7 research outputs found

    Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation

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    Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-02-21T12:59:37Z No. of bitstreams: 1 Alves MI Pyranochromones from Dictyoloma ....pdf: 205022 bytes, checksum: f93a791ebdf1e5e9ed9ed8df1fd3f84d (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-02-21T13:10:07Z (GMT) No. of bitstreams: 1 Alves MI Pyranochromones from Dictyoloma ....pdf: 205022 bytes, checksum: f93a791ebdf1e5e9ed9ed8df1fd3f84d (MD5)Made available in DSpace on 2018-02-21T13:10:07Z (GMT). No. of bitstreams: 1 Alves MI Pyranochromones from Dictyoloma ....pdf: 205022 bytes, checksum: f93a791ebdf1e5e9ed9ed8df1fd3f84d (MD5) Previous issue date: 2017CAPES and CNPqFederal University of Bahia. Institute of Chemistry. Salvador, BA, BrazilFederal University of Bahia. College of Pharmacy. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFederal University of Juiz de Fora. Department of Chemistry. Juiz de Fora, MG, BrazilFederal University of Bahia. Institute of Biology. Salvador, BA, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Institute of Chemistry. Salvador, BA, Brazil / Federal University of Bahia. College of Pharmacy. Salvador, BA, BrazilOne new chromone 3,3-dimethylallylspatheliachromene methyl ether (1), as well as five known chromones, 6-(3-methylbut-2-enyl) allopteroxylin methyl ether (2), 6-(3-methylbut-2-enyl) allopteroxylin (3), 3,3-dimethylallylspatheliachromene (4), 5-O-methylcneorumchromone K (5) and spatheliabischromene (6), two alkaloids, 8-methoxy-N-methylflindersine (7) and 8-methoxyflindersine (8), and two limonoids, limonin diosphenol (9) and rutaevin (10), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16-F10, HepG2, K562 and HL60 and non-tumor cells PBMC were evaluated for compounds 1 - 6. Compound 1 was the most active showing IC50values ranging from 6.26 to 14.82 μg/ml in B16-F10 and K562 cell lines, respectively, and presented IC50value of 11.65 μg/ml in PBMC cell line

    Antinociceptive compounds and LC-DAD-ESIMSn profile from Dictyoloma vandellianum leaves.

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    Limonoids, quinolone alkaloids and chromones have been reported as constituents of Dictyoloma vandellianum Adr. Juss. (Rutaceae). Although those compounds are known for their biological activities, only the anti-inflammatory activity of chromones isolated from the underground parts has been evaluated. There are no studies of the pharmacological properties of the aerial parts of D. vandellianum. The present study was carried out to determine the phytochemical profile and antinociceptive activity of the methanol extract, fractions and isolated compounds of leaves of D. vandellianum. The phytochemical profile was performed by HLPC-DAD-ESIMSn and pure substances obtained were characterized by MS and NMR spectroscopy. The antinociceptive activity was assessed using the formalin assay in mice, and the motor function in the rotarod test. ME and all the fractions obtained from ME produced antinociceptive effects. Among them, the ethyl ether fraction was the most active. Data from HPLC-DAD-ESIMSn showed that the ethyl ether fraction presented 42 compounds. The major compounds isolated from this fraction-gallic acid, methyl gallate and 1,2,6-tri-O-galloyl-β-d-glucopyranose-were tested and produced antinociceptive effects. Gallic acid, methyl gallate and 1,2,6-tri-O-galloyl-β-d-glucopyranose at antinociceptive doses did not affect the motor performance in mice in the rotarod test. This work is the first report of the occurrence of gallotanins in D. vandellianum. In addition, the pharmacological study showed that D. vandellianum leaves present antinociceptive activity, probably induced by gallic acid, methyl gallate and 1,2,6-tri-O-galloyl-β-d-glucopyranose

    Search for a Higgs boson in the mass range from 145 to 1000 GeV decaying to a pair of W or Z bosons

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