <2.5
nm. Significant reduction in false count probability is achieved by modifying
the ion beam set-up to allow for cryogenic operation of the SIGMA detector.
Using a detection window of 230 ns at 1 Hz, the probability of a false count
was measured as 1E-1 and 1E-4 for operation temperatures of 300K and 77K,
respectively. Low temperature operation and reduced false, dark, counts are
critical to achieving high confidence in single ion arrival. For the device
performance in this work, the confidence is calculated as a probability of >98%
for counting one and only one ion for a false count probability of 1E-4 at an
average ion number per gated window of 0.015.Comment: 10 pages, 5 figures, submitted to Nanotechnolog
Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12
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Midinfrared semiconductor optical metamaterials
We report on a novel class of semiconductor metamaterials that employ a strongly anisotropic dielectric function to achieve negative refraction in the midinfrared region of the spectrum, ~8.5–13 μm. We present two types of metamaterials, layered highly doped/undoped heterostructures and quantum well superlattices that are highly anisotropic. Contrary to other optical metamaterials these heterostructure systems are optically thick (up to 20 μm thick), planar, and require no additional fabrication steps beyond the initial growth. Using transmission and reflection measurements and modeling of the highly doped heterostructures, we demonstrate that these materials exhibit negative refraction. For the highly doped quantum well superlattices, we demonstrate anomalous reflection due to the strong anisotropy of the material but a determination of the sign of refraction is still difficult. This new class of semiconductor metamaterials has great potential for waveguiding and imaging applications in the long-wave infrared
Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice
Pathogenic variants in KMT5B, a lysine methyltransferase, are associated with global developmental delay, macrocephaly, autism, and congenital anomalies (OMIM# 617788). Given the relatively recent discovery of this disorder, it has not been fully characterized. Deep phenotyping of the largest (n = 43) patient cohort to date identified that hypotonia and congenital heart defects are prominent features that were previously not associated with this syndrome. Both missense variants and putative loss-of-function variants resulted in slow growth in patient-derived cell lines. KMT5B homozygous knockout mice were smaller in size than their wild-type littermates but did not have significantly smaller brains, suggesting relative macrocephaly, also noted as a prominent clinical feature. RNA sequencing of patient lymphoblasts and Kmt5b haploinsufficient mouse brains identified differentially expressed pathways associated with nervous system development and function including axon guidance signaling. Overall, we identified additional pathogenic variants and clinical features in KMT5B-related neurodevelopmental disorder and provide insights into the molecular mechanisms of the disorder using multiple model systems
Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor-1 through the downregulation of arylhydrocarbon receptor nuclear translocator
Effective in-service training design and delivery: evidence from an integrative literature review
Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
Pathogenic variants in KMT5B, a lysine methyltransferase, are associated with global developmental delay, macrocephaly, autism, and congenital anomalies (OMIM# 617788). Given the relatively recent discovery of this disorder, it has not been fully characterized. Deep phenotyping of the largest (n = 43) patient cohort to date identified that hypotonia and congenital heart defects are prominent features that were previously not associated with this syndrome. Both missense variants and putative loss-of-function variants resulted in slow growth in patient-derived cell lines. KMT5B homozygous knockout mice were smaller in size than their wild-type littermates but did not have significantly smaller brains, suggesting relative macrocephaly, also noted as a prominent clinical feature. RNA sequencing of patient lymphoblasts and Kmt5b haploinsufficient mouse brains identified differentially expressed pathways associated with nervous system development and function including axon guidance signaling. Overall, we identified additional pathogenic variants and clinical features in KMT5B-related neurodevelopmental disorder and provide insights into the molecular mechanisms of the disorder using multiple model systems
The Electrochemical Performance and Applications of Several Popular Lithium-ion Batteries for Electric Vehicles - A Review
The Lithium-ion battery is one of the most common batteries used in Electric Vehicles (EVs) due to the specific features of high energy density, power density, long life span and environment friendly. With the development of lithium-ion battery technology, different materials have been adopted in the design of the cathodes and anodes in order to gain a better performance. , , , and are five common lithium-ion batteries adopted in commercial EVs nowadays. The characteristics of these five lithium-ion batteries are reviewed and compared in the aspects of electrochemical performance and their practical applications
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