Siegener Netzwerk Schule (SiNet): Von der Universitätsschule zum Kooperationsverbund

Der Beitrag schildert die Entwicklung einer Partnerschaft zwischen der Universität Siegen und Schulen in der Region Südwestfalen und stellt das aktuelle Netzwerk als Ergebnis dieser Bemühungen vor. Im Schlussteil werden Potenziale und Probleme dieser Form der Zusammenarbeit erörtert. The article describes the development of a partnership between the University of Siegen and schools in the region of South Westphalia and presents the current network as a result of these efforts. In the concluding part, the potentials and problems of this form of cooperation are discussed

Повышение эффективности проведения геолого-технических мероприятий на месторождениях Западной Сибири

Цель работы - анализ проведенных геолого-технических мероприятий, предложение нового инновационного подхода к повышению эффективности проведения ГТМ на месторождениях Западной-Сибири. В процессе исследования проводился анализ имеющихся данных, на основе которых были выделение наиболее эффективные геолого-технические мероприятия, проводимые на месторождениях Западной Сибири.The purpose of the work is to analyze the geological and technical measures carried out, to propose a new innovative approach to improving the efficiency of GTM in the fields of Western Siberia. In the course of the study, the available data were analyzed, on the basis of which the most effective geological and technical measures carried out in the fields of Western Siberia were identified

Autoimmune aspects of psoriasis: Heritability and autoantigens

Chronic immune-mediated disorders (IMDs) constitute a major health burden. Understanding IMD pathogenesis is facing two major constraints: Missing heritability explaining familial clustering, and missing autoantigens. Pinpointing IMD risk genes and autoimmune targets, however, is of fundamental importance for developing novel causal therapies. The strongest association of all IMDs is seen with human leukocyte antigen (HLA) alleles. Using psoriasis as an IMD model this article reviews the pathogenic role HLA molecules may have within the polygenic predisposition of IMDs. It concludes that disease-associated HLA alleles account for both missing heritability and autoimmune mechanisms by facilitating tissue-specific autoimmune responses through autoantigen presentation. (C) 2017 The Author. Published by Elsevier B.V