Creative writing for publication:An action research study of motivation, engagement, and language development in Argentinian secondary schools

There has been much research on the connections between second language (L2) writing and learner motivation. However, few studies have focused on contexts in which L2 learning is mandatory, rather than elective. This technical action research-based study evaluated a project in which teenage learners in Argentina were engaged in creative writing tasks, with the goal of including their final written pieces in a formal publication. Through focus group interviews and group discussions, it was found that the project had increased the motivation not only of the learners, but also of the teachers. Further, the study highlights the importance of making such writing tasks student-centered, and calls attention to the role played by the teachers in motivating and engaging students. The study suggests that effort should be made to develop more initiatives in formal education settings in order to motivate and engage learners involved in mandatory language study

Concrete quantum cryptanalysis of binary elliptic curves

This paper analyzes and optimizes quantum circuits for computing discrete logarithms on binary elliptic curves, including reversible circuits for fixed-base-point scalar multiplication and the full stack of relevant subroutines. The main optimization target is the size of the quantum computer, i.e., the number of logical qubits required, as this appears to be the main obstacle to implementing Shor’s polynomial-time discrete-logarithm algorithm. The secondary optimization target is the number of logical Toffoli gates. For an elliptic curve over a field of 2n elements, this paper reduces the number of qubits to 7n + ⌊log2 (n)⌋ + 9. At the same time this paper reduces the number of Toffoli gates to 48n3 + 8nlog2(3)+1 + 352n2 log2 (n) + 512n2 + O(nlog2(3)) with double-and-add scalar multiplication, and a logarithmic factor smaller with fixed-window scalar multiplication. The number of CNOT gates is also O(n3). Exact gate counts are given for various sizes of elliptic curves currently used for cryptography

Concrete quantum cryptanalysis of binary elliptic curves

This paper analyzes and optimizes quantum circuits for computing discrete logarithms on binary elliptic curves, including reversible circuits for fixed-base-point scalar multiplication and the full stack of relevant subroutines. The main optimization target is the size of the quantum computer, i.e., the number of logical qubits required, as this appears to be the main obstacle to implementing Shor’s polynomial-time discrete-logarithm algorithm. The secondary optimization target is the number of logical Toffoli gates. For an elliptic curve over a field of 2n elements, this paper reduces the number of qubits to 7n + ⌊log2 (n)⌋ + 9. At the same time this paper reduces the number of Toffoli gates to 48n3 + 8nlog2(3)+1 + 352n2 log2 (n) + 512n2 + O(nlog2(3)) with double-and-add scalar multiplication, and a logarithmic factor smaller with fixed-window scalar multiplication. The number of CNOT gates is also O(n3). Exact gate counts are given for various sizes of elliptic curves currently used for cryptography

Cardiovascular preventive recommendations. PAPPS 2020 update

The recommendations of the semFYC's Program for Preventive Activities and Health Promotion (PAPPS) for the prevention of cardiovascular diseases (CVD) are presented. The following sections are included: Epidemiological review, where the current morbidity and mortality of CVD in Spain and its evolution as well as the main risk factors are described; Cardiovascular (CV) risk tables and recommendations for the calculation of CV risk; Main risk factors such as arterial hypertension, dyslipidemia and diabetes mellitus, describing the method for their diagnosis, therapeutic objectives and recommendations for lifestyle measures and pharmacological treatment; Indications for antiplatelet therapy, and recommendations for screening of atrial fibrillation. The quality of testing and the strength of the recommendation are included in the main recommendations.Se presentan las recomendaciones del Programa de Actividades Preventivas y Promoción de la Salud (PAPPS) de la semFYC, para la prevención de las enfermedades cardiovasculares (CV). Se incluyen los siguientes apartados: Revisión epidemiológica, donde se describe la morbimortalidadCV actual en España y su evolución y los principales factores de riesgo; Tablas de riesgo CV y recomendaciones para el cálculo del riesgo CV; Factores de riesgo mayores como hipertensión arterial, dislipidemia y diabetes mellitus, describiendo el método para su diagnóstico, los objetivos terapéuticos y las recomendaciones de medidas d estilo de vida y de tratamiento farmacológico; Indicaciones de antiagregación, y Recomendaciones para el cribado de la fibrilación auricular. Para las principales recomendaciones se incluyen tablas específicas que recogen la calidad de la evidencia y la fuerza de la recomendación

Concrete quantum cryptanalysis of binary elliptic curves

This paper analyzes and optimizes quantum circuits for computing discrete logarithms on binary elliptic curves, including reversible circuits for fixed-base-point scalar multiplication and the full stack of relevant subroutines. The main optimization target is the size of the quantum computer, i.e., the number of logical qubits required, as this appears to be the main obstacle to implementing Shor\u27s polynomial-time discrete-logarithm algorithm. The secondary optimization target is the number of logical Toffoli gates. For an elliptic curve over a field of 2^n elements, this paper reduces the number of qubits to 7n+[log_2(n)]+9. At the same time this paper reduces the number of Toffoli gates to 48n^3+8n^(log_2(3)+1)+352n^2 log_2(n)+512n^2+O(n^(log_2(3))) with double-and-add scalar multiplication, and a logarithmic factor smaller with fixed-window scalar multiplication. The number of CNOT gates is also O(n^3). Exact gate counts are given for various sizes of elliptic curves currently used for cryptography

Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat.

© 2023 The Authors. This document is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc /4.0/ This document is the Accepted version of a Published Work that appeared in final form in Biomedicines. To access the final edited and published work see https://doi.org/10.3390/biomedicines10061230This study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings. Dose– response curves to DAA-I were compared with those to angiotensin II (Ang II). The Ang II-type-1 (AT1) receptor blocker, losartan, was used to evaluate the role of AT1 receptors in the responses to DAA-I. Studies were also conducted of the responsiveness in aortic rings after endotheliumremoval, nitric oxide synthase inhibition, or AT2 receptor blockade. DAA-I induced a dose-related systemic pressor response that was shifted to the right compared with Ang II. Losartan markedly attenuated the responsiveness to DAA-I. DAA-I showed a similar pattern in renal vasculature and aortic rings. In aortic rings, removal of endothelium and nitric oxide inhibition increased the sensitivity and maximal response to DAA-I and Ang II. AT2 receptor blockade did not significantly affect the responsiveness to DAA-I. According to these findings, DAA-I increases the systemic blood pressure and vascular tone in conductance and resistance vessels via AT1 receptor activation. This vasoconstrictor effect of DAA-I participates in the homeostatic control of arterial pressure, which can also contribute to the pathogenesis of hypertension. DAA-I may therefore be a potential therapeutic target in cardiovascular disease

An investigation into CLIL-related sections of EFL coursebooks : issues of CLIL inclusion in the publishing market

The current ELT global coursebook market has embraced CLIL as a weak form of bilingual education and an innovative component to include in General English coursebooks for EFL contexts. In this paper I investigate how CLIL is included in ELT coursebooks aimed at teenaged learners, available to teachers in Argentina. My study is based on the content analysis of four series which include a section advertised as CLIL-oriented. Results suggest that such sections are characterised by (1) little correlation between featured subject specific content and school curricula in L1, (2) oversimplification of contents, and (3) dominance of reading skills development and lower-order thinking tasks. Through this study, I argue that CLIL components become superficial supplements rather than a meaningful attempt to promote weak forms of bilingual education

Relationship between clinic and ambulatory Blood-pressure measurements and mortality

Background Evidence for the influence of ambulatory blood pressure on prognosis derives mainly from population-based studies and a few relatively small clinical investigations. This study examined the associations of blood pressure measured in the clinic (clinic blood pressure) and 24-hour ambulatory blood pressure with all-cause and cardiovascular mortality in a large cohort of patients in primary care. Methods We analyzed data from a registry-based, multicenter, national cohort that included 63,910 adults recruited from 2004 through 2014 in Spain. Clinic and 24-hour ambulatory blood-pressure data were examined in the following categories: sustained hypertension (elevated clinic and elevated 24-hour ambulatory blood pressure), "white-coat" hypertension (elevated clinic and normal 24-hour ambulatory blood pressure), masked hypertension (normal clinic and elevated 24-hour ambulatory blood pressure), and normotension (normal clinic and normal 24-hour ambulatory blood pressure). Analyses were conducted with Cox regression models, adjusted for clinic and 24-hour ambulatory blood pressures and for confounders. Results During a median follow-up of 4.7 years, 3808 patients died from any cause, and 1295 of these patients died from cardiovascular causes. In a model that included both 24-hour and clinic measurements, 24-hour systolic pressure was more strongly associated with all-cause mortality (hazard ratio, 1.58 per 1-SD increase in pressure; 95% confidence interval [CI], 1.56 to 1.60, after adjustment for clinic blood pressure) than the clinic systolic pressure (hazard ratio, 1.02; 95% CI, 1.00 to 1.04, after adjustment for 24-hour blood pressure). Corresponding hazard ratios per 1-SD increase in pressure were 1.55 (95% CI, 1.53 to 1.57, after adjustment for clinic and daytime blood pressures) for nighttime ambulatory systolic pressure and 1.54 (95% CI, 1.52 to 1.56, after adjustment for clinic and nighttime blood pressures) for daytime ambulatory systolic pressure. These relationships were consistent across subgroups of age, sex, and status with respect to obesity, diabetes, cardiovascular disease, and antihypertensive treatment. Masked hypertension was more strongly associated with all-cause mortality (hazard ratio, 2.83; 95% CI, 2.12 to 3.79) than sustained hypertension (hazard ratio, 1.80; 95% CI, 1.41 to 2.31) or white-coat hypertension (hazard ratio, 1.79; 95% CI, 1.38 to 2.32). Results for cardiovascular mortality were similar to those for all-cause mortality. Conclusions Ambulatory blood-pressure measurements were a stronger predictor of all-cause and cardiovascular mortality than clinic blood-pressure measurements. White-coat hypertension was not benign, and masked hypertension was associated with a greater risk of death than sustained hypertension. (Funded by the Spanish Society of Hypertension and others.

Trends in hypertension control among the older population of Spain from 2000 to 2001 to 2008 to 2010: Role of frequency and intensity of drug treatment

This is the prepint version of the following article: Circulation: Cardiovascular Quality and Outcomes 8.1 (2015) , which has been published in final form at http://dx.doi.org/10.1161/CIRCOUTCOMES.114.001191Background—The use of antihypertensive medication and hypertension control has significantly increased during recent decades in some developed countries, but the impact of improved drug treatment on blood pressure (BP) control in the population is unknown. Methods and Results—Data were taken from 2 surveys representative of the population aged ≥60 years in Spain conducted with the same methodology in 2000 to 2001 and in 2008 to 2010. BP was measured 6×. The first BP reading was discarded, and the average of the remaining 3 to 5 BP readings was taken for analysis. Hypertension prevalence was 68.7% in 2000 to 2001 and 66.0% in 2008 to 2010. Between both time periods there was an improvement in hypertension awareness (63.6%–67.7%), drug treatment among those aware (84.5%–87.5%), and BP control among treated hypertensives (30.3%–42.9%). Overall, BP control among all hypertensives increased from 16.3% to 25.4%. After adjustment for age, sex, education, hypertension duration, smoking, alcohol consumption, body mass index, sedentary behavior, diabetes mellitus, cardiovascular disease, and visits to the physician through logistic regression, ≈7% of the improvement in BP control among all hypertensives was explained by higher hypertension awareness, and 36.2% was explained by a higher treatment rate. Among the treated hypertensives, 22.6% of the progress in BP control was because of the increase in the number of BP medications used in each patient. Conclusions—BP control among the older hypertensive population in Spain has improved from 2000 to 2001 to 2008 to 2010 because of a higher treatment rate and more intense antihypertensive drug treatmentThis work has been supported by Fondo de Investigación Sanitaria (FIS) grant PI13/02321 (Instituto de Salud Carlos III, Spain) and “Cátedra Universidad Autónoma de Madrid (UAM) de Epidemiología y Control del Riesgo Cardiovascular”, Madrid, Spain