8,504 research outputs found

    Analysis of Users' Behavior in Structured e-Commerce Websites

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    Online shopping is becoming more and more common in our daily lives. Understanding users'' interests and behavior is essential to adapt e-commerce websites to customers'' requirements. The information about users'' behavior is stored in the Web server logs. The analysis of such information has focused on applying data mining techniques, where a rather static characterization is used to model users'' behavior, and the sequence of the actions performed by them is not usually considered. Therefore, incorporating a view of the process followed by users during a session can be of great interest to identify more complex behavioral patterns. To address this issue, this paper proposes a linear-temporal logic model checking approach for the analysis of structured e-commerce Web logs. By defining a common way of mapping log records according to the e-commerce structure, Web logs can be easily converted into event logs where the behavior of users is captured. Then, different predefined queries can be performed to identify different behavioral patterns that consider the different actions performed by a user during a session. Finally, the usefulness of the proposed approach has been studied by applying it to a real case study of a Spanish e-commerce website. The results have identified interesting findings that have made possible to propose some improvements in the website design with the aim of increasing its efficiency

    A Case for Context-Free Grammar

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    System administrators agree that permutable methodologies are an interesting new topic in the field of programming languages, and electrical engineers concur. In this paper, authors demonstrate the study of DHCP, demonstrates the natural importance of machine learning. Our focus in our research is not on whether object-oriented languages and replication are often incompatible, but rather on constructing a psychoacoustic tool for evaluating I/O automata (Outlier)

    Multiple founder events explain the genetic diversity and structure of the model allopolyploid grass Brachypodium hybridum in the Iberian Peninsula hotspot

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    Background and Aims It is accepted that contemporary allopolyploid species have originated recurrently, but very few cases have been documented using multiple natural formations of the same species. To extend our knowledge, we have investigated the multiple origins, genetic variation and structure of the allotetraploid grass Brachypodium hybridum with respect to its progenitor diploid species B. distachyon (D genome) and B. stacei (S genome). For this, our primary focus is the Iberian Peninsula, an evolutionary hotspot for the genus Brachypodium. Methods We analysed 342 B. hybridum individuals from 36 populations using ten nuclear SSR loci and two plastid loci. The B. hybridum genetic profiles were compared with those previously reported for B. stacei and B. distachyon. In addition, phylogenetic analysis of the plastid data was performed for a reduced subset of individuals. Key Results The nuclear simple sequence repeat (SSR) genetic analysis detected medium to high genetic diversity, with a strong south-to-north genetic structure cline, and a high selfing rate in B. hybridum. Comparative genetic analysis showed a close relatedness of current B. hybridum D allelic profiles with those of B. distachyon, but a lack of similarity with those of B. stacei, suggesting another B. stacei source for the B. hybridum S alleles. Plastid analysis detected three different bidirectional allopolyploidization events: two involved distinct B. distachyon-like ancestors and one involved a B. stacei-like ancestor. The south-eastern Iberian Peninsula B. hybridum populations were more genetically diverse and could have originated from at least two hybridization events whereas north-eastern/north-western Iberian Peninsula B. hybridum populations were less diverse and may have derived from at least one hybridization event. Conclusions The genetic and evolutionary evidence supports the plausible in situ origin of the south-eastern and northern Iberian Peninsula B. hybridum allopolyploids from their respective local B. distachyon and unknown B. stacei ancestors. The untapped multiple origins and genetic variation detected in these B. hybridum populations opens the way to future evolutionary analysis of allopolyploid formation and genomic dominance and expression in the B. hybridum–B. distachyon–B. stacei grass model complex.info:eu-repo/semantics/publishedVersio

    Multi-site observations of Delta Scuti stars 7 Aql and 8 Aql (a new Delta Scuti variable): The twelfth STEPHI campaign in 2003

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    We present an analysis of the pulsation behaviour of the Delta Scuti stars 7 Aql (HD 174532) and 8 Aql (HD 174589) -- a new variable star -- observed in the framework of STEPHI XII campaign during 2003 June--July. 183 hours of high precision photometry were acquired by using four-channel photometers at three sites on three continents during 21 days. The light curves and amplitude spectra were obtained following a classical scheme of multi-channel photometry. Observations in different filters were also obtained and analyzed. Six and three frequencies have been unambiguously detected above a 99% confidence level in the range 0.090 mHz--0.300 mHz and 0.100 mHz-- 0.145 mHz in 7 Aql and 8 Aql respectively. A comparison of observed and theoretical frequencies shows that 7 Aql and 8 Aql may oscillate with p modes of low radial orders, typical among Delta Scuti stars. In terms of radial oscillations the range of 8 Aql goes from n=1 to n=3 while for 7 Aql the range spans from n=4 to n=7. Non-radial oscillations have to be present in both stars as well. The expected range of excited modes according to a non adiabatic analysis goes from n=1 to n=6 in both stars.Comment: 8 pages, 7 fugures, 5 tables, accepted for publication in Astronomical Journa

    Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia

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    Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth. Objectives We sought to identify the genetic cause of CPVT in this family, to preventively treat and clinically characterize the mutation-positive individuals, and to functionally characterize the pathogenic mechanisms of the mutation. Methods Genetic testing was performed for 1404 relatives. Mutation-positive individuals were preventively treated with β-blockers and clinically characterized with a serial exercise treadmill test (ETT) and Holter monitoring. In vitro functional studies included caffeine sensitivity and store overload–induced calcium release activity of the mutant channel in HEK293 cells. Results We identified the p.G357S_RyR2 mutation, in the cardiac ryanodine receptor, in 179 family members and in 6 SCD cases. No SCD was observed among treated mutation-positive individuals over a median follow-up of 37 months; however, 3 relatives who had refused genetic testing (confirmed mutation-positive individuals) experienced SCD. Holter monitoring did not provide relevant information for CPVT diagnosis. One single ETT was unable to detect complex cardiac arrhythmias in 72% of mutation-positive individuals, though the serial ETT improved the accuracy. Functional studies showed that the G357S mutation increased caffeine sensitivity and store overload–induced calcium release activity under conditions that mimic catecholaminergic stress. Conclusion Our study supports the use of genetic testing to identify individuals at risk of SCD to undertake prophylactic interventions. We also show that the pathogenic mechanisms of p.G357S_RyR2 appear to depend on β-adrenergic stimulation
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