Squeezed-light source for the superresolving microscopy

We propose a source of multimode squeezed light that can be used for the superresolving microscopy beyond the standard quantum limit. This source is an optical parametric amplifier with a properly chosen diaphragm on its output and a Fourier lens. We demonstrate that such an arrangement produces squeezed prolate spheroidal waves which are the eigen modes of the optical imaging scheme used in microscopy. The degree of squeezing and the number of spatial modes in illuminating light, necessary for the effective object field reconstruction, are evaluatedComment: 6 pages, 1 figure, RevTeX4. Shortened version will appear in Optics Letter

A quantum volume hologram

We propose a new scheme for parallel spatially multimode quantum memory for light. The scheme is based on counter-propagating quantum signal wave and strong classical reference wave, like in a classical volume hologram, and therefore can be called a quantum volume hologram. The medium for the hologram consists of a spatially extended ensemble of atoms placed in a magnetic field. The write-in and read-out of this quantum hologram is as simple as that of its classical counterpart and consists of a single pass illumination. In addition we show that the present scheme for a quantum hologram is less sensitive to diffraction and therefore is capable of achieving higher density of storage of spatial modes as compared to previous proposals. A quantum hologram capable of storing entangled images can become an important ingredient in quantum information processing and quantum imaging.Comment: 8 pages, 2 figure

Monitoring Subsystem for Wireless Systems Based on Miniature Spectrum Analyzers

The paper presents a substantiation of the effectiveness of the implementation of IEEE 802.11 wireless network analysis subsystem using miniature spectrum analyzers. A practical implementation scheme, approaches to the software solution and hardware are shown. Design and implementation is presented

Quantum memory for images - a quantum hologram

Matter-light quantum interface and quantum memory for light are important ingredients of quantum information protocols, such as quantum networks, distributed quantum computation, etc. In this Letter we present a spatially multimode scheme for quantum memory for light, which we call a quantum hologram. Our approach uses a multi-atom ensemble which has been shown to be efficient for a single spatial mode quantum memory. Due to the multi-atom nature of the ensemble it is capable of storing many spatial modes, a feature critical for the present proposal. A quantum hologram has a higher storage capacity compared to a classical hologram, and is capable of storing quantum features of an image, such as multimode superposition and entangled quantum states, something that a standard hologram is unable to achieve. Due to optical parallelism, the information capacity of the quantum hologram will obviously exceed that of a single-mode scheme.Comment: 5 pages, 3 figure

Walking pathways with positive feedback loops reveal DNA methylation

Background: the search for molecular biomarkers of early-onset colorectal cancer (CRC) is an important but still quite challenging and unsolved task. Detection of CpG methylation in human DNA obtained from blood or stool has been proposed as a promising approach to a noninvasive early diagnosis of CRC. Thousands of abnormally methylated CpG positions in CRC genomes are often located in non-coding parts of genes. Novel bioinformatic methods are thus urgently needed for multi-omics data analysis to reveal causative biomarkers with a potential driver role in early stages of cancer. Methods: we have developed a method for finding potential causal relationships between epigenetic changes (DNA methylations) in gene regulatory regions that affect transcription factor binding sites (TFBS) and gene expression changes. This method also considers the topology of the involved signal transduction pathways and searches for positive feedback loops that may cause the carcinogenic aberrations in gene expression. We call this method 'Walking pathways', since it searches for potential rewiring mechanisms in cancer pathways due to dynamic changes in the DNA methylation status of important gene regulatory regions ('epigenomic walking'). Results: in this paper, we analysed an extensive collection of full genome gene-expression data (RNA-seq) and DNA methylation data of genomic CpG islands (using Illumina methylation arrays) generated from a sample of tumor and normal gut epithelial tissues of 300 patients with colorectal cancer (at different stages of the disease) (data generated in the EU-supported SysCol project). Identification of potential epigenetic biomarkers of DNA methylation was performed using the fully automatic multi-omics analysis web service 'My Genome Enhancer' (MGE) (my-genome-enhancer.com). MGE uses the database on gene regulation TRANSFAC®, the signal transduction pathways database TRANSPATH®, and software that employs AI (artificial intelligence) methods for the analysis of cancer-specific enhancers. Conclusions: the identified biomarkers underwent experimental testing on an independent set of blood samples from patients with colorectal cancer. As a result, using advanced methods of statistics and machine learning, a minimum set of 6 biomarkers was selected, which together achieve the best cancer detection potential. The markers include hypermethylated positions in regulatory regions of the following genes: CALCA, ENO1, MYC, PDX1, TCF7, ZNF43

Toward a warmer Arctic Ocean: Spreading of the early 21st century Atlantic Water warm anomaly along the Eurasian Basin margins

We document through the analysis of 2002–2005 observational data the recent Atlantic Water (AW) warming along the Siberian continental margin due to several AW warm impulses that penetrated into the Arctic Ocean through Fram Strait in 1999–2000. The AW temperature record from our long-term monitoring site in the northern Laptev Sea shows several events of rapid AW temperature increase totaling 0.8°C in February–August 2004. We hypothesize the along-margin spreading of this warmer anomaly has disrupted the downstream thermal equilibrium of the late 1990s to earlier 2000s. The anomaly mean velocity of 2.4–2.5 ± 0.2 cm/s was obtained on the basis of travel time required between the northern Laptev Sea and two anomaly fronts delineated over the Eurasian flank of the Lomonosov Ridge by comparing the 2005 snapshot along-margin data with the AW pre-1990 mean. The magnitude of delineated anomalies exceeds the level of pre-1990 mean along-margin cooling and rises above the level of noise attributed to shifting of the AW jet across the basin margins. The anomaly mean velocity estimation is confirmed by comparing mooring-derived AW temperature time series from 2002 to 2005 with the downstream along-margin AW temperature distribution from 2005. Our mooring current meter data corroborate these estimations

Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning

We studied the interactions between short- and long-term plastic changes taking place during the acquisition of a classical eyeblink conditioning and following high-frequency stimulation (HFS) of the reuniens nucleus in behaving mice. Synaptic changes in strength were studied at the reuniens-medial prefrontal cortex (mPFC) and the reuniens-CA1 synapses. Input/output curves and a paired-pulse study enabled determining the functional capabilities of the two synapses and the optimal intensities to be applied at the reuniens nucleus during classical eyeblink conditioning and for HFS applied to the reuniens nucleus. Animals were conditioned using a trace paradigm, with a tone as conditioned stimulus (CS) and an electric shock to the trigeminal nerve as unconditioned stimulus (US). A single pulse was presented to the reuniens nucleus to evoke field EPSPs (fEPSPs) in mPFC and CA1 areas during the CS-US interval. No significant changes in synaptic strength were observed at the reuniens-mPFC and reuniens-CA1 synapses during the acquisition of eyelid conditioned responses (CRs). Two successive HFS sessions carried out during the first two conditioning days decreased the percentage of CRs, without evoking any long-term potentiation (LTP) at the recording sites. HFS of the reuniens nucleus also prevented the proper acquisition of an object discrimination task. A subsequent study revealed that HFS of the reuniens nucleus evoked a significant decrease of paired-pulse facilitation. In conclusion, reuniens nucleus projections to prefrontal and hippocampal circuits seem to participate in the acquisition of associative learning through a mechanism that does not required the development of LTP