702 research outputs found
Meandering instability of curved step edges on growth of a crystalline cone
We study the meandering instability during growth of an isolated
nanostructure, a crystalline cone, consisting of concentric circular steps. The
onset of the instability is studied analytically within the framework of the
standard Burton-Cabrera-Frank model, which is applied to describe step flow
growth in circular geometry. We derive the correction to the most unstable
wavelength and show that in general it depends on the curvature in a
complicated way. Only in the asymptotic limit where the curvature approaches
zero the results are shown to reduce to the rectangular case. The results
obtained here are of importance in estimating growth regimes for stable
nanostructures against step meandering.Comment: 4 pages, 3 figures, RevTe
Why do some people search for their files much more than others? A preliminary study
Purpose: Previous research has repeatedly shown that people only search for files in a small minority of cases when they do not remember the file's location. The current study aimed to examine whether there is a group of hyper-searchers who search significantly more than others. Based on previous neurocognitive studies, this study aims to hypothesize that if such a group exists, they will have superior verbal memory and reduced visuospatial memory. Design/methodology/approach: In total, 65 participants completed a questionnaire estimating their search percentages, as well as reporting demographic data. Verbal memory was measured using the Wechsler logical memory test, and visuospatial memory was assessed using an online card memory game. Findings: Hyper-searchers were defined as participants with search percentage of over one standard deviation (SD) above the mean. The average search percentage of the seven participants who met this criterion was 51% (SD = 14%), over five times more than the other participants (M = 10%, SD = 9%). Similar results were obtained by re-analyzing data from four previous papers (N = 1,252). The results further confirmed the hypothesis that hyper-searchers have significantly better verbal memory than other participants, possibly making searching easier and more successful for them. Lastly, the search percentage was positively predicted by verbal memory scores and negatively predicted by visuospatial memory scores. Explanations and future research are discussed. Originality/value: This preliminary study is the first to introduce the concept of hyper-searchers, demonstrate its existence and study its causes
Cholesterol metabolism is a potential therapeutic target in Duchenne muscular dystrophy
Background: Duchenne muscular dystrophy (DMD) is a lethal muscle disease detected in approximately 1:5000 male births. DMD is caused by mutations in the DMD gene, encoding a critical protein that links the cytoskeleton and the extracellular matrix in skeletal and cardiac muscles. The primary consequence of the disrupted link between the extracellular matrix and the myofibre actin cytoskeleton is thought to involve sarcolemma destabilization, perturbation of Ca homeostasis, activation of proteases, mitochondrial damage, and tissue degeneration. A recently emphasized secondary aspect of the dystrophic process is a progressive metabolic change of the dystrophic tissue; however, the mechanism and nature of the metabolic dysregulation are yet poorly understood. In this study, we characterized a molecular mechanism of metabolic perturbation in DMD. Methods: We sequenced plasma miRNA in a DMD cohort, comprising 54 DMD patients treated or not by glucocorticoid, compared with 27 healthy controls, in three groups of the ages of 4–8, 8–12, and 12–20 years. We developed an original approach for the biological interpretation of miRNA dysregulation and produced a novel hypothesis concerning metabolic perturbation in DMD. We used the mdx mouse model for DMD for the investigation of this hypothesis. Results: We identified 96 dysregulated miRNAs (adjusted P-value <0.1), of which 74 were up-regulated and 22 were down-regulated in DMD. We confirmed the dysregulation in DMD of Dystro-miRs, Cardio-miRs, and a large number of the DLK1-DIO3 miRNAs. We also identified numerous dysregulated miRNAs yet unreported in DMD. Bioinformatics analysis of both target and host genes for dysregulated miRNAs predicted that lipid metabolism might be a critical metabolic perturbation in DMD. Investigation of skeletal muscles of the mdx mouse uncovered dysregulation of transcription factors of cholesterol and fatty acid metabolism (SREBP-1 and SREBP-2), perturbation of the mevalonate pathway, and the accumulation of cholesterol in the dystrophic muscles. Elevated cholesterol level was also found in muscle biopsies of DMD patients. Treatment of mdx mice with Simvastatin, a cholesterol-reducing agent, normalized these perturbations and partially restored the dystrophic parameters. Conclusions: This investigation supports that cholesterol metabolism and the mevalonate pathway are potential therapeutic targets in DMD. 2
Renormalization of cellular automata and self-similarity
We study self-similarity in one-dimensional probabilistic cellular automata
(PCA) using the renormalization technique. We introduce a general framework for
algebraic construction of renormalization groups (RG) on cellular automata and
apply it to exhaustively search the rule space for automata displaying dynamic
criticality. Previous studies have shown that there exists several exactly
renormalizable deterministic automata. We show that the RG fixed points for
such self-similar CA are unstable in all directions under renormalization. This
implies that the large scale structure of self-similar deterministic elementary
cellular automata is destroyed by any finite error probability. As a second
result we show that the only non-trivial critical PCA are the different
versions of the well-studied phenomenon of directed percolation. We discuss how
the second result supports a conjecture regarding the universality class for
dynamic criticality defined by directed percolation.Comment: 14 pages, 4 figure
Cauchy-perturbative matching and outer boundary conditions: computational studies
We present results from a new technique which allows extraction of
gravitational radiation information from a generic three-dimensional numerical
relativity code and provides stable outer boundary conditions. In our approach
we match the solution of a Cauchy evolution of the nonlinear Einstein field
equations to a set of one-dimensional linear equations obtained through
perturbation techniques over a curved background. We discuss the validity of
this approach in the case of linear and mildly nonlinear gravitational waves
and show how a numerical module developed for this purpose is able to provide
an accurate and numerically convergent description of the gravitational wave
propagation and a stable numerical evolution.Comment: 20 pages, RevTe
Complementarity in classical dynamical systems
The concept of complementarity, originally defined for non-commuting
observables of quantum systems with states of non-vanishing dispersion, is
extended to classical dynamical systems with a partitioned phase space.
Interpreting partitions in terms of ensembles of epistemic states (symbols)
with corresponding classical observables, it is shown that such observables are
complementary to each other with respect to particular partitions unless those
partitions are generating. This explains why symbolic descriptions based on an
\emph{ad hoc} partition of an underlying phase space description should
generally be expected to be incompatible. Related approaches with different
background and different objectives are discussed.Comment: 18 pages, no figure
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A Phase I Trial of Pox PSA vaccines (PROSTVAC®-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM™) in Patients with Prostate Cancer
Purpose: Based on previous studies that demonstrated the safety profile and preliminary clinical activity of prostate specific antigen (PSA) targeted therapeutic vaccines, as well as recent laboratory data supporting the value of the addition of co-stimulatory molecules B7-1, ICAM-1, and LFA-3 (designated TRICOM™) to these vaccines, we conducted a Phase I study to evaluate the safety and immunogenicity of a novel vaccinia and fowlpox vaccine incorporating the PSA gene sequence and TRICOM. Methods: In this study, ten patients with androgen independent prostate cancer with or without metastatic disease were enrolled. Patients were treated with 2 × l08 pfu of a recombinant vaccinia virus vaccine (PROSTVAC-V) followed by 1 × 109 pfu of the booster recombinant fowlpox virus (PROSTVAC-F) both with gene sequences for PSA and TRICOM. The mean age of patients enrolled in the study was 70 (range 63 to 79). The mean PSA at baseline was 434 (range 9 - 1424). Results: There were no deaths, and no Grade 3 or 4 adverse events. The most commonly reported adverse events, regardless of causality, were injection site reactions and fatigue. One serious adverse event (SAE) occurred that was unrelated to vaccine; this patient developed progressive disease with a new sphenoid metastasis. PSA was measured at week 4 and week 8. Four patients had stable disease (with less than 25% increase in PSA) through the week 8 study period. Anti-PSA antibodies were not induced with therapy: however, anti-vaccinia titers increased in all patients. Conclusion: This study demonstrated that vaccination with PROSTVAC-V and PROSTVAC-F combined with TRICOM is well-tolerated and generated an immune response to vaccinia. Therefore, PROSTVAC-VF/TRICOM represents a feasible therapeutic approach for further phase II and III study in patients with prostate cancer
Storage of lyophilized cultures of Lactobacillus bulgaricus under different relative humidities and atmospheres
The viability of lyophilized cultures of Lactobacillus bulgaricus in skim milk, during storage at different temperatures, relative humidities, and atmospheres was investigated. Survival was greatest at 11% relative humidity and at 5°C. Indirect and direct evidence is presented supporting the hypothesis that membrane damage occurs during storage. Experiments on the lipid composition of the cell membrane demonstrate that changes occur with time that are probably the result of oxidation. A study on the lipid composition of the cell membrane by gas chromatography showed that the unsaturated/saturated fatty acid index changes with time during storage
Performance Evaluation of Pseudospectral Ultrasound Simulations on a Cluster of Xeon Phi Accelerators
The rapid development of novel procedures in medical ultrasonics, including treatment planning in therapeutic ultrasound and image reconstruction in photoacoustic tomography, leads to increasing demand for large-scale ultrasound simulations. However, routine execution of such simulations using traditional methods, e.g., finite difference time domain, is expensive and often considered intractable due to the computational and memory requirements. The k-space corrected pseudospectral time domain method used by the k-Wave toolbox allows for significant reductions in spatial and temporal grid resolution. These improvements are achieved at the cost of all-to-all communication, which are inherent to the multi-dimensional fast Fourier transforms. To improve data locality, reduce communication and allow efficient use of accelerators, we recently implemented a domain decomposition technique based on a local Fourier basis.
In this paper, we investigate whether it is feasible to run the distributed k-Wave implementation on the Salomon cluster equipped with 864 Intel Xeon Phi (Knight’s Corner) accelerators. The results show the immaturity of the KNC platform with issues ranging from limited support of Infiniband and LustreFS in Intel MPI on this platform to poor performance of 3D FFTs achieved by Intel MKL on the KNC architecture. Yet, we show that it is possible to achieve strong and weak scaling comparable to CPU-only platforms albeit with the runtime 1.8× to 4.3× longer. However, the accounting policy for Salomon’s accelerators is far more favorable and thus their employment reduces the computational cost significantly
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