A DC-Autotransformer based Multilevel Inverter for Automotive Applications.

This paper proposes a novel multilevel inverter for automotive applications. The topology consists of a modular DCDC converter and a tap selector, where the DC-DC converter provides several DC-output levels and the tap selector produces an AC signal by choosing different DC-output signals from the DC-DC converter. To produce the DC-levels, the DC-DC converter consists of a modular structure where the modules are connected in series. The novelty is that the modules are connected both, magnetically in the AC-domain and electrically in the DCdomain. Due to the usage of low power switches in the modules, the proposed structure provides high efficiency. Furthermore, the DC-DC converter is capable of self-balancing its modules and thus does not require large capacitors which yields a high power density. A prototype of the proposed converter is built and simulation, as well as experimental results, are used to verify the findings

Laser-zone Growth in a Ribbon-to-ribbon (RTR) Process Silicon Sheet Growth Development for the Large Area Silicon Sheet Task of the Low Cost Solar Array Project

A technique for growing limited-length ribbons continually was demonstrated. This Rigid Edge technique can be used to recrystallize about 95% of the polyribbon feedstock. A major advantage of this method is that only a single, constant length silicon ribbon is handled throughout the entire process sequence; this may be accomplished using cassettes similar to those presently in use for processing Czochralski waters. Thus a transition from Cz to ribbon technology can be smoothly affected. The maximum size being considered, 3 inches x 24 inches, is half a square foot, and will generate 6 watts for 12% efficiency at 1 sun. Silicon dioxide has been demonstrated as an effective, practical diffusion barrier for use during the polyribbon formation

Semi-empirical calibration of the Integral Equation Model for SAR data in C-band and cross polarization using radar images and field measurements

The estimation of surface soil parameters (moisture and roughness) from Synthetic Aperture Radar (SAR) images requires the use of well-calibrated backscattering models. The objective of this paper is to extend the semi-empirical calibration of the backscattering Integral Equation Model (IEM) initially proposed by Baghdadi et al. (2004 and 2006) for HH and VV polarizations to HV polarization. The approach consisted in replacing the measured correlation length by a fitting/calibration parameter so that model simulations would closely agree with radar measurements. This calibration in C-band covers radar configurations with incidence angles between 24° and 45.8°. Good agreement was found between the backscattering coefficient provided by the SAR and that simulated by the calibrated version of the IEM

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Many of the leading causes of death in humans, such as cardiovascular disease, type 2 diabetes and Alzheimer’s disease are influenced by biological mechanisms that become dysregulated with increasing age. Hence, by targeting these ageing-related mechanisms, we may be able to improve health in old age. Ageing is partly heritable and genetic studies have been moderately successful in identifying genetic variants associated with ageing-related phenotypes (lifespan, healthspan and longevity). To decipher the mechanisms by which the identified variants influence ageing, studies that focus on their functional validation are vital. In this perspective, we describe the steps that could be taken in the process of functional validation: (1) in silico characterisation using bioinformatic tools; (2) in vitro characterisation using cell lines or organoids; and (3) in vivo characterisation studies using model organisms. For the in vivo characterisation, it is important to focus on translational phenotypes that are indicative of both healthspan and lifespan, such as the frailty index, to inform subsequent intervention studies. The depth of functional validation of a genetic variant depends on its location in the genome and conservation in model organisms. Moreover, some variants may prove to be hard to characterise due to context-dependent effects related to the experimental environment or genetic background. Future efforts to functionally characterise the (newly) identified genetic variants should shed light on the mechanisms underlying ageing and will help in the design of targeted interventions to improve health in old age

Spatial heterogeneity enhances and modulates excitability in a mathematical model of the myometrium

The muscular layer of the uterus (myometrium) undergoes profound changes in global excitability prior to parturition. Here, a mathematical model of the myocyte network is developed to investigate the hypothesis that spatial heterogeneity is essential to the transition from local to global excitation which the myometrium undergoes just prior to birth. Each myometrial smooth muscle cell is represented by an element with FitzHugh–Nagumo dynamics. The cells are coupled through resistors that represent gap junctions. Spatial heterogeneity is introduced by means of stochastic variation in coupling strengths, with parameters derived from physiological data. Numerical simulations indicate that even modest increases in the heterogeneity of the system can amplify the ability of locally applied stimuli to elicit global excitation. Moreover, in networks driven by a pacemaker cell, global oscillations of excitation are impeded in fully connected and strongly coupled networks. The ability of a locally stimulated cell or pacemaker cell to excite the network is shown to be strongly dependent on the local spatial correlation structure of the couplings. In summary, spatial heterogeneity is a key factor in enhancing and modulating global excitability

Effects of vertical loading on lateral screw pile performance

The offshore wind energy sector faces new challenges as it moves into deeper water deployment. To meet these challenges, new and efficient foundation solutions are required. One potential solution is to upscale onshore screw piles but they require verification of performance for new geometries and demanding loading regimes. This paper presents a three-dimensional finite-element analysis investigation of screw pile behaviour when subjected to combined vertical and lateral loading in sand. In the investigation, the screw pile length and helical plate diameter were varied on piles with a fixed core diameter while subjecting the piles to combined axial and lateral loading. The results were compared with results from straight shafted piles with the same core diameter. The results of the analysis revealed that vertical compression loads increased the lateral capacity of the screw piles whereas vertical uplift loads marginally reduced the lateral capacity. The downside of this enhanced lateral capacity is that the screw piles experience higher bending moments. This suggests that, when using screw piles for offshore foundation applications, structures should be designed to maintain axial compressive loads on the piles and induced bending moments need to be adequately assessed when deciding on appropriate structural sections. </jats:p

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T₂ MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging

Post-COVID-19 Effects on Female Fertility: An In-Depth Scientific Investigation

This study aimed to comprehensively investigate the post-COVID-19 effects on female fertility in patients with a history of severe COVID-19 infection. Data were collected from 340 patients who had previously experienced severe COVID-19 symptoms and sought medical assistance at private clinics and fertility centers in various provinces of Iraq. A comparative control group of 280 patients, who had not contracted COVID-19 or had mild cases, was included. The study assessed ovarian reserve, hormonal imbalances, and endometrial health in the post-recovery phase. The findings revealed a significant decrease in ovarian reserve, hormonal disturbances, and endometrial abnormalities among patients with a history of severe COVID-19 infection compared to the control group. This in-depth investigation sheds light on the potential long-term impacts of severe COVID-19 on female fertility. The results emphasize the need for further research and targeted interventions to support women affected by post-COVID-19 fertility issues. Understanding these effects is crucial for providing appropriate medical care and support to women on their reproductive journey after recovering from severe COVID-19

Laser-zone growth in a Ribbon-To-Ribbon (RTR) process. Silicon sheet growth development for the large area sheet task of the low-cost solar array project

A new calculation of the effects of thermal stresses during growth on silicon ribbon quality is reported. Thermal stress distributions are computed for ribbon growth under a variety of temperature profiles. A growth rate of 55 cu cm/min with a single ribbon was achieved. The growth of RTR ribbon with a fairly uniform parallel dendritic structure was demonstrated. Results with two approaches were obtained for reducing the Mo impurity level in polycrystalline feedstock. Coating the Mo substrate with Si3N4 does not effect thermal shear separation of the polyribbon; this process shows promise of improving cell efficiency and also increasing the useful life of the molybdenum substrate. A number of solar cells were fabricated on RTR silicon grown from CVD feedstock