Follow-up observations of pulsating subdwarf B stars: Multisite campaigns on PG 1618+563B and PG 0048+091

We present follow-up observations of pulsating subdwarf B (sdB) stars as part of our efforts to resolve the pulsation spectra for use in asteroseismological analyses. This paper reports on multisite campaigns of the pulsating sdB stars PG 1618+563B and PG 0048+091. Data were obtained from observatories placed around the globe for coverage from all longitudes. For PG 1618+563B, our five-site campaign uncovered a dichotomy of pulsation states: Early during the campaign the amplitudes and phases (and perhaps frequencies) were quite variable while data obtained late in the campaign were able to fully resolve five stable pulsation frequencies. For PG 0048+091, our five-site campaign uncovered a plethora of frequencies with short pulsation lifetimes. We find them to have observed properties consistent with stochastically excited oscillations, an unexpected result for subdwarf B stars. We discuss our findings and their impact on subdwarf B asteroseismology.Comment: 50 pages including 17 figures and 10 tables. Accepted for publication in the Astrophysical Journa

Hydrodynamic Analysis of a Wave Energy Converter (WEC)

Honorable Mention Winner The UNF CREW competing in the U.S. Department of Energy 2021 Marine Energy Collegiate Competition developed a Wave Energy Converter (WEC) for quick deployment in disaster relief areas. When natural disasters disable coastal power grids, a WEC can be easily deployed close to shore and serve as a source of electricity. The ocean waves move magnets through a coil wired within the WEC to generate electricity. To initiate the design process, ANSYS AQWA software simulated both the oceanic environment and the device’s response in the WEC’s testing conditions. AQWA allows the user to change device dimensions easily and optimize the design ahead of physical construction. The resulting WEC proof of concept minimized prototype manufacturing waste and cost by eliminating poor designs in advance. The simulated geometry neglected hollow sections and used unidirectional, regular waves to account for software limitations. The software simulated the WEC for 20 seconds in an oceanic environment with a 40-meter depth and a 0.25-meter amplitude regular wave. Simulations produced graphs and animations describing the forces acting on the WEC as well as the WEC’s movement. The animation proved that the WEC reacts well in similar physical testing conditions. Based on the simulation results, the team constructed a 3D model for small-scale testing. Future investigations will involve more complex designs. Research conducted onward will focus on mass-damper systems and contact surfaces provided in the software

Optimization of Power Performance of a Wave Energy Converter

With climate change on the rise, unprecedented dependence on electricity, and an increased incidence of extreme weather, the UNF team participating in the U.S. Department of Energy 2021 Marine Energy Collegiate Competition: Powering the Blue Economy wants to give an alternative solution to provide renewable energy in areas that lose electricity as a result of a natural disaster, or that due to their isolated location cannot use traditional renewable energy sources. This led to the creation of the Osprey C.R.E.W (Cheap Reliable Energy from Waves). The Osprey C.R.E.W. is a wave energy converter that uses the vertical motion of the ocean waves to generate electricity. The principle of energy conversion is Faraday’s Law of Electromagnetic Induction, which states that a magnetic field moving past a conductor will generate electricity. The UNF team has developed a numerical simulation to test how different parameters influence the output and has built three small-scale prototypes that have been tested in a wave tank. A medium-sized prototype and a wave pool are being constructed, with the expectation that the size will also increase the output

Cost Analysis of Osprey C.R.E.W.

Renewable energy adoption is on the rise in the U.S. and abroad. More than ever, energy sourcing needs to shift away from harmful fossil fuels and towards fully renewable energy sources. Adapting from traditional fossil fuel energy sources to renewable energy sources is paramount for environmental health and public health. Fossil fuels emit harmful pollutants, which have led to changing weather conditions and exasperated natural disasters. Existing renewable sources are not ideal, either. For instance, solar cannot run continuously and wind turbines are subject to weather changes. The recent energy debacle in Texas shows the need for alternative renewable energy sources. The Osprey C.R.E.W. wave energy converter (WEC) alleviates many of the current problems existing renewable energy systems cannot solve. First, it provides reliable and constant service. With other renewable energy services, there will be stops in production. However, there are no stops in wave energy because the waves are constant. Another positive of the WEC device is that their deployments are flexible and scalable. This means that energy production levels can be changed rapidly and without delay. The average cost per device falls significantly with seamless scalability, making large increments of devices procured in a relatively cost-effective manner. Cost comparisons between competing energy sources show that the WEC is very cost-efficient as well. The cost of producing wave energy is found to be more efficient than solar energy and wind alternatives. Our cost figures also show that Osprey C.R.E.W provides a very competitive alternative to the primary fossil fuel producers such as coal and fuel

Dynamic inundation simulation of storm water interaction between sewer system and overland flows

Copyright © 2002 Taylor & FrancisThis is the Author's Accepted Manuscript of an article published in the Journal of the Chinese Institute of Engineers (2002), available online at: http://www.tandfonline.com/10.1080/02533839.2002.9670691An improved urban inundation model, coupling a 2D non‐inertia overland flow model with a storm water management model, is adopted to simulate inundation in urban areas. The model computes, not only the overland runoff and the water overflow through manholes where surface runoff exceeds the capacity of storm sewers, but also the bidirectional flow interactions between sewers and overland runoff. The model was verified by a typhoon event in Nov. 2000, which resulted in serious inundation in the Mucha area of Taipei City. The result shows that the present model indeed improves simulation accuracy over the earlier model, and can be used to provide a more reliable flood mitigation design

Epidemiology and Outcome of Fungemia in a Cancer Cohort of the Infectious Diseases Group (IDG) of the European Organization for Research and Treatment of Cancer (EORTC 65031)

In a prospective cohort study of 145 030 admissions of cancer patients from 13 European Organisation for Research and Treatment of Cancer centers fungemia occurred in 0.23%. Candida albicans was the predominant pathogen. Fungemia was associated with substantial mortality. Antifungal prophylaxis and remission of cancer predicted better surviva

An EORTC Phase II study of caspofungin as first-line therapy of invasive aspergillosis in haematological patients

Objectives Caspofungin was evaluated as first-line monotherapy of invasive aspergillosis (IA) in patients with haematological malignancies and undergoing autologous transplants. Methods Adults with proven or probable IA, defined strictly according to EORTC-MSG criteria, were eligible. Those with possible IA were enrolled, but were not evaluable for efficacy unless upgraded to proven/probable disease within 7 days of registration based on investigations performed within 48 h after enrolment. Caspofungin dosage was 70 mg (day 1) followed by 50 mg/day. The primary endpoint was the proportion of patients with complete or partial response at the end of caspofungin therapy in the modified intention to treat (MITT) group; secondary endpoints were response and survival at day 84 and safety. Results In the MITT group (n = 61), 75% of patients had cancer not in remission (relapsing or refractory), 85% were neutropenic at enrolment and 49% had a Karnofsky score of ≤50. At end of treatment, 1 and 19 patients had complete and partial response, respectively [success rate 33% (20/61)], 9 (15%) achieved stabilization and 31 (51%) had disease progression. One patient was not evaluable. The 6 and 12 week survival rates were 66% (40/61) and 53% (32/60), respectively. Baseline characteristics associated with survival at day 84 were an underlying disease in remission (not relapsing or refractory) and Karnofsky score. Recovery from neutropenia at the end of treatment was also significantly associated with survival. No serious drug-related adverse events or discontinuations due to drug-related adverse events were observed. Conclusions Caspofungin provided an observed response rate compatible with the null hypothesis of a true response rate of ≤35%. Underlying disease-related factors had a major impact on result

Health Risk Assessment for Exposure to Some Selected Heavy Metals via Drinking Water from Dadinkowa Dam and River Gombe Abba in Gombe State, Northeast Nigeria

Abstract The concentrations of eight heavy metals (Fe, Mn, Cu, Pb, Cd, Ni, Co and Zn) were determined by atomic absorption spectroscopy in water from Dadinkowa dam and Kwadon boreholes which are the major sources of drinking water to Gombe town in Gombe State, North-East, Nigeria. The concentrations of metals in water from Dadinkowa dam were in the order: Fe (1.86mg/l), Mn(0.68mg/l), Cu(0.92mg/l), Pb(0.19mg/l), Cd(0.50mg/l), Ni(0.59mg/l), Co(0.42mg/l) and Zn(0.83mg/l).The concentrations of the metals in water from Gombe Abba River were in the order Fe(0.21 mg/l), Mn (0.24 mg/l), Cu (0.29 mg/l), Pb (0.02 mg/l), Cd (0.10 mg/l), Ni( 0.04 mg/l), Co(0.12 mg/l) and Zn (0.41 mg/l). The human health risk assessment was performed by determining the chronic daily intake (CDI), hazard quotient (HQ) and total hazard index (THI) of the metals through human oral consumption for both adults and children. The HQ of iron, manganese, nickel and cobalt in water from Dadinkowa dam were all greater than unity and thus pose a potential health risk for both adults and children while cobalt was the only heavy metal of concern in water from Gombe Abba River as its HQ was greater than unity. The THI of water from all the sampled sites assessed were of high risk. Further monitoring of these sites is recommended as well as research by biomedical experts to reveal the exact adverse effects that heavy metal contamination of water might induce in humans, particularly among individuals in vulnerable populations such as children

Blind spots on western blots: Assessment of common problems in western blot figures and methods reporting with recommendations to improve them

Western blotting is a standard laboratory method used to detect proteins and assess their expression levels. Unfortunately, poor western blot image display practices and a lack of detailed methods reporting can limit a reader's ability to evaluate or reproduce western blot results. While several groups have studied the prevalence of image manipulation or provided recommendations for improving western blotting, data on the prevalence of common publication practices are scarce. We systematically examined 551 articles published in the top 25% of journals in neurosciences (n = 151) and cell biology (n = 400) that contained western blot images, focusing on practices that may omit important information. Our data show that most published western blots are cropped and blot source data are not made available to readers in the supplement. Publishing blots with visible molecular weight markers is rare, and many blots additionally lack molecular weight labels. Western blot methods sections often lack information on the amount of protein loaded on the gel, blocking steps, and antibody labeling protocol. Important antibody identifiers like company or supplier, catalog number, or RRID were omitted frequently for primary antibodies and regularly for secondary antibodies. We present detailed descriptions and visual examples to help scientists, peer reviewers, and editors to publish more informative western blot figures and methods. Additional resources include a toolbox to help scientists produce more reproducible western blot data, teaching slides in English and Spanish, and an antibody reporting template

Dietary elimination of children with food protein induced gastrointestinal allergy – micronutrient adequacy with and without a hypoallergenic formula?

Background: The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied. We set out to determine the dietary intake of children on an elimination diet for this food allergy and hypothesised that the type of elimination diet and the presence of a hypoallergenic formula (HF) significantly impacts on micronutrient intake. Method: A prospective observational study was conducted on children diagnosed with FPIGA on an exclusion diet who completed a 3 day semi-quantitative food diary 4 weeks after commencing the diet. Nutritional intake where HF was used was compared to those without HF, with or without a vitamin and mineral supplement (VMS). Results: One-hundred-and-five food diaries were included in the data analysis: 70 boys (66.7%) with median age of 21.8 months [IQR: 10 - 67.7]. Fifty-three children (50.5%) consumed a HF and the volume of consumption was correlated to micronutrient intake. Significantly (p <0.05) more children reached their micronutrient requirements if a HF was consumed. In those without a HF, some continued not to achieve requirements in particular for vitamin D and zinc, in spite of VMS. Conclusion: This study points towards the important micronutrient contribution of a HF in children with FPIGA. Children, who are not on a HF and without a VMS, are at increased risk of low intakes in particular vitamin D and zinc. Further studies need to be performed, to assess whether dietary intake translates into actual biological deficiencies