128 research outputs found
Hematopoietic cell transplantation in severe combined immunodeficiency : The SCETIDE 2006-2014 European cohort
Publisher Copyright: © 2021 The AuthorsBackground: Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), a group of monogenic immune disorders with an otherwise fatal outcome. Objective: We performed a comprehensive multicenter analysis of genotype-specific HSCT outcome, including detailed analysis of immune reconstitution (IR) and the predictive value for clinical outcome. Methods: HSCT outcome was studied in 338 patients with genetically confirmed SCID who underwent transplantation in 2006-2014 and who were registered in the SCETIDE registry. In a representative subgroup of 152 patients, data on IR and long-term clinical outcome were analyzed. Results: Two-year OS was similar with matched family and unrelated donors and better than mismatched donor HSCT (P 0.5 × 10e3/μL at +1 year were identified as independent predictors of favorable clinical and immunologic outcome. Conclusion: Recent advances in HSCT in SCID patients have resulted in improved OS and EFS in all genotypes and donor types. To achieve a favorable long-term outcome, treatment strategies should aim for optimal naive CD4 T lymphocyte regeneration.Peer reviewe
Hematopoietic stem cell transplantation for CD40 ligand deficiency : results from an EBMT/ESID-IEWP-SCETIDE-PIDTC Study
Suivi du cancer du sein par le médecin généraliste
In Belgium, breast cancer is the most frequent women's cancer accounting for to 35.3 % of the cases. In 2013, 10,778 newly diagnosed breast cancers have been reported in Belgium. Breast cancer has a relatively good prognosis with a 5 year overall survival of 88 %. Survival will be different regarding the subtype and stage at diagnosis. The review of the literature and the guidelines from ESMO and ASCO regarding the follow-up of patients with early breast cancer will be used as references. International guidelines recommend clinical visits (frequencies depending of the subtypes of breast cancer) with an annual mammography associated with an echography. MRI Imaging should be performed in " at risk " patients. A more extensive exploration should be proceede when a relapse is suspected during follow up. Indeed, studies have shown that intensive follow-up with several additional exams detect more recurrences without any impact on overall survival and lead to anxiety. The follow-up of patients treated for breast cancer has several objectives-Detect a local recurrence or a second tumor ;-Diagnosis of a distant relapse ;-Detect side effects of treatment ;-Psycho-social impact of the disease and improve the quality of life.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Le cancer du sein au masculin.
From 1974 till 1993, 9 patients have been treated in our Hospital for a breast cancer. Compared with the amount of women breast cancers treated, actually near 300 per year, this 0.3% figure seems small, and is lower than that found in the literature (1%). The therapeutic attitude is the same as that proposed for women. The follow-up varied from 9 to 120 months with a mean of 57. Five patients are actually still living without recurrence. One patient presented a local recurrence, one was lost sight off and two died from their cancer. Despite the fact that it was a small group of patients we can say that the symptoms, the clinical staging, the proposed treatments and the survival rate are the same as found in the literature.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Préserver pour la postérité : des anciens de l’ethnie bundjalung au musée national d’ethnologie des Pays-Bas1
Approche diagnostique et thérapeutique minimaliste des cancers du sein débutant
info:eu-repo/semantics/publishe
Detection of specific antinuclear reactivities in patients with negative anti-nuclear antibody immunofluorescence screening tests.
Detection and identification of antinuclear antibodies (ANA) in a large and consecutive cohort of serum samples referred for ANA testing.
Mise au point: cancer du sein et grossesse. Revue de la littérature.
The pregnancy-associated breast cancer seems to have become increasingly common with a high frequency of advanced breast cancer with axillary node metastases and so associated with poor prognosis.English AbstractJournal ArticleReviewSCOPUS: re.jinfo:eu-repo/semantics/publishe
Le carcinome métaplasique mammaire: revue de la littérature illustrée de 4 cas
info:eu-repo/semantics/publishe
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